{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T05:08:21Z","timestamp":1732338501278,"version":"3.28.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,21]]},"DOI":"10.7759\/cureus.74186","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:07:41Z","timestamp":1732248461000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Effects of Splenomegaly and Splenectomy in Beta-Thalassemia Major"],"prefix":"10.7759","author":[{"given":"Sumira","family":"Abbas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haris Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajeeha","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mian Mufarih","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.246062","article-title":"Thalassemia, a human blood disorder","volume":"83","author":"Shafique F","year":"2021","unstructured":"Shafique F, Ali S, Almansouri T, et al.. Thalassemia, a human blood disorder. Braz J Biol. 2021, 83:e246062. 10.1590\/1519-6984.246062","journal-title":"Braz J Biol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228771","article-title":"Management of iron overload in beta-thalassemia patients: clinical practice update based on case series","volume":"21","author":"Pinto VM","year":"2020","unstructured":"Pinto VM, Forni GL. Management of iron overload in beta-thalassemia patients: clinical practice update based on case series. Int J Mol Sci. 2020, 21:10.3390\/ijms21228771","journal-title":"Int J Mol Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.17582\/journal.pjz\/20190630160603","article-title":"Assessment of patients with \u03b2-thalassemia major, undergoing tertiary care at a regional thalassemia center in Pakistan","volume":"53","author":"Sharif Y","year":"2021","unstructured":"Sharif Y, Irshad S, Muazzam A, et al.. Assessment of patients with \u03b2-thalassemia major, undergoing tertiary care at a regional thalassemia center in Pakistan. Pak J Zool. 2021, 53:245. 10.17582\/journal.pjz\/20190630160603","journal-title":"Pak J Zool"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245831","article-title":"Extramedullary hematopoiesis of the liver and spleen","volume":"10","author":"Cenariu D","year":"2021","unstructured":"Cenariu D, Iluta S, Zimta AA, et al.. Extramedullary hematopoiesis of the liver and spleen. J Clin Med. 2021, 10:10.3390\/jcm10245831","journal-title":"J Clin Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.796837","article-title":"The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia\/hyposplenism and hypersplenism","volume":"13","author":"Peretz S","year":"2022","unstructured":"Peretz S, Livshits L, Pretorius E, et al.. The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia\/hyposplenism and hypersplenism. Front Physiol. 2022, 13:796837. 10.3389\/fphys.2022.796837","journal-title":"Front Physiol"},{"key":"ref6","article-title":"Effect of Splenectomy in thalassemia major patients on some blood parameters, hormones & blood transfusion frequency","volume":"1","author":"Azeez FS","year":"2022","unstructured":"Azeez FS. Effect of Splenectomy in thalassemia major patients on some blood parameters, hormones & blood transfusion frequency. Sumer Univ J Pure Sci. 2022, 1:26-32.","journal-title":"Sumer Univ J Pure Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15343","article-title":"Beta-thalassemia and the advent of new interventions beyond transfusion and iron chelation","volume":"88","author":"Chauhan W","year":"2022","unstructured":"Chauhan W, Shoaib S, Fatma R, Zaka-Ur-Rab Z, Afzal M. Beta-thalassemia and the advent of new interventions beyond transfusion and iron chelation. Br J Clin Pharmacol. 2022, 88:3610-26. 10.1111\/bcp.15343","journal-title":"Br J Clin Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019650","article-title":"Coronavirus disease 2019-associated thrombosis and coagulopathy: review of the pathophysiological characteristics and implications for antithrombotic management","volume":"10","author":"Ortega-Paz L","year":"2021","unstructured":"Ortega-Paz L, Capodanno D, Montalescot G, Angiolillo DJ. Coronavirus disease 2019-associated thrombosis and coagulopathy: review of the pathophysiological characteristics and implications for antithrombotic management. J Am Heart Assoc. 2021, 10:e019650. 10.1161\/JAHA.120.019650","journal-title":"J Am Heart Assoc"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19077","article-title":"Is splenectomy a good strategy for refractory immune thrombocytopenia in adults?","volume":"203","author":"Godeau B","year":"2023","unstructured":"Godeau B. Is splenectomy a good strategy for refractory immune thrombocytopenia in adults?. Br J Haematol. 2023, 203:86-95. 