{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T04:23:03Z","timestamp":1729916583719,"version":"3.28.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,25]]},"DOI":"10.7759\/cureus.72385","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T17:54:27Z","timestamp":1729878867000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between the Use of Proton Pump Inhibitors and Severe Clinical Outcomes in COVID-19 Patients: A Retrospective Observational Study"],"prefix":"10.7759","author":[{"given":"Sharon","family":"Pinto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadia","family":"Al Lawati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Al Raisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balqees Al","family":"Maawali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0308-3","article-title":"COVID-19: immunopathology and its implications for therapy","volume":"20","author":"Cao X","year":"2020","unstructured":"Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020, 20:269-70. 10.1038\/s41577-020-0308-3","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25766","article-title":"Coronavirus disease 2019: what we know?","volume":"92","author":"He F","year":"2020","unstructured":"He F, Deng Y, Li W. Coronavirus disease 2019: what we know?. J Med Virol. 2020, 92:719-25. 10.1002\/jmv.25766","journal-title":"J Med Virol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1804365","article-title":"Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis","volume":"14","author":"Hasan SS","year":"2020","unstructured":"Hasan SS, Capstick T, Ahmed R, Kow CS, Mazhar F, Merchant HA, Zaidi ST. Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis. Expert Rev Respir Med. 2020, 14:1149-63. 10.1080\/17476348.2020.1804365","journal-title":"Expert Rev Respir Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2020.60","article-title":"Epidemiology of COVID-19 infection in Oman: analysis of the first 1304 cases","volume":"35","author":"Khamis F","year":"2020","unstructured":"Khamis F, Al Rashidi B, Al-Zakwani I, Al Wahaibi AH, Al Awaidy ST. Epidemiology of COVID-19 infection in Oman: analysis of the first 1304 cases. Oman Med J. 2020, 35:e145. 10.5001\/omj.2020.60","journal-title":"Oman Med J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.06.003","article-title":"Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters","volume":"128","author":"Kuba K","year":"2010","unstructured":"Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 2010, 128:119-28. 10.1016\/j.pharmthera.2010.06.003","journal-title":"Pharmacol Ther"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.055","article-title":"Evidence for gastrointestinal infection of SARS-CoV-2","volume":"158","author":"Xiao F","year":"2020","unstructured":"Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020, 158:1831-3.e3. 10.1053\/j.gastro.2020.02.055","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.05.006","article-title":"Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study","volume":"22","author":"Tang WR","year":"2014","unstructured":"Tang WR, Chen WJ, Yu CT, Chang YC, Chen CM, Wang CH, Yang SH. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. Complement Ther Med. 2014, 22:581-91. 10.1016\/j.ctim.2014.05.006","journal-title":"Complement Ther Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trab042","article-title":"Gastrointestinal manifestations in COVID-19","volume":"115","author":"Kariyawasam JC","year":"2021","unstructured":"Kariyawasam JC, Jayarajah U, Riza R, Abeysuriya V, Seneviratne SL. Gastrointestinal manifestations in COVID-19. Trans R Soc Trop Med Hyg. 2021, 115:1362-88. 10.1093\/trstmh\/trab042","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.53350\/pjmhs211582206","article-title":"Prevalence, mechanism, and implications of gastrointestinal symptoms in COVID-19","volume":"15","author":"Zeb S","year":"2021","unstructured":"Zeb S, Almani K, Arshad I, et al.. Prevalence, mechanism, and implications of gastrointestinal symptoms in COVID-19. Pak J Med Health Sci. 2021, 15:2206-9. 10.53350\/pjmhs211582206","journal-title":"Pak J Med Health Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322248","article-title":"Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching","volume":"70","author":"Lee SW","year":"2021","unstructured":"Lee SW, Ha EK, Yeniova A\u00d6, et al.. Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching. Gut. 2021, 70:76-84. 10.1136\/gutjnl-2020-322248","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002013","article-title":"Pre-hospitalization proton pump inhibitor use and clinical outcomes in COVID-19","volume":"34","author":"Ramachandran P","year":"2022","unstructured":"Ramachandran P, Perisetti A, Gajendran M, Jean-Louis F, Bansal P, Dwivedi AK, Goyal H. Pre-hospitalization proton pump inhibitor use and clinical outcomes in COVID-19. Eur J Gastroenterol Hepatol. 2022, 34:137-41. 10.1097\/MEG.0000000000002013","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2019","article-title":"The physiology of the gastric parietal cell","volume":"100","author":"Engevik AC","year":"2020","unstructured":"Engevik AC, Kaji I, Goldenring JR. The physiology of the gastric parietal cell. Physiol Rev. 2020, 100:573-602. 10.1152\/physrev.00016.2019","journal-title":"Physiol Rev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/a-1236-3041","article-title":"The potential therapeutic role of proton pump inhibitors in COVID-19: hypotheses based on existing evidences","volume":"70","author":"Ray A","year":"2020","unstructured":"Ray A, Sharma S, Sadasivam B. The potential therapeutic role of proton pump inhibitors in COVID-19: hypotheses based on existing evidences. Drug Res (Stuttg). 2020, 70:484-8. 10.1055\/a-1236-3041","journal-title":"Drug Res (Stuttg)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.10.001","article-title":"Proton pump inhibitor use is associated with increased risk of severity and mortality from coronavirus disease 2019 (COVID-19) infection","volume":"52","author":"Hariyanto TI","year":"2020","unstructured":"Hariyanto TI, Prasetya IB, Kurniawan A. Proton pump inhibitor use is associated with increased risk of severity and mortality from coronavirus disease 2019 (COVID-19) infection. Dig Liver Dis. 2020, 52:1410-2. 10.1016\/j.dld.2020.10.001","journal-title":"Dig Liver Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-023-02007-5","article-title":"Proton pump inhibitor use and risk of pneumonia: a self-controlled case series study","volume":"58","author":"Maret-Ouda J","year":"2023","unstructured":"Maret-Ouda J, Panula J, Santoni G, Xie S, Lagergren J. Proton pump inhibitor use and risk of pneumonia: a self-controlled case series study. J Gastroenterol. 2023, 58:734-40. 10.1007\/s00535-023-02007-5","journal-title":"J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325701","article-title":"Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort","volume":"71","author":"Shah S","year":"2022","unstructured":"Shah S, Halvorson A, McBay B, et al.. Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Gut. 2022, 71:1447-50. 10.1136\/gutjnl-2021-325701","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8803862","article-title":"Use of proton-pump inhibitor is not associated with adverse clinical outcomes in COVID-19 patients: a territory-wide cohort study","volume":"13","author":"Yip TC","year":"2022","unstructured":"Yip TC, Chan FK, Lui GC, et al.. Use of proton-pump inhibitor is not associated with adverse clinical outcomes in COVID-19 patients: a territory-wide cohort study. GastroHep. 2022, 13:1-13. 10.1155\/2022\/8803862","journal-title":"GastroHep"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11680-0","article-title":"Proton pump inhibitor therapy usage and associated hospitalization rates and critical care outcomes of COVID-19 patients","volume":"12","author":"Shupp B","year":"2022","unstructured":"Shupp B, Mehta SV, Chirayath S, et al.. Proton pump inhibitor therapy usage and associated hospitalization rates and critical care outcomes of COVID-19 patients. Sci Rep. 2022, 12:7596. 10.1038\/s41598-022-11680-0","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221104365","article-title":"Impact of proton pump inhibitors on the in-hospital outcome of COVID-19 patients: a retrospective study","volume":"15","author":"Yao H","year":"2022","unstructured":"Yao H, Li H, Ma Z, et al.. Impact of proton pump inhibitors on the in-hospital outcome of COVID-19 patients: a retrospective study. Therap Adv Gastroenterol. 