{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:31:33Z","timestamp":1783459893054,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"DOI":"10.7759\/cureus.72268","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:18:17Z","timestamp":1729768697000},"source":"Crossref","is-referenced-by-count":4,"title":["Pilots, Astronauts, and the Aerospace Microbiota: A Narrative Review of Occupational Impact"],"prefix":"10.7759","author":[{"given":"Piercarlo","family":"Minoretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo M","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou K","year":"2022","unstructured":"Hou K, Wu ZX, Chen XY, et al.. Microbiota in health and diseases. Signal Transduct Target Ther. 2022, 7:135. 10.1038\/s41392-022-00974-4","journal-title":"Signal Transduct Target Ther"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.999001","article-title":"Human gut microbiota in health and disease: unveiling the relationship","volume":"13","author":"Afzaal M","year":"2022","unstructured":"Afzaal M, Saeed F, Shah YA, et al.. Human gut microbiota in health and disease: unveiling the relationship. Front Microbiol. 2022, 13:999001. 10.3389\/fmicb.2022.999001","journal-title":"Front Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061453","article-title":"Oral microbiome in health and disease: maintaining a healthy, balanced ecosystem and reversing dysbiosis","volume":"11","author":"Maier T","year":"2023","unstructured":"Maier T. Oral microbiome in health and disease: maintaining a healthy, balanced ecosystem and reversing dysbiosis. Microorganisms. 2023, 11:1453. 10.3390\/microorganisms11061453","journal-title":"Microorganisms"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00821-x","article-title":"The dynamic lung microbiome in health and disease","volume":"21","author":"Natalini JG","year":"2023","unstructured":"Natalini JG, Singh S, Segal LN. The dynamic lung microbiome in health and disease. Nat Rev Microbiol. 2023, 21:222-35. 10.1038\/s41579-022-00821-x","journal-title":"Nat Rev Microbiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13201","article-title":"Human skin microbiota in health and disease: the cutaneous communities' interplay in equilibrium and dysbiosis","volume":"130","author":"Bay L","year":"2022","unstructured":"Bay L, Ring HC. Human skin microbiota in health and disease: the cutaneous communities' interplay in equilibrium and dysbiosis. APMIS. 2022, 130:706-18. 10.1111\/apm.13201","journal-title":"APMIS"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.617002","article-title":"Urinary microbiome: yin and yang of the urinary tract","volume":"11","author":"Perez-Carrasco V","year":"2021","unstructured":"Perez-Carrasco V, Soriano-Lerma A, Soriano M, Guti\u00e9rrez-Fern\u00e1ndez J, Garcia-Salcedo JA. Urinary microbiome: yin and yang of the urinary tract. Front Cell Infect Microbiol. 2021, 11:617002. 10.3389\/fcimb.2021.617002","journal-title":"Front Cell Infect Microbiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2731","article-title":"Gut microbiome health and dysbiosis: a clinical primer","volume":"42","author":"Bidell MR","year":"2022","unstructured":"Bidell MR, Hobbs AL, Lodise TP. Gut microbiome health and dysbiosis: a clinical primer. Pharmacotherapy. 2022, 42:849-57. 10.1002\/phar.2731","journal-title":"Pharmacotherapy"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19031043","article-title":"WORKbiota: a systematic review about the effects of occupational exposure on microbiota and workers' health","volume":"19","author":"Mucci N","year":"2022","unstructured":"Mucci N, Tommasi E, Chiarelli A, Lulli LG, Traversini V, Galea RP, Arcangeli G. WORKbiota: a systematic review about the effects of occupational exposure on microbiota and workers' health. Int J Environ Res Public Health. 2022, 19:1043. 10.3390\/ijerph19031043","journal-title":"Int J Environ Res Public Health"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-023-00287-y","article-title":"Nationwide survey of medical student interest in and exposure to aerospace medicine","volume":"9","author":"Thamer SB","year":"2023","unstructured":"Thamer SB, Bello J, Stevanovic M, Obat D, Buckey JC. Nationwide survey of medical student interest in and exposure to aerospace medicine. NPJ Microgravity. 2023, 9:44. 10.1038\/s41526-023-00287-y","journal-title":"NPJ Microgravity"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38000","article-title":"Health in the skies: a narrative review of the issues faced by commercial airline pilots","volume":"15","author":"Minoretti P","year":"2023","unstructured":"Minoretti P, Emanuele E. Health in the skies: a narrative review of the issues faced by commercial airline pilots. Cureus. 