{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:06:56Z","timestamp":1767910016917,"version":"3.49.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,9]]},"DOI":"10.7759\/cureus.73324","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T12:37:23Z","timestamp":1731155843000},"source":"Crossref","is-referenced-by-count":3,"title":["Restoring Function in Pediatric Neurodegeneration: The Impact of Radio Electric Asymmetric Conveyor Neuroregenerative Treatment in a Child With Canavan Syndrome"],"prefix":"10.7759","author":[{"given":"Vania","family":"Fontani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1784-9","article-title":"Uncoupling N-acetylaspartate from brain pathology: Implications for canavan disease gene therapy","volume":"135","author":"von Jonquieres G","year":"2018","unstructured":"von Jonquieres G, Spencer ZH, Rowlands BD, et al.. Uncoupling N-acetylaspartate from brain pathology: Implications for canavan disease gene therapy. Acta Neuropathol. 2018, 135:95-113. 10.1007\/s00401-017-1784-9","journal-title":"Acta Neuropathol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2693-6","article-title":"Pathophysiology and treatment of canavan disease","volume":"45","author":"Pleasure D","year":"2020","unstructured":"Pleasure D, Guo F, Chechneva O, et al.. Pathophysiology and treatment of canavan disease. Neurochem Res. 2020, 45:561-5. 10.1007\/s11064-018-2693-6","journal-title":"Neurochem Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01659-3","article-title":"The natural history of canavan disease: 23 new cases and comparison with patients from literature","volume":"16","author":"Bley A","year":"2021","unstructured":"Bley A, Denecke J, Kohlsch\u00fctter A, et al.. The natural history of canavan disease: 23 new cases and comparison with patients from literature. Orphanet J Rare Dis. 2021, 16:227. 10.1186\/s13023-020-01659-3","journal-title":"Orphanet J Rare Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13121698","article-title":"REAC reparative treatment: A promising therapeutic option for alcoholic cirrhosis of the liver","volume":"13","author":"Pereira LJ","year":"2023","unstructured":"Pereira LJ, Pereira JA, Fontani V, Rinaldi S. REAC reparative treatment: A promising therapeutic option for alcoholic cirrhosis of the liver. J Pers Med. 2023, 13:1698. 10.3390\/jpm13121698","journal-title":"J Pers Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13061019","article-title":"Impact of REAC regenerative endogenous bioelectrical cell reprogramming on MCF7 breast cancer cells","volume":"13","author":"Fontani V","year":"2023","unstructured":"Fontani V, Cruciani S, Santaniello S, Rinaldi S, Maioli M. Impact of REAC regenerative endogenous bioelectrical cell reprogramming on MCF7 breast cancer cells. J Pers Med. 2023, 13:1019. 10.3390\/jpm13061019","journal-title":"J Pers Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28245","article-title":"Regenerative radio electric asymmetric conveyer treatment in generalized cerebral and cerebellar atrophy to improve motor control: A case report","volume":"14","author":"Rinaldi S","year":"2022","unstructured":"Rinaldi S, Rinaldi C, Fontani V. Regenerative radio electric asymmetric conveyer treatment in generalized cerebral and cerebellar atrophy to improve motor control: A case report. Cureus. 2022, 14:e28245. 10.7759\/cureus.28245","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/srep35719","article-title":"REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model","volume":"6","author":"Lorenzini L","year":"2016","unstructured":"Lorenzini L, Giuliani A, Sivilia S, et al.. REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model. Sci Rep. 2016, 6:35719. 10.1038\/srep35719","journal-title":"Sci Rep"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-017-0188-0","article-title":"Radio electric asymmetric conveyer technology modulates neuroinflammation in a mouse model of neurodegeneration","volume":"34","author":"Panaro MA","year":"2018","unstructured":"Panaro MA, Aloisi A, Nicolardi G, et al.. Radio electric asymmetric conveyer technology modulates neuroinflammation in a mouse model of neurodegeneration. Neurosci Bull. 2018, 34:270-82. 