2022, 15:17562848221104365. 10.1177\/17562848221104365","journal-title":"Therap Adv Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s42269-022-00825-w","article-title":"Clinical features, laboratory characteristics and risk factors for mortality of COVID-19 patients in a secondary hospital in Oman during the first wave of the SARS-CoV-2 pandemic","volume":"46","author":"Almayahi ZK","year":"2022","unstructured":"Almayahi ZK, Raveendran AV, Al Malki R, et al.. Clinical features, laboratory characteristics and risk factors for mortality of COVID-19 patients in a secondary hospital in Oman during the first wave of the SARS-CoV-2 pandemic. Bull Natl Res Cent. 2022, 46:139. 10.1186\/s42269-022-00825-w","journal-title":"Bull Natl Res Cent"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17343","article-title":"Clinical characteristics of confirmed cases of COVID-19 admitted at Al Nahdha Hospital, Oman: a cross-sectional descriptive study","volume":"13","author":"Al Harthi S","year":"2021","unstructured":"Al Harthi S, Al Osali M, Al Ismaili R, et al.. Clinical characteristics of confirmed cases of COVID-19 admitted at Al Nahdha Hospital, Oman: a cross-sectional descriptive study. Cureus. 2021, 13:e17343. 10.7759\/cureus.17343","journal-title":"Cureus"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.06.001","article-title":"Association of asthma and its genetic predisposition with the risk of severe COVID-19","volume":"146","author":"Zhu Z","year":"2020","unstructured":"Zhu Z, Hasegawa K, Ma B, Fujiogi M, Camargo CA Jr, Liang L. Association of asthma and its genetic predisposition with the risk of severe COVID-19. J Allergy Clin Immunol. 2020, 146:327-9.e4. 10.1016\/j.jaci.2020.06.001","journal-title":"J Allergy Clin Immunol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06369-0","article-title":"Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis","volume":"21","author":"Shi C","year":"2021","unstructured":"Shi C, Wang L, Ye J, et al.. Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis. BMC Infect Dis. 2021, 21:663. 10.1186\/s12879-021-06369-0","journal-title":"BMC Infect Dis"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.07.003","article-title":"Incidence and outcomes of COVID-19 in people with CKD: a systematic review and meta-analysis","volume":"78","author":"Chung EY","year":"2021","unstructured":"Chung EY, Palmer SC, Natale P, et al.. Incidence and outcomes of COVID-19 in people with CKD: a systematic review and meta-analysis. Am J Kidney Dis. 2021, 78:804-15. 10.1053\/j.ajkd.2021.07.003","journal-title":"Am J Kidney Dis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00089-9","article-title":"Associations between body-mass index and COVID-19 severity in 6\u00b79 million people in England: a prospective, community-based, cohort study","volume":"9","author":"Gao M","year":"2021","unstructured":"Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O'Rahilly S, Aveyard P, Jebb SA. Associations between body-mass index and COVID-19 severity in 6\u00b79 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021, 9:350-9. 10.1016\/S2213-8587(21)00089-9","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2020.101923","article-title":"COVID-19 disease severity and mortality determinants: a large population-based analysis in Oman","volume":"39","author":"Al Wahaibi A","year":"2021","unstructured":"Al Wahaibi A, Al Rawahi B, Patel PK, Al Khalili S, Al Maani A, Al-Abri S. COVID-19 disease severity and mortality determinants: a large population-based analysis in Oman. Travel Med Infect Dis. 2021, 39:101923. 10.1016\/j.tmaid.2020.101923","journal-title":"Travel Med Infect Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/310267-association-between-the-use-of-proton-pump-inhibitors-and-severe-clinical-outcomes-in-covid-19-patients-a-retrospective-observational-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T17:54:28Z","timestamp":1729878868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/310267-association-between-the-use-of-proton-pump-inhibitors-and-severe-clinical-outcomes-in-covid-19-patients-a-retrospective-observational-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.72385","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}