{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:31:17Z","timestamp":1771007477066,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"DOI":"10.7759\/cureus.70615","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T12:24:48Z","timestamp":1727785488000},"source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Large-Cell Neuroendocrine Carcinoma Metastasizing to the Brain: A Case Report"],"prefix":"10.7759","author":[{"given":"Yousif","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Salih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Suliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2008.10.23.8.35.c6714","article-title":"An overview of pancreatic neuroendocrine tumours","volume":"23","author":"Burgess A","year":"2008","unstructured":"Burgess A. An overview of pancreatic neuroendocrine tumours. Nurs Stand. 2008, 23:35-40. 10.7748\/ns2008.10.23.8.35.c6714","journal-title":"Nurs Stand"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11310","article-title":"CT evaluation of gastroenteric neuroendocrine tumors: relationship between CT features and the pathologic classification","volume":"203","author":"Feng ST","year":"2014","unstructured":"Feng ST, Luo Y, Chan T, Peng Z, Chen J, Chen M, Li ZP. CT evaluation of gastroenteric neuroendocrine tumors: relationship between CT features and the pathologic classification. AJR Am J Roentgenol. 2014, 203:W260-W266. 10.2214\/AJR.13.11310","journal-title":"AJR Am J Roentgenol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29020072","article-title":"A case of ALK-rearranged combined lung adenocarcinoma and neuroendocrine carcinoma with diffuse bone metastasis and partial response to alectinib","volume":"29","author":"Lim CA","year":"2022","unstructured":"Lim CA, Banyi N, Tucker T, Ionescu DN, Melosky B. A case of ALK-rearranged combined lung adenocarcinoma and neuroendocrine carcinoma with diffuse bone metastasis and partial response to alectinib. Curr Oncol. 2022, 29:848-852. 10.3390\/curroncol29020072","journal-title":"Curr Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010143","article-title":"Pancreatic neuroendocrine neoplasms: basic biology, current treatment strategies and prospects for the future","volume":"18","author":"Ohmoto A","year":"2017","unstructured":"Ohmoto A, Rokutan H, Yachida S. Pancreatic neuroendocrine neoplasms: basic biology, current treatment strategies and prospects for the future. Int J Mol Sci. 2017, 18:143. 10.3390\/ijms18010143","journal-title":"Int J Mol Sci"},{"key":"ref5","article-title":"WHO Classification of Tumors of the Digestive System","author":"Bosman FT","year":"2010","unstructured":"Bosman FT. WHO Classification of Tumors of the Digestive System. 2010."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24106","article-title":"Smear cytological features of large cell neuroendocrine carcinoma of the uterine cervix in pregnancy: a case report and review of the literature","volume":"47","author":"Erdem BE","year":"2019","unstructured":"Erdem BE, \u00c7i\u011fdem V, \u015eener G, Bahar M, Kursat YD, \u0130zzet Y. Smear cytological features of large cell neuroendocrine carcinoma of the uterine cervix in pregnancy: a case report and review of the literature. Diagn Cytopathol. 2019, 47:137-141. 10.1002\/dc.24106","journal-title":"Diagn Cytopathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-800945-1.00001-x","article-title":"Overview of brain tumor epidemiology","author":"Newton HB","year":"2016","unstructured":"Newton HB. Overview of brain tumor epidemiology. Handbook of Neuro-Oncology Neuroimaging (Second Edition). Elsevier BV, 2016. 3-8. 10.1016\/b978-0-12-800945-1.00001-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.111302","article-title":"Neuropathology of brain metastases","volume":"4","author":"Pekmezci M","year":"2013","unstructured":"Pekmezci M, Perry A. Neuropathology of brain metastases. Surg Neurol Int. 2013, 4:S245-S255. 10.4103\/2152-7806.111302","journal-title":"Surg Neurol Int"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041416","article-title":"Brain metastases in lung cancers with emerging targetable fusion drivers","volume":"21","author":"Tan AC","year":"2020","unstructured":"Tan AC, Itchins M, Khasraw M. Brain metastases in lung cancers with emerging targetable fusion drivers. Int J Mol Sci. 2020, 21:1416. 10.3390\/ijms21041416","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-69","article-title":"Multimodality treatment of brain metastases: an institutional survival analysis of 275 patients","volume":"9","author":"Elaimy AL","year":"2011","unstructured":"Elaimy AL, Mackay AR, Lamoreaux WT, et al.. Multimodality treatment of brain metastases: an institutional survival analysis of 275 patients. World J Surg Oncol. 2011, 9:69. 