{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:56:35Z","timestamp":1767182195962},"reference-count":101,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,23]]},"DOI":"10.7759\/cureus.70005","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T16:12:19Z","timestamp":1727107939000},"source":"Crossref","is-referenced-by-count":1,"title":["Exploring Aspirin\u2019s Potential in Cancer Prevention: A Comprehensive Review of the Current Evidence"],"prefix":"10.7759","author":[{"given":"Carla Isabella","family":"Miret Durazo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephin","family":"Zachariah Saji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada L","family":"Moti\u00f1o Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tutut","family":"Nurjanah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niharika","family":"Ryali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael Germ\u00e1n","family":"Zepeda Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josue A","family":"Cruz Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.10.008","article-title":"The first 3500\u202fyears of aspirin history from its roots - a concise summary","volume":"113","author":"Montinari MR","year":"2019","unstructured":"Montinari MR, Minelli S, De Caterina R. The first 3500\u202fyears of aspirin history from its roots - a concise summary. Vascul Pharmacol. 2019, 113:1-8. 10.1016\/j.vph.2018.10.008","journal-title":"Vascul Pharmacol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/173124","article-title":"Aspirin: pharmacology and clinical applications","volume":"2012","author":"Paez Espinosa EV","year":"2012","unstructured":"Paez Espinosa EV, Murad JP, Khasawneh FT. Aspirin: pharmacology and clinical applications. Thrombosis. 2012, 2012:173124. 10.1155\/2012\/173124","journal-title":"Thrombosis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12728","article-title":"Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid","volume":"12","author":"Undas A","year":"2014","unstructured":"Undas A, Brummel-Ziedins K, Mann KG. Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid. J Thromb Haemost. 2014, 12:1776-87. 10.1111\/jth.12728","journal-title":"J Thromb Haemost"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.501","article-title":"Aspirin for primary prevention of cardiovascular\u00a0events","volume":"73","author":"Abdelaziz HK","year":"2019","unstructured":"Abdelaziz HK, Saad M, Pothineni NV, et al.. Aspirin for primary prevention of cardiovascular\u00a0events. J Am Coll Cardiol. 2019, 73:2915-29. 10.1016\/j.jacc.2019.03.501","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.220124","article-title":"Aspirin and cancer: biological mechanisms and clinical outcomes","volume":"12","author":"Elwood P","year":"2022","unstructured":"Elwood P, Protty M, Morgan G, Pickering J, Delon C, Watkins J. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biol. 2022, 12:220124. 10.1098\/rsob.220124","journal-title":"Open Biol"},{"key":"ref6","unstructured":"Global cancer burden growing, amidst mounting need for services. (2024). Accessed. August 30, 2024: https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7150\/jca.49001","article-title":"Long-term aspirin use for primary cancer prevention: an updated systematic review and subgroup meta-analysis of 29 randomized clinical trials","volume":"11","author":"Wu Q","year":"2020","unstructured":"Wu Q, Yao X, Chen H, et al.. Long-term aspirin use for primary cancer prevention: an updated systematic review and subgroup meta-analysis of 29 randomized clinical trials. J Cancer. 2020, 11:6460-73. 10.7150\/jca.49001","journal-title":"J Cancer"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa114","article-title":"Effect of aspirin on cancer incidence and mortality in older adults","volume":"113","author":"McNeil JJ","year":"2021","unstructured":"McNeil JJ, Gibbs P, Orchard SG, et al.. Effect of aspirin on cancer incidence and mortality in older adults. J Natl Cancer Inst. 2021, 113:258-65. 10.1093\/jnci\/djaa114","journal-title":"J Natl Cancer Inst"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4156-5","article-title":"Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies","volume":"18","author":"Qiao Y","year":"2018","unstructured":"Qiao Y, Yang T, Gan Y, Li W, Wang C, Gong Y, Lu Z. Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies. BMC Cancer. 2018, 18:288. 10.1186\/s12885-018-4156-5","journal-title":"BMC Cancer"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01900","article-title":"Modification of the association between frequent aspirin use and ovarian cancer risk: a meta-analysis using individual-level data from two ovarian cancer consortia","volume":"40","author":"Hurwitz LM","year":"2022","unstructured":"Hurwitz LM, Townsend MK, Jordan SJ, et al.. Modification of the association between frequent aspirin use and ovarian cancer risk: a meta-analysis using individual-level data from two ovarian cancer consortia. J Clin Oncol. 2022, 40:4207-17. 10.1200\/JCO.21.01900","journal-title":"J Clin Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.05.015","article-title":"Prophylactic aspirin intake and breast cancer risk; a systematic review and meta-analysis of observational cohort studies","volume":"49","author":"Bakierzynska M","year":"2023","unstructured":"Bakierzynska M, Cullinane MC, Redmond HP, Corrigan M. Prophylactic aspirin intake and breast cancer risk; a systematic review and meta-analysis of observational cohort studies. Eur J Surg Oncol. 