{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:31:20Z","timestamp":1785227480667,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,10]]},"DOI":"10.7759\/cureus.73389","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T18:53:49Z","timestamp":1731264829000},"source":"Crossref","is-referenced-by-count":3,"title":["Botulinum Toxin Type A in Trigeminal Neuralgia Treatment: A Case Series and Literature Review"],"prefix":"10.7759","author":[{"given":"Rita F","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Cam\u00f5es-Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2020-002782","article-title":"Trigeminal neuralgia: a practical guide","volume":"21","author":"Lambru G","year":"2021","unstructured":"Lambru G, Zakrzewska J, Matharu M. Trigeminal neuralgia: a practical guide. Pract Neurol. 2021, 21:392-402. 10.1136\/practneurol-2020-002782","journal-title":"Pract Neurol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X17666191010094350","article-title":"Trigeminal neuralgia: basic and clinical aspects","volume":"18","author":"Araya EI","year":"2020","unstructured":"Araya EI, Claudino RF, Piovesan EJ, Chichorro JG. Trigeminal neuralgia: basic and clinical aspects. Curr Neuropharmacol. 2020, 18:109-19. 10.2174\/1570159X17666191010094350","journal-title":"Curr Neuropharmacol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202","article-title":"Headache classification committee of the international headache society (IHS) the international classification of headache disorders","volume":"38","author":"Olesen J","year":"2018","unstructured":"Olesen J. Headache classification committee of the international headache society (IHS) the international classification of headache disorders. Cephalalgia. 2018, 38:1-211. 10.1177\/0333102417738202","journal-title":"Cephalalgia"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(06)80042-4","article-title":"Chapter 38 Trigeminal neuralgia and other facial neuralgias","author":"Nurmikko TJ","year":"2006","unstructured":"Nurmikko TJ. Chapter 38 Trigeminal neuralgia and other facial neuralgias. Handbook of Clinical Neurology. Jensen TS (ed): Elsevier, 2006. 81:573-96. 10.1016\/S0072-9752(06)80042-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5603\/PJNNS.a2019.0030","article-title":"Botulinum toxin type A as an alternative way to treat trigeminal neuralgia: a systematic review","volume":"53","author":"Ostrowski H","year":"2019","unstructured":"Ostrowski H, Roszak J, Komisarek O. Botulinum toxin type A as an alternative way to treat trigeminal neuralgia: a systematic review. Neurol Neurochir Pol. 2019, 53:327-34. 10.5603\/PJNNS.a2019.0030","journal-title":"Neurol Neurochir Pol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1756285609359317","article-title":"Treatment options in trigeminal neuralgia","volume":"3","author":"Obermann M","year":"2010","unstructured":"Obermann M. Treatment options in trigeminal neuralgia. Ther Adv Neurol Disord. 2010, 3:107-15. 10.1177\/1756285609359317","journal-title":"Ther Adv Neurol Disord"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180940.98815.7","article-title":"An open study of botulinum-a toxin treatment of trigeminal neuralgia","volume":"65","author":"Piovesan EJ","year":"2005","unstructured":"Piovesan EJ, Teive HG, Kowacs PA, et al.. An open study of botulinum-a toxin treatment of trigeminal neuralgia. Neurology. 2005, 65:1306-8. 10.1212\/01.wnl.0000180940.98815.7","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1097\/00002508-200503000-00010","article-title":"Injections of botulinum toxin type a produce pain alleviation in intractable trigeminal neuralgia","volume":"21","author":"Allam N","year":"2005","unstructured":"Allam N, Brasil-Neto JP, Brown G, et al.. Injections of botulinum toxin type a produce pain alleviation in intractable trigeminal neuralgia. Clin J Pain. 2005, 21:182-4.","journal-title":"Clin J Pain"},{"key":"ref9","article-title":"Botulinum toxin type-A in pain management","author":"Gordon D","year":"2016","unstructured":"Gordon D, Finkelstein I, Freund B, Dhawan P. Botulinum toxin type-A in pain management. Pract Pain Manag. 2016,","journal-title":"Pract Pain Manag"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0744-z","article-title":"Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia","volume":"18","author":"Sandrini G","year":"2017","unstructured":"Sandrini G, De Icco R, Tassorelli C, Smania N, Tamburin S. Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia. J Headache Pain. 2017, 18:38. 