{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T05:30:43Z","timestamp":1733290243007,"version":"3.30.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,3]]},"DOI":"10.7759\/cureus.75061","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T02:42:11Z","timestamp":1733280131000},"source":"Crossref","is-referenced-by-count":0,"title":["Digital Ulcers and Microvascular Abnormalities Presenting As the Initial Manifestations of Pre-scleroderma"],"prefix":"10.7759","author":[{"given":"Alejandro","family":"Arango","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena N","family":"Yaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehreen","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Abril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Berianu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04745-5","article-title":"Raynaud's phenomenon - an update on diagnosis, classification and management","volume":"38","author":"Pauling JD","year":"2019","unstructured":"Pauling JD, Hughes M, Pope JE. Raynaud's phenomenon - an update on diagnosis, classification and management. Clin Rheumatol. 2019, 38:3317-30. 10.1007\/s10067-019-04745-5","journal-title":"Clin Rheumatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2020-0754","article-title":"Raynaud's phenomenon","volume":"20","author":"Haque A","year":"2020","unstructured":"Haque A, Hughes M. Raynaud's phenomenon. Clin Med (Lond). 2020, 20:580-7. 10.7861\/clinmed.2020-0754","journal-title":"Clin Med (Lond)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30480-1","article-title":"Systemic sclerosis-associated interstitial lung disease","volume":"8","author":"Perelas A","year":"2020","unstructured":"Perelas A, Silver RM, Arrossi AV, Highland KB. Systemic sclerosis-associated interstitial lung disease. Lancet Respir Med. 2020, 8:304-20. 10.1016\/S2213-2600(19)30480-1","journal-title":"Lancet Respir Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S82037","article-title":"Current perspectives on the immunopathogenesis of systemic sclerosis","volume":"5","author":"Fuschiotti P","year":"2016","unstructured":"Fuschiotti P. Current perspectives on the immunopathogenesis of systemic sclerosis. Immunotargets Ther. 2016, 5:21-35. 10.2147\/ITT.S82037","journal-title":"Immunotargets Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against rheumatism collaborative initiative","volume":"65","author":"van den Hoogen F","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, et al.. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against rheumatism collaborative initiative. Arthritis Rheum. 2013, 65:2737-47. 10.1002\/art.38098","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.010","article-title":"Mortality and survival in systemic sclerosis: systematic review and meta-analysis","volume":"44","author":"Rubio-Rivas M","year":"2014","unstructured":"Rubio-Rivas M, Royo C, Sime\u00f3n CP, Corbella X, Fonollosa V. Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Semin Arthritis Rheum. 2014, 44:208-19. 10.1016\/j.semarthrit.2014.05.010","journal-title":"Semin Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.106302","article-title":"The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy","volume":"68","author":"Matucci-Cerinic M","year":"2009","unstructured":"Matucci-Cerinic M, Allanore Y, Czirj\u00e1k L, et al.. The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy. Ann Rheum Dis. 2009, 68:1377-80. 10.1136\/ard.2008.106302","journal-title":"Ann Rheum Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203716","article-title":"Preliminary analysis of the very early diagnosis of systemic sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for suspicion of systemic sclerosis","volume":"73","author":"Minier T","year":"2014","unstructured":"Minier T, Guiducci S, Bellando-Randone S, et al.. Preliminary analysis of the very early diagnosis of systemic sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for suspicion of systemic sclerosis. Ann Rheum Dis. 2014, 73:2087-93. 10.1136\/annrheumdis-2013-203716","journal-title":"Ann Rheum Dis"},{"key":"ref9","article-title":"From VEDOSS to established systemic sclerosis diagnosis according to ACR\/EULAR 2013 classification criteria: a French-Italian capillaroscopic survey","volume":"36","author":"Vasile M","year":"2018","unstructured":"Vasile M, Avouac J, Sciarra I, et al.. From VEDOSS to established systemic sclerosis diagnosis according to ACR\/EULAR 2013 classification criteria: a French-Italian capillaroscopic survey. Clin Exp Rheumatol. 2018, 36:82-7.","journal-title":"Clin Exp Rheumatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02548-1","article-title":"Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort","volume":"23","author":"Jaafar S","year":"2021","unstructured":"Jaafar S, Lescoat A, Huang S, et al.. Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort. Arthritis Res Ther. 2021, 23:10.1186\/s13075-021-02548-1","journal-title":"Arthritis Res Ther"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/23971983221129211","article-title":"Very early diagnosis of systemic sclerosis: deciphering the heterogeneity of systemic sclerosis in the very early stages of the disease","volume":"8","author":"Lescoat A","year":"2023","unstructured":"Lescoat A. Very early diagnosis of systemic sclerosis: deciphering the heterogeneity of systemic sclerosis in the very early stages of the disease. J Scleroderma Relat Disord. 2023, 8:3-6. 10.1177\/23971983221129211","journal-title":"J Scleroderma Relat Disord"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160506","article-title":"Patterns of finger capillary abnormalities in connective tissue disease by \"wide-field\" microscopy","volume":"16","author":"Maricq HR","year":"1973","unstructured":"Maricq HR, LeRoy EC. Patterns of finger capillary abnormalities in connective tissue disease by \"wide-field\" microscopy. Arthritis Rheum. 1973, 16:619-28. 10.1002\/art.1780160506","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2017.66683","article-title":"Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis","volume":"55","author":"Shenavandeh S","year":"2017","unstructured":"Shenavandeh S, Haghighi MY, Nazarinia MA. Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis. Reumatologia. 2017, 55:15-23. 10.5114\/reum.2017.66683","journal-title":"Reumatologia"},{"key":"ref14","article-title":"OP0035 preliminary analysis of nailfold capillaroscopy in the very early diagnosis of systemic sclerosis (VEDOSS): the capi-vedoss experience","volume":"76","author":"Cutolo M","year":"2017","unstructured":"Cutolo M, Smith V, Distler O, Kowal-Bielecka O, Allanore Y, Matucci-Cerinic M. OP0035 preliminary analysis of nailfold capillaroscopy in the very early diagnosis of systemic sclerosis (VEDOSS): the capi-vedoss experience. Ann Rheum Dis. 2017, 76:65-6.","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/2397198318757699","article-title":"Advances in nailfold capillaroscopic analysis in systemic sclerosis","volume":"3","author":"Ruaro B","year":"2018","unstructured":"Ruaro B, Sulli A, Smith V, et al.. Advances in nailfold capillaroscopic analysis in systemic sclerosis. J Scleroderma Relat Disord. 2018, 3:122-31. 10.1177\/2397198318757699","journal-title":"J Scleroderma Relat Disord"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.11.006","article-title":"Antinuclear antibody-negative systemic sclerosis","volume":"44","author":"Salazar GA","year":"2015","unstructured":"Salazar GA, Assassi S, Wigley F, et al.. Antinuclear antibody-negative systemic sclerosis. Semin Arthritis Rheum. 2015, 44:680-6. 10.1016\/j.semarthrit.2014.11.006","journal-title":"Semin Arthritis Rheum"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767040-00003","article-title":"The diagnosis and treatment of Raynaud's phenomenon: a practical approach","volume":"67","author":"Pope JE","year":"2007","unstructured":"Pope JE. The diagnosis and treatment of Raynaud's phenomenon: a practical approach. Drugs. 2007, 67:517-25. 10.2165\/00003495-200767040-00003","journal-title":"Drugs"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3283398e53","article-title":"Statins and inflammation: an update","volume":"25","author":"Quist-Paulsen P","year":"2010","unstructured":"Quist-Paulsen P. Statins and inflammation: an update. Curr Opin Cardiol. 2010, 25:399-405. 10.1097\/HCO.0b013e3283398e53","journal-title":"Curr Opin Cardiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021331","article-title":"Hydroxychloroquine as an immunomodulatory and antithrombotic treatment in antiphospholipid syndrome","volume":"24","author":"Arachchillage DJ","year":"2023","unstructured":"Arachchillage DJ, Laffan M, Pericleous C. Hydroxychloroquine as an immunomodulatory and antithrombotic treatment in antiphospholipid syndrome. Int J Mol Sci. 2023, 24:10.3390\/ijms24021331","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez069","article-title":"Hydroxychloroquine significantly reduces serum markers of endothelial injury and NEMO videocapillaroscopy score in systemic sclerosis","volume":"58","author":"Basta F","year":"2019","unstructured":"Basta F, Irace R, Borgia A, Messiniti V, Riccardi A, Valentini G, Afeltra A. Hydroxychloroquine significantly reduces serum markers of endothelial injury and NEMO videocapillaroscopy score in systemic sclerosis. Rheumatology (Oxford). 2019, 58:1303-5. 10.1093\/rheumatology\/kez069","journal-title":"Rheumatology (Oxford)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/313650-digital-ulcers-and-microvascular-abnormalities-presenting-as-the-initial-manifestations-of-pre-scleroderma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T02:42:13Z","timestamp":1733280133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/313650-digital-ulcers-and-microvascular-abnormalities-presenting-as-the-initial-manifestations-of-pre-scleroderma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.75061","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,3]]}}}