{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:33:29Z","timestamp":1788183209263,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,12]]},"DOI":"10.7759\/cureus.75616","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T04:02:02Z","timestamp":1734062522000},"source":"Crossref","is-referenced-by-count":3,"title":["A Phase III, Double-Blind, Randomized, Multicenter, Clinical Trial to Evaluate the Efficacy and Safety of a Fixed-Dose Combination of Metformin Hydrochloride and Myo-Inositol Compared to Metformin in Patients With Polycystic Ovary Syndrome"],"prefix":"10.7759","author":[{"given":"Alka","family":"Kriplani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parikshit","family":"Tank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Maini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shymala","family":"Kaitala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Kantha G","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joydip","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvashi","family":"Bhatara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taruna","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Malvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13061113","article-title":"Current guidelines for diagnosing PCOS","volume":"13","author":"Christ JP","year":"2023","unstructured":"Christ JP, Cedars MI. Current guidelines for diagnosing PCOS. Diagnostics (Basel). 2023, 13:1113. 10.3390\/diagnostics13061113","journal-title":"Diagnostics (Basel)"},{"key":"ref2","unstructured":"World Health Organization. Polycystic ovary syndrome. (2023). Accessed. March 2, 2024: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/polycystic-ovary-syndrome."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1937_17","article-title":"Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India","volume":"150","author":"Ganie MA","year":"2019","unstructured":"Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics &amp; management of polycystic ovary syndrome in India. Indian J Med Res. 2019, 150:333-44. 10.4103\/ijmr.IJMR_1937_17","journal-title":"Indian J Med Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020583","article-title":"Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing","volume":"23","author":"Sadeghi HM","year":"2022","unstructured":"Sadeghi HM, Adeli I, Calina D, et al.. Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int J Mol Sci. 2022, 23:583. 10.3390\/ijms23020583","journal-title":"Int J Mol Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44493","article-title":"Role of metformin in polycystic ovary syndrome (PCOS)-related infertility","volume":"15","author":"Attia GM","year":"2023","unstructured":"Attia GM, Almouteri MM, Alnakhli FT. Role of metformin in polycystic ovary syndrome (PCOS)-related infertility. Cureus. 2023, 15:e44493. 10.7759\/cureus.44493","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100085","article-title":"A review: brief insight into polycystic ovarian syndrome","volume":"3","author":"Bulsara J","year":"2021","unstructured":"Bulsara J, Patel P, Soni A, Acharya S. A review: brief insight into polycystic ovarian syndrome. Endocr Metab Sci. 2021, 3:100085. 10.1016\/j.endmts.2021.100085","journal-title":"Endocr Metab Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15510","article-title":"Comparison of clinical, metabolic and hormonal effects of metformin versus combined therapy of metformin with myoinositol plus D-chiro-inositol in women with polycystic ovary syndrome (PCOS): a randomized controlled trial","volume":"13","author":"Bahadur A","year":"2021","unstructured":"Bahadur A, Arora H, Ravi AK, et al.. Comparison of clinical, metabolic and hormonal effects of metformin versus combined therapy of metformin with myoinositol plus D-chiro-inositol in women with polycystic ovary syndrome (PCOS): a randomized controlled trial. Cureus. 2021, 13:e15510. 10.7759\/cureus.15510","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41748","article-title":"Myoinositol versus metformin in the treatment of polycystic ovarian syndrome: a systematic review","volume":"15","author":"Bodepudi R","year":"2023","unstructured":"Bodepudi R, Seher S, Khan SA, et al.. Myoinositol versus metformin in the treatment of polycystic ovarian syndrome: a systematic review. Cureus. 2023, 15:e41748. 10.7759\/cureus.41748","journal-title":"Cureus"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20190309","article-title":"Effect of myoinositol and metformin in combination on clinical and hormonal profile in patients of polycystic ovarian syndrome","volume":"8","author":"Nagaria T","year":"2019","unstructured":"Nagaria T, Mohapatra A, Jaiswal J. Effect of myoinositol and metformin in combination on clinical and hormonal profile in patients of polycystic ovarian syndrome. Int J Reprod Contracept Obstet Gynecol. 2019, 8:702-9. 10.18203\/2320-1770.ijrcog20190309","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.189231","article-title":"The inositols and polycystic ovary syndrome","volume":"20","author":"Kalra B","year":"2016","unstructured":"Kalra B, Kalra S, Sharma JB. The inositols and polycystic ovary syndrome. Indian J Endocrinol Metab. 2016, 20:720-4. 10.4103\/2230-8210.189231","journal-title":"Indian J Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1549656","article-title":"Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial","volume":"35","author":"Agrawal A","year":"2019","unstructured":"Agrawal A, Mahey R, Kachhawa G, Khadgawat R, Vanamail P, Kriplani A. Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial. Gynecol Endocrinol. 2019, 35:511-4. 