10.1111\/bjh.19077","journal-title":"Br J Haematol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081764","article-title":"Thrombotic complications in patients with immune-mediated hemolysis","volume":"10","author":"Capecchi M","year":"2021","unstructured":"Capecchi M, Ciavarella A, Artoni A, Abbattista M, Martinelli I. Thrombotic complications in patients with immune-mediated hemolysis. J Clin Med. 2021, 10:10.3390\/jcm10081764","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2023.10.001","article-title":"Relationship between spleen pathologic changes and spleen stiffness in portal hypertension rat model","volume":"50","author":"Du L","year":"2024","unstructured":"Du L, Deng H, Wu X, Liu F, Yin T, Zheng J. Relationship between spleen pathologic changes and spleen stiffness in portal hypertension rat model. Ultrasound Med Biol. 2024, 50:216-23. 10.1016\/j.ultrasmedbio.2023.10.001","journal-title":"Ultrasound Med Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002468","article-title":"Long-term results of splenectomy in transfusion-dependent thalassemia","volume":"45","author":"Akca T","year":"2023","unstructured":"Akca T, Ozdemir GN, Aycicek A, Ozkaya G. Long-term results of splenectomy in transfusion-dependent thalassemia. J Pediatr Hematol Oncol. 2023, 45:143-8. 10.1097\/MPH.0000000000002468","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2022.103620","article-title":"The long-term efficacy in blood transfusions, hematologic parameter changes, and complications after splenectomy in patients with transfusion-dependent thalassemia","volume":"62","author":"Osataphan N","year":"2023","unstructured":"Osataphan N, Dumnil S, Tantiworawit A, et al.. The long-term efficacy in blood transfusions, hematologic parameter changes, and complications after splenectomy in patients with transfusion-dependent thalassemia. Transfus Apher Sci. 2023, 62:103620. 10.1016\/j.transci.2022.103620","journal-title":"Transfus Apher Sci"},{"key":"ref14","article-title":"Chapter 3: Splenectomy: clinical applications and outcomes","author":"Arumugaswamy PR","year":"2023","unstructured":"Arumugaswamy PR, Singh D, Rathore YS. Chapter 3: Splenectomy: clinical applications and outcomes. Advances in Health and Disease. Duncan LT (ed): Nova Science Publishers, Hauppauge; 2023. 72:119."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121864","article-title":"Iron overload, oxidative stress, and ferroptosis in the failing heart and liver","volume":"10","author":"Mancardi D","year":"2021","unstructured":"Mancardi D, Mezzanotte M, Arrigo E, Barinotti A, Roetto A. Iron overload, oxidative stress, and ferroptosis in the failing heart and liver. Antioxidants (Basel). 2021, 10:10.3390\/antiox10121864","journal-title":"Antioxidants (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612928","article-title":"Iron load toxicity in medicine: from molecular and cellular aspects to clinical implications","volume":"24","author":"Kontoghiorghes GJ","year":"2023","unstructured":"Kontoghiorghes GJ. Iron load toxicity in medicine: from molecular and cellular aspects to clinical implications. Int J Mol Sci. 2023, 24:10.3390\/ijms241612928","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.11.029","article-title":"Iron overload: effects on cellular biochemistry","volume":"504","author":"Sousa L","year":"2020","unstructured":"Sousa L, Oliveira MM, Pess\u00f4a MT, Barbosa LA. Iron overload: effects on cellular biochemistry. Clin Chim Acta. 2020, 504:180-9. 10.1016\/j.cca.2019.11.029","journal-title":"Clin Chim Acta"},{"key":"ref18","article-title":"Splenectomy in Patients with Beta Thalassaemia Major","volume":"2(1)","author":"Ikram N","year":"2022","unstructured":"Ikram N, Anwar T, Gul-e-Najaf, Ahmed B, Subhani FA.. Splenectomy in Patients with Beta Thalassaemia Major. J haematol stem cell res. 2022, 2(1):26-30.","journal-title":"J haematol stem cell res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2450\/2014.0247-13","article-title":"Splenectomy improves anaemia but does not reduce iron burden in patients with haemoglobin H Constant Spring disease","volume":"12","author":"Zhou YL","year":"2014","unstructured":"Zhou YL, Zhang XH, Liu TN, Wang L, Yin XL. Splenectomy improves anaemia but does not reduce iron burden in patients with haemoglobin H Constant Spring disease. Blood Transfus. 2014, 12:471-8. 10.2450\/2014.0247-13","journal-title":"Blood Transfus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323679","article-title":"Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension","volume":"135","author":"Zafeiropoulos S","year":"2024","unstructured":"Zafeiropoulos S, Ahmed U, Bekiaridou A, et al.. Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension. Circ Res. 2024, 135:41-56. 