2023, 49:106940. 10.1016\/j.ejso.2023.05.015","journal-title":"Eur J Surg Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51422","article-title":"Ten steps to conduct a systematic review","volume":"15","author":"Calderon Martinez E","year":"2023","unstructured":"Calderon Martinez E, Flores Vald\u00e9s JR, Castillo JL, et al.. Ten steps to conduct a systematic review. Cureus. 2023, 15:e51422. 10.7759\/cureus.51422","journal-title":"Cureus"},{"key":"ref13","article-title":"Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study","volume":"48","author":"Kune GA","year":"1988","unstructured":"Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res. 1988, 48:4399-404.","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112053252301","article-title":"Aspirin use and reduced risk of fatal colon cancer","volume":"325","author":"Thun MJ","year":"1991","unstructured":"Thun MJ, Namboodiri MM, Heath CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med. 1991, 325:1593-6. 10.1056\/NEJM199112053252301","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.289","article-title":"Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?","volume":"105","author":"Langley RE","year":"2011","unstructured":"Langley RE, Burdett S, Tierney JF, Cafferty F, Parmar MK, Venning G. Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?. Br J Cancer. 2011, 105:1107-13. 10.1038\/bjc.2011.289","journal-title":"Br J Cancer"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.8381548","article-title":"Signal transduction: from the molecular to the functional [Book in Spanish]","author":"Sampieri-Cabrera R","year":"2023","unstructured":"Sampieri-Cabrera R, Calder\u00f3n-Mart\u00ednez E. Signal transduction: from the molecular to the functional [Book in Spanish]. UNAM, Mexico City, Mexico; 2023. 10.5281\/zenodo.8381548"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_56_18","article-title":"Inflammation and cancer","volume":"18","author":"Singh N","year":"2019","unstructured":"Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019, 18:121-6. 10.4103\/aam.aam_56_18","journal-title":"Ann Afr Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-21-0572","article-title":"The COX-2-PGE2 pathway promotes tumor evasion in colorectal adenomas","volume":"15","author":"Wei J","year":"2022","unstructured":"Wei J, Zhang J, Wang D, Cen B, Lang JD, DuBois RN. The COX-2-PGE2 pathway promotes tumor evasion in colorectal adenomas. Cancer Prev Res (Phila). 2022, 15:285-96. 10.1158\/1940-6207.CAPR-21-0572","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12580","article-title":"Oncogenic Ras mutant causes the hyperactivation of NF-\u03baB via acceleration of its transcriptional activation","volume":"13","author":"Tago K","year":"2019","unstructured":"Tago K, Funakoshi-Tago M, Ohta S, et al.. Oncogenic Ras mutant causes the hyperactivation of NF-\u03baB via acceleration of its transcriptional activation. Mol Oncol. 2019, 13:2493-510. 10.1002\/1878-0261.12580","journal-title":"Mol Oncol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20331","article-title":"Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition","volume":"66","author":"Narayanan BA","year":"2006","unstructured":"Narayanan BA, Narayanan NK, Pttman B, Reddy BS. Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition. Prostate. 2006, 66:257-65. 10.1002\/pros.20331","journal-title":"Prostate"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0318-9","article-title":"COX-2 mediates pro-tumorigenic effects of PKC\u03b5 in prostate cancer","volume":"37","author":"Garg R","year":"2018","unstructured":"Garg R, Blando JM, Perez CJ, et al.. COX-2 mediates pro-tumorigenic effects of PKC\u03b5 in prostate cancer. Oncogene. 2018, 37:4735-49. 10.1038\/s41388-018-0318-9","journal-title":"Oncogene"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.519","article-title":"Roles of reactive oxygen species in inflammation and cancer","volume":"5","author":"Yu Y","year":"2024","unstructured":"Yu Y, Liu S, Yang L, et al.. Roles of reactive oxygen species in inflammation and cancer. MedComm (2020). 2024, 5:e519. 10.1002\/mco2.519","journal-title":"MedComm (2020)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121985","article-title":"Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1\/thromboxane A2","volume":"129","author":"Lucotti S","year":"2019","unstructured":"Lucotti S, Cerutti C, Soyer M, et al.. Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1\/thromboxane A2. J Clin Invest. 2019, 129:1845-62. 10.1172\/JCI121985","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.050","article-title":"Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells","volume":"142","author":"Din FV","year":"2012","unstructured":"Din FV, Valanciute A, Houde VP, et al.. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 2012, 142:1504-15.e3. 10.1053\/j.gastro.2012.02.050","journal-title":"Gastroenterology"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2023.00155","article-title":"Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer","volume":"4","author":"Hoskin AJ","year":"2023","unstructured":"Hoskin AJ, Holt AK, Legge DN, Collard TJ, Williams AC, Vincent EE. Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer. Explor Target Antitumor Ther. 2023, 4:600-15. 