{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:36:05Z","timestamp":1768095365324,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,2]]},"DOI":"10.7759\/cureus.70719","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T21:54:00Z","timestamp":1727906040000},"source":"Crossref","is-referenced-by-count":1,"title":["Diphenhydramine Overdose: A Case Report and Topic Review of Prehospital Diagnosis and Treatment"],"prefix":"10.7759","author":[{"given":"Marshall A","family":"Frank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Langley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Annis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas R","family":"Peredy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Antihistamines and decongestants","author":"Gosselin S","year":"2019","unstructured":"Gosselin S. Antihistamines and decongestants. Goldfrank's toxicologic emergencies. Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS (ed): McGraw-Hill, New York City, New York; 2019. 49:1-36."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2016.1245421","article-title":"2015 annual report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 33rd annual report","volume":"54","author":"Mowry JB","year":"2016","unstructured":"Mowry JB, Spyker DA, Brooks DE, Zimmerman A, Schauben JL. 2015 annual report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 33rd annual report. Clin Toxicol (Phila). 2016, 54:924-1109. 10.1080\/15563650.2016.1245421","journal-title":"Clin Toxicol (Phila)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7141a4","article-title":"Notes from the field: antihistamine positivity and involvement in drug overdose deaths - 44 jurisdictions, United States, 2019-2020","volume":"71","author":"Dinwiddie AT","year":"2022","unstructured":"Dinwiddie AT, Tanz LJ, Bitting J. Notes from the field: antihistamine positivity and involvement in drug overdose deaths - 44 jurisdictions, United States, 2019-2020. MMWR Morb Mortal Wkly Rep. 2022, 71:1308-10. 10.15585\/mmwr.mm7141a4","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1191\/096032700671040438","article-title":"Dose-dependent toxicity of diphenhydramine overdose","volume":"19","author":"Radovanovic D","year":"2000","unstructured":"Radovanovic D, Meier PJ, Guirguis M, Lorent JP, Kupferschmidt H. Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol. 2000, 19:489-95. 10.1191\/096032700671040438","journal-title":"Hum Exp Toxicol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2021.1891244","article-title":"Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity","volume":"59","author":"Hughes AR","year":"2021","unstructured":"Hughes AR, Lin A, Hendrickson RG. Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity. Clin Toxicol (Phila). 2021, 59:918-25. 10.1080\/15563650.2021.1891244","journal-title":"Clin Toxicol (Phila)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-0644(82)80501-5","article-title":"Massive diphenhydramine overdose resulting in death","volume":"11","author":"Krenzelok EP","year":"1982","unstructured":"Krenzelok EP, Anderson GM, Mirick M. Massive diphenhydramine overdose resulting in death. Ann Emerg Med. 1982, 11:212-3. 10.1016\/s0196-0644(82)80501-5","journal-title":"Ann Emerg Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2510(10)70302-8","article-title":"Balanced equations. The use of sodium bicarbonate during cardiac arrest resuscitation","volume":"35","author":"Davis J","year":"2010","unstructured":"Davis J. Balanced equations. The use of sodium bicarbonate during cardiac arrest resuscitation. JEMS. 2010, 35:48-55. 10.1016\/S0197-2510(10)70302-8","journal-title":"JEMS"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2005.08.012","article-title":"ECG manifestations: the poisoned patient","volume":"24","author":"Holstege CP","year":"2006","unstructured":"Holstege CP, Eldridge DL, Rowden AK. ECG manifestations: the poisoned patient. Emerg Med Clin North Am. 2006, 24:159-77, vii. 10.1016\/j.emc.2005.08.012","journal-title":"Emerg Med Clin North Am"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.351","article-title":"Cardiac arrest caused by diphenhydramine overdose","volume":"5","author":"Nishino T","year":"2018","unstructured":"Nishino T, Wakai S, Aoki H, Inokuchi S. Cardiac arrest caused by diphenhydramine overdose. Acute Med Surg. 2018, 5:380-3. 10.1002\/ams2.351","journal-title":"Acute Med Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2548","article-title":"Toxicology in the ICU: part 1: general overview and approach to treatment","volume":"140","author":"Levine M","year":"2011","unstructured":"Levine M, Brooks DE, Truitt CA, Wolk BJ, Boyer EW, Ruha AM. Toxicology in the ICU: part 1: general overview and approach to treatment. Chest. 2011, 140:795-806. 