{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:06:01Z","timestamp":1791828361708,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,21]]},"DOI":"10.7759\/cureus.69840","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T11:07:59Z","timestamp":1726916879000},"source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial Activity of Euphorbia helioscopia L. Against Methicillin-Resistant Staphylococcus aureus (MRSA) In Vitro"],"prefix":"10.7759","author":[{"given":"Tautvydas","family":"Ribinskas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astra","family":"Vitkauskiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Kareiviene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusta","family":"Zevzikoviene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"","year":"2019","unstructured":"Thirteenth General Programme of Work 2019-2023. World Health Organization, Geneva, Switzerland; 2019. https.\/\/iris.who.int\/bitstream\/handle\/10665\/324775\/WHO-PRP-18.1-eng.pdf?sequence=1."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555819972.ch21","article-title":"Staphylococcus aureus","author":"Park JY","year":"2019","unstructured":"Park JY, Seo KS. Staphylococcus aureus. Food Microbiology: Fundamentals and Frontiers. Doyle PM, Diez-Gonzalez F, Hill C (ed): Wiley, Hoboken (NJ); 2019. 555-84. 10.1128\/9781555819972.ch21"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner NA","year":"2019","unstructured":"Turner NA, Sharma-Kuinkel BK, Maskarinec SA, et al.. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research. Nat Rev Microbiol. 2019, 17:203-18. 10.1038\/s41579-018-0147-4","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1252-9","article-title":"Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice","volume":"18","author":"Harkins CP","year":"2017","unstructured":"Harkins CP, Pichon B, Doumith M, et al.. Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice. Genome Biol. 2017, 18:130. 10.1186\/s13059-017-1252-9","journal-title":"Genome Biol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11050606","article-title":"Recent developments in methicillin-resistant Staphylococcus aureus (MRSA) treatment: a review","volume":"11","author":"Nandhini P","year":"2022","unstructured":"Nandhini P, Kumar P, Mickymaray S, Alothaim AS, Somasundaram J, Rajan M. Recent developments in methicillin-resistant Staphylococcus aureus (MRSA) treatment: a review. Antibiotics (Basel). 2022, 11:606. 10.3390\/antibiotics11050606","journal-title":"Antibiotics (Basel)"},{"key":"ref6","unstructured":"Proportion of bloodstream infection due to methicillin-resistant Staphylococcus aureus (MRSA) (%). (2023). Accessed. August 21, 2024: https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator-details\/GHO\/sdg-3.d.2-amr-infect-mrsa."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/proceedings2019040032","article-title":"Natural products in clinical trials","volume":"40","author":"Yerer MB","year":"2019","unstructured":"Yerer MB. Natural products in clinical trials. Proceedings. 2019, 40:32. 10.3390\/proceedings2019040032","journal-title":"Proceedings"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153626","article-title":"Antibacterial plant compounds, extracts and essential oils: an updated review on their effects and putative mechanisms of action","volume":"90","author":"\u00c1lvarez-Mart\u00ednez FJ","year":"2021","unstructured":"\u00c1lvarez-Mart\u00ednez FJ, Barraj\u00f3n-Catal\u00e1n E, Herranz-L\u00f3pez M, Micol V. Antibacterial plant compounds, extracts and essential oils: an updated review on their effects and putative mechanisms of action. Phytomedicine. 2021, 90:153626. 10.1016\/j.phymed.2021.153626","journal-title":"Phytomedicine"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000044","article-title":"Plant polyphenols: chemical properties, biological activities, and synthesis","volume":"50","author":"Quideau S","year":"2011","unstructured":"Quideau S, Deffieux D, Douat-Casassus C, Pouys\u00e9gu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl. 2011, 50:586-621. 