{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:40:26Z","timestamp":1735778426720,"version":"3.32.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"DOI":"10.7759\/cureus.76757","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:19:18Z","timestamp":1735777158000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggressive T-cell Lymphoma Smoldering As Hemophagocytic Lymphohistiocytosis: A Diagnostic and Medical Challenge"],"prefix":"10.7759","author":[{"given":"Christina","family":"Said","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Bitar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadia","family":"Elias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13432","article-title":"Incidence and survival of haemophagocytic lymphohistiocytosis: a population-based cohort study from England","volume":"291","author":"West J","year":"2022","unstructured":"West J, Card TR, Bishton MJ, et al.. Incidence and survival of haemophagocytic lymphohistiocytosis: a population-based cohort study from England. J Intern Med. 2022, 291:493-504. 10.1111\/joim.13432","journal-title":"J Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter JI","year":"2007","unstructured":"Henter JI, Horne A, Aric\u00f3 M, et al.. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007, 48:124-31. 10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2023.12122","article-title":"Secondary hemophagocytic lymphohistiocytosis in children (Review)","volume":"26","author":"Benevenuta C","year":"2023","unstructured":"Benevenuta C, Mussinatto I, Orsi C, Timeus FS. Secondary hemophagocytic lymphohistiocytosis in children (Review). Exp Ther Med. 2023, 26:423. 10.3892\/etm.2023.12122","journal-title":"Exp Ther Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.4100","article-title":"Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis","volume":"89","author":"Osugi Y","year":"1997","unstructured":"Osugi Y, Hara J, Tagawa S, et al.. Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood. 1997, 89:4100-3. 10.1182\/blood.V89.11.4100","journal-title":"Blood"},{"key":"ref5","article-title":"Tumors of the lymph nodes and spleen","author":"Warnke et al.","year":"1995","unstructured":"Warnke et al.. Tumors of the lymph nodes and spleen. Atlas of Tumor Pathology. Armed Forces Institute of Pathology, Washington, DC; 1995."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5446.1957","article-title":"Perforin gene defects in familial hemophagocytic lymphohistiocytosis","volume":"286","author":"Stepp SE","year":"1999","unstructured":"Stepp SE, Dufourcq-Lagelouse R, Le Deist F, et al.. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999, 286:1957-9. 10.1126\/science.286.5446.1957","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22411","article-title":"Hemophagocytic lymphohistiocytosis and infection: a literature review","volume":"14","author":"Koumadoraki E","year":"2022","unstructured":"Koumadoraki E, Madouros N, Sharif S, Saleem A, Jarvis S, Khan S. Hemophagocytic lymphohistiocytosis and infection: a literature review. Cureus. 2022, 14:e22411. 10.7759\/cureus.22411","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01902","article-title":"Epstein-Barr virus and hemophagocytic lymphohistiocytosis","volume":"8","author":"Marsh RA","year":"2017","unstructured":"Marsh RA. Epstein-Barr virus and hemophagocytic lymphohistiocytosis. Front Immunol. 2017, 8:1902. 10.3389\/fimmu.2017.01902","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2263229","article-title":"An analysis of reported cases of hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination","volume":"19","author":"Zhang HQ","year":"2023","unstructured":"Zhang HQ, Cao BZ, Cao QT, Hun M, Cao L, Zhao MY. An analysis of reported cases of hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination. Hum Vaccin Immunother. 2023, 19:2263229. 10.1080\/21645515.2023.2263229","journal-title":"Hum Vaccin Immunother"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.863269","article-title":"Epidemiological characteristics of peripheral T-cell lymphoma: a population-based study","volume":"12","author":"Liu S","year":"2022","unstructured":"Liu S, Liu W, Li H, et al.. Epidemiological characteristics of peripheral T-cell lymphoma: a population-based study. Front Oncol. 2022, 12:863269. 10.3389\/fonc.2022.863269","journal-title":"Front Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02135-8","article-title":"Lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH): a scoping review unveils clinical and diagnostic patterns of a lymphoma subgroup with poor prognosis","volume":"38","author":"Knauft J","year":"2024","unstructured":"Knauft J, Schenk T, Ernst T, Schnetzke U, Hochhaus A, La Ros\u00e9e P, Birndt S. Lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH): a scoping review unveils clinical and diagnostic patterns of a lymphoma subgroup with poor prognosis. Leukemia. 2024, 38:235-49. 10.1038\/s41375-024-02135-8","journal-title":"Leukemia"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1101441","article-title":"PTCL, NOS: An update on classification, risk-stratification, and treatment","volume":"13","author":"Weiss J","year":"2023","unstructured":"Weiss J, Reneau J, Wilcox RA. PTCL, NOS: An update on classification, risk-stratification, and treatment. Front Oncol. 2023, 13:1101441. 10.3389\/fonc.2023.1101441","journal-title":"Front Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018894618","article-title":"Recommendations for the management of hemophagocytic lymphohistiocytosis in adults","volume":"133","author":"La Ros\u00e9e P","year":"2019","unstructured":"La Ros\u00e9e P, Horne A, Hines M, et al.. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019, 133:2465-77. 10.1182\/blood.2018894618","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3254-4","article-title":"Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents-a single centre experience of 20\u00a0years","volume":"97","author":"Strenger V","year":"2018","unstructured":"Strenger V, Merth G, Lackner H, et al.. Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents-a single centre experience of 20\u00a0years. Ann Hematol. 2018, 97:989-98. 10.1007\/s00277-018-3254-4","journal-title":"Ann Hematol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02941-3","article-title":"Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore","volume":"24","author":"Knaak C","year":"2020","unstructured":"Knaak C, Nyvlt P, Schuster FS, et al.. Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore. Crit Care. 2020, 24:244. 10.1186\/s13054-020-02941-3","journal-title":"Crit Care"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-019-00367-1","article-title":"Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management","volume":"22","author":"Henderson LA","year":"2020","unstructured":"Henderson LA, Cron RQ. Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management. Paediatr Drugs. 2020, 22:29-44. 10.1007\/s40272-019-00367-1","journal-title":"Paediatr Drugs"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788349","article-title":"Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study","volume":"130","author":"Bergsten E","year":"2017","unstructured":"Bergsten E, Horne A, Aric\u00f3 M, et al.. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study. Blood. 2017, 130:2728-38. 10.1182\/blood-2017-06-788349","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2113600","article-title":"Lymphoma-associated hemophagocytic syndrome: a retrospective study from a single center","volume":"27","author":"Li N","year":"2022","unstructured":"Li N, Jiang M, Wu WC, Zhou HJ, Zou LQ. Lymphoma-associated hemophagocytic syndrome: a retrospective study from a single center. Hematology. 2022, 27:909-16. 10.1080\/16078454.2022.2113600","journal-title":"Hematology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2021.1996139","article-title":"Requirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis","volume":"22","author":"Song Y","year":"2021","unstructured":"Song Y, Wang J, Wang Y, Wu L, Wang Z. Requirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis. Cancer Biol Ther. 2021, 22:598-606. 10.1080\/15384047.2021.1996139","journal-title":"Cancer Biol Ther"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/322819-aggressive-t-cell-lymphoma-smoldering-as-hemophagocytic-lymphohistiocytosis-a-diagnostic-and-medical-challenge","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:19:19Z","timestamp":1735777159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/322819-aggressive-t-cell-lymphoma-smoldering-as-hemophagocytic-lymphohistiocytosis-a-diagnostic-and-medical-challenge"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.76757","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,1]]}}}