{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:32:39Z","timestamp":1776778359473,"version":"3.51.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,29]]},"DOI":"10.7759\/cureus.76577","type":"journal-article","created":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T20:50:20Z","timestamp":1735505420000},"source":"Crossref","is-referenced-by-count":4,"title":["Analyzing the Effectiveness of Different Delivery Methods for Remineralization Agents in Pediatric Dental Health: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Bahija","family":"Basheer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmalik  A","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asem","family":"Abdullah Alowairdhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Nuri Alohali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0581-8","article-title":"Assessment of prevalence of dental caries and the associated factors among patients attending dental clinic in Debre Tabor general hospital: a hospital-based cross-sectional study","volume":"18","author":"Tafere Y","year":"2018","unstructured":"Tafere Y, Chanie S, Dessie T, Gedamu H. Assessment of prevalence of dental caries and the associated factors among patients attending dental clinic in Debre Tabor general hospital: a hospital-based cross-sectional study. BMC Oral Health. 2018, 18:119. 10.1186\/s12903-018-0581-8","journal-title":"BMC Oral Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics8020159","article-title":"Remineralization of dentinal lesions using biomimetic agents: a systematic review and meta-analysis","volume":"8","author":"Dawasaz AA","year":"2023","unstructured":"Dawasaz AA, Togoo RA, Mahmood Z, Ahmad A, Thirumulu Ponnuraj K. Remineralization of dentinal lesions using biomimetic agents: a systematic review and meta-analysis. Biomimetics (Basel). 2023, 8:159. 10.3390\/biomimetics8020159","journal-title":"Biomimetics (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.22514\/jocpd.2024.137","article-title":"Remineralization potential of a novel varnish: an in vitro comparative evaluation","volume":"48","author":"Gokce AN","year":"2024","unstructured":"Gokce AN, Kelesoglu E, Sag\u0131r K, Kargul B. Remineralization potential of a novel varnish: an in vitro comparative evaluation. J Clin Pediatr Dent. 2024, 48:173-80. 10.22514\/jocpd.2024.137","journal-title":"J Clin Pediatr Dent"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60111738","article-title":"The potential of silver diamine fluoride in non-operative management of dental caries in primary teeth: a systematic review","volume":"60","author":"Rogalnikovait\u0117 K","year":"2024","unstructured":"Rogalnikovait\u0117 K, Narbutait\u0117 J, Andru\u0161kevi\u010dien\u0117 V, Bendoraitien\u0117 EA, Razmien\u0117 J. The potential of silver diamine fluoride in non-operative management of dental caries in primary teeth: a systematic review. Medicina (Kaunas). 2024, 60:1738. 10.3390\/medicina60111738","journal-title":"Medicina (Kaunas)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103522","article-title":"Arresting early childhood caries using silver and fluoride products - a randomised trial","volume":"103","author":"Gao SS","year":"2020","unstructured":"Gao SS, Chen KJ, Duangthip D, Wong MC, Lo EC, Chu CH. Arresting early childhood caries using silver and fluoride products - a randomised trial. J Dent. 2020, 103:103522. 10.1016\/j.jdent.2020.103522","journal-title":"J Dent"},{"key":"ref6","article-title":"CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study","volume":"16","author":"Llena C","year":"2015","unstructured":"Llena C, Leyda AM, Forner L. CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study. Eur J Paediatr Dent. 2015, 16:181-6.","journal-title":"Eur J Paediatr Dent"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12243","article-title":"Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions","volume":"27","author":"Mohd Said SN","year":"2017","unstructured":"Mohd Said SN, Ekambaram M, Yiu CK. Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions. Int J Paediatr Dent. 2017, 27:163-73. 