{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T05:06:02Z","timestamp":1731560762131,"version":"3.28.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"DOI":"10.7759\/cureus.73562","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T04:06:02Z","timestamp":1731470762000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Vitamin E Levels and Cholesterol, Vitamin D, and Frequency of Pulmonary Exacerbations in Children With Cystic Fibrosis"],"prefix":"10.7759","author":[{"given":"Hasan M","family":"Isa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema  A","family":"Alkharsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra S","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra H","family":"Isa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batool H","family":"Isa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood J","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afaf  M","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1054-3589(08)60996-5","article-title":"Oxidative stress in cystic fibrosis: does it occur and does it matter?","volume":"38","author":"Van der Vliet A","year":"1997","unstructured":"Van der Vliet A, Eiserich JP, Marelich GP, Halliwell B, Cross CE. Oxidative stress in cystic fibrosis: does it occur and does it matter?. Adv Pharmacol. 1997, 38:491-513. 10.1016\/s1054-3589(08)60996-5","journal-title":"Adv Pharmacol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2165\/11316160-000000000-00000","article-title":"Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date","volume":"70","author":"Becq F","year":"2010","unstructured":"Becq F. Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date. Drugs. 2010, 70:241-59. 10.2165\/11316160-000000000-00000","journal-title":"Drugs"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0899-9007(98)00086-0","article-title":"Nutrition and cystic fibrosis","volume":"14","author":"Wilson DC","year":"1998","unstructured":"Wilson DC, Pencharz PB. Nutrition and cystic fibrosis. Nutrition. 1998, 14:792-5. 10.1016\/s0899-9007(98)00086-0","journal-title":"Nutrition"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010162","article-title":"Current and future therapeutic approaches of exocrine pancreatic insufficiency in children with cystic fibrosis in the era of personalized medicine","volume":"15","author":"Ritivoiu ME","year":"2023","unstructured":"Ritivoiu ME, Dr\u0103goi CM, Matei D, et al.. Current and future therapeutic approaches of exocrine pancreatic insufficiency in children with cystic fibrosis in the era of personalized medicine. Pharmaceutics. 2023, 15:182. 10.3390\/pharmaceutics15010162","journal-title":"Pharmaceutics"},{"key":"ref5","article-title":"The role of vitamin e in human health and some diseases","volume":"14","author":"Rizvi S","year":"2014","unstructured":"Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. The role of vitamin e in human health and some diseases. Sultan Qaboos Univ Med J. 2014, 14:e157-65.","journal-title":"Sultan Qaboos Univ Med J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201787","article-title":"Fat-soluble vitamin deficiency in children and adolescents with cystic fibrosis","volume":"67","author":"Rana M","year":"2014","unstructured":"Rana M, Wong-See D, Katz T, et al.. Fat-soluble vitamin deficiency in children and adolescents with cystic fibrosis. J Clin Pathol. 2014, 67:605-8. 10.1136\/jclinpath-2013-201787","journal-title":"J Clin Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.17226\/9810","article-title":"Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids","author":"Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds","year":"2000","unstructured":"Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academies Press, Washington (DC); 2000. 10.17226\/9810"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1549","article-title":"Cognitive function of children with cystic fibrosis: deleterious effect of early malnutrition","volume":"113","author":"Koscik RL","year":"2004","unstructured":"Koscik RL, Farrell PM, Kosorok MR, et al.. Cognitive function of children with cystic fibrosis: deleterious effect of early malnutrition. Pediatrics. 2004, 113:1549-58. 10.1542\/peds.113.6.1549","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31804069e5","article-title":"Vitamins A and E and pulmonary exacerbations in patients with cystic fibrosis","volume":"45","author":"Hakim F","year":"2007","unstructured":"Hakim F, Kerem E, Rivlin J, Bentur L, Stankiewicz H, Bdolach-Abram T, Wilschanski M. Vitamins A and E and pulmonary exacerbations in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2007, 45:347-53. 