{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:17:24Z","timestamp":1785842244046,"version":"3.56.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,17]]},"DOI":"10.7759\/cureus.71697","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T12:29:41Z","timestamp":1729168181000},"source":"Crossref","is-referenced-by-count":4,"title":["Revolutionizing Tuberculosis Management With Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas Technology: A Comprehensive Literature Review"],"prefix":"10.7759","author":[{"given":"Achal","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Kwas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayfa","family":"Rajhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Rangareddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5011","article-title":"CRISPR-Cas guides the future of genetic engineering","volume":"361","author":"Knott GJ","year":"2018","unstructured":"Knott GJ, Doudna JA. CRISPR-Cas guides the future of genetic engineering. Science. 2018, 361:866-9. 10.1126\/science.aat5011","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012740","article-title":"Repair of strand breaks by homologous recombination","volume":"5","author":"Jasin M","year":"2013","unstructured":"Jasin M, Rothstein R. Repair of strand breaks by homologous recombination. Cold Spring Harb Perspect Biol. 2013, 5:a012740. 10.1101\/cshperspect.a012740","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.005","article-title":"CRISPR-based technologies for the manipulation of eukaryotic genomes","volume":"169","author":"Komor AC","year":"2017","unstructured":"Komor AC, Badran AH, Liu DR. CRISPR-based technologies for the manipulation of eukaryotic genomes. Cell. 2017, 169:559. 10.1016\/j.cell.2017.04.005","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.032","article-title":"The biology of CRISPR-Cas: backward and forward","volume":"172","author":"Hille F","year":"2018","unstructured":"Hille F, Richter H, Wong SP, Bratovi\u010d M, Ressel S, Charpentier E. The biology of CRISPR-Cas: backward and forward. Cell. 2018, 172:1239-59. 10.1016\/j.cell.2017.11.032","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073327","article-title":"Novel CRISPR-Cas systems: an updated review of the current achievements, applications, and future research perspectives","volume":"22","author":"Nidhi S","year":"2021","unstructured":"Nidhi S, Anand U, Oleksak P, et al.. Novel CRISPR-Cas systems: an updated review of the current achievements, applications, and future research perspectives. Int J Mol Sci. 2021, 22:3327. 10.3390\/ijms22073327","journal-title":"Int J Mol Sci"},{"key":"ref6","unstructured":"World Health Organization. Tuberculosis. (2023). https.\/\/www.who.int\/news-room\/fact-sheets\/detail\/tuberculosis."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2165\/11595340-000000000-00000","article-title":"A systematic review of the cost and cost effectiveness of treatment for multidrug-resistant tuberculosis","volume":"30","author":"Fitzpatrick C","year":"2012","unstructured":"Fitzpatrick C, Floyd K. A systematic review of the cost and cost effectiveness of treatment for multidrug-resistant tuberculosis. Pharmacoeconomics. 2012, 30:63-80. 10.2165\/11595340-000000000-00000","journal-title":"Pharmacoeconomics"},{"key":"ref8","article-title":"Tuberculosis","author":"Bloom BR","year":"2017","unstructured":"Bloom BR, Atun R, Cohen T, et al.. Tuberculosis. Major Infectious Diseases. 3rd Edition. Holmes KK, Bertozzi S, Bloom BR, Jha P (ed): The International Bank for Reconstruction and Development\/The World Bank, Washington, DC; 2017."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2019.05.003","article-title":"Is cough really necessary for TB transmission?","volume":"117","author":"Patterson B","year":"2019","unstructured":"Patterson B, Wood R. Is cough really necessary for TB transmission?. Tuberculosis (Edinb). 2019, 117:31-5. 10.1016\/j.tube.2019.05.003","journal-title":"Tuberculosis (Edinb)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020340","article-title":"The immune escape mechanisms of Mycobacterium tuberculosis","volume":"20","author":"Zhai W","year":"2019","unstructured":"Zhai W, Wu F, Zhang Y, Fu Y, Liu Z. The immune escape mechanisms of Mycobacterium tuberculosis. Int J Mol Sci. 2019, 20:340. 10.3390\/ijms20020340","journal-title":"Int J Mol Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099384","article-title":"Protein kinase G from pathogenic mycobacteria promotes survival within macrophages","volume":"304","author":"Walburger A","year":"2004","unstructured":"Walburger A, Koul A, Ferrari G, et al.. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004, 304:1800-4. 10.1126\/science.1099384","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.09.002","article-title":"Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development","volume":"21","author":"Wong D","year":"2013","unstructured":"Wong D, Chao JD, Av-Gay Y. Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development. Trends Microbiol. 2013, 21:100-9. 10.1016\/j.tim.2012.09.002","journal-title":"Trends Microbiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2651","article-title":"NF-kappa B activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophages","volume":"181","author":"Gutierrez MG","year":"2008","unstructured":"Gutierrez MG, Mishra BB, Jordao L, Elliott E, Anes E, Griffiths G. NF-kappa B activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophages. J Immunol. 2008, 181:2651-63. 10.4049\/jimmunol.181.4.2651","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711159105","article-title":"Mycobacterial persistence requires the utilization of host cholesterol","volume":"105","author":"Pandey AK","year":"2008","unstructured":"Pandey AK, Sassetti CM. Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci U S A. 2008, 105:4376-80. 10.1073\/pnas.0711159105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030527","article-title":"Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+\/calmodulin-PI3K hVPS34 cascade","volume":"198","author":"Vergne I","year":"2003","unstructured":"Vergne I, Chua J, Deretic V. Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+\/calmodulin-PI3K hVPS34 cascade. J Exp Med. 2003, 198:653-9. 10.1084\/jem.20030527","journal-title":"J Exp Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00095-8","article-title":"Xpert MTB\/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis","volume":"3","author":"Detjen AK","year":"2015","unstructured":"Detjen AK, DiNardo AR, Leyden J, et al.. Xpert MTB\/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med. 2015, 3:451-61. 10.1016\/S2213-2600(15)00095-8","journal-title":"Lancet Respir Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.21.0195","article-title":"TB testing in HIV-positive patients prior to antiretroviral treatment","volume":"26","author":"Spooner E","year":"2022","unstructured":"Spooner E, Reddy S, Ntoyanto S, et al.. TB testing in HIV-positive patients prior to antiretroviral treatment. Int J Tuberc Lung Dis. 2022, 26:224-31. 10.5588\/ijtld.21.0195","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref18","unstructured":"WHO consolidated guidelines on tuberculosis. module 4: treatment: drug-resistant tuberculosis treatment. (2020). https:\/\/www.who.int\/publications\/i\/item\/9789240007048."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017863","article-title":"Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis","volume":"5","author":"Seung KJ","year":"2015","unstructured":"Seung KJ, Keshavjee S, Rich ML. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Cold Spring Harb Perspect Med. 2015, 5:a017863. 10.1101\/cshperspect.a017863","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.10.003","article-title":"CRISPR\/Cas: a powerful tool for gene function study and crop improvement","volume":"29","author":"Zhang D","year":"2021","unstructured":"Zhang D, Zhang Z, Unver T, Zhang B. CRISPR\/Cas: a powerful tool for gene function study and crop improvement. J Adv Res. 2021, 29:207-21. 10.1016\/j.jare.2020.10.003","journal-title":"J Adv Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.041","article-title":"The heroes of CRISPR","volume":"164","author":"Lander ES","year":"2016","unstructured":"Lander ES. The heroes of CRISPR. Cell. 2016, 164:18-28. 10.1016\/j.cell.2015.12.041","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800557RR","article-title":"Mycobacterium tuberculosis type III-A CRISPR\/Cas system crRNA and its maturation have atypical features","volume":"33","author":"Wei W","year":"2019","unstructured":"Wei W, Zhang S, Fleming J, et al.. Mycobacterium tuberculosis type III-A CRISPR\/Cas system crRNA and its maturation have atypical features. FASEB J. 2019, 33:1496-509. 10.1096\/fj.201800557RR","journal-title":"FASEB J"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24121","article-title":"Comparative genomic structures of Mycobacterium CRISPR-Cas","volume":"113","author":"He L","year":"2012","unstructured":"He L, Fan X, Xie J. Comparative genomic structures of Mycobacterium CRISPR-Cas. J Cell Biochem. 2012, 113:2464-73. 