10.1080\/09513590.2018.1549656","journal-title":"Gynecol Endocrinol"},{"key":"ref12","article-title":"A comparative study of efficacy and safety of myo inositol versus metformin in polycystic ovarian syndrome in women","volume":"5","author":"Nehra J","year":"2016","unstructured":"Nehra J, Kaushal J, Singhal SR, Ghalaut VS. A comparative study of efficacy and safety of myo inositol versus metformin in polycystic ovarian syndrome in women. World J Pharma Pharmaceut Sci. 2016, 5:884-96.","journal-title":"World J Pharma Pharmaceut Sci"},{"key":"ref13","article-title":"Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer","volume":"41","author":"Hu L","year":"2014","unstructured":"Hu L, Shen H, Wu QF, Tian L, Hu MH. Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer. Clin Exp Obstet Gynecol. 2014, 41:288-92.","journal-title":"Clin Exp Obstet Gynecol"},{"key":"ref14","article-title":"Efficacy of pretreatment of insulin resistant PCOS patients by metformin alone vs metformin plus myo-inositol before induction of ovulation","volume":"3","author":"Begum MR","year":"2020","unstructured":"Begum MR, Ehsan N, Mariya E, Sharif AB. Efficacy of pretreatment of insulin resistant PCOS patients by metformin alone vs metformin plus myo-inositol before induction of ovulation. Online J Gyne Obste Maternity Care. 2020, 3:180016.","journal-title":"Online J Gyne Obste Maternity Care"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5455\/2320-1770.ijrcog20150234","article-title":"A comparative study of metabolic and hormonal effects of myoinositol vs. metformin in women with polycystic ovary syndrome: a randomised controlled trial","volume":"4","author":"Angik R","year":"2017","unstructured":"Angik R, Jajoo SS, Hariharan C, Chimote A. A comparative study of metabolic and hormonal effects of myoinositol vs. metformin in women with polycystic ovary syndrome: a randomised controlled trial. Int J Reprod Contracept Obstet Gynecol. 2017, 4:189-94. 10.5455\/2320-1770.ijrcog20150234","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975-8232.8(4).1664-70","article-title":"A comparative study of myo inositol versus metformin on biochemical profile in polycystic ovarian syndrome in women","volume":"8","author":"Nehra J","year":"2017","unstructured":"Nehra J, Kaushal J, Singhal SR, Ghalaut VS. A comparative study of myo inositol versus metformin on biochemical profile in polycystic ovarian syndrome in women. Int J Pharma Sci Res. 2017, 8:1664-70. 10.13040\/IJPSR.0975-8232.8(4).1664-70","journal-title":"Int J Pharma Sci Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.02.002","article-title":"Inositols in polycystic ovary syndrome: an overview on the advances","volume":"31","author":"Facchinetti F","year":"2020","unstructured":"Facchinetti F, Unfer V, Dewailly D, et al.. Inositols in polycystic ovary syndrome: an overview on the advances. Trends Endocrinol Metab. 2020, 31:435-47. 10.1016\/j.tem.2020.02.002","journal-title":"Trends Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1849162","article-title":"Effects of inositol(s) in women with PCOS: a systematic review of randomized controlled trials","volume":"2016","author":"Unfer V","year":"2016","unstructured":"Unfer V, Nestler JE, Kamenov ZA, Prapas N, Facchinetti F. Effects of inositol(s) in women with PCOS: a systematic review of randomized controlled trials. Int J Endocrinol. 2016, 2016:1849162. 10.1155\/2016\/1849162","journal-title":"Int J Endocrinol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53951","article-title":"The effectiveness of myo-inositol in women with polycystic ovary syndrome: a prospective clinical study","volume":"16","author":"Sharon PM","year":"2024","unstructured":"Sharon PM, Mellonie P, Manivannan A, Thangaraj P, Logeswari BM. The effectiveness of myo-inositol in women with polycystic ovary syndrome: a prospective clinical study. Cureus. 2024, 16:e53951. 10.7759\/cureus.53951","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20202345","article-title":"Randomised controlled trial: comparing effects of metformin versus myoinositol versus metformin and myoinositol on ovarian functions and metabolic factors in polycystic ovarian syndrome","volume":"9","author":"Thakur SS","year":"2020","unstructured":"Thakur SS, Anjum S, Siddiqui SS. Randomised controlled trial: comparing effects of metformin versus myoinositol versus metformin and myoinositol on ovarian functions and metabolic factors in polycystic ovarian syndrome. Int J Reprod Contracept Obstet Gynecol. 2020, 9:2542-9. 10.18203\/2320-1770.ijrcog20202345","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14931","article-title":"A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome","volume":"99","author":"Nazirudeen R","year":"2023","unstructured":"Nazirudeen R, Sridhar S, Priyanka R, et al.. A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2023, 99:198-205. 10.1111\/cen.14931","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/322342-a-phase-iii-double-blind-randomized-multicenter-clinical-trial-to-evaluate-the-efficacy-and-safety-of-a-fixed-dose-combination-of-metformin-hydrochloride-and-myo-inositol-compared-to-metformin-in-patients-with-polycystic-ovary-syndrome","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T04:02:33Z","timestamp":1734062553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/322342-a-phase-iii-double-blind-randomized-multicenter-clinical-trial-to-evaluate-the-efficacy-and-safety-of-a-fixed-dose-combination-of-metformin-hydrochloride-and-myo-inositol-compared-to-metformin-in-patients-with-polycystic-ovary-syndrome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.75616","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}