2023, 15:e38000. 10.7759\/cureus.38000","journal-title":"Cureus"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X2300612X","article-title":"Space medicine: the next frontier of medical education","volume":"38","author":"Waisberg E","year":"2023","unstructured":"Waisberg E, Ong J, Masalkhi M, Lee AG. Space medicine: the next frontier of medical education. Prehosp Disaster Med. 2023, 38:677-9. 10.1017\/S1049023X2300612X","journal-title":"Prehosp Disaster Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39841","article-title":"A preliminary study of gut microbiota in airline pilots: comparison with construction workers and fitness instructors","volume":"15","author":"Minoretti P","year":"2023","unstructured":"Minoretti P, Sigurt\u00e0 C, Fachinetti A, Cerone E, Rotta F, Emanuele E. A preliminary study of gut microbiota in airline pilots: comparison with construction workers and fitness instructors. Cureus. 2023, 15:e39841. 10.7759\/cureus.39841","journal-title":"Cureus"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa-2023-0060","article-title":"Space medicine: gut microbiome of hardy species is a potential source to counter disorders during space travel","volume":"9","author":"Siddiqui R","year":"2023","unstructured":"Siddiqui R, Elmoselhi AB, Khan NA. Space medicine: gut microbiome of hardy species is a potential source to counter disorders during space travel. Future Sci OA. 2023, 9:FSO868. 10.2144\/fsoa-2023-0060","journal-title":"Future Sci OA"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.553929","article-title":"Gut microbiome and space travelers' health: state of the art and possible pro\/prebiotic strategies for long-term space missions","volume":"11","author":"Turroni S","year":"2020","unstructured":"Turroni S, Magnani M, Kc P, Lesnik P, Vidal H, Heer M. Gut microbiome and space travelers' health: state of the art and possible pro\/prebiotic strategies for long-term space missions. Front Physiol. 2020, 11:553929. 10.3389\/fphys.2020.553929","journal-title":"Front Physiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2019.1710091","article-title":"Effects of spaceflight on the composition and function of the human gut microbiota","volume":"11","author":"Liu Z","year":"2020","unstructured":"Liu Z, Luo G, Du R, et al.. Effects of spaceflight on the composition and function of the human gut microbiota. Gut Microbes. 2020, 11:807-19. 10.1080\/19490976.2019.1710091","journal-title":"Gut Microbes"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26196076","article-title":"Probiotics regulate gut microbiota: an effective method to improve immunity","volume":"26","author":"Wang X","year":"2021","unstructured":"Wang X, Zhang P, Zhang X. Probiotics regulate gut microbiota: an effective method to improve immunity. Molecules. 2021, 26:6076. 10.3390\/molecules26196076","journal-title":"Molecules"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-018-1191-3","article-title":"The airplane cabin microbiome","volume":"77","author":"Weiss H","year":"2019","unstructured":"Weiss H, Hertzberg VS, Dupont C, Espinoza JL, Levy S, Nelson K, Norris S. The airplane cabin microbiome. Microb Ecol. 2019, 77:87-95. 10.1007\/s00248-018-1191-3","journal-title":"Microb Ecol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11040924","article-title":"SYNBIO\u00ae probiotic and antioxidant dietary supplementation: clinical trial evaluation of potential effects on airline flight crew members' well-being","volume":"11","author":"Coman MM","year":"2023","unstructured":"Coman MM, Micioni Di Bonaventura MV, Cifani C, Silvi S, Verdenelli MC. SYNBIO\u00ae probiotic and antioxidant dietary supplementation: clinical trial evaluation of potential effects on airline flight crew members' well-being. Microorganisms. 2023, 11:924. 10.3390\/microorganisms11040924","journal-title":"Microorganisms"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52502","article-title":"Probiotic supplementation with saccharomyces boulardii and enterococcus faecium improves gastric pain and bloating in airline pilots with chronic non-atrophic gastritis: an open-label study","volume":"16","author":"Minoretti P","year":"2024","unstructured":"Minoretti P, Lia\u00f1o Riera M, Santiago S\u00e1ez A, G\u00f3mez Serrano M, Garc\u00eda Mart\u00edn \u00c1. Probiotic supplementation with saccharomyces boulardii and enterococcus faecium improves gastric pain and bloating in airline pilots with chronic non-atrophic gastritis: an open-label study. Cureus. 2024, 16:e52502. 10.7759\/cureus.52502","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66426","article-title":"Clear skies, cloudy mind: probiotic-related brain fogginess in a commercial airline pilot","volume":"16","author":"Minoretti P","year":"2024","unstructured":"Minoretti P. Clear skies, cloudy mind: probiotic-related brain fogginess in a commercial airline pilot. Cureus. 