10.1186\/1477-7819-9-69","journal-title":"World J Surg Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fbinf.2022.812314","article-title":"Identification of biomarker in brain-specific gene regulatory network using structural controllability analysis","volume":"2","author":"Chen Z","year":"2022","unstructured":"Chen Z, Chen S, Qiang X. Identification of biomarker in brain-specific gene regulatory network using structural controllability analysis. Front Bioinform. 2022, 2:812314. 10.3389\/fbinf.2022.812314","journal-title":"Front Bioinform"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184624","article-title":"Conceptual development of immunotherapeutic approaches to gastrointestinal cancer","volume":"20","author":"Abolarinwa BA","year":"2019","unstructured":"Abolarinwa BA, Ibrahim RB, Huang YH. Conceptual development of immunotherapeutic approaches to gastrointestinal cancer. Int J Mol Sci. 2019, 20:4624. 10.3390\/ijms20184624","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.02.029","article-title":"Disseminated glioneuronal tumor with neuropil-like islands of the spinal cord: a distinctive entity","volume":"80","author":"Serra SM","year":"2013","unstructured":"Serra SM, Dabdoub CB, da Cunha AH, Salazar B, Lima TP, Azevedo-Filho HC. Disseminated glioneuronal tumor with neuropil-like islands of the spinal cord: a distinctive entity. World Neurosurg. 2013, 80:655.e1-655.e5. 10.1016\/j.wneu.2013.02.029","journal-title":"World Neurosurg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000223437.51435.6e","article-title":"Pathobiology of pituitary adenomas and carcinomas","volume":"59","author":"Scheithauer BW","year":"2006","unstructured":"Scheithauer BW, Gaffey TA, Lloyd RV, et al.. Pathobiology of pituitary adenomas and carcinomas. Neurosurgery. 2006, 59:341-353. 10.1227\/01.neu.0000223437.51435.6e","journal-title":"Neurosurgery"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2014.06.003","article-title":"Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy","volume":"16","author":"Baker GJ","year":"2014","unstructured":"Baker GJ, Yadav VN, Motsch S, et al.. Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy. Neoplasia. 2014, 16:543-561. 10.1016\/j.neo.2014.06.003","journal-title":"Neoplasia"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-1001-9","article-title":"Miliary breast cancer brain metastasis: a rare and aggressive form of central nervous system metastasis","volume":"123","author":"Mills MN","year":"2020","unstructured":"Mills MN, Ahmed KA. Miliary breast cancer brain metastasis: a rare and aggressive form of central nervous system metastasis. Br J Cancer. 2020, 123:1349-1350. 10.1038\/s41416-020-1001-9","journal-title":"Br J Cancer"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64690-1","article-title":"The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells","volume":"158","author":"Maes B","year":"2001","unstructured":"Maes B, Vanhentenrijk V, Wlodarska I, Cools J, Peeters B, Marynen P, de Wolf-Peeters C. The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells. Am J Pathol. 2001, 158:2185-2193. 10.1016\/S0002-9440(10)64690-1","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-esgo.500","article-title":"EP441 Synchronous small cell neuroendocrine carcinoma and adenocarcinoma in situ of the cervix","volume":"29","author":"Zovko G","year":"2019","unstructured":"Zovko G, Mad\u017earac V. EP441 Synchronous small cell neuroendocrine carcinoma and adenocarcinoma in situ of the cervix. Int J Gynecol Cancer. 2019, 29:A285. 10.1136\/ijgc-2019-esgo.500","journal-title":"Int J Gynecol Cancer"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2349\/biij.6.2.e28","article-title":"Uncomplicated term vaginal delivery following magnetic resonance-guided focused ultrasound surgery for uterine fibroids","volume":"6","author":"Zaher S","year":"2010","unstructured":"Zaher S, Lyons D, Regan L. Uncomplicated term vaginal delivery following magnetic resonance-guided focused ultrasound surgery for uterine fibroids. Biomed Imaging Interv J. 2010, 6:e28. 10.2349\/biij.6.2.e28","journal-title":"Biomed Imaging Interv J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/973946","article-title":"Treatment of neuroendocrine tumor liver metastases","volume":"2012","author":"Lewis MA","year":"2012","unstructured":"Lewis MA, Hobday TJ. Treatment of neuroendocrine tumor liver metastases. Int J Hepatol. 2012, 2012:973946. 10.1155\/2012\/973946","journal-title":"Int J Hepatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/300204-a-rare-case-of-large-cell-neuroendocrine-carcinoma-metastasizing-to-the-brain-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T12:24:51Z","timestamp":1727785491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/300204-a-rare-case-of-large-cell-neuroendocrine-carcinoma-metastasizing-to-the-brain-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.70615","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}