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Lancet. 2007, 370:319-28. 10.1016\/S0140-6736(07)61162-3","journal-title":"Lancet"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/s42238-022-00142-z","article-title":"Medical cannabis regulation: an overview of models around the world with emphasis on the Brazilian scenario","volume":"4","author":"de Souza MR","year":"2022","unstructured":"de Souza MR, Henriques AT, Limberger RP. Medical cannabis regulation: an overview of models around the world with emphasis on the Brazilian scenario. J Cannabis Res. 2022, 4:33. 10.1186\/s42238-022-00142-z","journal-title":"J Cannabis Res"},{"key":"ref60","article-title":"Cannabis and Cannabis-Derived Compounds: Quality Considerations for Clinical Research Guidance for Industry","year":"2023","unstructured":"Cannabis and Cannabis-Derived Compounds. Quality Considerations for Clinical Research Guidance for Industry. Center for Drug Evaluation and Research, Maryland; 2023."},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.26913","article-title":"Efficacy, safety, and regulation of cannabidiol on chronic pain: a systematic review","volume":"14","author":"Villanueva MR","year":"2022","unstructured":"Villanueva MR, Joshaghani N, Villa N, et al.. Efficacy, safety, and regulation of cannabidiol on chronic pain: a systematic review. Cureus. 2022, 14:e26913. 10.7759\/cureus.26913","journal-title":"Cureus"},{"key":"ref62","article-title":"Cannabis Laws in Europe: Questions and Answers for Policymaking","year":"2023","unstructured":"Cannabis Laws in Europe. Questions and Answers for Policymaking. European Monitoring Centre for Drugs and Drug Addiction, Luxembourg; 2023."},{"key":"ref63","unstructured":"Cannabis Policy. Status and Recent Developments. (2024). Accessed: August 25, 2024: https:\/\/www.euda.europa.eu\/publications\/topic-overviews\/cannabis-policy\/html_en."},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2020.0452","article-title":"Role of cannabis in inflammatory bowel diseases","volume":"33","author":"Perisetti A","year":"2020","unstructured":"Perisetti A, Rimu AH, Khan SA, Bansal P, Goyal H. Role of cannabis in inflammatory bowel diseases. Ann Gastroenterol. 2020, 33:134-44. 10.20524\/aog.2020.0452","journal-title":"Ann Gastroenterol"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10390","article-title":"Cannabis for the treatment of inflammatory bowel disease: a true medicine or a false promise?","volume":"11","author":"Naftali T","year":"2020","unstructured":"Naftali T, Dor M. Cannabis for the treatment of inflammatory bowel disease: a true medicine or a false promise?. 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