10.1111\/ipd.12243","journal-title":"Int J Paediatr Dent"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.30","article-title":"Dental caries","volume":"3","author":"Pitts NB","year":"2017","unstructured":"Pitts NB, Zero DT, Marsh PD, et al.. Dental caries. Nat Rev Dis Primers. 2017, 3:17030. 10.1038\/nrdp.2017.30","journal-title":"Nat Rev Dis Primers"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-016-0138-9","article-title":"Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): a clinical trial","volume":"17","author":"Singh S","year":"2016","unstructured":"Singh S, Singh SP, Goyal A, Utreja AK, Jena AK. Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): a clinical trial. Prog Orthod. 2016, 17:25. 10.1186\/s40510-016-0138-9","journal-title":"Prog Orthod"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0171-6","article-title":"Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review","volume":"16","author":"Gao SS","year":"2016","unstructured":"Gao SS, Zhang S, Mei ML, Lo EC, Chu CH. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. BMC Oral Health. 2016, 16:12. 10.1186\/s12903-016-0171-6","journal-title":"BMC Oral Health"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04305-9","article-title":"Effects of different remineralization agents on MIH defects: a randomized clinical study","volume":"26","author":"Olgen IC","year":"2022","unstructured":"Olgen IC, Sonmez H, Bezgin T. Effects of different remineralization agents on MIH defects: a randomized clinical study. Clin Oral Investig. 2022, 26:3227-38. 10.1007\/s00784-021-04305-9","journal-title":"Clin Oral Investig"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2019.1582796","article-title":"Adjunctive use of fluoride rinsing and brush-on gel increased incipient caries-like lesion remineralization compared with fluoride toothpaste alone in situ","volume":"77","author":"Bhongsatiern P","year":"2019","unstructured":"Bhongsatiern P, Manovilas P, Songvejkasem M, et al.. Adjunctive use of fluoride rinsing and brush-on gel increased incipient caries-like lesion remineralization compared with fluoride toothpaste alone in situ. Acta Odontol Scand. 2019, 77:419-25. 10.1080\/00016357.2019.1582796","journal-title":"Acta Odontol Scand"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-028352","article-title":"Outcome and comparator choice in molar incisor hypomineralisation (MIH) intervention studies: a systematic review and social network analysis","volume":"9","author":"Elhennawy K","year":"2019","unstructured":"Elhennawy K, Krois J, Jost-Brinkmann PG, Schwendicke F. Outcome and comparator choice in molar incisor hypomineralisation (MIH) intervention studies: a systematic review and social network analysis. BMJ Open. 2019, 9:e028352. 10.1136\/bmjopen-2018-028352","journal-title":"BMJ Open"},{"key":"ref14","article-title":"Assessment of enamel surface microhardness with different fluoride varnishes-an in vitro study","volume":"19","author":"Punathil S","year":"2018","unstructured":"Punathil S, Pulayath CV, Ismail SP, Bavabeedu SS, Moyin S, Uthappa R. Assessment of enamel surface microhardness with different fluoride varnishes-an in vitro study. J Contemp Dent Pract. 2018, 19:1317-21.","journal-title":"J Contemp Dent Pract"},{"key":"ref15","article-title":"Casein phosphopeptide amorphous calcium phosphate fluoride varnish in remineralization of early carious lesions in primary dentition: randomized clinical trial","volume":"43","author":"Mekky AI","year":"2021","unstructured":"Mekky AI, Dowidar KM, Talaat DM. Casein phosphopeptide amorphous calcium phosphate fluoride varnish in remineralization of early carious lesions in primary dentition: randomized clinical trial. Pediatr Dent. 2021, 43:17-23.","journal-title":"Pediatr Dent"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2024.03.003","article-title":"A comparison of the fluoride 'paint- on' vs tray application techniques for enamel remineralisation","volume":"74","author":"Keratibumrungpong K","year":"2024","unstructured":"Keratibumrungpong K, Trairatvorakul C, Jirakran K, Govitvattana N. A comparison of the fluoride 'paint- on' vs tray application techniques for enamel remineralisation. Int Dent J. 2024, 74:1006-15. 