{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:15:54Z","timestamp":1772122554387,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"DOI":"10.7759\/cureus.76770","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T06:49:48Z","timestamp":1735800588000},"source":"Crossref","is-referenced-by-count":5,"title":["Assessing the Potential Benefits of Stem Cell Therapy in Cardiac Regeneration for Patients With Ischemic Heart Disease"],"prefix":"10.7759","author":[{"given":"Syed Ahsan","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulkiffil","family":"Mubarak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manahil","family":"Asad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Taha","family":"Sarfraz Chaudhri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiah","family":"Bilal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tehniat","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek N","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thasneem","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falaknaz","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathima","family":"Masharifa Ahamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoaib","family":"Tarar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0120","article-title":"Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure (SafeCell Heart): a systematic review and meta-analysis","volume":"7","author":"Lalu MM","year":"2018","unstructured":"Lalu MM, Mazzarello S, Zlepnig J, et al.. Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure (SafeCell Heart): a systematic review and meta-analysis. Stem Cells Transl Med. 2018, 7:857-866. 10.1002\/sctm.18-0120","journal-title":"Stem Cells Transl Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.18926\/AMO\/59948","article-title":"Stem cell therapy in heart disease: limitations and future possibilities","volume":"74","author":"Sano T","year":"2020","unstructured":"Sano T, Ishigami S, Ito T, Sano S. Stem cell therapy in heart disease: limitations and future possibilities. Acta Med Okayama. 2020, 74:185-190. 10.18926\/AMO\/59948","journal-title":"Acta Med Okayama"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000492704","article-title":"Stem cell therapy in heart diseases - Cell types, mechanisms and improvement strategies","volume":"48","author":"M\u00fcller P","year":"2018","unstructured":"M\u00fcller P, Lemcke H, David R. Stem cell therapy in heart diseases - Cell types, mechanisms and improvement strategies. Cell Physiol Biochem. 2018, 48:2607-2655. 10.1159\/000492704","journal-title":"Cell Physiol Biochem"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029607","article-title":"Stem cell therapy for congenital heart disease: a systematic review","volume":"136","author":"Tsilimigras DI","year":"2017","unstructured":"Tsilimigras DI, Oikonomou EK, Moris D, Schizas D, Economopoulos KP, Mylonas KS. Stem cell therapy for congenital heart disease: a systematic review. Circulation. 2017, 136:2373-2385. 10.1161\/CIRCULATIONAHA.117.029607","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1098","article-title":"Mesenchymal stem cell (MSCs) therapy for ischemic heart disease: a promising frontier","volume":"17","author":"Poomani MS","year":"2022","unstructured":"Poomani MS, Mariappan I, Perumal R, Regurajan R, Muthan K, Subramanian V. Mesenchymal stem cell (MSCs) therapy for ischemic heart disease: a promising frontier. Glob Heart. 2022, 17:19. 10.5334\/gh.1098","journal-title":"Glob Heart"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312486","article-title":"Preclinical studies of stem cell therapy for heart disease","volume":"122","author":"Tompkins BA","year":"2018","unstructured":"Tompkins BA, Balkan W, Winkler J, Gy\u00f6ngy\u00f6si M, Goliasch G, Fern\u00e1ndez-Avil\u00e9s F, Hare JM. Preclinical studies of stem cell therapy for heart disease. Circ Res. 2018, 122:1006-1020. 10.1161\/CIRCRESAHA.117.312486","journal-title":"Circ Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i157","article-title":"PRISMA harms checklist: improving harms reporting in systematic reviews","volume":"352","author":"Zorzela L","year":"2016","unstructured":"Zorzela L, Loke YK, Ioannidis JP, et al.. PRISMA harms checklist: improving harms reporting in systematic reviews. BMJ. 2016, 352:i157. 