{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:00:35Z","timestamp":1783396835334,"version":"3.54.6"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,23]]},"DOI":"10.7759\/cureus.72179","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:10:43Z","timestamp":1729674643000},"source":"Crossref","is-referenced-by-count":1,"title":["Alterations in Small Non-coding MicroRNAs (miRNAs) and the Potential Role in the Development of Aseptic Loosening After Total Hip Replacement: Study Protocol for an Observational, Cross-Sectional Study"],"prefix":"10.7759","author":[{"given":"Spyridon","family":"Papagiannis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irini","family":"Tatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kyriakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinon","family":"Kokkalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Megas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Stathopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Grafanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lakoumentas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200202000-00002","article-title":"Twenty-five-year survivorship of two thousand consecutive primary Charnley total hip replacements: Factors affecting survivorship of acetabular and femoral components","volume":"84","author":"Berry DJ","year":"2002","unstructured":"Berry DJ, Harmsen WS, Cabanela ME, Morrey BF. Twenty-five-year survivorship of two thousand consecutive primary Charnley total hip replacements: Factors affecting survivorship of acetabular and femoral components. J Bone Joint Surg Am. 2002, 84:171-7. 10.2106\/00004623-200202000-00002","journal-title":"J Bone Joint Surg Am"},{"key":"ref2","article-title":"The national joint registry 17th annual report","author":"Ben-Shlomo Y","year":"2020","unstructured":"Ben-Shlomo Y, Blom A, Boulton C, et al.. The national joint registry 17th annual report. National Joint Registry (ed): London, UK; 2020."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122091","article-title":"Periprosthetic osteolysis: Mechanisms, prevention and treatment","volume":"8","author":"Goodman SB","year":"2019","unstructured":"Goodman SB, Gallo J. Periprosthetic osteolysis: Mechanisms, prevention and treatment. J Clin Med. 2019, 8:2091. 10.3390\/jcm8122091","journal-title":"J Clin Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: Mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer Y","year":"2007","unstructured":"Abu-Amer Y, Darwech I, Clohisy JC. Aseptic loosening of total joint replacements: Mechanisms underlying osteolysis and potential therapies. Arthritis Res Ther. 2007, 9:S6. 10.1186\/ar2170","journal-title":"Arthritis Res Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-013-0192-6","article-title":"Periprosthetic osteolysis after total hip replacement: Molecular pathology and clinical management","volume":"21","author":"Howie DW","year":"2013","unstructured":"Howie DW, Neale SD, Haynes DR, et al.. Periprosthetic osteolysis after total hip replacement: Molecular pathology and clinical management. Inflammopharmacology. 2013, 21:389-96. 10.1007\/s10787-013-0192-6","journal-title":"Inflammopharmacology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.046","article-title":"Cellular chemotaxis induced by wear particles from joint replacements","volume":"31","author":"Goodman SB","year":"2010","unstructured":"Goodman SB, Ma T. Cellular chemotaxis induced by wear particles from joint replacements. Biomaterials. 2010, 31:5045-50. 10.1016\/j.biomaterials.2010.03.046","journal-title":"Biomaterials"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22128","article-title":"miR-21 expression is related to particle-induced osteolysis pathogenesis","volume":"30","author":"Zhou Y","year":"2012","unstructured":"Zhou Y, Liu Y, Cheng L. miR-21 expression is related to particle-induced osteolysis pathogenesis. J Orthop Res. 2012, 30:1837-42. 10.1002\/jor.22128","journal-title":"J Orthop Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2018.1514626","article-title":"miR-130b participates in wear particle-induced inflammation and osteolysis via FOXF2\/NF-\u03baB pathway","volume":"40","author":"Zheng DZ","year":"2018","unstructured":"Zheng DZ, Bu YM, Wang L. miR-130b participates in wear particle-induced inflammation and osteolysis via FOXF2\/NF-\u03baB pathway. Immunopharmacol Immunotoxicol. 2018, 40:408-14. 