10.1007\/s12264-017-0188-0","journal-title":"Neurosci Bull"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20065144","article-title":"Trunk control measurement scale (TCMS): Psychometric properties of cross-cultural adaptation and validation of the Spanish version","volume":"20","author":"L\u00f3pez-Ruiz J","year":"2023","unstructured":"L\u00f3pez-Ruiz J, Estrada-Barranco C, Mart\u00edn-G\u00f3mez C, Egea-G\u00e1mez RM, Valera-Calero JA, Mart\u00edn-Casas P, L\u00f3pez-de-Uralde-Villanueva I. Trunk control measurement scale (TCMS): Psychometric properties of cross-cultural adaptation and validation of the Spanish version. Int J Environ Res Public Health. 2023, 20:10.3390\/ijerph20065144","journal-title":"Int J Environ Res Public Health"},{"key":"ref10","article-title":"Modified Ashworth Scale","author":"Harb A","year":"2023","unstructured":"Harb A, Kishner S. Modified Ashworth Scale. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-021-10257-9","article-title":"Validation of the Italian version of the functional oral intake scale (FOIS-It) against fiberoptic endoscopic evaluation of swallowing and nutritional status","volume":"37","author":"Ninfa A","year":"2022","unstructured":"Ninfa A, Pizzorni N, Eplite A, Moltisanti C, Schindler A. Validation of the Italian version of the functional oral intake scale (FOIS-It) against fiberoptic endoscopic evaluation of swallowing and nutritional status. Dysphagia. 2022, 37:137-47. 10.1007\/s00455-021-10257-9","journal-title":"Dysphagia"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X600966","article-title":"Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle differentiation in mouse embryonic stem cells: A new tool for improving tissue regeneration","volume":"21","author":"Maioli M","year":"2012","unstructured":"Maioli M, Rinaldi S, Santaniello S, et al.. Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle differentiation in mouse embryonic stem cells: A new tool for improving tissue regeneration. Cell Transplant. 2012, 21:1225-33. 10.3727\/096368911X600966","journal-title":"Cell Transplant"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657297","article-title":"Radio electric conveyed fields directly reprogram human dermal skin fibroblasts toward cardiac, neuronal, and skeletal muscle-like lineages","volume":"22","author":"Maioli M","year":"2013","unstructured":"Maioli M, Rinaldi S, Santaniello S, et al.. Radio electric conveyed fields directly reprogram human dermal skin fibroblasts toward cardiac, neuronal, and skeletal muscle-like lineages. Cell Transplant. 2013, 22:1227-35. 10.3727\/096368912X657297","journal-title":"Cell Transplant"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/srep05668","article-title":"Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study","volume":"4","author":"Rinaldi S","year":"2014","unstructured":"Rinaldi S, Mura M, Castagna A, Fontani V. Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study. Sci Rep. 2014, 4:5668. 10.1038\/srep05668","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25768","article-title":"Long-lasting efficacy of radio electric asymmetric conveyer neuromodulation treatment on functional dysmetria, an adaptive motor behavior","volume":"14","author":"Fontani V","year":"2022","unstructured":"Fontani V, Rinaldi A, Rinaldi C, et al.. Long-lasting efficacy of radio electric asymmetric conveyer neuromodulation treatment on functional dysmetria, an adaptive motor behavior. Cureus. 2022, 14:e25768. 10.7759\/cureus.25768","journal-title":"Cureus"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/315683-restoring-function-in-pediatric-neurodegeneration-the-impact-of-radio-electric-asymmetric-conveyor-neuroregenerative-treatment-in-a-child-with-canavan-syndrome","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T12:37:24Z","timestamp":1731155844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/315683-restoring-function-in-pediatric-neurodegeneration-the-impact-of-radio-electric-asymmetric-conveyor-neuroregenerative-treatment-in-a-child-with-canavan-syndrome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,9]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.73324","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,9]]}}}