2024, 16:e66426. 10.7759\/cureus.66426","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00163-22","article-title":"The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies","volume":"37","author":"Etlin S","year":"2024","unstructured":"Etlin S, Rose J, Bielski L, Walter C, Kleinman AS, Mason CE. The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies. Clin Microbiol Rev. 2024, 37:e00163-22. 10.1128\/cmr.00163-22","journal-title":"Clin Microbiol Rev"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/life12101498","article-title":"Skin microbial changes during space flights: a systematic review","volume":"12","author":"Tozzo P","year":"2022","unstructured":"Tozzo P, Delicati A, Caenazzo L. Skin microbial changes during space flights: a systematic review. Life (Basel). 2022, 12:1498. 10.3390\/life12101498","journal-title":"Life (Basel)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14789","article-title":"Gut microbiome and human health under the space environment","volume":"130","author":"Siddiqui R","year":"2021","unstructured":"Siddiqui R, Akbar N, Khan NA. Gut microbiome and human health under the space environment. J Appl Microbiol. 2021, 130:14-24. 10.1111\/jam.14789","journal-title":"J Appl Microbiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2015.1027821","article-title":"Dysbiosis and immune dysregulation in outer space","volume":"35","author":"Cervantes JL","year":"2016","unstructured":"Cervantes JL, Hong BY. Dysbiosis and immune dysregulation in outer space. Int Rev Immunol. 2016, 35:67-82. 10.3109\/08830185.2015.1027821","journal-title":"Int Rev Immunol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/life12040495","article-title":"Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions","volume":"12","author":"Tesei D","year":"2022","unstructured":"Tesei D, Jewczynko A, Lynch AM, Urbaniak C. Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions. Life (Basel). 2022, 12:495. 10.3390\/life12040495","journal-title":"Life (Basel)"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.82","article-title":"The microbiome: the forgotten organ of the astronaut's body - probiotics beyond terrestrial limits","volume":"7","author":"Saei AA","year":"2012","unstructured":"Saei AA, Barzegari A. The microbiome: the forgotten organ of the astronaut's body - probiotics beyond terrestrial limits. Future Microbiol. 2012, 7:1037-46. 10.2217\/fmb.12.82","journal-title":"Future Microbiol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1101\/2020.11.10.376954","article-title":"Genetic and immunological evidence for microbial transfer between the international space station and an astronaut [PREPRINT]","author":"Danko DC","year":"2020","unstructured":"Danko DC, Singh N, Butler DJ, et al.. Genetic and immunological evidence for microbial transfer between the international space station and an astronaut [PREPRINT]. bioRxiv. 2020, 10.1101\/2020.11.10.376954","journal-title":"bioRxiv"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau8650","article-title":"The NASA twins study: a multidimensional analysis of a year-long human spaceflight","volume":"364","author":"Garrett-Bakelman FE","year":"2019","unstructured":"Garrett-Bakelman FE, Darshi M, Green SJ, et al.. The NASA twins study: a multidimensional analysis of a year-long human spaceflight. Science. 2019, 364:eaau8650. 10.1126\/science.aau8650","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46303-8","article-title":"Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome","volume":"9","author":"Voorhies AA","year":"2019","unstructured":"Voorhies AA, Mark Ott C, Mehta S, et al.. Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome. Sci Rep. 2019, 9:9911. 10.1038\/s41598-019-46303-8","journal-title":"Sci Rep"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lssr.2024.03.003","article-title":"Gut permeability among astronauts during space missions","volume":"41","author":"Akinsuyi OS","year":"2024","unstructured":"Akinsuyi OS, Xhumari J, Ojeda A, Roesch LF. Gut permeability among astronauts during space missions. Life Sci Space Res (Amst). 2024, 41:171-80. 10.1016\/j.lssr.2024.03.003","journal-title":"Life Sci Space Res (Amst)"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv121","article-title":"Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station","volume":"54","author":"Sugita T","year":"2016","unstructured":"Sugita T, Yamazaki T, Makimura K, Cho O, Yamada S, Ohshima H, Mukai C. Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station. Med Mycol. 