10.1161\/CIRCRESAHA.123.323679","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.15078","article-title":"Cardiac complications in thalassemia throughout the lifespan: victories and challenges","volume":"1530","author":"Wood JC","year":"2023","unstructured":"Wood JC. Cardiac complications in thalassemia throughout the lifespan: victories and challenges. Ann N Y Acad Sci. 2023, 1530:64-73. 10.1111\/nyas.15078","journal-title":"Ann N Y Acad Sci"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-024-01821-y","article-title":"Multiparametric cardiac magnetic resonance in patients with thalassemia intermedia: new insights from the E-MIOT network","author":"Meloni A","year":"2024","unstructured":"Meloni A, Pistoia L, Ricchi P, et al.. Multiparametric cardiac magnetic resonance in patients with thalassemia intermedia: new insights from the E-MIOT network. 2024. 10.1007\/s11547-024-01821-y"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2019.102388","article-title":"Splenectomy and the incidence of venous thromboembolism and sepsis in patients with autoimmune hemolytic anemia","volume":"81","author":"Ho G","year":"2020","unstructured":"Ho G, Brunson A, Keegan THM, Wun T. Splenectomy and the incidence of venous thromboembolism and sepsis in patients with autoimmune hemolytic anemia. Blood Cells Mol Dis. 2020, 81:102388. 10.1016\/j.bcmd.2019.102388","journal-title":"Blood Cells Mol Dis"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072547","article-title":"Long-term health-related quality of life and clinical outcomes in patients with \u03b2-thalassemia after splenectomy","volume":"12","author":"Caocci G","year":"2023","unstructured":"Caocci G, Mulas O, Barella S, et al.. Long-term health-related quality of life and clinical outcomes in patients with \u03b2-thalassemia after splenectomy. J Clin Med. 2023, 12:10.3390\/jcm12072547","journal-title":"J Clin Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.07.3924","article-title":"A case of post-splenectomy pulmonary hypertension","volume":"164","author":"Bonaguro AMG","year":"2023","unstructured":"Bonaguro AMG, Walsh C, Leghari MO, et al.. A case of post-splenectomy pulmonary hypertension. Chest. 2023, 164:A6092-A3. 10.1016\/j.chest.2023.07.3924","journal-title":"Chest"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6898","article-title":"Post-splenectomy sepsis: a review of the literature","volume":"12","author":"Tahir F","year":"2020","unstructured":"Tahir F, Ahmed J, Malik F. Post-splenectomy sepsis: a review of the literature. Cureus. 2020, 12:e6898. 10.7759\/cureus.6898","journal-title":"Cureus"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.686225","article-title":"Pre-operative hemostatic status in dogs undergoing splenectomy for splenic masses","volume":"9","author":"McPhetridge JB","year":"2022","unstructured":"McPhetridge JB, Lynch AM, Webster CR, McCobb E, de Laforcade AM, O'Toole TE. Pre-operative hemostatic status in dogs undergoing splenectomy for splenic masses. Front Vet Sci. 2022, 9:686225. 10.3389\/fvets.2022.686225","journal-title":"Front Vet Sci"},{"key":"ref28","article-title":"Chapter 12: Splenomegaly and splenectomy","author":"Daar S","year":"2023","unstructured":"Daar S, Taher A. Chapter 12: Splenomegaly and splenectomy. 2021 Guidelines: For the Management of Transfusion Dependent Thalassaemia (TDT) [Internet], 4th edition. Eleftheriou P, Porter J (ed): Thalassemia International Federation, Nicosia; 2023."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02458-y","article-title":"The correlation of cardiac biomarkers and myocardial iron overload based on T2* MRI in major beta-thalassemia","volume":"38","author":"Saadatifar H","year":"2022","unstructured":"Saadatifar H, Niayeshfar A, Mard-Soltani M, Bahrampour E, Khalili S, Alinezhad Dezfuli D, Pouriamehr S. The correlation of cardiac biomarkers and myocardial iron overload based on T2* MRI in major beta-thalassemia. Int J Cardiovasc Imaging. 2022, 38:833-40. 10.1007\/s10554-021-02458-y","journal-title":"Int J Cardiovasc Imaging"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.47577\/tssj.v8i1.580","article-title":"Predictive factors of heart failure in patients with beta-thalassemia major","volume":"8","author":"Stanca I","year":"2020","unstructured":"Stanca I, Rus M, Albu A, Fica S. Predictive factors of heart failure in patients with beta-thalassemia major. Technium Soc Sci J. 2020, 8:670. 10.47577\/tssj.v8i1.580","journal-title":"Technium Soc Sci J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/310817-cardiovascular-effects-of-splenomegaly-and-splenectomy-in-beta-thalassemia-major","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:08:29Z","timestamp":1732248509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/310817-cardiovascular-effects-of-splenomegaly-and-splenectomy-in-beta-thalassemia-major"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.74186","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}