10.1136\/bmj.i157","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-017-0663-8","article-title":"Evaluations of the uptake and impact of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Statement and extensions: a scoping review","volume":"6","author":"Page MJ","year":"2017","unstructured":"Page MJ, Moher D. Evaluations of the uptake and impact of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Statement and extensions: a scoping review. Syst Rev. 2017, 6:263. 10.1186\/s13643-017-0663-8","journal-title":"Syst Rev"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa651","article-title":"The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial","volume":"41","author":"Mathur A","year":"2020","unstructured":"Mathur A, Fern\u00e1ndez-Avil\u00e9s F, Bartunek J, et al.. The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial. Eur Heart J. 2020, 41:3702-3710. 10.1093\/eurheartj\/ehaa651","journal-title":"Eur Heart J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.12.019","article-title":"Mesenchymal stromal cell therapy for heart failure","volume":"81","author":"Menasch\u00e9 P","year":"2023","unstructured":"Menasch\u00e9 P. Mesenchymal stromal cell therapy for heart failure. J Am Coll Cardiol. 2023, 81:864-866. 10.1016\/j.jacc.2022.12.019","journal-title":"J Am Coll Cardiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007888.pub3","article-title":"Stem cell therapy for chronic ischaemic heart disease and congestive heart failure","volume":"12","author":"Fisher SA","year":"2016","unstructured":"Fisher SA, Doree C, Mathur A, Taggart DP, Martin-Rendon E. Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. Cochrane Database Syst Rev. 2016, 12:CD007888. 10.1002\/14651858.CD007888.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303614","article-title":"Use of mesenchymal stem cells for therapy of cardiac disease","volume":"116","author":"Karantalis V","year":"2015","unstructured":"Karantalis V, Hare JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res. 2015, 116:1413-1430. 10.1161\/CIRCRESAHA.116.303614","journal-title":"Circ Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0484","article-title":"Concise review: mesenchymal stem cells in cardiovascular regeneration: emerging research directions and clinical applications","volume":"6","author":"Majka M","year":"2017","unstructured":"Majka M, Su\u0142kowski M, Badyra B, Musia\u0142ek P. Concise review: mesenchymal stem cells in cardiovascular regeneration: emerging research directions and clinical applications. Stem Cells Transl Med. 2017, 6:1859-1867. 10.1002\/sctm.16-0484","journal-title":"Stem Cells Transl Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.047","article-title":"Transplantation of human embryonic stem\u00a0cell-derived cardiovascular progenitors for severe\u00a0ischemic left\u00a0ventricular dysfunction","volume":"71","author":"Menasch\u00e9 P","year":"2018","unstructured":"Menasch\u00e9 P, Vanneaux V, Hag\u00e8ge A, et al.. Transplantation of human embryonic stem\u00a0cell-derived cardiovascular progenitors for severe\u00a0ischemic left\u00a0ventricular dysfunction. J Am Coll Cardiol. 2018, 71:429-438. 10.1016\/j.jacc.2017.11.047","journal-title":"J Am Coll Cardiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3584-0_7","article-title":"Paracrine mechanisms of mesenchymal stem cells in tissue repair","volume":"1416","author":"Gnecchi M","year":"2016","unstructured":"Gnecchi M, Danieli P, Malpasso G, Ciuffreda MC. Paracrine mechanisms of mesenchymal stem cells in tissue repair. Methods Mol Biol. 2016, 1416:123-146. 10.1007\/978-1-4939-3584-0_7","journal-title":"Methods Mol Biol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21037\/sci.2017.11.07","article-title":"Extracellular vesicles and cardiovascular disease therapy","volume":"4","author":"Amosse J","year":"2017","unstructured":"Amosse J, Martinez MC, Lay SL. Extracellular vesicles and cardiovascular disease therapy. Stem Cell Investig. 