{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:56:11Z","timestamp":1785768971853,"version":"3.56.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,14]]},"DOI":"10.7759\/cureus.73712","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T01:10:50Z","timestamp":1731633050000},"source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Idea of Human Reproduction in Space: A Potential Area for Future Research"],"prefix":"10.7759","author":[{"given":"Priyanka","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avir","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Astronauts &amp; cosmonauts. Accessed. May 22, 2023: https:\/\/www.worldspaceflight.com\/."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.icrp.2013.05.004","article-title":"ICRP Publication 123: Assessment of radiation exposure of astronauts in space","volume":"42","author":"Dietze G","year":"2013","unstructured":"Dietze G, Bartlett DT, Cool DA, et al.. ICRP Publication 123: Assessment of radiation exposure of astronauts in space. Ann ICRP. 2013, 42:1-339. 10.1016\/j.icrp.2013.05.004","journal-title":"Ann ICRP"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1667\/RR1330.1","article-title":"Physical and biological organ dosimetry analysis for international space station astronauts","volume":"170","author":"Cucinotta FA","year":"2008","unstructured":"Cucinotta FA, Kim MH, Willingham V, George KA. Physical and biological organ dosimetry analysis for international space station astronauts. Radiat Res. 2008, 170:127-38. 10.1667\/RR1330.1","journal-title":"Radiat Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.007252","article-title":"Models to study gravitational biology of mammalian reproduction","volume":"67","author":"Tou J","year":"2002","unstructured":"Tou J, Ronca A, Grindeland R, Wade C. Models to study gravitational biology of mammalian reproduction. Biol Reprod. 2002, 67:1681-7. 10.1095\/biolreprod.102.007252","journal-title":"Biol Reprod"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20-0084","article-title":"The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells","volume":"9","author":"Grimm D","year":"2020","unstructured":"Grimm D, Wehland M, Corydon TJ, et al.. The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells. Stem Cells Transl Med. 2020, 9:882-94. 10.1002\/sctm.20-0084","journal-title":"Stem Cells Transl Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020862","article-title":"Survival pathways are differently affected by microgravity in normal and cancerous breast cells","volume":"22","author":"Monti N","year":"2021","unstructured":"Monti N, Masiello MG, Proietti S, et al.. Survival pathways are differently affected by microgravity in normal and cancerous breast cells. Int J Mol Sci. 2021, 22:862. 10.3390\/ijms22020862","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063073","article-title":"The fight against cancer by microgravity: the multicellular spheroid as a metastasis model","volume":"23","author":"Grimm D","year":"2022","unstructured":"Grimm D, Schulz H, Kr\u00fcger M, et al.. The fight against cancer by microgravity: the multicellular spheroid as a metastasis model. Int J Mol Sci. 2022, 23:3073. 10.3390\/ijms23063073","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200002000-00025","article-title":"Gynecological and reproductive issues for women in space: a review","volume":"55","author":"Jennings RT","year":"2000","unstructured":"Jennings RT, Baker ES. Gynecological and reproductive issues for women in space: a review. Obstet Gynecol Surv. 2000, 55:109-16. 10.1097\/00006254-200002000-00025","journal-title":"Obstet Gynecol Surv"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/npjmgrav.2016.8","article-title":"Medically induced amenorrhea in female astronauts","volume":"2","author":"Jain V","year":"2016","unstructured":"Jain V, Wotring VE. Medically induced amenorrhea in female astronauts. NPJ Microgravity. 2016, 2:16008. 10.1038\/npjmgrav.2016.8","journal-title":"NPJ Microgravity"},{"key":"ref10","article-title":"Effect of weightlessness on the reproductive system of mammals. (Article in Russian)","volume":"23","author":"Serova LV","year":"1989","unstructured":"Serova LV. Effect of weightlessness on the reproductive system of mammals. (Article in Russian). Kosm Biol Aviakosm Med. 1989, 23:11-6.","journal-title":"Kosm Biol Aviakosm Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.4915","article-title":"Effects of sex and gender on adaptations to space: reproductive health","volume":"23","author":"Ronca AE","year":"2014","unstructured":"Ronca AE, Baker ES, Bavendam TG, Beck KD, Miller VM, Tash JS, Jenkins M. Effects of sex and gender on adaptations to space: reproductive health. J Womens Health (Larchmt). 2014, 23:967-74. 10.1089\/jwh.2014.4915","journal-title":"J Womens Health (Larchmt)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-023-00248-5","article-title":"Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells","volume":"9","author":"Cheng K","year":"2023","unstructured":"Cheng K, Feng X, Yang C, et al.. Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells. NPJ Microgravity. 2023, 9:7. 10.1038\/s41526-023-00248-5","journal-title":"NPJ Microgravity"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022214","article-title":"Simulated microgravity compromises mouse oocyte maturation by disrupting meiotic spindle organization and inducing cytoplasmic blebbing","volume":"6","author":"Wu C","year":"2011","unstructured":"Wu C, Guo X, Wang F, et al.. Simulated microgravity compromises mouse oocyte maturation by disrupting meiotic spindle organization and inducing cytoplasmic blebbing. PLoS One. 2011, 6:e22214. 