{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:06:58Z","timestamp":1773076018372,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"DOI":"10.7759\/cureus.76068","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T13:03:14Z","timestamp":1734699794000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological Characteristics of Thyroid Cancer: A 10-Year Experience at a Tertiary Care Center in Saudi Arabia"],"prefix":"10.7759","author":[{"given":"Awad","family":"Alshahrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameerah","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Ajwah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Alotay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal S","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0520","article-title":"Cancer incidence and survival trends by subtype using data from the surveillance epidemiology and end results program, 1992-2013","volume":"26","author":"Noone AM","year":"2017","unstructured":"Noone AM, Cronin KA, Altekruse SF, Howlader N, Lewis DR, Petkov VI, Penberthy L. Cancer incidence and survival trends by subtype using data from the surveillance epidemiology and end results program, 1992-2013. Cancer Epidemiol Biomarkers Prev. 2017, 26:632-41. 10.1158\/1055-9965.EPI-16-0520","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29634","article-title":"Thyroid cancer incidence attributable to overdiagnosis in the United States 1981-2011","volume":"137","author":"O'Grady TJ","year":"2015","unstructured":"O'Grady TJ, Gates MA, Boscoe FP. Thyroid cancer incidence attributable to overdiagnosis in the United States 1981-2011. Int J Cancer. 2015, 137:2664-73. 10.1002\/ijc.29634","journal-title":"Int J Cancer"},{"key":"ref3","unstructured":"Cancer Stat Facts. Thyroid Cancer. (2023). Accessed: January 10, 2023: https:\/\/seer.cancer.gov\/statfacts\/html\/thyro.html."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2013.05.004","article-title":"Incidence of thyroid cancer in the Kingdom of Saudi Arabia, 2000-2010","volume":"6","author":"Hussain F","year":"2013","unstructured":"Hussain F, Iqbal S, Mehmood A, Bazarbashi S, ElHassan T, Chaudhri N. Incidence of thyroid cancer in the Kingdom of Saudi Arabia, 2000-2010. Hematol Oncol Stem Cell Ther. 2013, 6:58-64. 10.1016\/j.hemonc.2013.05.004","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1604412","article-title":"Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis","volume":"375","author":"Vaccarella S","year":"2016","unstructured":"Vaccarella S, Franceschi S, Bray F, Wild CP, Plummer M, Dal Maso L. Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med. 2016, 375:614-7. 10.1056\/NEJMp1604412","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719","article-title":"Trends in thyroid cancer incidence and mortality in the United States, 1974-2013","volume":"317","author":"Lim H","year":"2017","unstructured":"Lim H, Devesa SS, Sosa JA, Check D, Kitahara CM. Trends in thyroid cancer incidence and mortality in the United States, 1974-2013. JAMA. 2017, 317:1338-48. 10.1001\/jama.2017.2719","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-1440","article-title":"Epidemiology of thyroid cancer","volume":"31","author":"Kitahara CM","year":"2022","unstructured":"Kitahara CM, Schneider AB. Epidemiology of thyroid cancer. Cancer Epidemiol Biomarkers Prev. 2022, 31:1284-97. 10.1158\/1055-9965.EPI-21-1440","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02380-8","article-title":"Correlation of TIRADS and bethesda scoring systems with final histopathology of thyroid nodules - an institutional experience","volume":"74","author":"George NA","year":"2022","unstructured":"George NA, Suresh S, Jiji V, et al.. Correlation of TIRADS and bethesda scoring systems with final histopathology of thyroid nodules - an institutional experience. Indian J Otolaryngol Head Neck Surg. 2022, 74:5753-8. 10.1007\/s12070-021-02380-8","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0141","article-title":"The 2023 Bethesda system for reporting thyroid cytopathology","volume":"33","author":"Ali SZ","year":"2023","unstructured":"Ali SZ, Baloch ZW, Cochand-Priollet B, Schmitt FC, Vielh P, VanderLaan PA. The 2023 Bethesda system for reporting thyroid cytopathology. Thyroid. 2023, 33:1039-44. 