{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:47:48Z","timestamp":1787593668164,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"DOI":"10.7759\/cureus.76053","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:05:42Z","timestamp":1734685542000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of F-Biotic\u2122 in Combination With Metformin for Type 2 Diabetes Mellitus: Results From a Randomized, Double-Blind Clinical Trial"],"prefix":"10.7759","author":[{"given":"Smiju","family":"Devassy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheejamol","family":"S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh","family":"Kumar A K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balprakash","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70112-8","article-title":"Diabetes: a 21st century challenge","volume":"2","author":"Zimmet PZ","year":"2014","unstructured":"Zimmet PZ, Magliano DJ, Herman WH, Shaw JE. Diabetes: a 21st century challenge. Lancet Diabetes Endocrinol. 2014, 2:56-64. 10.1016\/S2213-8587(13)70112-8","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref2","unstructured":"International Diabetes Federation. IDF diabetes atlas. (2021). Accessed: September 15, 2024: https:\/\/diabetesatlas.org\/.."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-Sint","article-title":"Introduction: Standards of medical care in diabetes-2022","volume":"45","author":"American Diabetes Association","year":"2022","unstructured":"American Diabetes Association. Introduction: Standards of medical care in diabetes-2022. Diabetes Care. 2022, 45:S1-2. 10.2337\/dc22-Sint","journal-title":"Diabetes Care"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.10.014","article-title":"Metformin-associated lactic acidosis: Current perspectives on causes and risk","volume":"65","author":"DeFronzo R","year":"2016","unstructured":"DeFronzo R, Fleming GA, Chen K, Bicsak TA. Metformin-associated lactic acidosis: Current perspectives on causes and risk. Metabolism. 2016, 65:20-9. 10.1016\/j.metabol.2015.10.014","journal-title":"Metabolism"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2006.tb00076.x","article-title":"Resistant starch-a review","volume":"5","author":"Sajilata MG","year":"2006","unstructured":"Sajilata MG, Singhal RS, Kulkarni PR. Resistant starch-a review. Compr Rev Food Sci Food Saf. 2006, 5:1-17. 10.1111\/j.1541-4337.2006.tb00076.x","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.82.3.559","article-title":"Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism","volume":"82","author":"Robertson MD","year":"2005","unstructured":"Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr. 2005, 82:559-67. 10.1093\/ajcn.82.3.559","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.004325","article-title":"Resistant starch: promise for improving human health","volume":"4","author":"Birt DF","year":"2013","unstructured":"Birt DF, Boylston T, Hendrich S, et al.. Resistant starch: promise for improving human health. Adv Nutr. 2013, 4:587-601. 10.3945\/an.113.004325","journal-title":"Adv Nutr"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/EC-14-0036","article-title":"Efficacy of increased resistant starch consumption in human type 2 diabetes","volume":"3","author":"Bodinham CL","year":"2014","unstructured":"Bodinham CL, Smith L, Thomas EL, et al.. Efficacy of increased resistant starch consumption in human type 2 diabetes. Endocr Connect. 2014, 3:75-84. 10.1530\/EC-14-0036","journal-title":"Endocr Connect"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1127-z","article-title":"Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis","volume":"18","author":"Gao C","year":"2019","unstructured":"Gao C, Rao M, Huang W, et al.. Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis. Lipids Health Dis. 2019, 18:205. 10.1186\/s12944-019-1127-z","journal-title":"Lipids Health Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000605","article-title":"Dietary-resistant starch improves maternal glycemic control in Goto-Kakizaki rat","volume":"55","author":"Shen L","year":"2011","unstructured":"Shen L, Keenan MJ, Raggio A, Williams C, Martin RJ. Dietary-resistant starch improves maternal glycemic control in Goto-Kakizaki rat. Mol Nutr Food Res. 2011, 55:1499-508. 10.1002\/mnfr.201000605","journal-title":"Mol Nutr Food Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90637.2008","article-title":"Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents","volume":"295","author":"Zhou J","year":"2008","unstructured":"Zhou J, Martin RJ, Tulley RT, et al.. Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab. 2008, 295:E1160-6. 10.1152\/ajpendo.90637.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy121","article-title":"Effect of 12 wk of resistant starch supplementation on cardiometabolic risk factors in adults with prediabetes: a randomized controlled trial","volume":"108","author":"Peterson CM","year":"2018","unstructured":"Peterson CM, Beyl RA, Marlatt KL, et al.. Effect of 12 wk of resistant starch supplementation on cardiometabolic risk factors in adults with prediabetes: a randomized controlled trial. Am J Clin Nutr. 2018, 108:492-501. 10.1093\/ajcn\/nqy121","journal-title":"Am J Clin Nutr"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.11.037","article-title":"Meta-analysis of randomized controlled trials of the effects of probiotics on type 2 diabetes in adults","volume":"41","author":"Zhang C","year":"2022","unstructured":"Zhang C, Jiang J, Wang C, et al.. Meta-analysis of randomized controlled trials of the effects of probiotics on type 2 diabetes in adults. Clin Nutr. 2022, 41:365-73. 10.1016\/j.clnu.2021.11.037","journal-title":"Clin Nutr"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132121","article-title":"Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials","volume":"10","author":"Ruan Y","year":"2015","unstructured":"Ruan Y, Sun J, He J, Chen F, Chen R, Chen H. Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials. PLoS One. 2015, 10:e0132121. 10.1371\/journal.pone.0132121","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800101-1.00002-8","article-title":"Regulation of glucose homeostasis by GLP-1","volume":"121","author":"Nadkarni P","year":"2014","unstructured":"Nadkarni P, Chepurny OG, Holz GG. Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci. 2014, 121:23-65. 10.1016\/B978-0-12-800101-1.00002-8","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821038-3.00064-1","article-title":"Prebiotics: safety and toxicity considerations","volume":"1016","author":"Anad\u00f3n A","year":"2021106180","unstructured":"Anad\u00f3n A, Ares I, Mart\u00ednez-Larra\u00f1aga M-R, Mart\u00ednez M-A. Prebiotics: safety and toxicity considerations. Gupta RC, Lall R, Srivastava ABT-N. 2021106180, 1016:978-0. 10.1016\/B978-0-12-821038-3.00064-1","journal-title":"Gupta RC, Lall R, Srivastava ABT-N"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu15214690","article-title":"The effects of oral probiotics on type 2 diabetes mellitus (T2DM): a clinical trial systematic literature review","volume":"15","author":"Paquette S","year":"2023","unstructured":"Paquette S, Thomas SC, Venkataraman K, Appanna VD, Tharmalingam S. The effects of oral probiotics on type 2 diabetes mellitus (T2DM): a clinical trial systematic literature review. Nutrients. 2023, 15:10.3390\/nu15214690","journal-title":"Nutrients"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/307383-efficacy-and-safety-of-f-biotic-in-combination-with-metformin-for-type-2-diabetes-mellitus-results-from-a-randomized-double-blind-clinical-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:05:45Z","timestamp":1734685545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/307383-efficacy-and-safety-of-f-biotic-in-combination-with-metformin-for-type-2-diabetes-mellitus-results-from-a-randomized-double-blind-clinical-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.76053","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,20]]}}}