2017, 4:10.21037\/sci.2017.11.07","journal-title":"Stem Cell Investig"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.18297\/etd\/2390","article-title":"Cell-Based Therapies for Ischemic Cardiomyopathy : Investigations of Intramyocardial Retention and Safety of High Dose Intracoronary Delivery of c-Kit Positive Cardiac Progenitor Cells, and Therapeutic Utility of a Novel Population of Cardiac Mesenchymal Stem Cells Expressing Stage-Specific Embryonic Antigen-3 (SSEA-3). Electronic Theses and Dissertations","author":"Keith M","year":"2016","unstructured":"Keith M. Cell-Based Therapies for Ischemic Cardiomyopathy : Investigations of Intramyocardial Retention and Safety of High Dose Intracoronary Delivery of c-Kit Positive Cardiac Progenitor Cells, and Therapeutic Utility of a Novel Population of Cardiac Mesenchymal Stem Cells Expressing Stage-Specific Embryonic Antigen-3 (SSEA-3). Electronic Theses and Dissertations. 2016. 10.18297\/etd\/2390"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2020_592","article-title":"Embryonic stem cells in clinical trials: current overview of developments and challenges","volume":"1312","author":"Golchin A","year":"2021","unstructured":"Golchin A, Chatziparasidou A, Ranjbarvan P, Niknam Z, Ardeshirylajimi A. Embryonic stem cells in clinical trials: current overview of developments and challenges. Adv Exp Med Biol. 2021, 1312:19-37. 10.1007\/5584_2020_592","journal-title":"Adv Exp Med Biol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2225","article-title":"Adult stem cell therapy and heart failure, 2000 to 2016: a systematic review","volume":"1","author":"Nguyen PK","year":"2016","unstructured":"Nguyen PK, Rhee JW, Wu JC. Adult stem cell therapy and heart failure, 2000 to 2016: a systematic review. JAMA Cardiol. 2016, 1:831-841. 10.1001\/jamacardio.2016.2225","journal-title":"JAMA Cardiol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.723236","article-title":"Stem cell-derived exosomes potential therapeutic roles in cardiovascular diseases","volume":"8","author":"Jayaraman S","year":"2021","unstructured":"Jayaraman S, Gnanasampanthapandian D, Rajasingh J, Palaniyandi K. Stem cell-derived exosomes potential therapeutic roles in cardiovascular diseases. Front Cardiovasc Med. 2021, 8:723236. 10.3389\/fcvm.2021.723236","journal-title":"Front Cardiovasc Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306593","article-title":"Exosomes as potential alternatives to stem cell therapy in mediating cardiac regeneration","volume":"117","author":"Ong SG","year":"2015","unstructured":"Ong SG, Wu JC. Exosomes as potential alternatives to stem cell therapy in mediating cardiac regeneration. Circ Res. 2015, 117:7-9. 10.1161\/CIRCRESAHA.115.306593","journal-title":"Circ Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw113","article-title":"Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure","volume":"37","author":"Madonna R","year":"2016","unstructured":"Madonna R, Van Laake LW, Davidson SM, et al.. Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. Eur Heart J. 2016, 37:1789-1798. 10.1093\/eurheartj\/ehw113","journal-title":"Eur Heart J"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1258-1","article-title":"Efficacy of mesenchymal stem cell therapy in systolic heart failure: a systematic review and meta-analysis","volume":"10","author":"Fan M","year":"2019","unstructured":"Fan M, Huang Y, Chen Z, et al.. Efficacy of mesenchymal stem cell therapy in systolic heart failure: a systematic review and meta-analysis. Stem Cell Res Ther. 2019, 10:150. 10.1186\/s13287-019-1258-1","journal-title":"Stem Cell Res Ther"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311769","article-title":"Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs","volume":"122","author":"Adamiak M","year":"2018","unstructured":"Adamiak M, Cheng G, Bobis-Wozowicz S, et al.. Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs. Circ Res. 2018, 122:296-309. 10.1161\/CIRCRESAHA.117.311769","journal-title":"Circ Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.9","article-title":"Cell therapy for cardiac repair--lessons from clinical trials","volume":"11","author":"Behfar A","year":"2014","unstructured":"Behfar A, Crespo-Diaz R, Terzic A, Gersh BJ. Cell therapy for cardiac repair--lessons from clinical trials. Nat Rev Cardiol. 2014, 11:232-246. 