10.37349\/etat.2023.00155","journal-title":"Explor Target Antitumor Ther"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines5030043","article-title":"Aspirin prevention of colorectal cancer: focus on NF-\u03baB signalling and the nucleolus","volume":"5","author":"Chen J","year":"2017","unstructured":"Chen J, Stark LA. Aspirin prevention of colorectal cancer: focus on NF-\u03baB signalling and the nucleolus. Biomedicines. 2017, 5:43. 10.3390\/biomedicines5030043","journal-title":"Biomedicines"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt009","article-title":"Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma","volume":"34","author":"Carlson LM","year":"2013","unstructured":"Carlson LM, Rasmuson A, Idborg H, Segerstr\u00f6m L, Jakobsson PJ, Sveinbj\u00f6rnsson B, Kogner P. Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. Carcinogenesis. 2013, 34:1081-8. 10.1093\/carcin\/bgt009","journal-title":"Carcinogenesis"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2881","article-title":"Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis","volume":"9","author":"Rohwer N","year":"2020","unstructured":"Rohwer N, K\u00fchl AA, Ostermann AI, et al.. Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. Cancer Med. 2020, 9:2535-50. 10.1002\/cam4.2881","journal-title":"Cancer Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00181","article-title":"COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs","volume":"3","author":"Gurpinar E","year":"2013","unstructured":"Gurpinar E, Grizzle WE, Piazza GA. COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs. Front Oncol. 2013, 3:181. 10.3389\/fonc.2013.00181","journal-title":"Front Oncol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-020-01357-2","article-title":"Associations between daily aspirin use and cancer risk across strata of major cancer risk factors in two large U.S. cohorts","volume":"32","author":"Hurwitz LM","year":"2021","unstructured":"Hurwitz LM, Michels KA, Cook MB, Pfeiffer RM, Trabert B. Associations between daily aspirin use and cancer risk across strata of major cancer risk factors in two large U.S. cohorts. Cancer Causes Control. 2021, 32:57-65. 10.1007\/s10552-020-01357-2","journal-title":"Cancer Causes Control"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13857","article-title":"Systematic review with meta-analysis: the comparative effectiveness of aspirin vs. screening for colorectal cancer prevention","volume":"45","author":"Emilsson L","year":"2017","unstructured":"Emilsson L, Holme \u00d8, Bretthauer M, et al.. Systematic review with meta-analysis: the comparative effectiveness of aspirin vs. screening for colorectal cancer prevention. Aliment Pharmacol Ther. 2017, 45:193-204. 10.1111\/apt.13857","journal-title":"Aliment Pharmacol Ther"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.690219","article-title":"Aspirin use and common cancer risk: a meta-analysis of cohort studies and randomized controlled trials","volume":"11","author":"Wang L","year":"2021","unstructured":"Wang L, Zhang R, Yu L, et al.. Aspirin use and common cancer risk: a meta-analysis of cohort studies and randomized controlled trials. Front Oncol. 2021, 11:690219. 10.3389\/fonc.2021.690219","journal-title":"Front Oncol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002695","article-title":"Low-dose aspirin and prevention of colorectal cancer: evidence from a nationwide registry-based cohort in Norway","volume":"119","author":"Nafisi S","year":"2024","unstructured":"Nafisi S, St\u00f8er NC, Veier\u00f8d MB, et al.. Low-dose aspirin and prevention of colorectal cancer: evidence from a nationwide registry-based cohort in Norway. Am J Gastroenterol. 2024, 119:1402-11. 10.14309\/ajg.0000000000002695","journal-title":"Am J Gastroenterol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-03942-1","article-title":"Meta-analysis of aspirin-guided therapy of colorectal cancer","volume":"148","author":"M\u00e4dge JC","year":"2022","unstructured":"M\u00e4dge JC, Stallmach A, Kleebusch L, Schlattmann P. Meta-analysis of aspirin-guided therapy of colorectal cancer. J Cancer Res Clin Oncol. 2022, 148:1407-17. 10.1007\/s00432-022-03942-1","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30366-4","article-title":"Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial","volume":"395","author":"Burn J","year":"2020","unstructured":"Burn J, Sheth H, Elliott F, et al.. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial. Lancet. 2020, 395:1855-63. 10.1016\/S0140-6736(20)30366-4","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021917","article-title":"Aspirin might reduce the incidence of breast cancer: an updated meta-analysis of 38 observational studies","volume":"99","author":"Cao Y","year":"2020","unstructured":"Cao Y, Tan A. Aspirin might reduce the incidence of breast cancer: an updated meta-analysis of 38 observational studies. Medicine (Baltimore). 2020, 99:e21917. 10.1097\/MD.0000000000021917","journal-title":"Medicine (Baltimore)"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01335-1","article-title":"Aspirin use and risk of breast cancer in African American women","volume":"22","author":"Bertrand KA","year":"2020","unstructured":"Bertrand KA, Bethea TN, Gerlovin H, Coogan PF, Barber L, Rosenberg L, Palmer JR. Aspirin use and risk of breast cancer in African American women. Breast Cancer Res. 2020, 22:96. 10.1186\/s13058-020-01335-1","journal-title":"Breast Cancer Res"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026870","article-title":"Effect of aspirin use on survival benefits of breast cancer patients: a meta-analysis","volume":"100","author":"Liu J","year":"2021","unstructured":"Liu J, Zheng F, Yang M, Wu X, Liu A. Effect of aspirin use on survival benefits of breast cancer patients: a meta-analysis. Medicine (Baltimore). 