10.1002\/anie.201000044","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref10","article-title":"Polyphenols, dietary sources and bioavailability","volume":"43","author":"D'Archivio M","year":"2007","unstructured":"D'Archivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita. 2007, 43:348-61.","journal-title":"Ann Ist Super Sanita"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14062202","article-title":"Phenolics: from chemistry to biology","volume":"14","author":"Pereira DM","year":"2009","unstructured":"Pereira DM, Valent\u00e3o P, Pereira JA, Andrade PB. Phenolics: from chemistry to biology. Molecules. 2009, 14:2202-11. 10.3390\/molecules14062202","journal-title":"Molecules"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12814","article-title":"Effect of phenolic compounds on the growth of selected probiotic and pathogenic bacteria","volume":"66","author":"Pacheco-Ordaz R","year":"2018","unstructured":"Pacheco-Ordaz R, Wall-Medrano A, Go\u00f1i MG, Ramos-Clamont-Montfort G, Ayala-Zavala JF, Gonz\u00e1lez-Aguilar GA. Effect of phenolic compounds on the growth of selected probiotic and pathogenic bacteria. Lett Appl Microbiol. 2018, 66:25-31. 10.1111\/lam.12814","journal-title":"Lett Appl Microbiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00840-13","article-title":"Uncovering the Lactobacillus plantarum WCFS1 gallate decarboxylase involved in tannin degradation","volume":"79","author":"Jim\u00e9nez N","year":"2013","unstructured":"Jim\u00e9nez N, Curiel JA, Rever\u00f3n I, de Las Rivas B, Mu\u00f1oz R. Uncovering the Lactobacillus plantarum WCFS1 gallate decarboxylase involved in tannin degradation. Appl Environ Microbiol. 2013, 79:4253-63. 10.1128\/AEM.00840-13","journal-title":"Appl Environ Microbiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008397506963","article-title":"Microbial degradation of tannins - a current perspective","volume":"9","author":"Bhat TK","year":"1998","unstructured":"Bhat TK, Singh B, Sharma OP. Microbial degradation of tannins - a current perspective. Biodegradation. 1998, 9:343-57. 10.1023\/a:1008397506963","journal-title":"Biodegradation"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cofs.2016.02.002","article-title":"Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects","volume":"8","author":"Zhang H","year":"2016","unstructured":"Zhang H, Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci. 2016, 8:33-42. 10.1016\/j.cofs.2016.02.002","journal-title":"Curr Opin Food Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.31080\/ASNH.2020.04.0659","article-title":"Antioxidant enzymes and their role in preventing cell damage","volume":"4(3)","author":"Bratovcic A","year":"2020","unstructured":"Bratovcic A. Antioxidant enzymes and their role in preventing cell damage. Act Sci Nutr Health. 2020, 4(3):132-8. 10.31080\/ASNH.2020.04.0659","journal-title":"Act Sci Nutr Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00519","article-title":"Macrocyclic diterpenoids from Euphorbia helioscopia and their potential anti-inflammatory activity","volume":"82","author":"Su JC","year":"2019","unstructured":"Su JC, Cheng W, Song JG, et al.. Macrocyclic diterpenoids from Euphorbia helioscopia and their potential anti-inflammatory activity. J Nat Prod. 2019, 82:2818-27. 10.1021\/acs.jnatprod.9b00519","journal-title":"J Nat Prod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12338","article-title":"Acute irritant bullous contact dermatitis caused by Euphorbia helioscopia","volume":"72","author":"Almi\u015f H","year":"2015","unstructured":"Almi\u015f H, Bucak IH, Tekin M, Konca \u00c7, Turgut M. Acute irritant bullous contact dermatitis caused by Euphorbia helioscopia. Contact Dermatitis. 2015, 72:184-5. 10.1111\/cod.12338","journal-title":"Contact Dermatitis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112649","article-title":"Euphorbia helioscopia L.: a phytochemical and pharmacological overview","volume":"184","author":"Yang Y","year":"2021","unstructured":"Yang Y, Chen X, Luan F, Wang M, Wang Z, Wang J, He X. Euphorbia helioscopia L.: a phytochemical and pharmacological overview. Phytochemistry. 2021, 184:112649. 