{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T13:47:52Z","timestamp":1746452872939,"version":"3.28.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,21]]},"DOI":"10.7759\/cureus.71995","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:27:13Z","timestamp":1729502833000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Bromelain and Diclofenac in the Management of Postoperative Pain and Quality of Life Following Root Canal Therapy: A Randomized Controlled Trial"],"prefix":"10.7759","author":[{"given":"Akbarbasha","family":"Sherin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subha","family":"Anirudhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minu","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80098-1","article-title":"Effectiveness of various medications on postoperative pain following complete instrumentation","volume":"20","author":"Torabinejad M","year":"1994","unstructured":"Torabinejad M, Cymerman JJ, Frankson M, Lemon RR, Maggio JD, Schilder H. Effectiveness of various medications on postoperative pain following complete instrumentation. J Endod. 1994, 20:345-54. 10.1016\/S0099-2399(06)80098-1","journal-title":"J Endod"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(88)80181-X","article-title":"Factors associated with endodontic interappointment emergencies of teeth with necrotic pulps","volume":"14","author":"Torabinejad M","year":"1988","unstructured":"Torabinejad M, Kettering JD, McGraw JC, Cummings RR, Dwyer TG, Tobias TS. Factors associated with endodontic interappointment emergencies of teeth with necrotic pulps. J Endod. 1988, 14:261-6. 10.1016\/S0099-2399(88)80181-X","journal-title":"J Endod"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(85)80220-X","article-title":"Flare-ups in endodontics: I. Etiological factors","volume":"11","author":"Seltzer S","year":"1985","unstructured":"Seltzer S, Naidorf IJ. Flare-ups in endodontics: I. Etiological factors. J Endod. 1985, 11:472-8. 10.1016\/S0099-2399(85)80220-X","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.107440","article-title":"Prevalence of and factors affecting post-obturation pain following single visit root canal treatment in Indian population: A prospective, randomized clinical trial","volume":"3","author":"Ali SG","year":"2012","unstructured":"Ali SG, Mulay S, Palekar A, Sejpal D, Joshi A, Gufran H. Prevalence of and factors affecting post-obturation pain following single visit root canal treatment in Indian population: A prospective, randomized clinical trial. Contemp Clin Dent. 2012, 3:459-63. 10.4103\/0976-237X.107440","journal-title":"Contemp Clin Dent"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.05.015","article-title":"Effect of preoperative corticosteroids in patients with symptomatic pulpitis on postoperative pain after single-visit root canal treatment: A systematic review and meta-analysis","volume":"44","author":"Suneelkumar C","year":"2018","unstructured":"Suneelkumar C, Subha A, Gogala D. Effect of preoperative corticosteroids in patients with symptomatic pulpitis on postoperative pain after single-visit root canal treatment: A systematic review and meta-analysis. J Endod. 2018, 44:1347-54. 10.1016\/j.joen.2018.05.015","journal-title":"J Endod"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000936","article-title":"Bromelain: Biochemistry, pharmacology and medical use","volume":"58","author":"Maurer HR","year":"2001","unstructured":"Maurer HR. Bromelain: Biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001, 58:1234-45. 10.1007\/PL00000936","journal-title":"Cell Mol Life Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/nu16132060","article-title":"Exploring the therapeutic potential of bromelain: Applications, benefits, and mechanisms","volume":"16","author":"Kansakar U","year":"2024","unstructured":"Kansakar U, Trimarco V, Manzi MV, Cervi E, Mone P, Santulli G. Exploring the therapeutic potential of bromelain: Applications, benefits, and mechanisms. Nutrients. 2024, 16:2060. 10.3390\/nu16132060","journal-title":"Nutrients"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(88)90127-4","article-title":"Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update","volume":"22","author":"Taussig SJ","year":"1988","unstructured":"Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1988, 22:191-203. 10.1016\/0378-8741(88)90127-4","journal-title":"J Ethnopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.07.028","article-title":"Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis","volume":"48","author":"de A C Almeida R","year":"2019","unstructured":"de A C Almeida R, de Sousa Lima FC, do E Vasconcelos BC. Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2019, 48:651-8. 10.1016\/j.ijom.2018.07.028","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200019010-00003","article-title":"Short-term treatment of painful osteoarthritis of the knee with oral enzymes","volume":"19","author":"Klein G","year":"2000","unstructured":"Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Investig. 2000, 19:15-23. 10.2165\/00044011-200019010-00003","journal-title":"Clin Drug Investig"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.adoms.2021.100112","article-title":"Comparison of efficacy and safety of bromelain with diclofenac sodium in the management of postoperative pain and swelling following mandibular third molar surgery","volume":"3","author":"Bhoobalakrishnan MS","year":"2021","unstructured":"Bhoobalakrishnan MS, Rattan V, Rai S, Jolly SS, Malhotra S. Comparison of efficacy and safety of bromelain with diclofenac sodium in the management of postoperative pain and swelling following mandibular third molar surgery. Adv  Oral Maxillofacial Surg. 2021, 3:100112. 