10.1186\/s10194-017-0744-z","journal-title":"J Headache Pain"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2015.12.002","article-title":"The analgesic effect of abobotulinum and incobotulinum toxins type A in central poststroke pain: Two case reports","volume":"8","author":"Camoes-Barbosa A","year":"2016","unstructured":"Camoes-Barbosa A, Neves AF. The analgesic effect of abobotulinum and incobotulinum toxins type A in central poststroke pain: Two case reports. PM&amp;R. 2016, 8:384-7. 10.1016\/j.pmrj.2015.12.002","journal-title":"PM&R"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v11i5.3590","article-title":"Efficacy of incobotulinumtoxinA for spasticity-associated pain in a series of patients with spasticity of diverse etiologies","volume":"11","author":"Camoes-Barbosa","year":"2023","unstructured":"Camoes-Barbosa, A. Efficacy of incobotulinumtoxinA for spasticity-associated pain in a series of patients with spasticity of diverse etiologies. Med Res Arch. 2023, 11:5. 10.18103\/mra.v11i5.3590","journal-title":"Med Res Arch"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13120887","article-title":"Pain reduction in adults with limb spasticity following treatment with incobotulinumtoxinA: a pooled analysis","volume":"13","author":"Wissel J","year":"2021","unstructured":"Wissel J, Cam\u00f5es-Barbosa A, Comes G, Althaus M, Scheschonka A, Simpson DM. Pain reduction in adults with limb spasticity following treatment with incobotulinumtoxinA: a pooled analysis. Toxins (Basel). 2021, 13:887. 10.3390\/toxins13120887","journal-title":"Toxins (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.25759\/spmfr.232","article-title":"Ombro Doloroso Do Hemipl\u00e9gico: Da Preven\u00e7\u00e3o Ao Tratamento.","volume":"28","author":"Neves AF","year":"2016","unstructured":"Neves AF, Cam\u00f5es-Barbosa A. Ombro Doloroso Do Hemipl\u00e9gico: Da Preven\u00e7\u00e3o Ao Tratamento.. Revista Da Sociedade Portuguesa de Medicina F\u00edsica E de Reabilita\u00e7\u00e3o. 2016, 28:24. 10.25759\/spmfr.232","journal-title":"Revista Da Sociedade Portuguesa de Medicina F\u00edsica E de Reabilita\u00e7\u00e3o"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MRR.0000000000000495","article-title":"Botulinum toxin type A therapy for bilateral focal neuropathic pruritus in multiple sclerosis: a case report","volume":"44","author":"Portugal DM","year":"2021","unstructured":"Portugal DM, Ferreira EF, Cam\u00f5es-Barbosa A. Botulinum toxin type A therapy for bilateral focal neuropathic pruritus in multiple sclerosis: a case report. Int J Rehabil Res. 2021, 44:382-3. 10.1097\/MRR.0000000000000495","journal-title":"Int J Rehabil Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1740::AID-MUS17>3.0.CO;2-V","article-title":"Hemifacial spasm: clinical findings and treatment","volume":"21","author":"Wang A","year":"1998","unstructured":"Wang A, Jankovic J. Hemifacial spasm: clinical findings and treatment. Muscle Nerve. 1998, 21:12-1740. 10.1002\/(SICI)1097-4598(199812)21:12&lt;1740::AID-MUS17&gt;3.0.CO;2-V","journal-title":"Muscle Nerve"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2024.101804","article-title":"IncobotulinumtoxinA in refractory temporomandibular disorder due to disk dislocation: a prospective study","volume":"125","author":"Ferreira EF","year":"2024","unstructured":"Ferreira EF, Cam\u00f5es-Barbosa A. IncobotulinumtoxinA in refractory temporomandibular disorder due to disk dislocation: a prospective study. J Stomatol Oral Maxillofac Surg. 2024, 125:101804. 10.1016\/j.jormas.2024.101804","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/BF03022619","article-title":"The effects of botulinum toxin A on mechanical and cold allodynia in a rat model of neuropathic pain","volume":"53","author":"Park HJ","year":"2006","unstructured":"Park HJ, Lee Y, Lee J, Park C, Moon DE. The effects of botulinum toxin A on mechanical and cold allodynia in a rat model of neuropathic pain. Can J Anaesth. 2006, 53:470-7. 10.1007\/BF03022619","journal-title":"Can J Anaesth"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412441721","article-title":"Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial","volume":"32","author":"Wu CJ","year":"2012","unstructured":"Wu CJ, Lian YJ, Zheng YK, et al.. Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial. Cephalalgia. 2012, 32:443-50. 10.1177\/0333102412441721","journal-title":"Cephalalgia"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-92","article-title":"Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia?","volume":"14","author":"Shehata HS","year":"2013","unstructured":"Shehata HS, El-Tamawy MS, Shalaby NM, Ramzy G. Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia?. J Headache Pain. 2013, 14:92. 10.1186\/1129-2377-14-92","journal-title":"J Headache Pain"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e31829cb60e","article-title":"Acute treatment of trigeminal neuralgia with onabotulinum toxin A","volume":"36","author":"Z\u00fa\u00f1iga C","year":"2013","unstructured":"Z\u00fa\u00f1iga C, Piedimonte F, D\u00edaz S, Micheli F. Acute treatment of trigeminal neuralgia with onabotulinum toxin A. Clin Neuropharmacol. 2013, 36:146-50. 10.1097\/WNF.0b013e31829cb60e","journal-title":"Clin Neuropharmacol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-65","article-title":"Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Zhang H","year":"2014","unstructured":"Zhang H, Lian Y, Ma Y, Chen Y, He C, Xie N, Wu C. Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial. J Headache Pain. 2014, 15:65. 10.1186\/1129-2377-15-65","journal-title":"J Headache Pain"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326598.83183.04","article-title":"Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies","volume":"71","author":"Gronseth G","year":"2008","unstructured":"Gronseth G, Cruccu G, Alksne J, et al.. Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008, 71:1183-90. 10.1212\/01.wnl.0000326598.83183.04","journal-title":"Neurology"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1517\/14656561003767449","article-title":"Medical management of trigeminal neuropathic pains","volume":"11","author":"Zakrzewska JM","year":"2010","unstructured":"Zakrzewska JM. Medical management of trigeminal neuropathic pains. Expert Opin Pharmacother. 2010, 11:1239-54. 10.1517\/14656561003767449","journal-title":"Expert Opin Pharmacother"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.05.001","article-title":"Operative strategies for minimizing hearing loss and other major complications associated with microvascular decompression for trigeminal neuralgia","volume":"74","author":"Bond AE","year":"2010","unstructured":"Bond AE, Zada G, Gonzalez AA, Hansen C, Giannotta SL. Operative strategies for minimizing hearing loss and other major complications associated with microvascular decompression for trigeminal neuralgia. World Neurosurg. 2010, 74:172-7. 10.1016\/j.wneu.2010.05.001","journal-title":"World Neurosurg"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1097\/00002826-200209000-00006","article-title":"Beneficial effects of botulinum toxin type a for patients with painful tic convulsif","volume":"25","author":"Micheli F","year":"2002","unstructured":"Micheli F, Scorticati MC, Raina G. Beneficial effects of botulinum toxin type a for patients with painful tic convulsif. Clin Neuropharmacol. 2002, 25:260-2.","journal-title":"Clin Neuropharmacol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.43.7s.3.x","article-title":"Evidence for antinociceptive activity of botulinum toxin type A in pain management","volume":"43 Suppl 1","author":"Aoki KR","year":"2003","unstructured":"Aoki KR. Evidence for antinociceptive activity of botulinum toxin type A in pain management. Headache. 2003, 43 Suppl 1:S9-15. 10.1046\/j.1526-4610.43.7s.3.x","journal-title":"Headache"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2071-2","article-title":"Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia","volume":"5","author":"Wu C","year":"2016","unstructured":"Wu C, Xie N, Lian Y, et al.. Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia. Springerplus. 2016, 5:431. 10.1186\/s40064-016-2071-2","journal-title":"Springerplus"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/00220345166592","article-title":"Antinociceptive effects of botulinum toxin type A on trigeminal neuropathic pain","volume":"95","author":"Yang KY","year":"2016","unstructured":"Yang KY, Kim MJ, Ju JS, et al.. Antinociceptive effects of botulinum toxin type A on trigeminal neuropathic pain. J Dent Res. 2016, 95:1183-90. 10.1177\/00220345166592","journal-title":"J Dent Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/291897-botulinum-toxin-type-a-in-trigeminal-neuralgia-treatment-a-case-series-and-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T18:53:52Z","timestamp":1731264832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/291897-botulinum-toxin-type-a-in-trigeminal-neuralgia-treatment-a-case-series-and-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.73389","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,10]]}}}