{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:00:22Z","timestamp":1787032822676,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,28]]},"DOI":"10.7759\/cureus.70371","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:39:15Z","timestamp":1727498355000},"source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Vonoprazan and Acotiamide-Refractory Patients With Functional Dyspepsia Partly Exhibit Pancreatic Enzyme Abnormalities"],"prefix":"10.7759","author":[{"given":"Ken","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Agawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Higashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Onda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Kawawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Habiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011194.pub3","article-title":"Proton pump inhibitors for functional dyspepsia","volume":"11","author":"Pinto-Sanchez MI","year":"2017","unstructured":"Pinto-Sanchez MI, Yuan Y, Hassan A, Bercik P, Moayyedi P. Proton pump inhibitors for functional dyspepsia. Cochrane Database Syst Rev. 2017, 11:CD011194. 10.1002\/14651858.CD011194.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.828","article-title":"Efficacy of a potassium-competitive acid blocker for improving symptoms in patients with reflux esophagitis, non-erosive reflux disease, and functional dyspepsia","volume":"6","author":"Asaoka D","year":"2017","unstructured":"Asaoka D, Nagahara A, Hojo M, et al.. Efficacy of a potassium-competitive acid blocker for improving symptoms in patients with reflux esophagitis, non-erosive reflux disease, and functional dyspepsia. Biomed Rep. 2017, 6:175-80. 10.3892\/br.2016.828","journal-title":"Biomed Rep"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.234.237","article-title":"Efficacy of acotiamide in combination with esomeprazole for functional dyspepsia refractory to proton-pump inhibitor monotherapy","volume":"234","author":"Mayanagi S","year":"2014","unstructured":"Mayanagi S, Kishino M, Kitagawa Y, Sunamura M. Efficacy of acotiamide in combination with esomeprazole for functional dyspepsia refractory to proton-pump inhibitor monotherapy. Tohoku J Exp Med. 2014, 234:237-40. 10.1620\/tjem.234.237","journal-title":"Tohoku J Exp Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.8193","article-title":"Postprandial symptoms felt at the lower part of the epigastrium and a possible association of pancreatic exocrine dysfunction with the pathogenesis of functional dyspepsia","volume":"56","author":"Fujikawa Y","year":"2017","unstructured":"Fujikawa Y, Tominaga K, Tanaka F, et al.. Postprandial symptoms felt at the lower part of the epigastrium and a possible association of pancreatic exocrine dysfunction with the pathogenesis of functional dyspepsia. Intern Med. 2017, 56:1629-35. 10.2169\/internalmedicine.56.8193","journal-title":"Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.21-67","article-title":"State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities","volume":"70","author":"Agawa S","year":"2022","unstructured":"Agawa S, Futagami S, Yamawaki H, et al.. State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities. J Clin Biochem Nutr. 2022, 70:175-81. 10.3164\/jcbn.21-67","journal-title":"J Clin Biochem Nutr"},{"key":"ref6","article-title":"Exocrine pancreatic function in patients with dyspepsia","volume":"29","author":"Andersen BN","year":"1982","unstructured":"Andersen BN, Scheel J, Rune SJ, Worning H. Exocrine pancreatic function in patients with dyspepsia. Hepatogastroenterology. 1982, 29:35-7.","journal-title":"Hepatogastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02924544","article-title":"Exocrine pancreatic function and chronic unexplained dyspepsia. A case-control study","volume":"8","author":"Smith RC","year":"1991","unstructured":"Smith RC, Talley NJ, Dent OF, Jones M, Waller SL. Exocrine pancreatic function and chronic unexplained dyspepsia. A case-control study. Int J Pancreatol. 1991, 8:253-62. 10.1007\/BF02924544","journal-title":"Int J Pancreatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2000.107910","article-title":"EUS to detect evidence of pancreatic disease in patients with persistent or nonspecific dyspepsia","volume":"52","author":"Sahai AV","year":"2000","unstructured":"Sahai AV, Mishra G, Penman ID, et al.. EUS to detect evidence of pancreatic disease in patients with persistent or nonspecific dyspepsia. Gastrointest Endosc. 2000, 52:153-9. 10.1067\/mge.2000.107910","journal-title":"Gastrointest Endosc"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.17-41","article-title":"Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography","volume":"61","author":"Hashimoto S","year":"2017","unstructured":"Hashimoto S, Futagami S, Yamawaki H, et al.. Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography. J Clin Biochem Nutr. 2017, 61:140-5. 10.3164\/jcbn.17-41","journal-title":"J Clin Biochem Nutr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205165","article-title":"Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients","volume":"13","author":"Wakabayashi M","year":"2018","unstructured":"Wakabayashi M, Futagami S, Yamawaki H, et al.. Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients. PLoS One. 2018, 13:e0205165. 10.1371\/journal.pone.0205165","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.008","article-title":"The functional gastrointestinal disorders and the Rome III process","volume":"130","author":"Drossman DA","year":"2006","unstructured":"Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006, 130:1377-90. 10.1053\/j.gastro.2006.03.008","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535722","article-title":"GSRS--a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease","volume":"33","author":"Svedlund J","year":"1988","unstructured":"Svedlund J, Sj\u00f6din I, Dotevall G. GSRS--a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci. 1988, 33:129-34. 10.1007\/BF01535722","journal-title":"Dig Dis Sci"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1149-x","article-title":"Evidence-based clinical practice guidelines for chronic pancreatitis 2015","volume":"51","author":"Ito T","year":"2016","unstructured":"Ito T, Ishiguro H, Ohara H, et al.. Evidence-based clinical practice guidelines for chronic pancreatitis 2015. J Gastroenterol. 2016, 51:85-92. 10.1007\/s00535-015-1149-x","journal-title":"J Gastroenterol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/srep34305","article-title":"Increased duodenal eosinophil degranulation in patients with functional dyspepsia: a prospective study","volume":"6","author":"Du L","year":"2016","unstructured":"Du L, Shen J, Kim JJ, Yu Y, Ma L, Dai N. Increased duodenal eosinophil degranulation in patients with functional dyspepsia: a prospective study. Sci Rep. 2016, 6:34305. 10.1038\/srep34305","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857","article-title":"Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia","volume":"63","author":"Vanheel H","year":"2014","unstructured":"Vanheel H, Vicario M, Vanuytsel T, et al.. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut. 2014, 63:262-71. 10.1136\/gutjnl-2012-303857","journal-title":"Gut"},{"key":"ref16","article-title":"Anxiety and depression are associated with increased counts and degranulation of duodenal mast cells in functional dyspepsia","volume":"5","author":"Yuan HP","year":"201515","unstructured":"Yuan HP, Li Z, Zhang Y, Li XP, Li FK, Li YQ. Anxiety and depression are associated with increased counts and degranulation of duodenal mast cells in functional dyspepsia. Int J Clin Exp Med. 201515, 5:8010-4.","journal-title":"Int J Clin Exp Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318536","article-title":"Novel concepts in the pathophysiology and treatment of functional dyspepsia","volume":"69","author":"Wauters L","year":"2020","unstructured":"Wauters L, Talley NJ, Walker MM, Tack J, Vanuytsel T. Novel concepts in the pathophysiology and treatment of functional dyspepsia. Gut. 2020, 69:591-600. 10.1136\/gutjnl-2019-318536","journal-title":"Gut"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618799120","article-title":"Altered duodenal bile salt concentration and receptor expression in functional dyspepsia","volume":"6","author":"Beeckmans D","year":"2018","unstructured":"Beeckmans D, Riethorst D, Augustijns P, Vanuytsel T, Farr\u00e9 R, Tack J, Vanheel H. Altered duodenal bile salt concentration and receptor expression in functional dyspepsia. United European Gastroenterol J. 2018, 6:1347-55. 10.1177\/2050640618799120","journal-title":"United European Gastroenterol J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism","volume":"63","author":"Vanuytsel T","year":"2014","unstructured":"Vanuytsel T, van Wanrooy S, Vanheel H, et al.. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut. 2014, 63:1293-9. 10.1136\/gutjnl-2013-305690","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.333","article-title":"Proton pump inhibitors and risk for recurrent Clostridium difficile infection among inpatients","volume":"108","author":"Freedberg DE","year":"2013","unstructured":"Freedberg DE, Salmasian H, Friedman C, Abrams JA. Proton pump inhibitors and risk for recurrent Clostridium difficile infection among inpatients. Am J Gastroenterol. 2013, 108:1794-801. 10.1038\/ajg.2013.333","journal-title":"Am J Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(81)90009-x","article-title":"Effect of vagotomy on exocrine pancreatic and biliary secretion in man","volume":"141","author":"Smith RB","year":"1981","unstructured":"Smith RB, Edwards JP, Johnston D. Effect of vagotomy on exocrine pancreatic and biliary secretion in man. Am J Surg. 1981, 141:40-7. 10.1016\/0002-9610(81)90009-x","journal-title":"Am J Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019822","article-title":"Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat","volume":"469","author":"Barrett J","year":"1993","unstructured":"Barrett J, McDougall JJ, Morrison JD. Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat. J Physiol. 1993, 469:443-57. 