10.1038\/nrcardio.2014.9","journal-title":"Nat Rev Cardiol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091848","article-title":"Extracellular vesicles: a new frontier for cardiac repair","volume":"14","author":"You B","year":"2022","unstructured":"You B, Yang Y, Zhou Z, Yan Y, Zhang L, Jin J, Qian H. Extracellular vesicles: a new frontier for cardiac repair. Pharmaceutics. 2022, 14:1848. 10.3390\/pharmaceutics14091848","journal-title":"Pharmaceutics"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2995","article-title":"Mesenchymal stem cell therapy: a promising cell-based therapy for treatment of myocardial infarction","volume":"19","author":"Shafei AE","year":"2017","unstructured":"Shafei AE, Ali MA, Ghanem HG, et al.. Mesenchymal stem cell therapy: a promising cell-based therapy for treatment of myocardial infarction. J Gene Med. 2017, 19:e2995. 10.1002\/jgm.2995","journal-title":"J Gene Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2021.0006","article-title":"The vital roles of mesenchymal stem cells and the derived extracellular vesicles in promoting angiogenesis after acute myocardial infarction","volume":"30","author":"Zhang LL","year":"2021","unstructured":"Zhang LL, Xiong YY, Yang YJ. The vital roles of mesenchymal stem cells and the derived extracellular vesicles in promoting angiogenesis after acute myocardial infarction. Stem Cells Dev. 2021, 30:561-577. 10.1089\/scd.2021.0006","journal-title":"Stem Cells Dev"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.01.018","article-title":"Mechanisms of cardiac regeneration","volume":"36","author":"Uygur A","year":"2016","unstructured":"Uygur A, Lee RT. Mechanisms of cardiac regeneration. Dev Cell. 2016, 36:362-374. 10.1016\/j.devcel.2016.01.018","journal-title":"Dev Cell"},{"key":"ref30","article-title":"Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends","volume":"137","author":"Pawani H","year":"2013","unstructured":"Pawani H, Bhartiya D. Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends. Indian J Med Res. 2013, 137:270-282.","journal-title":"Indian J Med Res"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1073140","article-title":"Extracellular vesicles: evolving factors in stem cell biology","volume":"2016","author":"Nawaz M","year":"2016","unstructured":"Nawaz M, Fatima F, Vallabhaneni KC, et al.. Extracellular vesicles: evolving factors in stem cell biology. Stem Cells Int. 2016, 2016:1073140. 10.1155\/2016\/1073140","journal-title":"Stem Cells Int"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101257","article-title":"Stem cells for treatment of cardiovascular diseases: an umbrella review of randomized controlled trials","volume":"67","author":"Demurtas J","year":"2021","unstructured":"Demurtas J, Fanelli GN, Romano SL, et al.. Stem cells for treatment of cardiovascular diseases: an umbrella review of randomized controlled trials. Ageing Res Rev. 2021, 67:101257. 10.1016\/j.arr.2021.101257","journal-title":"Ageing Res Rev"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v9.i4.68","article-title":"Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction","volume":"9","author":"Micheu MM","year":"2017","unstructured":"Micheu MM, Dorobantu M. Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction. World J Stem Cells. 2017, 9:68-76. 10.4252\/wjsc.v9.i4.68","journal-title":"World J Stem Cells"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez B","year":"2018","unstructured":"Ibanez B, James S, Agewall S, et al.. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018, 39:119-177. 10.1093\/eurheartj\/ehx393","journal-title":"Eur Heart J"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2016.11.002","article-title":"New developments in cardiac regeneration","volume":"26","author":"Le TY","year":"2017","unstructured":"Le TY, Thavapalachandran S, Kizana E, Chong JJ. New developments in cardiac regeneration. Heart Lung Circ. 2017, 26:316-322. 10.1016\/j.hlc.2016.11.002","journal-title":"Heart Lung Circ"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201900182","article-title":"Stem cell therapy of myocardial infarction: a promising opportunity in bioengineering","volume":"3","author":"Jiang B","year":"2020","unstructured":"Jiang B, Yan L, Shamul JG, Hakun M, He X. Stem cell therapy of myocardial infarction: a promising opportunity in bioengineering. Adv Ther (Weinh). 2020, 3:1900182. 