10.1097\/MPG.0b013e31804069e5","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515000215","article-title":"Vitamin E intake, \u03b1-tocopherol levels and pulmonary function in children and adolescents with cystic fibrosis","volume":"113","author":"Woestenenk JW","year":"2015","unstructured":"Woestenenk JW, Broos N, Stellato RK, Arets HG, van der Ent CK, Houwen RH. Vitamin E intake, \u03b1-tocopherol levels and pulmonary function in children and adolescents with cystic fibrosis. Br J Nutr. 2015, 113:1096-101. 10.1017\/S0007114515000215","journal-title":"Br J Nutr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","article-title":"Should video laryngoscopy or direct laryngoscopy be used for adults undergoing endotracheal intubation in the pre-hospital setting? A critical appraisal of a systematic review","volume":"15","author":"Pennington E","year":"2023","unstructured":"Pennington E, Bell S, Hill JE. Should video laryngoscopy or direct laryngoscopy be used for adults undergoing endotracheal intubation in the pre-hospital setting? A critical appraisal of a systematic review. J Paramed Pract. 2023, 15:255-9. 10.1002\/14651858","journal-title":"J Paramed Pract"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0729-1","article-title":"Dosage and formulation issues: oral vitamin E therapy in children","volume":"66","author":"Westergren T","year":"2010","unstructured":"Westergren T, Kalikstad B. Dosage and formulation issues: oral vitamin E therapy in children. Eur J Clin Pharmacol. 2010, 66:109-18. 10.1007\/s00228-009-0729-1","journal-title":"Eur J Clin Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001331","article-title":"Oral tocofersolan corrects or prevents vitamin E deficiency in children with chronic cholestasis","volume":"63","author":"Th\u00e9baut A","year":"2016","unstructured":"Th\u00e9baut A, Nemeth A, Le Mouha\u00ebr J, et al.. Oral tocofersolan corrects or prevents vitamin E deficiency in children with chronic cholestasis. J Pediatr Gastroenterol Nutr. 2016, 63:610-15. 10.1097\/MPG.0000000000001331","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1987.04460020060027","article-title":"Intramuscular vitamin E repletion in children with chronic cholestasis","volume":"141","author":"Perlmutter DH","year":"1987","unstructured":"Perlmutter DH, Gross P, Jones HR, Fulton A, Grand RJ. Intramuscular vitamin E repletion in children with chronic cholestasis. Am J Dis Child. 1987, 141:170-4. 10.1001\/archpedi.1987.04460020060027","journal-title":"Am J Dis Child"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2009.01027.x","article-title":"Bioavailability of oral vitamin E formulations in adult volunteers and children with chronic cholestasis or cystic fibrosis","volume":"34","author":"Jacquemin E","year":"2009","unstructured":"Jacquemin E, Hermeziu B, Kibleur Y, et al.. Bioavailability of oral vitamin E formulations in adult volunteers and children with chronic cholestasis or cystic fibrosis. J Clin Pharm Ther. 2009, 34:515-22. 10.1111\/j.1365-2710.2009.01027.x","journal-title":"J Clin Pharm Ther"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2015.05.006","article-title":"The road for survival improvement of cystic fibrosis patients in Arab countries","volume":"2","author":"Banjar H","year":"2015","unstructured":"Banjar H, Angyalosi G. The road for survival improvement of cystic fibrosis patients in Arab countries. Int J Pediatr Adolesc Med. 2015, 2:47-58. 10.1016\/j.ijpam.2015.05.006","journal-title":"Int J Pediatr Adolesc Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/44.1.35","article-title":"Cystic fibrosis in bahrain incidence, phenotype, and outcome","volume":"44","author":"Al-Mahroos F","year":"1998","unstructured":"Al-Mahroos F. Cystic fibrosis in bahrain incidence, phenotype, and outcome. J Trop Pediatr. 1998, 44:35-9. 10.1093\/tropej\/44.1.35","journal-title":"J Trop Pediatr"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/48.6.348","article-title":"Cystic fibrosis transmembrane regulator gene mutations in Bahrain","volume":"48","author":"Eskandarani HA","year":"2002","unstructured":"Eskandarani HA. Cystic fibrosis transmembrane regulator gene mutations in Bahrain. J Trop Pediatr. 2002, 48:348-50. 