10.1016\/j.identj.2024.03.003","journal-title":"Int Dent J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8357621","article-title":"A 12-week assessment of the treatment of white spot lesions with CPP-ACP paste and\/or fluoride varnish","volume":"2016","author":"G\u00fc\u00e7l\u00fc ZA","year":"2016","unstructured":"G\u00fc\u00e7l\u00fc ZA, Ala\u00e7am A, Coleman NJ. A 12-week assessment of the treatment of white spot lesions with CPP-ACP paste and\/or fluoride varnish. Biomed Res Int. 2016, 2016:8357621. 10.1155\/2016\/8357621","journal-title":"Biomed Res Int"},{"key":"ref18","article-title":"Remineralization capacity of three fissure sealants with and without gaseous ozone on non-cavitated incipient pit and fissure caries","volume":"39","author":"Unal M","year":"2015","unstructured":"Unal M, Oztas N. Remineralization capacity of three fissure sealants with and without gaseous ozone on non-cavitated incipient pit and fissure caries. J Clin Pediatr Dent. 2015, 39:364-70.","journal-title":"J Clin Pediatr Dent"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12778","article-title":"Remineralization effect of NaF, NaF with TCP, NaF with CPP-ACP and NaF with CXP varnishes on newly erupted first permanent molars: a randomized controlled trial","volume":"22","author":"Erkmen Almaz M","year":"2024","unstructured":"Erkmen Almaz M, Ulusoy NB, Akbay Oba A, Dokumac\u0131 A. Remineralization effect of NaF, NaF with TCP, NaF with CPP-ACP and NaF with CXP varnishes on newly erupted first permanent molars: a randomized controlled trial. Int J Dent Hyg. 2024, 22:703-10. 10.1111\/idh.12778","journal-title":"Int J Dent Hyg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517730531","article-title":"Self-assembling peptide P(11)-4 and fluoride for regenerating enamel","volume":"97","author":"Alkilzy M","year":"2018","unstructured":"Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH. Self-assembling peptide P(11)-4 and fluoride for regenerating enamel. J Dent Res. 2018, 97:148-54. 10.1177\/0022034517730531","journal-title":"J Dent Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000379750","article-title":"Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial","volume":"24","author":"Memarpour M","year":"2015","unstructured":"Memarpour M, Fakhraei E, Dadaein S, Vossoughi M. Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial. Med Princ Pract. 2015, 24:231-7. 10.1159\/000379750","journal-title":"Med Princ Pract"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000434728","article-title":"Effect of CPP-ACP paste on enamel carious lesion of primary upper anterior teeth assessed by quantitative light-induced fluorescence: a one-year clinical trial","volume":"49","author":"Sitthisettapong T","year":"2015","unstructured":"Sitthisettapong T, Doi T, Nishida Y, Kambara M, Phantumvanit P. Effect of CPP-ACP paste on enamel carious lesion of primary upper anterior teeth assessed by quantitative light-induced fluorescence: a one-year clinical trial. Caries Res. 2015, 49:434-41. 10.1159\/000434728","journal-title":"Caries Res"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.23804\/ejpd.2024.2158","article-title":"Laser and remineralising agents in dental erosion: a systematic review and meta-analysis","author":"Pardo A","year":"2024","unstructured":"Pardo A, Butera A, Signoriello A, et al.. Laser and remineralising agents in dental erosion: a systematic review and meta-analysis. Eur J Paediatr Dent. 2024, 1. 10.23804\/ejpd.2024.2158","journal-title":"Eur J Paediatr Dent"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a39749","article-title":"Use of casein amorphous calcium phosphate (CPP-ACP) on white-spot lesions: randomised clinical trial","volume":"16","author":"Mendes AC","year":"2018","unstructured":"Mendes AC, Restrepo M, Bussaneli D, Zuanon AC. Use of casein amorphous calcium phosphate (CPP-ACP) on white-spot lesions: randomised clinical trial. Oral Health Prev Dent. 2018, 16:27-31. 