2016, 54:232-9. 10.1093\/mmy\/myv121","journal-title":"Med Mycol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myaa067","article-title":"The skin mycobiome of an astronaut during a 1-year stay on the International Space Station","volume":"59","author":"Sugita T","year":"2021","unstructured":"Sugita T, Yamazaki T, Cho O, Furukawa S, Mukai C. The skin mycobiome of an astronaut during a 1-year stay on the International Space Station. Med Mycol. 2021, 59:106-9. 10.1093\/mmy\/myaa067","journal-title":"Med Mycol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00830-z","article-title":"The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation","volume":"8","author":"Urbaniak C","year":"2020","unstructured":"Urbaniak C, Lorenzi H, Thissen J, et al.. The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation. Microbiome. 2020, 8:56. 10.1186\/s40168-020-00830-z","journal-title":"Microbiome"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12872","article-title":"Identification of fungi isolated from astronaut nasal and pharyngeal smears and saliva","volume":"65","author":"Satoh K","year":"2021","unstructured":"Satoh K, Yamazaki T, Furukawa S, Mukai C, Makimura K. Identification of fungi isolated from astronaut nasal and pharyngeal smears and saliva. Microbiol Immunol. 2021, 65:89-94. 10.1111\/1348-0421.12872","journal-title":"Microbiol Immunol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/life13030727","article-title":"Prospective use of probiotics to maintain astronaut health during spaceflight","volume":"13","author":"Bharindwal S","year":"2023","unstructured":"Bharindwal S, Goswami N, Jha P, Pandey S, Jobby R. Prospective use of probiotics to maintain astronaut health during spaceflight. Life (Basel). 2023, 13:727. 10.3390\/life13030727","journal-title":"Life (Basel)"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082666","article-title":"Transcriptional profiling of the probiotic Escherichia coli Nissle 1917 strain under simulated microgravity","volume":"21","author":"Yim J","year":"2020","unstructured":"Yim J, Cho SW, Kim B, Park S, Han YH, Seo SW. Transcriptional profiling of the probiotic Escherichia coli Nissle 1917 strain under simulated microgravity. Int J Mol Sci. 2020, 21:2666. 10.3390\/ijms21082666","journal-title":"Int J Mol Sci"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2301416","article-title":"Expectations for employing Escherichia coli Nissle 1917 in food science and nutrition","author":"Hu M","year":"2024","unstructured":"Hu M, Zhang T, Miao M, Li K, Luan Q, Sun G. Expectations for employing Escherichia coli Nissle 1917 in food science and nutrition. Crit Rev Food Sci Nutr. 2024, 1-9. 10.1080\/10408398.2023.2301416","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.5851\/kosfa.2015.35.4.541","article-title":"Screening of immune-active lactic acid bacteria","volume":"35","author":"Hwang EN","year":"2015","unstructured":"Hwang EN, Kang SM, Kim MJ, Lee JW. Screening of immune-active lactic acid bacteria. Korean J Food Sci Anim Resour. 2015, 35:541-50. 10.5851\/kosfa.2015.35.4.541","journal-title":"Korean J Food Sci Anim Resour"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15405","article-title":"Shotgun metagenomic analysis of kombucha mutualistic community exposed to Mars-like environment outside the International Space Station","volume":"23","author":"G\u00f3es-Neto A","year":"2021","unstructured":"G\u00f3es-Neto A, Kukharenko O, Orlovska I, et al.. Shotgun metagenomic analysis of kombucha mutualistic community exposed to Mars-like environment outside the International Space Station. Environ Microbiol. 2021, 23:3727-42. 10.1111\/1462-2920.15405","journal-title":"Environ Microbiol"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.748950","article-title":"Shelf life and simulated gastrointestinal tract survival of selected commercial probiotics during a simulated round-trip journey to Mars","volume":"12","author":"Fajardo-Cavazos P","year":"2021","unstructured":"Fajardo-Cavazos P, Nicholson WL. Shelf life and simulated gastrointestinal tract survival of selected commercial probiotics during a simulated round-trip journey to Mars. Front Microbiol. 2021, 12:748950. 10.3389\/fmicb.2021.748950","journal-title":"Front Microbiol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247039","article-title":"Association between physical activity and changes in intestinal microbiota composition: a systematic review","volume":"16","author":"Aya V","year":"2021","unstructured":"Aya V, Fl\u00f3rez A, Perez L, Ram\u00edrez JD. Association between physical activity and changes in intestinal microbiota composition: a systematic review. PLoS One. 2021, 16:e0247039. 