10.1002\/jcb.24121","journal-title":"J Cell Biochem"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2517","article-title":"Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis","volume":"45","author":"Supply P","year":"2013","unstructured":"Supply P, Marceau M, Mangenot S, et al.. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet. 2013, 45:172-9. 10.1038\/ng.2517","journal-title":"Nat Genet"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00932-4","article-title":"The future of CRISPR in Mycobacterium tuberculosis infection","volume":"30","author":"Zein-Eddine R","year":"2023","unstructured":"Zein-Eddine R, Refr\u00e9gier G, Cervantes J, Yokobori NK. The future of CRISPR in Mycobacterium tuberculosis infection. J Biomed Sci. 2023, 30:34. 10.1186\/s12929-023-00932-4","journal-title":"J Biomed Sci"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074584","article-title":"Identification of a DNA nonhomologous end-joining complex in bacteria","volume":"297","author":"Weller GR","year":"2002","unstructured":"Weller GR, Kysela B, Roy R, et al.. Identification of a DNA nonhomologous end-joining complex in bacteria. Science. 2002, 297:1686-9. 10.1126\/science.1074584","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(01)02589-3","article-title":"Identification of bacterial homologues of the Ku DNA repair proteins","volume":"500","author":"Doherty AJ","year":"2001","unstructured":"Doherty AJ, Jackson SP, Weller GR. Identification of bacterial homologues of the Ku DNA repair proteins. FEBS Lett. 2001, 500:186-8. 10.1016\/s0014-5793(01)02589-3","journal-title":"FEBS Lett"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7267","article-title":"Gene silencing by CRISPR interference in mycobacteria","volume":"6","author":"Choudhary E","year":"2015","unstructured":"Choudhary E, Thakur P, Pareek M, Agarwal N. Gene silencing by CRISPR interference in mycobacteria. Nat Commun. 2015, 6:6267. 10.1038\/ncomms7267","journal-title":"Nat Commun"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007975","article-title":"Tuberculosis drug discovery in the CRISPR era","volume":"15","author":"Rock J","year":"2019","unstructured":"Rock J. Tuberculosis drug discovery in the CRISPR era. PLoS Pathog. 2019, 15:e1007975. 10.1371\/journal.ppat.1007975","journal-title":"PLoS Pathog"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00947-17","article-title":"CRISPR-Cas12a-assisted recombineering in bacteria","volume":"83","author":"Yan MY","year":"2017","unstructured":"Yan MY, Yan HQ, Ren GX, Zhao JP, Guo XP, Sun YC. CRISPR-Cas12a-assisted recombineering in bacteria. Appl Environ Microbiol. 2017, 83:e00947-17. 10.1128\/AEM.00947-17","journal-title":"Appl Environ Microbiol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201700588","article-title":"A CRISPR-Cpf1-assisted non-homologous end joining genome editing system of Mycobacterium smegmatis","volume":"13","author":"Sun B","year":"2018","unstructured":"Sun B, Yang J, Yang S, Ye RD, Chen D, Jiang Y. A CRISPR-Cpf1-assisted non-homologous end joining genome editing system of Mycobacterium smegmatis. Biotechnol J. 2018, 13:e1700588. 10.1002\/biot.201700588","journal-title":"Biotechnol J"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02364-19","article-title":"A CRISPR-assisted nonhomologous end-joining strategy for efficient genome editing in Mycobacterium tuberculosis","volume":"11","author":"Yan MY","year":"2020","unstructured":"Yan MY, Li SS, Ding XY, Guo XP, Jin Q, Sun YC. A CRISPR-assisted nonhomologous end-joining strategy for efficient genome editing in Mycobacterium tuberculosis. mBio. 2020, 11:10.1128\/mBio.02364-19","journal-title":"mBio"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2020.101983","article-title":"Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9","volume":"124","author":"Meijers AS","year":"2020","unstructured":"Meijers AS, Troost R, Ummels R, et al.. Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9. Tuberculosis (Edinb). 2020, 124:101983. 10.1016\/j.tube.2020.101983","journal-title":"Tuberculosis (Edinb)"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2021.01.008","article-title":"Reprogramming Mycobacterium tuberculosis CRISPR system for gene editing and genome-wide RNA interference screening","volume":"20","author":"Rahman K","year":"2022","unstructured":"Rahman K, Jamal M, Chen X, et al.. Reprogramming Mycobacterium tuberculosis CRISPR system for gene editing and genome-wide RNA interference screening. Genomics Proteomics Bioinformatics. 2022, 20:1180-96. 