10.1016\/j.phytochem.2020.112649","journal-title":"Phytochemistry"},{"key":"ref20","article-title":"In vitro antibacterial and antifungal activities of different solvent extracted samples from the stem of Euphorbia heliscopia","volume":"30","author":"Bakht J","year":"2017","unstructured":"Bakht J, Faiza -, Shafi M, Iqbal A. In vitro antibacterial and antifungal activities of different solvent extracted samples from the stem of Euphorbia heliscopia. Pak J Pharm Sci. 2017, 30:1371-6.","journal-title":"Pak J Pharm Sci"},{"key":"ref21","article-title":"Antioxidant proprieties of methanolic and ethanolic extracts of Euphorbia helioscopia, (L.) aerial parts","volume":"19","author":"Maoulainine BM","year":"2012","unstructured":"Maoulainine BM, Jelassi A, Hassen I, Ould OM, Boukhari A. Antioxidant proprieties of methanolic and ethanolic extracts of Euphorbia helioscopia, (L.) aerial parts. Int Food Res J. 2012, 19:1125-30.","journal-title":"Int Food Res J"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1388-1","article-title":"Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum","volume":"8","author":"Iloki-Assanga SB","year":"2015","unstructured":"Iloki-Assanga SB, Lewis-Luj\u00e1n LM, Lara-Espinoza CL, Gil-Salido AA, Fernandez-Angulo D, Rubio-Pino JL, Haines DD. Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum. BMC Res Notes. 2015, 8:396. 10.1186\/s13104-015-1388-1","journal-title":"BMC Res Notes"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent","volume":"299","author":"Singleton VL","year":"1999","unstructured":"Singleton VL, Orthofer R, Lamuela-Ravent\u00f3s RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 1999, 299:152-78. 10.1016\/S0076-6879(99)99017-1","journal-title":"Methods Enzymol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2174\/157340108785133301","article-title":"Analysis of phenolic acids in propolis using the high-performance liquid chromatography technique","volume":"4","author":"Ramanauskiene K","year":"2008","unstructured":"Ramanauskiene K, Savickas A, Ivanauskas L, et al.. Analysis of phenolic acids in propolis using the high-performance liquid chromatography technique. Curr Nutr Food Sci. 2008, 4:209-12. 10.2174\/157340108785133301","journal-title":"Curr Nutr Food Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.138198","article-title":"Natural phenolic compounds: antimicrobial properties, antimicrobial mechanisms, and potential utilization in the preservation of aquatic products","volume":"440","author":"Chen X","year":"2024","unstructured":"Chen X, Lan W, Xie J. Natural phenolic compounds: antimicrobial properties, antimicrobial mechanisms, and potential utilization in the preservation of aquatic products. Food Chem. 2024, 440:138198. 10.1016\/j.foodchem.2023.138198","journal-title":"Food Chem"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1074559","article-title":"The effects of antibiotics combined with natural polyphenols against clinical methicillin-resistant Staphylococcus aureus (MRSA)","volume":"74","author":"Lin RD","year":"2008","unstructured":"Lin RD, Chin YP, Hou WC, Lee MH. The effects of antibiotics combined with natural polyphenols against clinical methicillin-resistant Staphylococcus aureus (MRSA). Planta Med. 2008, 74:840-6. 10.1055\/s-2008-1074559","journal-title":"Planta Med"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.992","article-title":"Glycosylated flavones as selective inhibitors of topoisomerase IV","volume":"41","author":"Bernard FX","year":"1997","unstructured":"Bernard FX, Sabl\u00e9 S, Cameron B, Provost J, Desnottes JF, Crouzet J, Blanche F. Glycosylated flavones as selective inhibitors of topoisomerase IV. Antimicrob Agents Chemother. 1997, 41:992-8. 10.1128\/AAC.41.5.992","journal-title":"Antimicrob Agents Chemother"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2016.12.003","article-title":"Phytochemicals for human disease: an update on plant-derived compounds antibacterial activity","volume":"196","author":"Barbieri R","year":"2017","unstructured":"Barbieri R, Coppo E, Marchese A, Daglia M, Sobarzo-S\u00e1nchez E, Nabavi SF, Nabavi SM. Phytochemicals for human disease: an update on plant-derived compounds antibacterial activity. Microbiol Res. 2017, 196:44-68. 10.1016\/j.micres.2016.12.003","journal-title":"Microbiol Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102321","article-title":"Phenolic compounds diminish antibiotic resistance of Staphylococcus aureus clinical strains","volume":"15","author":"Miklasi\u0144ska-Majdanik M","year":"2018","unstructured":"Miklasi\u0144ska-Majdanik M, K\u0119pa M, Wojtyczka RD, Idzik D, W\u0105sik TJ. Phenolic compounds diminish antibiotic resistance of Staphylococcus aureus clinical strains. Int J Environ Res Public Health. 2018, 15:2321. 