10.1371\/journal.pone.0247039","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3390\/clockssleep5040050","article-title":"Microbiota composition and probiotics supplementations on sleep quality-a systematic review and meta-analysis","volume":"5","author":"Santi D","year":"2023","unstructured":"Santi D, Debbi V, Costantino F, Spaggiari G, Simoni M, Greco C, Casarini L. Microbiota composition and probiotics supplementations on sleep quality-a systematic review and meta-analysis. Clocks Sleep. 2023, 5:770-92. 10.3390\/clockssleep5040050","journal-title":"Clocks Sleep"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/nu15061382","article-title":"A microbial-based approach to mental health: the potential of probiotics in the treatment of depression","volume":"15","author":"Johnson D","year":"2023","unstructured":"Johnson D, Letchumanan V, Thum CC, Thurairajasingam S, Lee LH. A microbial-based approach to mental health: the potential of probiotics in the treatment of depression. Nutrients. 2023, 15:1382. 10.3390\/nu15061382","journal-title":"Nutrients"},{"key":"ref44","article-title":"Probiotics and disease: a comprehensive summary-part 3, cardiometabolic disease and fatigue syndromes","volume":"16","author":"Williamson CB","year":"2017","unstructured":"Williamson CB, Burns CM, Gossard CM, et al.. Probiotics and disease: a comprehensive summary-part 3, cardiometabolic disease and fatigue syndromes. Integr Med (Encinitas). 2017, 16:30-41.","journal-title":"Integr Med (Encinitas)"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.796025","article-title":"The power of microbiome studies: some considerations on which alpha and beta metrics to use and how to report results","volume":"12","author":"Kers JG","year":"2022","unstructured":"Kers JG, Saccenti E. The power of microbiome studies: some considerations on which alpha and beta metrics to use and how to report results. Front Microbiol. 2022, 12:796025. 10.3389\/fmicb.2021.796025","journal-title":"Front Microbiol"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.420","article-title":"Probiotics, prebiotics, and postbiotics in health and disease","volume":"4","author":"Ji J","year":"2023","unstructured":"Ji J, Jin W, Liu SJ, Jiao Z, Li X. Probiotics, prebiotics, and postbiotics in health and disease. MedComm (2020). 2023, 4:e420. 10.1002\/mco2.420","journal-title":"MedComm (2020)"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioflm.2023.100109","article-title":"Migration of surface-associated microbial communities in spaceflight habitats","volume":"5","author":"Marra D","year":"2023","unstructured":"Marra D, Karapantsios T, Caserta S, et al.. Migration of surface-associated microbial communities in spaceflight habitats. Biofilm. 2023, 5:100109. 10.1016\/j.bioflm.2023.100109","journal-title":"Biofilm"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1237564","article-title":"How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond","volume":"14","author":"Mortazavi SM","year":"2024","unstructured":"Mortazavi SM, Said-Salman I, Mortazavi AR, El Khatib S, Sihver L. How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond. Front Microbiol. 2024, 14:1237564. 10.3389\/fmicb.2023.1237564","journal-title":"Front Microbiol"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07639-y","article-title":"The Space Omics and Medical Atlas (SOMA) and international astronaut biobank","volume":"632","author":"Overbey EG","year":"2024","unstructured":"Overbey EG, Kim J, Tierney BT, et al.. The Space Omics and Medical Atlas (SOMA) and international astronaut biobank. Nature. 2024, 632:1145-54. 10.1038\/s41586-024-07639-y","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3390\/genes13122280","article-title":"Comparison of metagenomics and metatranscriptomics tools: a guide to making the right choice","volume":"13","author":"Terr\u00f3n-Camero LC","year":"2022","unstructured":"Terr\u00f3n-Camero LC, Gordillo-Gonz\u00e1lez F, Salas-Espejo E, Andr\u00e9s-Le\u00f3n E. Comparison of metagenomics and metatranscriptomics tools: a guide to making the right choice. Genes (Basel). 2022, 13:2280. 10.3390\/genes13122280","journal-title":"Genes (Basel)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/305547-pilots-astronauts-and-the-aerospace-microbiota-a-narrative-review-of-occupational-impact","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:18:20Z","timestamp":1729768700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/305547-pilots-astronauts-and-the-aerospace-microbiota-a-narrative-review-of-occupational-impact"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":50,"URL":"https:\/\/doi.org\/10.7759\/cureus.72268","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,24]]}}}