2021, 100:e26870. 10.1097\/MD.0000000000026870","journal-title":"Medicine (Baltimore)"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.10.044","article-title":"Low-dose aspirin use does not increase survival in 2\u00a0independent population-based cohorts of patients with\u00a0esophageal or gastric cancer","volume":"154","author":"Spence AD","year":"2018","unstructured":"Spence AD, Busby J, Johnston BT, Baron JA, Hughes CM, Coleman HG, Cardwell CR. Low-dose aspirin use does not increase survival in 2\u00a0independent population-based cohorts of patients with\u00a0esophageal or gastric cancer. Gastroenterology. 2018, 154:849-860.e1. 10.1053\/j.gastro.2017.10.044","journal-title":"Gastroenterology"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.012","article-title":"Aspirin and the risk of colorectal and other digestive tract cancers: an\u00a0updated meta-analysis through 2019","volume":"31","author":"Bosetti C","year":"2020","unstructured":"Bosetti C, Santucci C, Gallus S, Martinetti M, La Vecchia C. Aspirin and the risk of colorectal and other digestive tract cancers: an\u00a0updated meta-analysis through 2019. Ann Oncol. 2020, 31:558-68. 10.1016\/j.annonc.2020.02.012","journal-title":"Ann Oncol"},{"key":"ref41","article-title":"Aspirin use is associated with lower risk of Barrett\u2019s esophagus in women","volume":"8","author":"Jovani M","year":"2017","unstructured":"Jovani M, Cao Y, Feskanich D, et al.. Aspirin use is associated with lower risk of Barrett\u2019s esophagus in women. Clin Transl Gastroenterol. 2017, 8:e131.","journal-title":"Clin Transl Gastroenterol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0703-4","article-title":"Aspirin use and the risk of prostate cancer: a meta-analysis of 24 epidemiologic studies","volume":"46","author":"Huang TB","year":"2014","unstructured":"Huang TB, Yan Y, Guo ZF, et al.. Aspirin use and the risk of prostate cancer: a meta-analysis of 24 epidemiologic studies. Int Urol Nephrol. 2014, 46:1715-28. 10.1007\/s11255-014-0703-4","journal-title":"Int Urol Nephrol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133518","article-title":"The effect of aspirin use on incident hepatocellular carcinoma-an updated systematic review and meta-analysis","volume":"15","author":"Abdelmalak J","year":"2023","unstructured":"Abdelmalak J, Tan N, Con D, Eslick G, Majeed A, Kemp W, Roberts SK. The effect of aspirin use on incident hepatocellular carcinoma-an updated systematic review and meta-analysis. Cancers (Basel). 2023, 15:3518. 10.3390\/cancers15133518","journal-title":"Cancers (Basel)"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39436","article-title":"Aminotransferases in relation to the severity of dengue: a systematic review","volume":"15","author":"Kalluru PK","year":"2023","unstructured":"Kalluru PK, Mamilla M, Valisekka SS, et al.. Aminotransferases in relation to the severity of dengue: a systematic review. Cureus. 2023, 15:e39436. 10.7759\/cureus.39436","journal-title":"Cureus"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47608","article-title":"Impact of silymarin supplements on liver enzyme levels: a systematic review","volume":"15","author":"Calderon Martinez E","year":"2023","unstructured":"Calderon Martinez E, Herrera D, Mogan S, et al.. Impact of silymarin supplements on liver enzyme levels: a systematic review. Cureus. 2023, 15:e47608. 10.7759\/cureus.47608","journal-title":"Cureus"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v15.i8.939","article-title":"Liver transplant in primary sclerosing cholangitis: current trends and future directions","volume":"15","author":"Shah YR","year":"2023","unstructured":"Shah YR, Nombera-Aznaran N, Guevara-Lazo D, et al.. Liver transplant in primary sclerosing cholangitis: current trends and future directions. World J Hepatol. 2023, 15:939-53. 10.4254\/wjh.v15.i8.939","journal-title":"World J Hepatol"},{"key":"ref47","unstructured":"Asp-PSC. effect of aspirin on reducing cancer & improving outcomes in primary sclerosing cholangitis. (2023). Accessed: August 30, 2024: https:\/\/www.isrctn.com\/ISRCTN12358813."},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-023-03556-7","article-title":"Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies","volume":"79","author":"Ma S","year":"2023","unstructured":"Ma S, Xia W, Wu B, et al.. Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies. Eur J Clin Pharmacol. 2023, 79:1475-503. 10.1007\/s00228-023-03556-7","journal-title":"Eur J Clin Pharmacol"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912035","article-title":"Association of aspirin with hepatocellular carcinoma and liver-related mortality","volume":"382","author":"Simon TG","year":"2020","unstructured":"Simon TG, Duberg AS, Aleman S, Chung RT, Chan AT, Ludvigsson JF. Association of aspirin with hepatocellular carcinoma and liver-related mortality. N Engl J Med. 2020, 382:1018-28. 10.1056\/NEJMoa1912035","journal-title":"N Engl J Med"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.203000","article-title":"Effect of aspirin and NSAIDs on risk and survival from colorectal cancer","volume":"59","author":"Din FV","year":"2010","unstructured":"Din FV, Theodoratou E, Farrington SM, et al.. Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut. 2010, 59:1670-9. 