10.1016\/j.adoms.2021.100112","journal-title":"Adv  Oral Maxillofacial Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2016.06.012","article-title":"How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance","volume":"13","author":"Heller GZ","year":"2016","unstructured":"Heller GZ, Manuguerra M, Chow R. How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance. Scand J Pain. 2016, 13:67-75. 10.1016\/j.sjpain.2016.06.012","journal-title":"Scand J Pain"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/976203","article-title":"Properties and therapeutic application of bromelain: A review","volume":"2012","author":"Pavan R","year":"2012","unstructured":"Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: A review. Biotechnol Res Int. 2012, 2012:976203. 10.1155\/2012\/976203","journal-title":"Biotechnol Res Int"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003154","article-title":"Effect of oral administration of bromelain on postoperative discomfort after third molar surgery","volume":"28","author":"Ghensi P","year":"2017","unstructured":"Ghensi P, Cucchi A, Creminelli L, Tomasi C, Zavan B, Maiorana C. Effect of oral administration of bromelain on postoperative discomfort after third molar surgery. J Craniofac Surg. 2017, 28:e191-7. 10.1097\/SCS.0000000000003154","journal-title":"J Craniofac Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(95)90486-7","article-title":"Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars","volume":"53","author":"Schultze-Mosgau S","year":"1995","unstructured":"Schultze-Mosgau S, Schmelzeisen R, Fr\u00f6lich JC, Schmele H. Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars. J Oral Maxillofac Surg. 1995, 53:2-7. 10.1016\/0278-2391(95)90486-7","journal-title":"J Oral Maxillofac Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-17-00088","article-title":"Validation of digital visual analog scale pain scoring with a traditional paper-based visual analog scale in adults","volume":"2","author":"Delgado DA","year":"2018","unstructured":"Delgado DA, Lambert BS, Boutris N, McCulloch PC, Robbins AB, Moreno MR, Harris JD. Validation of digital visual analog scale pain scoring with a traditional paper-based visual analog scale in adults. J Am Acad Orthop Surg Glob Res Rev. 2018, 2:e088. 10.5435\/JAAOSGlobal-D-17-00088","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.082","article-title":"Comparison of quality of life after surgical endodontic treatment using two techniques: A prospective study","volume":"99","author":"Tsesis I","year":"2005","unstructured":"Tsesis I, Shoshani Y, Givol N, Yahalom R, Fuss Z, Taicher S. Comparison of quality of life after surgical endodontic treatment using two techniques: A prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005, 99:367-71. 10.1016\/j.tripleo.2004.06.082","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.12.035","article-title":"Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: A randomized, double-blind, placebo-controlled clinical trial","volume":"72","author":"Majid OW","year":"2014","unstructured":"Majid OW, Al-Mashhadani BA. Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: A randomized, double-blind, placebo-controlled clinical trial. J Oral Maxillofac Surg. 2014, 72:1043-8. 10.1016\/j.joms.2013.12.035","journal-title":"J Oral Maxillofac Surg"},{"key":"ref19","article-title":"Clinical trial with bromelain in third molar exodontia","volume":"14","author":"Inchingolo F","year":"2010","unstructured":"Inchingolo F, Tatullo M, Marrelli M, et al.. Clinical trial with bromelain in third molar exodontia. Eur Rev Med Pharmacol Sci. 2010, 14:771-4.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref20","article-title":"Evaluating the effect of oral bromelain (pineapple) on episiotomy wound healing in primiparus women","volume":"15","author":"Golozar S","year":"2011","unstructured":"Golozar S, Abbaspour zahra, Namjouian F, Latifi SM, Mirahi A. Evaluating the effect of oral bromelain (pineapple) on episiotomy wound healing in primiparus women. Feyz Medical Sciences Journal. 2011, 15:84-90.","journal-title":"Feyz Medical Sciences Journal"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6244","article-title":"Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis","volume":"33","author":"de Souza GM","year":"2019","unstructured":"de Souza GM, Fernandes IA, Dos Santos CR, Falci SG. Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis. Phytother Res. 2019, 33:473-81. 10.1002\/ptr.6244","journal-title":"Phytother Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/299966-comparison-of-bromelain-and-diclofenac-in-the-management-of-postoperative-pain-and-quality-of-life-following-root-canal-therapy-a-randomized-controlled-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:27:14Z","timestamp":1729502834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/299966-comparison-of-bromelain-and-diclofenac-in-the-management-of-postoperative-pain-and-quality-of-life-following-root-canal-therapy-a-randomized-controlled-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.71995","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}