10.1093\/tropej\/48.6.348","journal-title":"J Trop Pediatr"},{"key":"ref19","article-title":"Mucoviscidosis (cystic fibrosis of the pancreas) in Bahrain, Arabian Gulf","volume":"7","author":"Khan IM","year":"1985","unstructured":"Khan IM, Mohammad AM. Mucoviscidosis (cystic fibrosis of the pancreas) in Bahrain, Arabian Gulf. Bahrain Med Bull. 1985, 7:17-23.","journal-title":"Bahrain Med Bull"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2016.3.13476","article-title":"Growth assessment and risk factors of malnutrition in children with cystic fibrosis","volume":"37","author":"Isa HM","year":"2016","unstructured":"Isa HM, Al-Ali LF, Mohamed AM. Growth assessment and risk factors of malnutrition in children with cystic fibrosis. Saudi Med J. 2016, 37:293-8. 10.15537\/smj.2016.3.13476","journal-title":"Saudi Med J"},{"key":"ref21","unstructured":"Cystic fibrosis diagnosis. (2023). Accessed. December 11, 2023: https:\/\/www.nhlbi.nih.gov\/health\/cystic-fibrosis."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab019","article-title":"Vitamin E","volume":"12","author":"Traber MG","year":"2021","unstructured":"Traber MG. Vitamin E. Adv Nutr. 2021, 12:1047-8. 10.1093\/advances\/nmab019","journal-title":"Adv Nutr"},{"key":"ref23","unstructured":"Vitamin E deficiency. (2023). Accessed. December 11, 2023: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519051\/."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008227.pub3","article-title":"Pancreatic enzyme replacement therapy for people with cystic fibrosis","volume":"11","author":"Somaraju UR","year":"2016","unstructured":"Somaraju UR, Solis-Moya A. Pancreatic enzyme replacement therapy for people with cystic fibrosis. Cochrane Database Syst Rev. 2016, 11:CD008227. 10.1002\/14651858.CD008227.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201801-0105OC","article-title":"Effects of an antioxidant-enriched multivitamin in cystic fibrosis. A randomized, controlled, multicenter clinical trial","volume":"198","author":"Sagel SD","year":"2018","unstructured":"Sagel SD, Khan U, Jain R, et al.. Effects of an antioxidant-enriched multivitamin in cystic fibrosis. A randomized, controlled, multicenter clinical trial. Am J Respir Crit Care Med. 2018, 198:639-47. 10.1164\/rccm.201801-0105OC","journal-title":"Am J Respir Crit Care Med"},{"key":"ref26","article-title":"Leukocytosis: basics of clinical assessment","volume":"62","author":"Abramson N","year":"2000","unstructured":"Abramson N, Melton B. Leukocytosis: basics of clinical assessment. Am Fam Physician. 2000, 62:2053-60.","journal-title":"Am Fam Physician"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.648442","article-title":"The association between vitamin E deficiency and critically ill children with sepsis and septic shock","volume":"8","author":"Dang H","year":"2021","unstructured":"Dang H, Li J, Liu C, Xu F. The association between vitamin E deficiency and critically ill children with sepsis and septic shock. Front Nutr. 2021, 8:648442. 10.3389\/fnut.2021.648442","journal-title":"Front Nutr"},{"key":"ref28","article-title":"Hemolytic anemia","author":"Baldwin C","year":"2022","unstructured":"Baldwin C, Pandey J, Olarewaju O. Hemolytic anemia. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2022."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/000992289403300101","article-title":"Severe hemolytic anemia associated with vitamin E deficiency in infants with cystic fibrosis. Implications for neonatal screening","volume":"33","author":"Wilfond BS","year":"1994","unstructured":"Wilfond BS, Farrell PM, Laxova A, Mischler E. Severe hemolytic anemia associated with vitamin E deficiency in infants with cystic fibrosis. Implications for neonatal screening. Clin Pediatr (Phila). 1994, 33:2-7. 10.1177\/000992289403300101","journal-title":"Clin Pediatr (Phila)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j. nutres.2012.03.012","article-title":"Vitamin E supplementation protects erythrocyte membranes from oxidative stress in healthy Chinese middle-aged and elderly people","volume":"32","author":"Sun Y","year":"2012","unstructured":"Sun Y, Ma A, Li Y, Han X, Wang Q, Liang H. Vitamin E supplementation protects erythrocyte membranes from oxidative stress in healthy Chinese middle-aged and elderly people. Nutr Res. 2012, 32:328-34. 10.1016\/j. nutres.2012.03.012","journal-title":"Nutr Res"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.11.022","article-title":"Inborn defects in the antioxidant systems of human red blood cells","volume":"67","author":"van Zwieten R","year":"2014","unstructured":"van Zwieten R, Verhoeven AJ, Roos D. Inborn defects in the antioxidant systems of human red blood cells. Free Radic Biol Med. 2014, 67:377-86. 