10.1136\/gut.2009.203000","journal-title":"Gut"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170775","article-title":"The influence of BRAF and KRAS mutation status on the association between aspirin use and survival after colon cancer diagnosis","volume":"12","author":"Frouws MA","year":"2017","unstructured":"Frouws MA, Reimers MS, Swets M, et al.. The influence of BRAF and KRAS mutation status on the association between aspirin use and survival after colon cancer diagnosis. PLoS One. 2017, 12:e0170775. 10.1371\/journal.pone.0170775","journal-title":"PLoS One"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1112","article-title":"Aspirin use and survival after diagnosis of colorectal cancer","volume":"302","author":"Chan AT","year":"2009","unstructured":"Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009, 302:649-58. 10.1001\/jama.2009.1112","journal-title":"JAMA"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials","volume":"13","author":"Algra AM","year":"2012","unstructured":"Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 2012, 13:518-27. 10.1016\/S1470-2045(12)70112-2","journal-title":"Lancet Oncol"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkab067","article-title":"Timing of aspirin use among patients with colorectal cancer in relation to mortality: a systematic review and meta-analysis","volume":"5","author":"Xiao S","year":"2021","unstructured":"Xiao S, Xie W, Fan Y, Zhou L. Timing of aspirin use among patients with colorectal cancer in relation to mortality: a systematic review and meta-analysis. JNCI Cancer Spectr. 2021, 5:pkab067. 10.1093\/jncics\/pkab067","journal-title":"JNCI Cancer Spectr"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.511","article-title":"Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer","volume":"174","author":"Reimers MS","year":"2014","unstructured":"Reimers MS, Bastiaannet E, Langley RE, et al.. Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer. JAMA Intern Med. 2014, 174:732-9. 10.1001\/jamainternmed.2014.511","journal-title":"JAMA Intern Med"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.101","article-title":"Use of aspirin postdiagnosis improves survival for colon cancer patients","volume":"106","author":"Bastiaannet E","year":"2012","unstructured":"Bastiaannet E, Sampieri K, Dekkers OM, et al.. Use of aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer. 2012, 106:1564-70. 10.1038\/bjc.2012.101","journal-title":"Br J Cancer"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2021.1258","article-title":"Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers","volume":"15","author":"Elwood PC","year":"2021","unstructured":"Elwood PC, Morgan G, Delon C, et al.. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. Ecancermedicalscience. 2021, 15:1258. 10.3332\/ecancer.2021.1258","journal-title":"Ecancermedicalscience"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1815","article-title":"Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants","volume":"313","author":"Nan H","year":"2015","unstructured":"Nan H, Hutter CM, Lin Y, et al.. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA. 2015, 313:1133-42. 10.1001\/jama.2015.1815","journal-title":"JAMA"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","author":"Baigent C","year":"2009","unstructured":"Baigent C, Blackwell L, Collins R, et al.. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009, 373:1849-60. 10.1016\/S0140-6736(09)60503-1","journal-title":"Lancet"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-050510","article-title":"Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population-based cohort study","volume":"12","author":"Shami JJ","year":"2022","unstructured":"Shami JJ, Zhao J, Pathadka S, et al.. Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population-based cohort study. BMJ Open. 2022, 12:e050510. 10.1136\/bmjopen-2021-050510","journal-title":"BMJ Open"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldw028","article-title":"The role of aspirin in preventing colorectal cancer","volume":"119","author":"Burn J","year":"2016","unstructured":"Burn J, Sheth H. The role of aspirin in preventing colorectal cancer. Br Med Bull. 2016, 119:17-24. 10.1093\/bmb\/ldw028","journal-title":"Br Med Bull"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150915111000","article-title":"Can we select patients for colorectal cancer prevention with aspirin?","volume":"21","author":"Kraus S","year":"2015","unstructured":"Kraus S, Sion D, Arber N. Can we select patients for colorectal cancer prevention with aspirin?. Curr Pharm Des. 2015, 21:5127-34. 10.2174\/1381612821666150915111000","journal-title":"Curr Pharm Des"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-013-0351-3","article-title":"Role of aspirin in cancer prevention","volume":"15","author":"Thorat MA","year":"2013","unstructured":"Thorat MA, Cuzick J. Role of aspirin in cancer prevention. Curr Oncol Rep. 2013, 15:533-40. 10.1007\/s11912-013-0351-3","journal-title":"Curr Oncol Rep"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5402","article-title":"Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression","volume":"6","author":"Stamatakis K","year":"2015","unstructured":"Stamatakis K, Jimenez-Martinez M, Jimenez-Segovia A, et al.. Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. Oncotarget. 2015, 6:39941-59. 10.18632\/oncotarget.5402","journal-title":"Oncotarget"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008481","article-title":"Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD)","volume":"6","author":"Fink SP","year":"2014","unstructured":"Fink SP, Yamauchi M, Nishihara R, et al.. Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). Sci Transl Med. 2014, 6:233re2. 10.1126\/scitranslmed.3008481","journal-title":"Sci Transl Med"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096502","article-title":"High frequency of mutations of the PIK3CA gene in human cancers","volume":"304","author":"Samuels Y","year":"2004","unstructured":"Samuels Y, Wang Z, Bardelli A, et al.. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004, 304:554. 10.1126\/science.1096502","journal-title":"Science"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24757","article-title":"Cyclooxygenase-2 inhibition inhibits PI3K\/AKT kinase activity in epithelial ovarian cancer","volume":"126","author":"Uddin S","year":"2010","unstructured":"Uddin S, Ahmed M, Hussain A, et al.. Cyclooxygenase-2 inhibition inhibits PI3K\/AKT kinase activity in epithelial ovarian cancer. Int J Cancer. 2010, 126:382-94. 10.1002\/ijc.24757","journal-title":"Int J Cancer"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207756","article-title":"Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival","volume":"367","author":"Liao X","year":"2012","unstructured":"Liao X, Lochhead P, Nishihara R, et al.. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med. 2012, 367:1596-606. 10.1056\/NEJMoa1207756","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20972","article-title":"Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells","volume":"8","author":"Gu M","year":"2017","unstructured":"Gu M, Nishihara R, Chen Y, et al.. Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells. Oncotarget. 2017, 8:87379-89. 10.18632\/oncotarget.20972","journal-title":"Oncotarget"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004115","article-title":"Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer","volume":"10","author":"Michelakos T","year":"2022","unstructured":"Michelakos T, Kontos F, Kurokawa T, et al.. Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer. J Immunother Cancer. 2022, 10:e004115. 10.1136\/jitc-2021-004115","journal-title":"J Immunother Cancer"},{"key":"ref71","unstructured":"BioRender. (2024). Accessed. September 18, 2024: http:\/\/BioRender.com\/a62p649."},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90246-1","article-title":"Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas","volume":"107","author":"Eberhart CE","year":"1994","unstructured":"Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994, 107:1183-8. 10.1016\/0016-5085(94)90246-1","journal-title":"Gastroenterology"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01346-2","article-title":"Using aspirin to prevent and treat cancer","volume":"32","author":"Lichtenberger LM","year":"2024","unstructured":"Lichtenberger LM. Using aspirin to prevent and treat cancer. Inflammopharmacology. 2024, 32:903-8. 10.1007\/s10787-023-01346-2","journal-title":"Inflammopharmacology"},{"key":"ref74","article-title":"Aspirin for chemoprevention of colorectal adenoma and cancer [Article in Japanese]","volume":"48","author":"Ishikawa H","year":"2021","unstructured":"Ishikawa H. Aspirin for chemoprevention of colorectal adenoma and cancer [Article in Japanese]. Gan To Kagaku Ryoho. 2021, 48:1425-8.","journal-title":"Gan To Kagaku Ryoho"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25891","article-title":"Does the combined use of aspirin and immunotherapy result in better outcomes in non-small cell lung cancer than immunotherapy alone?","volume":"14","author":"Aiad M","year":"2022","unstructured":"Aiad M, Tahir A, Fresco K, et al.. Does the combined use of aspirin and immunotherapy result in better outcomes in non-small cell lung cancer than immunotherapy alone?. Cureus. 2022, 14:e25891. 10.7759\/cureus.25891","journal-title":"Cureus"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110350","article-title":"Aspirin induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer","volume":"121","author":"Lei J","year":"2023","unstructured":"Lei J, Zhou Z, Fang J, et al.. Aspirin induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer. Int Immunopharmacol. 2023, 121:110350. 10.1016\/j.intimp.2023.110350","journal-title":"Int Immunopharmacol"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2022.23.11.3801","article-title":"Aspirin restores radiosensitivity in cervical cancer cells by inducing mitotic catastrophe through downregulating G2\/M effectors","volume":"23","author":"Das S","year":"2022","unstructured":"Das S, Ray DK, Sengupta D, Mahapatra E, Biswas S, Roy M, Mukherjee S. Aspirin restores radiosensitivity in cervical cancer cells by inducing mitotic catastrophe through downregulating G2\/M effectors. Asian Pac J Cancer Prev. 2022, 23:3801-13. 10.31557\/APJCP.2022.23.11.3801","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100267","article-title":"The multiple effects of aspirin in prostate cancer patients","volume":"26","author":"Joshi SN","year":"2021","unstructured":"Joshi SN, Murphy EA, Olaniyi P, Bryant RJ. The multiple effects of aspirin in prostate cancer patients. Cancer Treat Res Commun. 2021, 26:100267. 10.1016\/j.ctarc.2020.100267","journal-title":"Cancer Treat Res Commun"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.09.027","article-title":"Functional outcomes and complications following radiation therapy for prostate cancer: a critical analysis of the literature","volume":"61","author":"Bud\u00e4us L","year":"2012","unstructured":"Bud\u00e4us L, Bolla M, Bossi A, Cozzarini C, Crook J, Widmark A, Wiegel T. Functional outcomes and complications following radiation therapy for prostate cancer: a critical analysis of the literature. Eur Urol. 2012, 61:112-27. 