{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T04:04:25Z","timestamp":1728705865035},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,11]]},"DOI":"10.7759\/cureus.71241","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:16:27Z","timestamp":1728634587000},"source":"Crossref","is-referenced-by-count":0,"title":["Elevated Telomeric Repeat-Containing RNA (TERRA) Levels Linked to Telomere Dysfunction and Telomerase Inactivity in Blood Cells of Children With Aplastic Anemia"],"prefix":"10.7759","author":[{"given":"Jayitri","family":"Mazumdar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badal Chandra","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan Kumar","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utpal","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-019729","article-title":"Telomere maintenance and human bone marrow failure","volume":"111","author":"Calado RT","year":"2008","unstructured":"Calado RT, Young NS. Telomere maintenance and human bone marrow failure. Blood. 2008, 111:4446-55. 10.1182\/blood-2007-08-019729","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01445.x","article-title":"Accelerated telomere shortening and telomerase activation in Fanconi's anaemia","volume":"105","author":"Leteurtre F","year":"1999","unstructured":"Leteurtre F, Li X, Guardiola P, et al.. Accelerated telomere shortening and telomerase activation in Fanconi's anaemia. Br J Haematol. 1999, 105:883-93. 10.1046\/j.1365-2141.1999.01445.x","journal-title":"Br J Haematol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-010777","article-title":"Current concepts in the pathophysiology and treatment of aplastic anemia","volume":"108","author":"Young NS","year":"2006","unstructured":"Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood. 2006, 108:2509-19. 10.1182\/blood-2006-03-010777","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.96","article-title":"Bone marrow failure: a child is not just a small adult (but an adult can have a childhood disease)","volume":"1","author":"Alter BP","year":"2005","unstructured":"Alter BP. Bone marrow failure: a child is not just a small adult (but an adult can have a childhood disease). Hematology Am Soc Hematol Educ Program. 2005, 1:96-103. 10.1182\/asheducation-2005.1.96","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1179\/102453312X13336169155132","article-title":"Bone marrow failure and the new telomere diseases: practice and research","volume":"17 Suppl 1","author":"Young NS","year":"2012","unstructured":"Young NS. Bone marrow failure and the new telomere diseases: practice and research. Hematology. 2012, 17 Suppl 1:S18-21. 10.1179\/102453312X13336169155132","journal-title":"Hematology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare AJ","year":"2010","unstructured":"Cesare AJ, Reddel RR. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet. 2010, 11:319-30. 10.1038\/nrg2763","journal-title":"Nat Rev Genet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80538-3","article-title":"hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization","volume":"90","author":"Meyerson M","year":"1997","unstructured":"Meyerson M, Counter C M, Eaton E N, et al.. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell. 1997, 90:785-95. 10.1016\/S0092-8674(00)80538-3","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.7544491","article-title":"The RNA component of human telomerase","volume":"269","author":"Feng J","year":"1995","unstructured":"Feng J, Funk WD, Wang SS, et al.. The RNA component of human telomerase. Science. 1995, 269:1236-41. 10.1126\/science.7544491","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042980","article-title":"Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia","volume":"352","author":"Yamaguchi H","year":"2005","unstructured":"Yamaguchi H, Calado RT, Ly H, et al.. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005, 352:1413-24. 10.1056\/NEJMoa042980","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212952.58597.84","article-title":"Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome","volume":"28","author":"Field JJ","year":"2006","unstructured":"Field JJ, Mason PJ, An P, et al.. Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome. J Pediatr Hematol Oncol. 2006, 28:450-3. 10.1097\/01.mph.0000212952.58597.84","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00603-08","article-title":"Unusual telomeric DNAs in human telomerase-negative immortalized cells","volume":"29","author":"Nabetani A","year":"2009","unstructured":"Nabetani A, Ishikawa F. Unusual telomeric DNAs in human telomerase-negative immortalized cells. Mol Cell Biol. 2009, 29:703-13. 10.1128\/MCB.00603-08","journal-title":"Mol Cell Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1346005","article-title":"Shelterin: the protein complex that shapes and safeguards human telomeres","volume":"19","author":"de Lange T","year":"2005","unstructured":"de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19:2100-10. 10.1101\/gad.1346005","journal-title":"Genes Dev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.06.029","article-title":"Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair\/recombination endonucleases","volume":"138","author":"Fekairi S","year":"2009","unstructured":"Fekairi S, Scaglione S, Chahwan C, et al.. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair\/recombination endonucleases. Cell. 2009, 138:78-89. 10.1016\/j.cell.2009.06.029","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-07-0672","article-title":"PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres","volume":"17","author":"Gomez M","year":"2006","unstructured":"Gomez M, Wu J, Schreiber V, Dunlap J, Dantzer F, Wang Y, Liu Y. PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Mol Biol Cell. 2006, 17:1686-96. 10.1091\/mbc.e05-07-0672","journal-title":"Mol Biol Cell"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701413200","article-title":"Disruption of telomere maintenance by depletion of the MRE11\/RAD50\/NBS1 complex in cells that use alternative lengthening of telomeres","volume":"282","author":"Zhong ZH","year":"2007","unstructured":"Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR. Disruption of telomere maintenance by depletion of the MRE11\/RAD50\/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem. 2007, 282:29314-22. 