10.1016\/j.freeradbiomed.2013.11.022","journal-title":"Free Radic Biol Med"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310283291804","article-title":"Correlation between genotype and phenotype in patients with cystic fibrosis","volume":"329","author":"The Cystic Fibrosis Genotype-Phenotype Consortium","year":"1993","unstructured":"The Cystic Fibrosis Genotype-Phenotype Consortium. Correlation between genotype and phenotype in patients with cystic fibrosis. N Engl J Med. 1993, 329:1308-13. 10.1056\/NEJM199310283291804","journal-title":"N Engl J Med"},{"key":"ref33","unstructured":"Drugs for the gastrointestinal tract. (2021). Accessed. January 17, 2024: https:\/\/www.rbht.nhs.uk\/care-children-cystic-fibrosis-drugs-gastrointestinal-tract."},{"key":"ref34","article-title":"Vitamin E: metabolism and requirements","author":"Traber MG","year":"2013","unstructured":"Traber MG. Vitamin E: metabolism and requirements. Encyclopedia of Human Nutrition. Caballero B (ed): Elsevier, Amsterdam; 2013. 383-9."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/218691","article-title":"Vitamin d deficiency in cystic fibrosis","volume":"2010","author":"Hall WB","year":"2010","unstructured":"Hall WB, Sparks AA, Aris RM. Vitamin d deficiency in cystic fibrosis. Int J Endocrinol. 2010, 2010:218691. 10.1155\/2010\/218691","journal-title":"Int J Endocrinol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.26719\/emhj.19.084","article-title":"Vitamin D deficiency in healthy children in Bahrain: do gender and age matter?","volume":"26","author":"Isa H","year":"2020","unstructured":"Isa H, Almaliki M, Alsabea A, Mohamed A. Vitamin D deficiency in healthy children in Bahrain: do gender and age matter?. East Mediterr Health J. 2020, 26:260-7. 10.26719\/emhj.19.084","journal-title":"East Mediterr Health J"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614562839","article-title":"Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis","volume":"30","author":"Norton L","year":"2015","unstructured":"Norton L, Page S, Sheehan M, Mazurak V, Brunet-Wood K, Larsen B. Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis. Nutr Clin Pract. 2015, 30:111-16. 10.1177\/0884533614562839","journal-title":"Nutr Clin Pract"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/nu14235189","article-title":"Comprehensive analysis of seasonal and geographical variation in UVB radiation relevant for vitamin D production in Europe","volume":"14","author":"Khanna T","year":"2022","unstructured":"Khanna T, Shraim R, Zarkovic M, van Weele M, van Geffen J, Zgaga L. Comprehensive analysis of seasonal and geographical variation in UVB radiation relevant for vitamin D production in Europe. Nutrients. 2022, 14:5189. 10.3390\/nu14235189","journal-title":"Nutrients"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.02.010","article-title":"Dietary intake and lipid profile in children and adolescents with cystic fibrosis","volume":"16","author":"Woestenenk JW","year":"2017","unstructured":"Woestenenk JW, Schulkes DA, Schipper HS, van der Ent CK, Houwen RH. Dietary intake and lipid profile in children and adolescents with cystic fibrosis. J Cyst Fibros. 2017, 16:410-17. 10.1016\/j.jcf.2017.02.010","journal-title":"J Cyst Fibros"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-1151","article-title":"Reduced absorption and enhanced synthesis of cholesterol in patients with cystic fibrosis: a preliminary study of plasma sterols","volume":"54","author":"Gelzo M","year":"2016","unstructured":"Gelzo M, Sica C, Elce A, et al.. Reduced absorption and enhanced synthesis of cholesterol in patients with cystic fibrosis: a preliminary study of plasma sterols. Clin Chem Lab Med. 2016, 54:1461-6. 10.1515\/cclm-2015-1151","journal-title":"Clin Chem Lab Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/313575-correlation-between-vitamin-e-levels-and-cholesterol-vitamin-d-and-frequency-of-pulmonary-exacerbations-in-children-with-cystic-fibrosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T04:06:22Z","timestamp":1731470782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/313575-correlation-between-vitamin-e-levels-and-cholesterol-vitamin-d-and-frequency-of-pulmonary-exacerbations-in-children-with-cystic-fibrosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":40,"URL":"https:\/\/doi.org\/10.7759\/cureus.73562","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,12]]}}}