10.1113\/jphysiol.1993.sp019822","journal-title":"J Physiol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.5387\/fms.2016-14","article-title":"Early diagnosis of chronic pancreatitis: understanding the factors associated with the development of chronic pancreatitis","volume":"63","author":"Yamabe A","year":"2017","unstructured":"Yamabe A, Irisawa A, Shibukawa G, et al.. Early diagnosis of chronic pancreatitis: understanding the factors associated with the development of chronic pancreatitis. Fukushima J Med Sci. 2017, 63:1-7. 10.5387\/fms.2016-14","journal-title":"Fukushima J Med Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(04)02758-0","article-title":"Age-related changes in the pancreas identified by EUS: a prospective evaluation","volume":"61","author":"Rajan E","year":"2005","unstructured":"Rajan E, Clain JE, Levy MJ, et al.. Age-related changes in the pancreas identified by EUS: a prospective evaluation. Gastrointest Endosc. 2005, 61:401-6. 10.1016\/s0016-5107(04)02758-0","journal-title":"Gastrointest Endosc"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199407000-00014","article-title":"Morphologic changes in the pancreas detected by screening ultrasonography in a mass survey, with special reference to main duct dilatation, cyst formation, and calcification","volume":"9","author":"Ikeda M","year":"1994","unstructured":"Ikeda M, Sato T, Morozumi A, Fujino MA, Yoda Y, Ochiai M, Kobayashi K. Morphologic changes in the pancreas detected by screening ultrasonography in a mass survey, with special reference to main duct dilatation, cyst formation, and calcification. Pancreas. 1994, 9:508-12. 10.1097\/00006676-199407000-00014","journal-title":"Pancreas"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000314599","article-title":"Chronic pancreatitis-like changes detected by endoscopic ultrasound in subjects without signs of pancreatic disease: do these indicate age-related changes, effects of xenobiotics, or early chronic pancreatitis?","volume":"10","author":"Petrone MC","year":"2010","unstructured":"Petrone MC, Arcidiacono PG, Perri F, Carrara S, Boemo C, Testoni PA. Chronic pancreatitis-like changes detected by endoscopic ultrasound in subjects without signs of pancreatic disease: do these indicate age-related changes, effects of xenobiotics, or early chronic pancreatitis?. Pancreatology. 2010, 10:597-602. 10.1159\/000314599","journal-title":"Pancreatology"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275341","article-title":"Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities","volume":"17","author":"Agawa S","year":"2022","unstructured":"Agawa S, Futagami S, Yamawaki H, et al.. Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities. PLoS One. 2022, 17:e0275341. 10.1371\/journal.pone.0275341","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2022_89-311","article-title":"Pancreatic dysfunction and duodenal inflammatory responses coordinate with refractory epigastric pain including functional dyspepsia: a narrative review","volume":"89","author":"Futagami S","year":"2022","unstructured":"Futagami S, Wakabayashi M. Pancreatic dysfunction and duodenal inflammatory responses coordinate with refractory epigastric pain including functional dyspepsia: a narrative review. J Nippon Med Sch. 2022, 89:255-62. 10.1272\/jnms.JNMS.2022_89-311","journal-title":"J Nippon Med Sch"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.01.027","article-title":"Diagnostic performance of measurement of fecal elastase-1 in detection of exocrine pancreatic insufficiency: systematic review and meta-analysis","volume":"16","author":"Vanga RR","year":"2018","unstructured":"Vanga RR, Tansel A, Sidiq S, El-Serag HB, Othman MO. Diagnostic performance of measurement of fecal elastase-1 in detection of exocrine pancreatic insufficiency: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2018, 16:1220-8.e4. 10.1016\/j.cgh.2018.01.027","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.08.025","article-title":"Low serum trypsinogen levels in chronic pancreatitis: correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based Cambridge severity scores for fibrosis","volume":"20","author":"Zhan W","year":"2020","unstructured":"Zhan W, Akshintala V, Greer PJ, et al.. Low serum trypsinogen levels in chronic pancreatitis: correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based Cambridge severity scores for fibrosis. Pancreatology. 2020, 20:1368-78. 10.1016\/j.pan.2020.08.025","journal-title":"Pancreatology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/295920-long-term-vonoprazan-and-acotiamide-refractory-patients-with-functional-dyspepsia-partly-exhibit-pancreatic-enzyme-abnormalities","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:39:17Z","timestamp":1727498357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/295920-long-term-vonoprazan-and-acotiamide-refractory-patients-with-functional-dyspepsia-partly-exhibit-pancreatic-enzyme-abnormalities"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.70371","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,28]]}}}