10.1089\/thy.2023.0141","journal-title":"Thyroid"},{"key":"ref10","article-title":"Reproductive history and cigarette smoking as risk factors for thyroid cancer in women: A population-based case-control study","volume":"5","author":"Galanti MR","year":"1996","unstructured":"Galanti MR, Hansson L, Lund E, et al.. Reproductive history and cigarette smoking as risk factors for thyroid cancer in women: A population-based case-control study. Cancer Epidemiol Biomarkers Prev. 1996, 5:425-31.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051679","article-title":"Parity and risk of thyroid cancer: A nested case-control study of a nationwide Swedish cohort","volume":"6","author":"Galanti MR","year":"1995","unstructured":"Galanti MR, Lambe M, Ekbom A, Spar\u00e9n P, Pettersson B. Parity and risk of thyroid cancer: A nested case-control study of a nationwide Swedish cohort. Cancer Causes Control. 1995, 6:37-44. 10.1007\/BF00051679","journal-title":"Cancer Causes Control"},{"key":"ref12","article-title":"The role of hCG in regulation of the thyroid gland in normal and abnormal pregnancy","volume":"78","author":"Kennedy RL","year":"1991","unstructured":"Kennedy RL, Darne J. The role of hCG in regulation of the thyroid gland in normal and abnormal pregnancy. Obstet Gynecol. 1991, 78:298-307.","journal-title":"Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/27673.10095","article-title":"An Indian tertiary care hospital scenario of papillary carcinoma of thyroid","volume":"11","author":"Karkuzhali P","year":"2017","unstructured":"Karkuzhali P, Yogambal M, Kumar M. An Indian tertiary care hospital scenario of papillary carcinoma of thyroid. J Clin Diagn Res. 2017, 11:EC26-9. 10.7860\/JCDR\/2017\/27673.10095","journal-title":"J Clin Diagn Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8044","article-title":"Clinicopathological characteristics of thyroid cancer in a Saudi academic hospital","volume":"12","author":"Samargandy S","year":"2020","unstructured":"Samargandy S, Qari R, Aljadani A, et al..  Clinicopathological characteristics of thyroid cancer in a Saudi academic hospital. Cureus. 2020, 12:e8044. 10.7759\/cureus.8044","journal-title":"Cureus"},{"key":"ref15","article-title":"Epidemiology and surgical characteristics of thyroid cancer in United Arab Emirates: Review of 100 consecutive patients","volume":"3","author":"Alawadhi R","year":"2020","unstructured":"Alawadhi R, Matalkah A, Alzaabi S, et al.. Epidemiology and surgical characteristics of thyroid cancer in United Arab Emirates: Review of 100 consecutive patients. J Diabetes Endocrine Pract. 2020, 3:79-83.","journal-title":"J Diabetes Endocrine Pract"},{"key":"ref16","unstructured":"Saudi Cancer Registry-Annual report. (2023). Accessed. October 10, 2023: https:\/\/shc.gov.sa\/Arabic\/NCC\/Activities\/Pages\/AnnualReports.aspx."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2018052","article-title":"National Epidemiologic Survey of Thyroid cancer (NEST) in Korea","volume":"40","author":"Oh CM","year":"2018","unstructured":"Oh CM, Kong HJ, Kim E, Kim H, Jung KW, Park S, Won YJ. National Epidemiologic Survey of Thyroid cancer (NEST) in Korea. Epidemiol Health. 2018, 40:e2018052. 10.4178\/epih.e2018052","journal-title":"Epidemiol Health"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61744-X","article-title":"Patchy progress on obesity prevention: Emerging examples, entrenched barriers, and new thinking","volume":"385","author":"Roberto CA","year":"2015","unstructured":"Roberto CA, Swinburn B, Hawkes C, et al.. Patchy progress on obesity prevention: Emerging examples, entrenched barriers, and new thinking. The Lancet. 2015, 385:2400-9. 10.1016\/S0140-6736(14)61744-X","journal-title":"The Lancet"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12321","article-title":"Adiposity and risk of thyroid cancer: A systematic review and meta-analysis","volume":"16","author":"Schmid D","year":"2015","unstructured":"Schmid D, Ricci C, Behrens G, Leitzmann MF. Adiposity and risk of thyroid cancer: A systematic review and meta-analysis. Obes Rev. 2015, 16:1042-54. 10.1111\/obr.12321","journal-title":"Obes Rev"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.105085","article-title":"Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer - Pooled results of 24 million cohorts","volume":"112","author":"Youssef MR","year":"2021","unstructured":"Youssef MR, Reisner AS, Attia AS, et al.. Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer - Pooled results of 24 million cohorts. Oral Oncol. 2021, 112:105085. 