10.3390\/ijerph15102321","journal-title":"Int J Environ Res Public Health"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X20953249","article-title":"Chemical composition and antimicrobial activity of the essential oil from Euphorbia helioscopia L","volume":"15","author":"Zhu Q","year":"2020","unstructured":"Zhu Q, Jiang ML, Shao F, Ma GQ, Shi Q, Liu RH. Chemical composition and antimicrobial activity of the essential oil from Euphorbia helioscopia L. Nat Prod Commun. 2020, 15:10.1177\/1934578X20953249","journal-title":"Nat Prod Commun"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-012-0283-1","article-title":"Anthelmintic and antimicrobial activity of methanolic and aqueous extracts of Euphorbia helioscopia L","volume":"45","author":"Lone BA","year":"2013","unstructured":"Lone BA, Bandh SA, Chishti MZ, Bhat FA, Tak H, Nisa H. Anthelmintic and antimicrobial activity of methanolic and aqueous extracts of Euphorbia helioscopia L. Trop Anim Health Prod. 2013, 45:743-9. 10.1007\/s11250-012-0283-1","journal-title":"Trop Anim Health Prod"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03237-x","article-title":"Efficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts","volume":"21","author":"Mustafa I","year":"2021","unstructured":"Mustafa I, Faisal MN, Hussain G, et al.. Efficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts. BMC Complement Med Ther. 2021, 21:62. 10.1186\/s12906-021-03237-x","journal-title":"BMC Complement Med Ther"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(17)30103-6","article-title":"Advances in extraction and analysis of phenolic compounds from plant materials","volume":"15","author":"Xu CC","year":"2017","unstructured":"Xu CC, Wang B, Pu YQ, Tao JS, Zhang T. Advances in extraction and analysis of phenolic compounds from plant materials. Chin J Nat Med. 2017, 15:721-31. 10.1016\/S1875-5364(17)30103-6","journal-title":"Chin J Nat Med"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02158-6","article-title":"A metabolomics approach to evaluate the effect of lyophilization versus oven drying on the chemical composition of plant extracts","volume":"11","author":"ElNaker NA","year":"2021","unstructured":"ElNaker NA, Daou M, Ochsenk\u00fchn MA, Amin SA, Yousef AF, Yousef LF. A metabolomics approach to evaluate the effect of lyophilization versus oven drying on the chemical composition of plant extracts. Sci Rep. 2021, 11:22679. 10.1038\/s41598-021-02158-6","journal-title":"Sci Rep"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2014.03.001","article-title":"Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L","volume":"181","author":"Cateni F","year":"2014","unstructured":"Cateni F, Zilic J, Altieri T, et al.. Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L. Chem Phys Lipids. 2014, 181:90-8. 10.1016\/j.chemphyslip.2014.03.001","journal-title":"Chem Phys Lipids"},{"key":"ref36","article-title":"Screening of plant extracts for antioxidant properties","volume":"35","author":"Nikolova M","year":"2011","unstructured":"Nikolova M, Evstatieva L, Nguyen DT. Screening of plant extracts for antioxidant properties. Bot Serb. 2011, 35:43-8.","journal-title":"Bot Serb"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60260-1","article-title":"Investigation of in vivo antioxidant activity of Euphorbia helioscopia latex and leaves methanol extract: a target against oxidative stress induced toxicity","volume":"7S1","author":"Saleem U","year":"2014","unstructured":"Saleem U, Ahmad B, Ahmad M, Hussain K, Bukhari NI. Investigation of in vivo antioxidant activity of Euphorbia helioscopia latex and leaves methanol extract: a target against oxidative stress induced toxicity. Asian Pac J Trop Med. 2014, 7S1:S369-75. 10.1016\/S1995-7645(14)60260-1","journal-title":"Asian Pac J Trop Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/292382-antimicrobial-activity-of-euphorbia-helioscopia-l-against-methicillin-resistant-staphylococcus-aureus-mrsa-in-vitro","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T11:08:01Z","timestamp":1726916881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/292382-antimicrobial-activity-of-euphorbia-helioscopia-l-against-methicillin-resistant-staphylococcus-aureus-mrsa-in-vitro"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":37,"URL":"https:\/\/doi.org\/10.7759\/cureus.69840","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,21]]}}}