10.1080\/08923973.2018.1514626","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15376","article-title":"MiR-106b inhibition suppresses inflammatory bone destruction of wear debris-induced periprosthetic osteolysis in rats","volume":"24","author":"Yu B","year":"2020","unstructured":"Yu B, Bai J, Shi J, et al.. MiR-106b inhibition suppresses inflammatory bone destruction of wear debris-induced periprosthetic osteolysis in rats. J Cell Mol Med. 2020, 24:7490-503. 10.1111\/jcmm.15376","journal-title":"J Cell Mol Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11143","article-title":"MiR-377 inhibits wear particle-induced osteolysis via targeting RANKL","volume":"43","author":"Li W","year":"2019","unstructured":"Li W, Wang X, Chang L, Wang F. MiR-377 inhibits wear particle-induced osteolysis via targeting RANKL. Cell Biol Int. 2019, 43:658-68. 10.1002\/cbin.11143","journal-title":"Cell Biol Int"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel DP","year":"2004","unstructured":"Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 2004, 116:281-97. 10.1016\/s0092-8674(04)00045-5","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel DP","year":"2009","unstructured":"Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell. 2009, 136:215-33. 10.1016\/j.cell.2009.01.002","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian MR","year":"2010","unstructured":"Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010, 79:351-79. 10.1146\/annurev-biochem-060308-103103","journal-title":"Annu Rev Biochem"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen X","year":"2008","unstructured":"Chen X, Ba Y, Ma L, et al.. Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008, 18:997-1006. 10.1038\/cr.2008.282","journal-title":"Cell Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.2.160058","article-title":"Imaging in peri-prosthetic assessment: An orthopaedic perspective","volume":"2","author":"Lohmann CH","year":"2017","unstructured":"Lohmann CH, Rampal S, Lohrengel M, Singh G. Imaging in peri-prosthetic assessment: An orthopaedic perspective. EFORT Open Rev. 2017, 2:117-25. 10.1302\/2058-5241.2.160058","journal-title":"EFORT Open Rev"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003325","article-title":"The role of MicroRNAS in ankylosing spondylitis","volume":"95","author":"Li Z","year":"2016","unstructured":"Li Z, Wong SH, Shen J, Chan MT, Wu WK. The role of MicroRNAS in ankylosing spondylitis. Medicine. 2016, 95:e3325. 10.1097\/MD.0000000000003325","journal-title":"Medicine"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05212-6","article-title":"Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes","volume":"63","author":"Krause C","year":"2020","unstructured":"Krause C, Gei\u00dfler C, Tackenberg H, et al.. Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes. Diabetologia. 2020, 63:2182-93. 10.1007\/s00125-020-05212-6","journal-title":"Diabetologia"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111266","article-title":"MiR-30a-3p negatively regulates BAFF synthesis in systemic sclerosis and rheumatoid arthritis fibroblasts","volume":"9","author":"Alsaleh G","year":"2014","unstructured":"Alsaleh G, Fran\u00e7ois A, Philippe L, et al.. MiR-30a-3p negatively regulates BAFF synthesis in systemic sclerosis and rheumatoid arthritis fibroblasts. PLoS One. 2014, 9:e111266. 10.1371\/journal.pone.0111266","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2020_190808N731","article-title":"Upregulation of SNHG12 accelerates cell proliferation, migration, invasion and restrain cell apoptosis in breast cancer by enhancing regulating SALL4 expression via sponging miR-15a-5p","volume":"67","author":"Yuan JH","year":"2020","unstructured":"Yuan JH, Li WX, Hu C, Zhang B. Upregulation of SNHG12 accelerates cell proliferation, migration, invasion and restrain cell apoptosis in breast cancer by enhancing regulating SALL4 expression via sponging miR-15a-5p. Neoplasma. 2020, 67:861-70. 10.4149\/neo_2020_190808N731","journal-title":"Neoplasma"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.05.013","article-title":"MicroRNA-mediated immune modulation as a therapeutic strategy in host-implant integration","volume":"88","author":"Ong SM","year":"2015","unstructured":"Ong SM, Biswas SK, Wong SC. MicroRNA-mediated immune modulation as a therapeutic strategy in host-implant integration. Adv Drug Deliv Rev. 2015, 88:92-107. 