10.1016\/j.oraloncology.2020.105085","journal-title":"Oral Oncol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2503","article-title":"The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations","volume":"99","author":"Jung CK","year":"2014","unstructured":"Jung CK, Little MP, Lubin JH, Brenner AV, Wells SA Jr, Sigurdson AJ, Nikiforov YE. The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations. J Clin Endocrinol Metab. 2014, 99:E276-85. 10.1210\/jc.2013-2503","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0976","article-title":"Gender is an age-specific effect modifier for papillary cancers of the thyroid gland","volume":"18","author":"Kilfoy BA","year":"2009","unstructured":"Kilfoy BA, Devesa SS, Ward MH, Zhang Y, Rosenberg PS, Holford TR, Anderson WF. Gender is an age-specific effect modifier for papillary cancers of the thyroid gland. Cancer Epidemiol Biomarkers Prev. 2009, 18:1092-100. 10.1158\/1055-9965.EPI-08-0976","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.36959\/433\/561","article-title":"Epidemiology of thyroid cancer in Oman","volume":"1","author":"Pambinezhuth F","year":"2017","unstructured":"Pambinezhuth F, Al Busaidi N, Al Musalhi H. Epidemiology of thyroid cancer in Oman. Ann Endocrinol Metab. 2017, 1:11-7. 10.36959\/433\/561","journal-title":"Ann Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-3919-5","article-title":"Clinico-pathological correlation of thyroid nodule ultrasound and cytology using the TIRADS and Bethesda classifications","volume":"41","author":"Singaporewalla RM","year":"2017","unstructured":"Singaporewalla RM, Hwee J, Lang TU, Desai V. Clinico-pathological correlation of thyroid nodule ultrasound and cytology using the TIRADS and Bethesda classifications. World J Surg. 2017, 41:1807-11. 10.1007\/s00268-017-3919-5","journal-title":"World J Surg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1724","article-title":"An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management","volume":"94","author":"Horvath E","year":"2009","unstructured":"Horvath E, Majlis S, Rossi R, Franco C, Niedmann JP, Castro A, Dominguez M. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab. 2009, 94:1748-51. 10.1210\/jc.2008-1724","journal-title":"J Clin Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2017.1924","article-title":"Relationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinoma","volume":"17","author":"Sezer A","year":"2017","unstructured":"Sezer A, Celik M, Yilmaz Bulbul B, et al.. Relationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinoma. Bosn J Basic Med Sci. 2017, 17:144-51. 10.17305\/bjbms.2017.1924","journal-title":"Bosn J Basic Med Sci"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.5.489","article-title":"Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer","volume":"141","author":"Stulak JM","year":"2006","unstructured":"Stulak JM, Grant CS, Farley DR, et al.. Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer. Arch Surg. 2006, 141:489-96. 10.1001\/archsurg.141.5.489","journal-title":"Arch Surg"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00265","article-title":"Risk factors for lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis","volume":"11","author":"Mao J","year":"2020","unstructured":"Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G. Risk factors for lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis. Front Endocrinol. 2020, 11:265. 10.3389\/fendo.2020.00265","journal-title":"Front Endocrinol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen BR","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, et al.. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016, 26:1-133. 10.1089\/thy.2015.0020","journal-title":"Thyroid"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000506474","article-title":"Preoperative factors associated with extrathyroidal extension in papillary thyroid cancer","volume":"9","author":"Kuo CY","year":"2020","unstructured":"Kuo CY, Yang PS, Chien MN, Cheng SP. Preoperative factors associated with extrathyroidal extension in papillary thyroid cancer. Eur Thyroid J. 2020, 9:256-62. 10.1159\/000506474","journal-title":"Eur Thyroid J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/284162-clinicopathological-characteristics-of-thyroid-cancer-a-10-year-experience-at-a-tertiary-care-center-in-saudi-arabia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T13:03:19Z","timestamp":1734699799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/284162-clinicopathological-characteristics-of-thyroid-cancer-a-10-year-experience-at-a-tertiary-care-center-in-saudi-arabia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.76068","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,20]]}}}