10.1016\/j.eururo.2011.09.027","journal-title":"Eur Urol"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30289-4","article-title":"Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial","volume":"4","author":"Joharatnam-Hogan N","year":"2019","unstructured":"Joharatnam-Hogan N, Cafferty F, Hubner R, et al.. Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. Lancet Gastroenterol Hepatol. 2019, 4:854-62. 10.1016\/S2468-1253(19)30289-4","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1172\/JCI169598","article-title":"Aspirin and immunotherapy: a Faustian bargain?","volume":"133","author":"Goethe EA","year":"2023","unstructured":"Goethe EA, Heimberger AB, Rao G. Aspirin and immunotherapy: a Faustian bargain?. J Clin Invest. 2023, 133:e169598. 10.1172\/JCI169598","journal-title":"J Clin Invest"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3310\/hta17430","article-title":"Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews","volume":"17","author":"Sutcliffe P","year":"2013","unstructured":"Sutcliffe P, Connock M, Gurung T, et al.. Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews. Health Technol Assess. 2013, 17:1-253. 10.3310\/hta17430","journal-title":"Health Technol Assess"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803955","article-title":"Effect of aspirin on all-cause mortality in the healthy elderly","volume":"379","author":"McNeil JJ","year":"2018","unstructured":"McNeil JJ, Nelson MR, Woods RL, et al.. Effect of aspirin on all-cause mortality in the healthy elderly. N Engl J Med. 2018, 379:1519-28. 10.1056\/NEJMoa1803955","journal-title":"N Engl J Med"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805819","article-title":"Effect of aspirin on cardiovascular events and bleeding in the healthy elderly","volume":"379","author":"McNeil JJ","year":"2018","unstructured":"McNeil JJ, Wolfe R, Woods RL, et al.. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. N Engl J Med. 2018, 379:1509-18. 10.1056\/NEJMoa1805819","journal-title":"N Engl J Med"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2020-000453","article-title":"Risk of lower gastrointestinal bleeding and colorectal neoplasms following initiation of low-dose aspirin: a Danish population-based cohort study","volume":"7","author":"Troelsen FS","year":"2020","unstructured":"Troelsen FS, Farkas DK, Erichsen R, S\u00f8rensen HT. Risk of lower gastrointestinal bleeding and colorectal neoplasms following initiation of low-dose aspirin: a Danish population-based cohort study. BMJ Open Gastroenterol. 2020, 7:e000453. 10.1136\/bmjgast-2020-000453","journal-title":"BMJ Open Gastroenterol"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48954","article-title":"Assessing the predictive factors for bleeding in esophageal variceal disease: a systematic review","volume":"15","author":"Guinazu C","year":"2023","unstructured":"Guinazu C, Fern\u00e1ndez Mu\u00f1oz A, Maldonado MD, De La Cruz JA, Herrera D, Arruarana VS, Calderon Martinez E. Assessing the predictive factors for bleeding in esophageal variceal disease: a systematic review. Cureus. 2023, 15:e48954. 10.7759\/cureus.48954","journal-title":"Cureus"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.09.113","article-title":"Tranexamic acid in coronary artery surgery: one-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial","volume":"157","author":"Myles PS","year":"2019","unstructured":"Myles PS, Smith JA, Kasza J, et al.. Tranexamic acid in coronary artery surgery: one-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial. J Thorac Cardiovasc Surg. 2019, 157:644-652.e9. 10.1016\/j.jtcvs.2018.09.113","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52111","article-title":"Effectiveness of tranexamic acid in trauma patients: a systematic review","volume":"16","author":"Meza Monge K","year":"2024","unstructured":"Meza Monge K, Domene SS, Diaz Mendoza DL, et al.. Effectiveness of tranexamic acid in trauma patients: a systematic review. Cureus. 2024, 16:e52111. 10.7759\/cureus.52111","journal-title":"Cureus"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.19080\/JOCCT.2023.18.555989","article-title":"An overview of the identification, prevention, and management of immunological reactions to blood transfusion","volume":"18","author":"Aggarwal P","year":"2023","unstructured":"Aggarwal P, Martinez EC, Quijano BE, et al.. An overview of the identification, prevention, and management of immunological reactions to blood transfusion. J Cardiol Cardiovasc Ther. 2023, 18:555989. 10.19080\/JOCCT.2023.18.555989","journal-title":"J Cardiol Cardiovasc Ther"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026985","article-title":"Safety of transrectal ultrasound-guided prostate biopsy in patients receiving aspirin: an update meta-analysis including 3373 patients","volume":"100","author":"Chen D","year":"2021","unstructured":"Chen D, Liu G, Xie Y, Chen C, Luo Z, Liu Y. Safety of transrectal ultrasound-guided prostate biopsy in patients receiving aspirin: an update meta-analysis including 3373 patients. Medicine (Baltimore). 2021, 100:e26985. 