10.1016\/j.addr.2015.05.013","journal-title":"Adv Drug Deliv Rev"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32971","article-title":"Macrophage and dendritic cell phenotypic diversity in the context of biomaterials","volume":"96","author":"Kou PM","year":"2011","unstructured":"Kou PM, Babensee JE. Macrophage and dendritic cell phenotypic diversity in the context of biomaterials. J Biomed Mater Res A. 2011, 96:239-60. 10.1002\/jbm.a.32971","journal-title":"J Biomed Mater Res A"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.128","article-title":"Mediators of the inflammatory response to joint replacement devices","volume":"7","author":"Cobelli N","year":"2011","unstructured":"Cobelli N, Scharf B, Crisi GM, Hardin J, Santambrogio L. Mediators of the inflammatory response to joint replacement devices. Nat Rev Rheumatol. 2011, 7:600-8. 10.1038\/nrrheum.2011.128","journal-title":"Nat Rev Rheumatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20826","article-title":"Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity","volume":"27","author":"Caicedo MS","year":"2009","unstructured":"Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity. J Orthop Res. 2009, 27:847-54. 10.1002\/jor.20826","journal-title":"J Orthop Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.327031","article-title":"Identifying functional microRNAs in macrophages with polarized phenotypes","volume":"287","author":"Graff JW","year":"2012","unstructured":"Graff JW, Dickson AM, Clay G, McCaffrey AP, Wilson ME. Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem. 2012, 287:21816-25. 10.1074\/jbc.M111.327031","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000798","article-title":"MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages","volume":"185","author":"Zhu QY","year":"2010","unstructured":"Zhu QY, Liu Q, Chen JX, Lan K, Ge BX. MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages. J Immunol. 2010, 185:7435-42. 10.4049\/jimmunol.1000798","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.056317","article-title":"miR-146a is critical for endotoxin-induced tolerance","volume":"284","author":"Nahid MA","year":"2009","unstructured":"Nahid MA, Pauley KM, Satoh M, Chan EK. miR-146a is critical for endotoxin-induced tolerance. J Biol Chem. 2009, 284:34590-9. 10.1074\/jbc.M109.056317","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201516","article-title":"NLRP3 inflammasome activity is negatively controlled by miR-223","volume":"189","author":"Bauernfeind F","year":"2012","unstructured":"Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V. NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol. 2012, 189:4175-81. 10.4049\/jimmunol.1201516","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.08.056","article-title":"MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2","volume":"439","author":"Bandyopadhyay S","year":"2013","unstructured":"Bandyopadhyay S, Lane T, Venugopal R, et al.. MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2. Biochem Biophys Res Commun. 2013, 439:407-12. 10.1016\/j.bbrc.2013.08.056","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43492-5_7","article-title":"The role of microRNAs in the control and mechanism of action of IL-10","volume":"380","author":"Quinn SR","year":"2014","unstructured":"Quinn SR, O'Neill LA. The role of microRNAs in the control and mechanism of action of IL-10. Curr Top Microbiol Immunol. 2014, 380:145-55. 10.1007\/978-3-662-43492-5_7","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.77","article-title":"Biotribology of artificial hip joints","volume":"6","author":"Di Puccio F","year":"2015","unstructured":"Di Puccio F, Mattei L. Biotribology of artificial hip joints. World J Orthop. 2015, 6:77-94. 10.5312\/wjo.v6.i1.77","journal-title":"World J Orthop"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/309519-alterations-in-small-non-coding-micrornas-mirnas-and-the-potential-role-in-the-development-of-aseptic-loosening-after-total-hip-replacement-study-protocol-for-an-observational-cross-sectional-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:10:46Z","timestamp":1729674646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/309519-alterations-in-small-non-coding-micrornas-mirnas-and-the-potential-role-in-the-development-of-aseptic-loosening-after-total-hip-replacement-study-protocol-for-an-observational-cross-sectional-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.72179","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,23]]}}}