10.1378\/chest.10-2548","journal-title":"Chest"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(00)70057-6","article-title":"A comparison of physostigmine and benzodiazepines for the treatment of anticholinergic poisoning","volume":"35","author":"Burns MJ","year":"2000","unstructured":"Burns MJ, Linden CH, Graudins A, Brown RM, Fletcher KE. A comparison of physostigmine and benzodiazepines for the treatment of anticholinergic poisoning. Ann Emerg Med. 2000, 35:374-81. 10.1016\/S0196-0644(00)70057-6","journal-title":"Ann Emerg Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.05.019","article-title":"Intralipid emulsion treatment as an antidote in lipophilic drug intoxications","volume":"32","author":"Eren Cevik S","year":"2014","unstructured":"Eren Cevik S, Tasyurek T, Guneysel O. Intralipid emulsion treatment as an antidote in lipophilic drug intoxications. Am J Emerg Med. 2014, 32:1103-8. 10.1016\/j.ajem.2014.05.019","journal-title":"Am J Emerg Med"},{"key":"ref13","article-title":"Cyclic antidepressants","author":"Valento M","year":"2019","unstructured":"Valento M, Liebelt EL. Cyclic antidepressants. Goldfrank's toxicologic emergencies. Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS (ed): McGraw-Hill, New York City, New York; 2019. 68:1-26."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2165\/00139709-200524030-00012","article-title":"Management of the cardiovascular complications of tricyclic antidepressant poisoning : role of sodium bicarbonate","volume":"24","author":"Bradberry SM","year":"2005","unstructured":"Bradberry SM, Thanacoody HK, Watt BE, Thomas SH, Vale JA. Management of the cardiovascular complications of tricyclic antidepressant poisoning : role of sodium bicarbonate. Toxicol Rev. 2005, 24:195-204. 10.2165\/00139709-200524030-00012","journal-title":"Toxicol Rev"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-6757(02)42248-6","article-title":"Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate","volume":"21","author":"Sharma AN","year":"2003","unstructured":"Sharma AN, Hexdall AH, Chang EK, Nelson LS, Hoffman RS. Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med. 2003, 21:212-5. 10.1016\/s0735-6757(02)42248-6","journal-title":"Am J Emerg Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21980\/J85H1P","article-title":"Electrocardiogram abnormalities following diphenhydramine ingestion: a case report","volume":"8","author":"Bruss P","year":"2023","unstructured":"Bruss P, Bowman C, Carroll T. Electrocardiogram abnormalities following diphenhydramine ingestion: a case report. J Educ Teach Emerg Med. 2023, 8:V11-3. 10.21980\/J85H1P","journal-title":"J Educ Teach Emerg Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31823b0e47","article-title":"Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate","volume":"27","author":"Cole JB","year":"2011","unstructured":"Cole JB, Stellpflug SJ, Gross EA, Smith SW. Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate. Pediatr Emerg Care. 2011, 27:1175-7. 10.1097\/PEC.0b013e31823b0e47","journal-title":"Pediatr Emerg Care"},{"key":"ref18","unstructured":"Academy of Medicine of Cincinnati protocols for Southwest Ohio prehospital care clinical practice guidelines. (2022). Accessed. September 23,\u00a02024: https:\/\/kbems.ky.gov\/Medical-Direction\/Documents\/2022%20EMS%20Protocol%20NKY%2012.1.22.pdf."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-0644(05)80897-2","article-title":"Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: successful treatment with sodium bicarbonate","volume":"21","author":"Clark RF","year":"1992","unstructured":"Clark RF, Vance MV. Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: successful treatment with sodium bicarbonate. Ann Emerg Med. 1992, 21:318-21. 10.1016\/s0196-0644(05)80897-2","journal-title":"Ann Emerg Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.487050","article-title":"What is the role of lidocaine or phenytoin in tricyclic antidepressant-induced cardiotoxicity?","volume":"48","author":"Foianini A","year":"2010","unstructured":"Foianini A, Joseph Wiegand T, Benowitz N. What is the role of lidocaine or phenytoin in tricyclic antidepressant-induced cardiotoxicity?. Clin Toxicol (Phila). 2010, 48:325-30. 10.3109\/15563650.2010.487050","journal-title":"Clin Toxicol (Phila)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/282887-diphenhydramine-overdose-a-case-report-and-topic-review-of-prehospital-diagnosis-and-treatment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T21:54:03Z","timestamp":1727906043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/282887-diphenhydramine-overdose-a-case-report-and-topic-review-of-prehospital-diagnosis-and-treatment"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.70719","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,2]]}}}