10.1002\/adtp.201900182","journal-title":"Adv Ther (Weinh)"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldw059","article-title":"Stem cell therapy for ischemic heart diseases","volume":"121","author":"Yu H","year":"2017","unstructured":"Yu H, Lu K, Zhu J, Wang J. Stem cell therapy for ischemic heart diseases. Br Med Bull. 2017, 121:135-154. 10.1093\/bmb\/ldw059","journal-title":"Br Med Bull"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.704903","article-title":"Regenerative medicine for the treatment of ischemic heart disease; status and future perspectives","volume":"9","author":"Arjmand B","year":"2021","unstructured":"Arjmand B, Abedi M, Arabi M, et al.. Regenerative medicine for the treatment of ischemic heart disease; status and future perspectives. Front Cell Dev Biol. 2021, 9:704903. 10.3389\/fcell.2021.704903","journal-title":"Front Cell Dev Biol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2020.0518","article-title":"Challenges and limitations of strategies to promote therapeutic potential of human mesenchymal stem cells for cell-based cardiac repair","volume":"51","author":"Bui TV","year":"2021","unstructured":"Bui TV, Hwang JW, Lee JH, Park HJ, Ban K. Challenges and limitations of strategies to promote therapeutic potential of human mesenchymal stem cells for cell-based cardiac repair. Korean Circ J. 2021, 51:97-113. 10.4070\/kcj.2020.0518","journal-title":"Korean Circ J"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2171035","article-title":"Cell therapy in ischemic heart disease: interventions that modulate cardiac regeneration","volume":"2016","author":"Schaun MI","year":"2016","unstructured":"Schaun MI, Eibel B, Kristocheck M, Sausen G, Machado L, Koche A, Markoski MM. Cell therapy in ischemic heart disease: interventions that modulate cardiac regeneration. Stem Cells Int. 2016, 2016:2171035. 10.1155\/2016\/2171035","journal-title":"Stem Cells Int"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9576-1","article-title":"New strategies for improving stem cell therapy in ischemic heart disease","volume":"21","author":"Huang P","year":"2016","unstructured":"Huang P, Tian X, Li Q, Yang Y. New strategies for improving stem cell therapy in ischemic heart disease. Heart Fail Rev. 2016, 21:737-752. 10.1007\/s10741-016-9576-1","journal-title":"Heart Fail Rev"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-019-02071-z","article-title":"CRISPR\/Cas9 facilitates genomic editing for large-scale functional studies in pluripotent stem cell cultures","volume":"138","author":"Li XF","year":"2019","unstructured":"Li XF, Zhou YW, Cai PF, Fu WC, Wang JH, Chen JY, Yang QN. CRISPR\/Cas9 facilitates genomic editing for large-scale functional studies in pluripotent stem cell cultures. Hum Genet. 2019, 138:1217-1225. 10.1007\/s00439-019-02071-z","journal-title":"Hum Genet"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311206","article-title":"Stem cell therapy for hypoplastic left heart syndrome: mechanism, clinical application, and future directions","volume":"123","author":"Bittle GJ","year":"2018","unstructured":"Bittle GJ, Morales D, Deatrick KB, et al.. Stem cell therapy for hypoplastic left heart syndrome: mechanism, clinical application, and future directions. Circ Res. 2018, 123:288-300. 10.1161\/CIRCRESAHA.117.311206","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1276-z","article-title":"Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases","volume":"10","author":"Bian X","year":"2019","unstructured":"Bian X, Ma K, Zhang C, Fu X. Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases. Stem Cell Res Ther. 2019, 10:158. 10.1186\/s13287-019-1276-z","journal-title":"Stem Cell Res Ther"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/316745-assessing-the-potential-benefits-of-stem-cell-therapy-in-cardiac-regeneration-for-patients-with-ischemic-heart-disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T06:49:50Z","timestamp":1735800590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/316745-assessing-the-potential-benefits-of-stem-cell-therapy-in-cardiac-regeneration-for-patients-with-ischemic-heart-disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":44,"URL":"https:\/\/doi.org\/10.7759\/cureus.76770","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,1]]}}}