10.3290\/j.ohpd.a39749","journal-title":"Oral Health Prev Dent"},{"key":"ref25","article-title":"Comparative assessment of fluoride varnish and\u00a0fluoride film for remineralization of postorthodontic white spot lesions in adolescents and adults over a 6-month period: A single-center, randomized controlled clinical trial","volume":"149","author":"He T","year":"2016","unstructured":"He T, Li X, Dong Y, Zhang N, Zhong Y, Yin W, Hu D. Comparative assessment of fluoride varnish and\u00a0fluoride film for remineralization of postorthodontic white spot lesions in adolescents and adults over a 6-month period: A single-center, randomized controlled clinical trial. Am J Orthod Dentofacial Orthop. 2016, 149:810-9.","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000262404","article-title":"Reproducibility and accuracy of three methods for assessment of demineralization depth of the occlusal surface: an in vitro examination","volume":"31","author":"Ekstrand KR","year":"1997","unstructured":"Ekstrand KR, Ricketts DN, Kidd EA. Reproducibility and accuracy of three methods for assessment of demineralization depth of the occlusal surface: an in vitro examination. Caries Res. 1997, 31:224-31. 10.1159\/000262404","journal-title":"Caries Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03610-z","article-title":"Effectiveness of remineralizing agents in the prevention and reversal of orthodontically induced white spot lesions: a systematic review and network meta-analysis","volume":"24","author":"Hu H","year":"2020","unstructured":"Hu H, Feng C, Jiang Z, et al.. Effectiveness of remineralizing agents in the prevention and reversal of orthodontically induced white spot lesions: a systematic review and network meta-analysis. Clin Oral Investig. 2020, 24:4153-67. 10.1007\/s00784-020-03610-z","journal-title":"Clin Oral Investig"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12391","article-title":"Effectiveness of casein phosphopeptide-amorphous calcium phosphate-containing products in the prevention and treatment of white spot lesions in orthodontic patients: a systematic review","volume":"10","author":"Pithon MM","year":"2019","unstructured":"Pithon MM, Bai\u00e3o FS, Sant'Anna LI, Tanaka OM, Cople-Maia L. Effectiveness of casein phosphopeptide-amorphous calcium phosphate-containing products in the prevention and treatment of white spot lesions in orthodontic patients: a systematic review. J Investig Clin Dent. 2019, 10:e12391. 10.1111\/jicd.12391","journal-title":"J Investig Clin Dent"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2016-228","article-title":"Treatment of post-orthodontic white spot lesions with CPP-ACP paste: a three year follow up study","volume":"36","author":"Karabekiro\u011flu S","year":"2017","unstructured":"Karabekiro\u011flu S, \u00dcnl\u00fc N, K\u00fc\u00e7\u00fckyilmaz E, \u015eener S, Botsali MS, Malko\u00e7 S. Treatment of post-orthodontic white spot lesions with CPP-ACP paste: a three year follow up study. Dent Mater J. 2017, 36:791-7. 10.4012\/dmj.2016-228","journal-title":"Dent Mater J"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-011-0034-1","article-title":"Factors associated with reduced compliance of children to dental preventive measures","volume":"100","author":"Ashkenazi M","year":"2012","unstructured":"Ashkenazi M, Bidoosi M, Levin L. Factors associated with reduced compliance of children to dental preventive measures. Odontology. 2012, 100:241-8. 10.1007\/s10266-011-0034-1","journal-title":"Odontology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/327617-analyzing-the-effectiveness-of-different-delivery-methods-for-remineralization-agents-in-pediatric-dental-health-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T20:50:23Z","timestamp":1735505423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/327617-analyzing-the-effectiveness-of-different-delivery-methods-for-remineralization-agents-in-pediatric-dental-health-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,29]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.76577","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,29]]}}}