{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:48:59Z","timestamp":1782175739388,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,24]]},"DOI":"10.7759\/cureus.70066","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T07:58:52Z","timestamp":1727164732000},"source":"Crossref","is-referenced-by-count":1,"title":["Decreased CD3+CD56+ Natural Killer T Lymphocytes and Increased Human Leukocyte Antigen-DR+ Cells in the Inflamed Area of Pouchitis in Ulcerative Colitis Patients"],"prefix":"10.7759","author":[{"given":"Masaya","family":"Iwamuro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab041","article-title":"Expression of MAdCAM-1 and gut-homing T cells in inflamed pouch mucosa","volume":"15","author":"de Krijger M","year":"2021","unstructured":"de Krijger M, Wildenberg ME, Mookhoek A, Verheul S, de Jonge WJ, Ponsioen CY. Expression of MAdCAM-1 and gut-homing T cells in inflamed pouch mucosa. J Crohns Colitis. 2021, 15:1491-9. 10.1093\/ecco-jcc\/jjab041","journal-title":"J Crohns Colitis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001027","article-title":"Early transcriptomic changes in the ileal pouch provide insight into the molecular pathogenesis of pouchitis and ulcerative colitis","volume":"23","author":"Huang Y","year":"2017","unstructured":"Huang Y, Dalal S, Antonopoulos D, et al.. Early transcriptomic changes in the ileal pouch provide insight into the molecular pathogenesis of pouchitis and ulcerative colitis. Inflamm Bowel Dis. 2017, 23:366-78. 10.1097\/MIB.0000000000001027","journal-title":"Inflamm Bowel Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.9665","article-title":"Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis","volume":"20","author":"Angriman I","year":"2014","unstructured":"Angriman I, Scarpa M, Castagliuolo I. Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis. World J Gastroenterol. 2014, 20:9665-74. 10.3748\/wjg.v20.i29.9665","journal-title":"World J Gastroenterol"},{"key":"ref4","article-title":"Pouchitis: insight into the pathogenesis and clinical aspects","volume":"14","author":"de Negreiros LM","year":"2022","unstructured":"de Negreiros LM, Pascoal LB, Genaro LM, et al.. Pouchitis: insight into the pathogenesis and clinical aspects. Am J Transl Res. 2022, 14:4406-25.","journal-title":"Am J Transl Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy267","article-title":"A comprehensive approach to pouch disorders","volume":"25","author":"Quinn KP","year":"2019","unstructured":"Quinn KP, Lightner AL, Faubion WA, Raffals LE. A comprehensive approach to pouch disorders. Inflamm Bowel Dis. 2019, 25:460-71. 10.1093\/ibd\/izy267","journal-title":"Inflamm Bowel Dis"},{"key":"ref6","article-title":"An endoscopic biopsy specimen contains adequate lymphocytes for flow cytometric analysis of light chain expression in the gastrointestinal mucosa","volume":"50","author":"Iwamuro M","year":"2020","unstructured":"Iwamuro M, Matsueda K, Takahashi T, et al.. An endoscopic biopsy specimen contains adequate lymphocytes for flow cytometric analysis of light chain expression in the gastrointestinal mucosa. Ann Clin Lab Sci. 2020, 50:348-53.","journal-title":"Ann Clin Lab Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2020.101095","article-title":"Technique for single-step lymphocyte isolation from an endoscopic biopsy specimen for the diagnosis of gastrointestinal lymphoma","volume":"7","author":"Iwamuro M","year":"2020","unstructured":"Iwamuro M, Takahashi T, Watanabe N, et al.. Technique for single-step lymphocyte isolation from an endoscopic biopsy specimen for the diagnosis of gastrointestinal lymphoma. MethodsX. 2020, 7:101095. 10.1016\/j.mex.2020.101095","journal-title":"MethodsX"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/20587384211051982","article-title":"Enriched CD45RA(-)CD62L(+) central memory T and decreased CD3(+)CD56(+) natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients","volume":"36","author":"Iwamuro M","year":"2022","unstructured":"Iwamuro M, Takahashi T, Watanabe N, et al.. Enriched CD45RA(-)CD62L(+) central memory T and decreased CD3(+)CD56(+) natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients. Int J Immunopathol Pharmacol. 2022, 36:20587384211051982. 10.1177\/20587384211051982","journal-title":"Int J Immunopathol Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nri1132","article-title":"The immunological and genetic basis of inflammatory bowel disease","volume":"3","author":"Bouma G","year":"2003","unstructured":"Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003, 3:521-33. 10.1038\/nri1132","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-020-00246-4","article-title":"Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies","volume":"17","author":"Kaur A","year":"2020","unstructured":"Kaur A, Goggolidou P. Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies. J Inflamm (Lond). 2020, 17:15. 10.1186\/s12950-020-00246-4","journal-title":"J Inflamm (Lond)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20683","article-title":"Is the Th1\/Th2 paradigm of immune regulation applicable to IBD?","volume":"14 Suppl 2","author":"Fuss IJ","year":"2008","unstructured":"Fuss IJ. Is the Th1\/Th2 paradigm of immune regulation applicable to IBD?. Inflamm Bowel Dis. 2008, 14 Suppl 2:S110-2. 10.1002\/ibd.20683","journal-title":"Inflamm Bowel Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2018-0036","article-title":"Immune response and inflammatory pathway of ulcerative colitis","volume":"30","author":"Tatiya-Aphiradee N","year":"2018","unstructured":"Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K. Immune response and inflammatory pathway of ulcerative colitis. J Basic Clin Physiol Pharmacol. 