10.1016\/j.gpb.2021.01.008","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fgeed.2021.734436","article-title":"Programmable base editing in Mycobacterium tuberculosis using an engineered CRISPR RNA-guided cytidine deaminase","volume":"3","author":"Ding XY","year":"2021","unstructured":"Ding XY, Li SS, Geng YM, Yan MY, Li GB, Zhang GL, Sun YC. Programmable base editing in Mycobacterium tuberculosis using an engineered CRISPR RNA-guided cytidine deaminase. Front Genome Ed. 2021, 3:734436. 10.3389\/fgeed.2021.734436","journal-title":"Front Genome Ed"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.07.004","article-title":"A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic-resistant mutations in M. tuberculosis","volume":"29","author":"Feng S","year":"2022","unstructured":"Feng S, Liang L, Shen C, et al.. A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic-resistant mutations in M. tuberculosis. Mol Ther Nucleic Acids. 2022, 29:354-67. 10.1016\/j.omtn.2022.07.004","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00760-7","article-title":"CRISPR-based diagnostics","volume":"5","author":"Kaminski MM","year":"2021","unstructured":"Kaminski MM, Abudayyeh OO, Gootenberg JS, Zhang F, Collins JJ. CRISPR-based diagnostics. Nat Biomed Eng. 2021, 5:643-56. 10.1038\/s41551-021-00760-7","journal-title":"Nat Biomed Eng"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.9b00209","article-title":"HOLMESv2: a CRISPR-Cas12b-assisted platform for nucleic acid detection and DNA methylation quantitation","volume":"8","author":"Li L","year":"2019","unstructured":"Li L, Li S, Wu N, Wu J, Wang G, Zhao G, Wang J. HOLMESv2: a CRISPR-Cas12b-assisted platform for nucleic acid detection and DNA methylation quantitation. ACS Synth Biol. 2019, 8:2228-37. 10.1021\/acssynbio.9b00209","journal-title":"ACS Synth Biol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0295610","article-title":"Rapid detection of Mycobacterium tuberculosis using recombinase polymerase amplification: a pilot study","volume":"18","author":"Sciaudone M","year":"2023","unstructured":"Sciaudone M, Carpena R, Calder\u00f3n M, et al.. Rapid detection of Mycobacterium tuberculosis using recombinase polymerase amplification: a pilot study. PLoS One. 2023, 18:e0295610. 10.1371\/journal.pone.0295610","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c04422","article-title":"Loop-mediated isothermal amplification-integrated CRISPR methods for infectious disease diagnosis at point of care","volume":"8","author":"Yigci D","year":"2023","unstructured":"Yigci D, At\u00e7eken N, Yetisen AK, Tasoglu S. Loop-mediated isothermal amplification-integrated CRISPR methods for infectious disease diagnosis at point of care. ACS Omega. 2023, 8:43357-73. 10.1021\/acsomega.3c04422","journal-title":"ACS Omega"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.04.032","article-title":"TB-QUICK: CRISPR-Cas12b-assisted rapid and sensitive detection of Mycobacterium tuberculosis","volume":"83","author":"Sam IK","year":"2021","unstructured":"Sam IK, Chen YY, Ma J, et al.. TB-QUICK: CRISPR-Cas12b-assisted rapid and sensitive detection of Mycobacterium tuberculosis. J Infect. 2021, 83:54-60. 10.1016\/j.jinf.2021.04.032","journal-title":"J Infect"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1664939","article-title":"CRISPR-based rapid and ultra-sensitive diagnostic test for Mycobacterium tuberculosis","volume":"8","author":"Ai JW","year":"2019","unstructured":"Ai JW, Zhou X, Xu T, et al.. CRISPR-based rapid and ultra-sensitive diagnostic test for Mycobacterium tuberculosis. Emerg Microbes Infect. 2019, 8:1361-9. 10.1080\/22221751.2019.1664939","journal-title":"Emerg Microbes Infect"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00541-1","article-title":"Prime editing for precise and highly versatile genome manipulation","volume":"24","author":"Chen PJ","year":"2023","unstructured":"Chen PJ, Liu DR. Prime editing for precise and highly versatile genome manipulation. Nat Rev Genet. 2023, 24:161-77. 10.1038\/s41576-022-00541-1","journal-title":"Nat Rev Genet"},{"key":"ref44","unstructured":"Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. (2021). https.\/\/www.who.int\/publications\/i\/item\/9789240028173."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/305740-revolutionizing-tuberculosis-management-with-clustered-regularly-interspaced-short-palindromic-repeats-crispr-cas-technology-a-comprehensive-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T12:29:46Z","timestamp":1729168186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/305740-revolutionizing-tuberculosis-management-with-clustered-regularly-interspaced-short-palindromic-repeats-crispr-cas-technology-a-comprehensive-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":44,"URL":"https:\/\/doi.org\/10.7759\/cureus.71697","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}