10.1371\/journal.pone.0022214","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1090193","article-title":"Effects of space flight on ovarian-hypophyseal function in postpartum rats","volume":"109","author":"Burden HW","year":"1997","unstructured":"Burden HW, Zary J, Lawrence IE, Jonnalagadda P, Davis M, Hodson CA. Effects of space flight on ovarian-hypophyseal function in postpartum rats. J Reprod Fertil. 1997, 109:193-7. 10.1530\/jrf.0.1090193","journal-title":"J Reprod Fertil"},{"key":"ref15","article-title":"The effects of space flight during gestation on rat uterine smooth muscle","volume":"5","author":"Burden HW","year":"1998","unstructured":"Burden HW, Poole MC, Zary J, Jeansonne B, Alberts JR. The effects of space flight during gestation on rat uterine smooth muscle. J Gravit Physiol. 1998, 5:23-9.","journal-title":"J Gravit Physiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.849","article-title":"Physiology of a microgravity environment selected contribution: effects of spaceflight during pregnancy on labor and birth at 1 G","volume":"89","author":"Ronca AE","year":"2000","unstructured":"Ronca AE, Alberts JR. Physiology of a microgravity environment selected contribution: effects of spaceflight during pregnancy on labor and birth at 1 G. J Appl Physiol (1985). 2000, 89:849-54. 10.1152\/jappl.2000.89.2.849","journal-title":"J Appl Physiol (1985)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-021-00139-7","article-title":"Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression","volume":"7","author":"Hong X","year":"2021","unstructured":"Hong X, Ratri A, Choi SY, Tash JS, Ronca AE, Alwood JS, Christenson LK. Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression. NPJ Microgravity. 2021, 7:11. 10.1038\/s41526-021-00139-7","journal-title":"NPJ Microgravity"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40789-y","article-title":"Behavior of mice aboard the International Space Station","volume":"9","author":"Ronca AE","year":"2019","unstructured":"Ronca AE, Moyer EL, Talyansky Y, et al.. Behavior of mice aboard the International Space Station. Sci Rep. 2019, 9:4717. 10.1038\/s41598-019-40789-y","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006753","article-title":"Detrimental effects of microgravity on mouse preimplantation development in vitro","volume":"4","author":"Wakayama S","year":"2009","unstructured":"Wakayama S, Kawahara Y, Li C, Yamagata K, Yuge L, Wakayama T. Detrimental effects of microgravity on mouse preimplantation development in vitro. PLoS One. 2009, 4:e6753. 10.1371\/journal.pone.0006753","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.3.770","article-title":"Clinostat rotation induces apoptosis in luteal cells of the pregnant rat","volume":"66","author":"Yang H","year":"2002","unstructured":"Yang H, Bhat GK, Sridaran R. Clinostat rotation induces apoptosis in luteal cells of the pregnant rat. Biol Reprod. 2002, 66:770-7. 10.1095\/biolreprod66.3.770","journal-title":"Biol Reprod"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1967.212.1.164","article-title":"Reproduction and growth of mice and rats under conditions of simulated increased gravity","volume":"212","author":"Oyama J","year":"1967","unstructured":"Oyama J, Platt WT. Reproduction and growth of mice and rats under conditions of simulated increased gravity. Am J Physiol. 1967, 212:164-6. 10.1152\/ajplegacy.1967.212.1.164","journal-title":"Am J Physiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2233","article-title":"Long-duration space flight and bed rest effects on testosterone and other steroids","volume":"97","author":"Smith SM","year":"2012","unstructured":"Smith SM, Heer M, Wang Z, Huntoon CL, Zwart SR. Long-duration space flight and bed rest effects on testosterone and other steroids. J Clin Endocrinol Metab. 2012, 97:270-8. 10.1210\/jc.2011-2233","journal-title":"J Clin Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0273-1177(92)90106-8","article-title":"Comparative study of spermatogonial survival after x-ray exposure, high LET (HZE) irradiation or spaceflight","volume":"12","author":"Sapp WJ","year":"1992","unstructured":"Sapp WJ, Philpott DE, Williams CS, Williams JW, Kato K, Miquel JM, Serova L. Comparative study of spermatogonial survival after x-ray exposure, high LET (HZE) irradiation or spaceflight. Adv Space Res. 1992, 12:179-89. 10.1016\/0273-1177(92)90106-8","journal-title":"Adv Space Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035418","article-title":"The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis","volume":"7","author":"Masini MA","year":"2012","unstructured":"Masini MA, Albi E, Barmo C, et al.. The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis. PLoS One. 2012, 7:e35418. 10.1371\/journal.pone.0035418","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.07.014","article-title":"Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice","volume":"65","author":"Li H","year":"2016","unstructured":"Li H, He Y, Yan J, Zhao Q, Di C, Zhang H. Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice. Reprod Toxicol. 2016, 65:148-58. 10.1016\/j.reprotox.2016.07.014","journal-title":"Reprod Toxicol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/306301-exploring-the-idea-of-human-reproduction-in-space-a-potential-area-for-future-research","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T01:10:54Z","timestamp":1731633054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/306301-exploring-the-idea-of-human-reproduction-in-space-a-potential-area-for-future-research"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.73712","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,14]]}}}