2018, 30:1-10. 10.1515\/jbcpp-2018-0036","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxae019","article-title":"Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds","volume":"36","author":"Iwabuchi K","year":"2024","unstructured":"Iwabuchi K, Satoh M, Yoshino K, Ishimori N. Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds. Int Immunol. 2024, 36:377-92. 10.1093\/intimm\/dxae019","journal-title":"Int Immunol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69511-0_10","article-title":"NKT cells and autoimmune diseases: unraveling the complexity","volume":"314","author":"Miyake S","year":"2007","unstructured":"Miyake S, Yamamura T. NKT cells and autoimmune diseases: unraveling the complexity. Curr Top Microbiol Immunol. 2007, 314:251-67. 10.1007\/978-3-540-69511-0_10","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205174","article-title":"The current landscape of NKT cell immunotherapy and the hills ahead","volume":"13","author":"Nelson A","year":"2021","unstructured":"Nelson A, Lukacs JD, Johnston B. The current landscape of NKT cell immunotherapy and the hills ahead. Cancers (Basel). 2021, 13:5174. 10.3390\/cancers13205174","journal-title":"Cancers (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01314","article-title":"Editorial: NKT cells in cancer immunotherapy","volume":"11","author":"Webb TJ","year":"2020","unstructured":"Webb TJ, Yuan W, Meyer E, Dellabona P. Editorial: NKT cells in cancer immunotherapy. Front Immunol. 2020, 11:1314. 10.3389\/fimmu.2020.01314","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032743","article-title":"Natural killer T-like cells: immunobiology and role in disease","volume":"24","author":"Almeida JS","year":"2023","unstructured":"Almeida JS, Casanova JM, Santos-Rosa M, Tarazona R, Solana R, Rodrigues-Santos P. Natural killer T-like cells: immunobiology and role in disease. Int J Mol Sci. 2023, 24:2743. 10.3390\/ijms24032743","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02493","article-title":"NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors","volume":"10","author":"Almeida JS","year":"2019","unstructured":"Almeida JS, Couceiro P, L\u00f3pez-Sejas N, et al.. NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. Front Immunol. 2019, 10:2493. 10.3389\/fimmu.2019.02493","journal-title":"Front Immunol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24109047","article-title":"Alterations in the CD56(-) and CD56(+) T cell subsets during COVID-19","volume":"24","author":"Vavilova JD","year":"2023","unstructured":"Vavilova JD, Ustiuzhanina MO, Boyko AA, et al.. Alterations in the CD56(-) and CD56(+) T cell subsets during COVID-19. Int J Mol Sci. 2023, 24:9047. 10.3390\/ijms24109047","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-023-00543-y","article-title":"Intestinal Peyer\u2019s patches: structure, function, and in vitro modeling","volume":"20","author":"Park JI","year":"2023","unstructured":"Park JI, Cho SW, Kang JH, Park TE. Intestinal Peyer\u2019s patches: structure, function, and in vitro modeling. Tissue Eng Regen Med. 2023, 20:341-53. 10.1007\/s13770-023-00543-y","journal-title":"Tissue Eng Regen Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02345","article-title":"The roles of Peyer\u2019s patches and microfold cells in the gut immune system: relevance to autoimmune diseases","volume":"10","author":"Kobayashi N","year":"2019","unstructured":"Kobayashi N, Takahashi D, Takano S, Kimura S, Hase K. The roles of Peyer\u2019s patches and microfold cells in the gut immune system: relevance to autoimmune diseases. Front Immunol. 2019, 10:2345. 10.3389\/fimmu.2019.02345","journal-title":"Front Immunol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000067305","article-title":"Peyer's patches: organized lymphoid structures for the induction of mucosal immune responses in the intestine","volume":"70","author":"Makala LH","year":"2002","unstructured":"Makala LH, Suzuki N, Nagasawa H. Peyer's patches: organized lymphoid structures for the induction of mucosal immune responses in the intestine. Pathobiology. 2002, 70:55-68. 10.1159\/000067305","journal-title":"Pathobiology"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12400","article-title":"Peyer's patches: organizing B-cell responses at the intestinal frontier","volume":"271","author":"Reboldi A","year":"2016","unstructured":"Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016, 271:230-45. 10.1111\/imr.12400","journal-title":"Immunol Rev"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000182","article-title":"Innate immune factors in the development and maintenance of pouchitis","volume":"20","author":"Landy J","year":"2014","unstructured":"Landy J, Al-Hassi HO, Ronde E, et al.. Innate immune factors in the development and maintenance of pouchitis. Inflamm Bowel Dis. 2014, 20:1942-9. 10.1097\/MIB.0000000000000182","journal-title":"Inflamm Bowel Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/292715-decreased-cd3cd56-natural-killer-t-lymphocytes-and-increased-human-leukocyte-antigen-dr-cells-in-the-inflamed-area-of-pouchitis-in-ulcerative-colitis-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T07:58:55Z","timestamp":1727164735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/292715-decreased-cd3cd56-natural-killer-t-lymphocytes-and-increased-human-leukocyte-antigen-dr-cells-in-the-inflamed-area-of-pouchitis-in-ulcerative-colitis-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.70066","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}