10.1097\/MD.0000000000026985","journal-title":"Medicine (Baltimore)"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.33588\/fem.263.1279","article-title":"Reflections on the design of an ultrasound study program in medical undergraduate","volume":"26","author":"Calder\u00f3n-Mart\u00ednez E","year":"2023","unstructured":"Calder\u00f3n-Mart\u00ednez E, Pe\u00f1a-Carranza R, Sampieri-Cabrera R. Reflections on the design of an ultrasound study program in medical undergraduate. Revista de la Fundaci\u00f3n Educaci\u00f3n M\u00e9dica. 2023, 26:93-9. 10.33588\/fem.263.1279","journal-title":"Revista de la Fundaci\u00f3n Educaci\u00f3n M\u00e9dica"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.13140\/RG.2.2.14194.48320","article-title":"Ultrasonograf\u00eda did\u00e1ctica para profesores de pregrado mediante herramientas virtuales [Article in Spanish]","author":"Sampieri-Cabrera R","year":"2022","unstructured":"Sampieri-Cabrera R, Reyes JM, Caldero\u0301n-Marti\u0301nez E. Ultrasonograf\u00eda did\u00e1ctica para profesores de pregrado mediante herramientas virtuales [Article in Spanish]. 1er Congreso Internacional de Educaci\u00f3n en Ciencias de la Salud. 2022, 10.13140\/RG.2.2.14194.48320","journal-title":"1er Congreso Internacional de Educaci\u00f3n en Ciencias de la Salud"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S54324","article-title":"Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment","volume":"7","author":"Cryer B","year":"2014","unstructured":"Cryer B, Mahaffey KW. Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. J Multidiscip Healthc. 2014, 7:137-46. 10.2147\/JMDH.S54324","journal-title":"J Multidiscip Healthc"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.25803","article-title":"Low-dose aspirin and the risk of stroke and intracerebral bleeding in healthy older people: secondary analysis of a randomized clinical trial","volume":"6","author":"Cloud GC","year":"2023","unstructured":"Cloud GC, Williamson JD, Thao LT, et al.. Low-dose aspirin and the risk of stroke and intracerebral bleeding in healthy older people: secondary analysis of a randomized clinical trial. JAMA Netw Open. 2023, 6:e2325803. 10.1001\/jamanetworkopen.2023.25803","journal-title":"JAMA Netw Open"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2019.1591635","article-title":"Low-dose aspirin and risk of upper\/lower gastrointestinal bleeding by bleed severity: a cohort study with nested case-control analysis using primary care electronic health records from the United Kingdom","volume":"51","author":"Garc\u00eda Rodr\u00edguez LA","year":"2019","unstructured":"Garc\u00eda Rodr\u00edguez LA, Lanas A, Soriano-Gabarr\u00f3 M, Cea Soriano L. Low-dose aspirin and risk of upper\/lower gastrointestinal bleeding by bleed severity: a cohort study with nested case-control analysis using primary care electronic health records from the United Kingdom. Ann Med. 2019, 51:182-92. 10.1080\/07853890.2019.1591635","journal-title":"Ann Med"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61543-7","article-title":"Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials","volume":"376","author":"Rothwell PM","year":"2010","unstructured":"Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, Meade TW. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010, 376:1741-50. 10.1016\/S0140-6736(10)61543-7","journal-title":"Lancet"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.049","article-title":"Systematic review of complications of prostate biopsy","volume":"64","author":"Loeb S","year":"2013","unstructured":"Loeb S, Vellekoop A, Ahmed HU, et al.. Systematic review of complications of prostate biopsy. Eur Urol. 2013, 64:876-92. 10.1016\/j.eururo.2013.05.049","journal-title":"Eur Urol"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321585","article-title":"Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial","volume":"70","author":"Mahady SE","year":"2021","unstructured":"Mahady SE, Margolis KL, Chan A, et al.. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut. 2021, 70:717-24. 10.1136\/gutjnl-2020-321585","journal-title":"Gut"},{"key":"ref99","unstructured":"Archived. aspirin use to prevent cardiovascular disease and colorectal cancer: preventive medication. (2016). Accessed: August 30, 2024: https:\/\/www.uspreventiveservicestaskforce.org\/uspstf\/recommendation\/aspirin-to-prevent-cardiovascular-disease-and-can...."},{"key":"ref100","unstructured":"Aspirin use to prevent cardiovascular disease. preventive medication. (2022). Accessed: August 30, 2024: https:\/\/www.uspreventiveservicestaskforce.org\/uspstf\/recommendation\/aspirin-to-prevent-cardiovascular-disease-prevent...."},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.5281\/ZENODO.8374707","article-title":"En La Educaci\u00f3n M\u00e9dica Del Siglo XXI: De La Teor\u00eda a La Pr\u00e1ctica [Book in Spanish]","author":"Sampieri-Cabrera R","year":"2023","unstructured":"Sampieri-Cabrera R, Caldero\u0301n-Marti\u0301nez E. En La Educaci\u00f3n M\u00e9dica Del Siglo XXI: De La Teor\u00eda a La Pr\u00e1ctica [Book in Spanish]. UNAM, Mexico; 2023. 10.5281\/ZENODO.8374707"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/296612-exploring-aspirins-potential-in-cancer-prevention-a-comprehensive-review-of-the-current-evidence","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T16:12:24Z","timestamp":1727107944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/296612-exploring-aspirins-potential-in-cancer-prevention-a-comprehensive-review-of-the-current-evidence"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":101,"URL":"https:\/\/doi.org\/10.7759\/cureus.70005","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,23]]}}}