10.1074\/jbc.M701413200","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1867","article-title":"Telomere recombination requires the MUS81 endonuclease","volume":"11","author":"Zeng S","year":"2009","unstructured":"Zeng S, Xiang T, Pandita TK, Gonzalez-Suarez I, Gonzalo S, Harris CC, Yang Q. Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol. 2009, 11:616-23. 10.1038\/ncb1867","journal-title":"Nat Cell Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21813","article-title":"NOLA1 gene mutations in acquired aplastic anemia","volume":"52","author":"Pigullo S","year":"2009","unstructured":"Pigullo S, Pavesi E, Dianzani I, et al.. NOLA1 gene mutations in acquired aplastic anemia. Pediatr Blood Cancer. 2009, 52:376-8. 10.1002\/pbc.21813","journal-title":"Pediatr Blood Cancer"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-383182","article-title":"Human telomere disease due to disruption of the CCAAT box of the TERC promoter","volume":"119","author":"Aalbers AM","year":"2012","unstructured":"Aalbers AM, Kajigaya S, van den Heuvel-Eibrink MM, van der Velden VH, Calado RT, Young NS. Human telomere disease due to disruption of the CCAAT box of the TERC promoter. Blood. 2012, 119:3060-3. 10.1182\/blood-2011-10-383182","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147182","article-title":"Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends","volume":"318","author":"Azzalin CM","year":"2007","unstructured":"Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science. 2007, 318:798-801. 10.1126\/science.1147182","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00143","article-title":"Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity","volume":"6","author":"Cusanelli E","year":"2015","unstructured":"Cusanelli E, Chartrand P. Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity. Front Genet. 2015, 6:143. 10.3389\/fgene.2015.00143","journal-title":"Front Genet"},{"key":"ref21","article-title":"The Inherited Pancytopenias","author":"Dror Y","unstructured":"Dror Y, Freedman M H. The Inherited Pancytopenias. Nelson Textbook of Pediatrics. 2016 (ed): Elsevier , Amsterdam; chapter 468:20th edition:2365."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn1027","article-title":"Telomere length measurement by a novel monochrome multiplex quantitative PCR method","volume":"37","author":"Cawthon RM","year":"2009","unstructured":"Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res. 2009, 37:e21. 10.1093\/nar\/gkn1027","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4238\/vol9-3gmr818","article-title":"Comparison of three methods of DNA extraction from peripheral blood mononuclear cells and lung fragments of equines","volume":"9","author":"Santos EM","year":"2010","unstructured":"Santos EM, Paula JF, Motta PM, et al.. Comparison of three methods of DNA extraction from peripheral blood mononuclear cells and lung fragments of equines. Genet Mol Res. 2010, 9:1591-8. 10.4238\/vol9-3gmr818","journal-title":"Genet Mol Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00460-10","article-title":"Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways","volume":"30","author":"Porro A","year":"2010","unstructured":"Porro A, Feuerhahn S, Reichenbach P, Lingner J. Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol. 2010, 30:4808-17. 10.1128\/MCB.00460-10","journal-title":"Mol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1007\/s12013-017-0835-0","article-title":"Expression of telomere-associated proteins is interdependent to stabilize native telomere structure and telomere dysfunction by G-quadruplex ligand causes TERRA up-regulation","volume":"76","author":"Sadhukhan S","year":"2018","unstructured":"Sadhukhan S, Choudhury P, Ghosh U, Ghosh S. Expression of telomere-associated proteins is interdependent to stabilize native telomere structure and telomere dysfunction by G-quadruplex ligand causes TERRA up-regulation. Cell Biochem Biophys. 2018, 76:311-9.","journal-title":"Cell Biochem Biophys"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3659","article-title":"Functional characterization of telomerase RNA variants found in patients with hematologic disorders","volume":"105","author":"Ly H","year":"2005","unstructured":"Ly H, Calado RT, Allard P, Baerlocher GM, Lansdorp PM, Young NS, Parslow TG. Functional characterization of telomerase RNA variants found in patients with hematologic disorders. Blood. 2005, 105:2332-9. 10.1182\/blood-2004-09-3659","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1275","article-title":"DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion","volume":"7","author":"Celli GB","year":"2005","unstructured":"Celli GB, de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol. 2005, 7:712-8. 10.1038\/ncb1275","journal-title":"Nat Cell Biol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2007.11.006","article-title":"Telomere uncapping and alternative lengthening of telomeres","volume":"129","author":"Cesare AJ","year":"2008","unstructured":"Cesare AJ, Reddel RR. Telomere uncapping and alternative lengthening of telomeres. Mech Ageing Dev. 2008, 129:99-108. 10.1016\/j.mad.2007.11.006","journal-title":"Mech Ageing Dev"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6379","article-title":"Functional characterization of the TERRA transcriptome at damaged telomeres","volume":"5","author":"Porro A","year":"2014","unstructured":"Porro A, Feuerhahn S, Delafontaine J, Riethman H, Rougemont J, Lingner J. Functional characterization of the TERRA transcriptome at damaged telomeres. Nat Commun. 2014, 5:5379. 10.1038\/ncomms6379","journal-title":"Nat Commun"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/254318-elevated-telomeric-repeat-containing-rna-terra-levels-linked-to-telomere-dysfunction-and-telomerase-inactivity-in-blood-cells-of-children-with-aplastic-anemia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:16:31Z","timestamp":1728634591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/254318-elevated-telomeric-repeat-containing-rna-terra-levels-linked-to-telomere-dysfunction-and-telomerase-inactivity-in-blood-cells-of-children-with-aplastic-anemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.71241","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,11]]}}}