{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:49:21Z","timestamp":1765547361718,"version":"3.32.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,2]]},"DOI":"10.7759\/cureus.76781","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T11:37:27Z","timestamp":1735817847000},"source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the Efficacy of Subgingivally Delivered Liquorice Gel on Clinical Parameters and Prostaglandin E2 Levels in Chronic Periodontitis: A Clinico-Biochemical Study"],"prefix":"10.7759","author":[{"given":"Bipin","family":"Kumar Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diksha","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kumar Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajai","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081135","article-title":"Periodontitis: a multifaceted disease of tooth-supporting tissues","volume":"8","author":"K\u00f6n\u00f6nen E","year":"2019","unstructured":"K\u00f6n\u00f6nen E, Gursoy M, Gursoy UK. Periodontitis: a multifaceted disease of tooth-supporting tissues. J Clin Med. 2019, 8:1135. 10.3390\/jcm8081135","journal-title":"J Clin Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1979.tb02186.x","article-title":"Periodontal therapy by local delivery of tetracycline","volume":"6","author":"Goodson JM","year":"1979","unstructured":"Goodson JM, Haffajee A, Socransky SS. Periodontal therapy by local delivery of tetracycline. J Clin Periodontol. 1979, 6:83-92. 10.1111\/j.1600-051x.1979.tb02186.x","journal-title":"J Clin Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2019.19.003254","article-title":"Herbal extracts used in dental disorders","volume":"19","author":"Sener B","year":"2019","unstructured":"Sener B, Kilic M. Herbal extracts used in dental disorders. Biomed J Sci Tech Res. 2019, 19:14107-11. 10.26717\/BJSTR.2019.19.003254","journal-title":"Biomed J Sci Tech Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.08.001","article-title":"Dual inhibitory effect of Glycyrrhiza glabra (GutGard\u2122) on COX and LOX products","volume":"18","author":"Chandrasekaran CV","year":"2011","unstructured":"Chandrasekaran CV, Deepak HB, Thiyagarajan P, Kathiresan S, Sangli GK, Deepak M, Agarwal A. Dual inhibitory effect of Glycyrrhiza glabra (GutGard\u2122) on COX and LOX products. Phytomedicine. 2011, 18:278-84. 10.1016\/j.phymed.2010.08.001","journal-title":"Phytomedicine"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01023-12","article-title":"18\u03b2-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression","volume":"57","author":"Long DR","year":"2013","unstructured":"Long DR, Mead J, Hendricks JM, Hardy ME, Voyich JM. 18\u03b2-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. Antimicrob Agents Chemother. 2013, 57:241-7. 10.1128\/AAC.01023-12","journal-title":"Antimicrob Agents Chemother"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.07.009","article-title":"Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa","volume":"125","author":"Wittschier N","year":"2009","unstructured":"Wittschier N, Faller G, Hensel A. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J Ethnopharmacol. 2009, 125:218-23. 10.1016\/j.jep.2009.07.009","journal-title":"J Ethnopharmacol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2011.822","article-title":"The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells","volume":"29","author":"Kim HS","year":"2012","unstructured":"Kim HS, Suh KS, Sul D, Kim BJ, Lee SK, Jung WW. The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells. Int J Mol Med. 2012, 29:169-77. 10.3892\/ijmm.2011.822","journal-title":"Int J Mol Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00170.x","article-title":"The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease","volume":"43","author":"Noguchi K","year":"2007","unstructured":"Noguchi K, Ishikawa I. The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease. Periodontol 2000. 2007, 43:85-101. 10.1111\/j.1600-0757.2006.00170.x","journal-title":"Periodontol 2000"},{"key":"ref9","article-title":"Liquorice as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a clinico-microbiological study","volume":"6","author":"Shivprasad BM","year":"2017","unstructured":"Shivprasad BM, Sonali C, Navnita S, Shilpa S, Sruthi KN, Savita S. Liquorice as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a clinico-microbiological study. Int J Sci Res. 2017, 6:73-6.","journal-title":"Int J Sci Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy. II. correlation between oral hygiene and periodontal condtion","volume":"22","author":"Silness J","year":"1964","unstructured":"Silness J, L\u00f6e H. Periodontal disease in pregnancy. II. correlation between oral hygiene and periodontal condtion. Acta Odontol Scand. 1964, 22:121-35. 10.3109\/00016356408993968","journal-title":"Acta Odontol Scand"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy. I. Prevalence and severity","volume":"21","author":"L\u00f6e H","year":"1963","unstructured":"L\u00f6e H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand. 1963, 21:533-51. 10.3109\/00016356309011240","journal-title":"Acta Odontol Scand"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.034","article-title":"Anti-immunology: evasion of the host immune system by bacterial and viral pathogens","volume":"124","author":"Finlay BB","year":"2006","unstructured":"Finlay BB, McFadden G. Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. Cell. 2006, 124:767-82. 10.1016\/j.cell.2006.01.034","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63396","article-title":"Role of prostaglandin E2 in tissue repair and regeneration","volume":"11","author":"Cheng H","year":"2021","unstructured":"Cheng H, Huang H, Guo Z, Chang Y, Li Z. Role of prostaglandin E2 in tissue repair and regeneration. Theranostics. 2021, 11:8836-54. 10.7150\/thno.63396","journal-title":"Theranostics"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2018.02.002","article-title":"A systematic review of biomarkers of gingival crevicular fluid: their predictive role in diagnosis of periodontal disease status","volume":"8","author":"Gupta S","year":"2018","unstructured":"Gupta S, Chhina S, Arora SA. A systematic review of biomarkers of gingival crevicular fluid: their predictive role in diagnosis of periodontal disease status. J Oral Biol Craniofac Res. 2018, 8:98-104. 10.1016\/j.jobcr.2018.02.002","journal-title":"J Oral Biol Craniofac Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-2812-1","article-title":"Effectiveness of herbal oral care products in reducing dental plaque & gingivitis - a systematic review and meta-analysis","volume":"20","author":"Janakiram C","year":"2020","unstructured":"Janakiram C, Venkitachalam R, Fontelo P, Iafolla TJ, Dye BA. Effectiveness of herbal oral care products in reducing dental plaque & gingivitis - a systematic review and meta-analysis. BMC Complement Med Ther. 2020, 20:43. 10.1186\/s12906-020-2812-1","journal-title":"BMC Complement Med Ther"},{"key":"ref16","article-title":"Glycyrrhiza glabra-a plant for the future","volume":"2","author":"Sharma VA","year":"2013","unstructured":"Sharma VA, Agrawal RC. Glycyrrhiza glabra-a plant for the future. Mintage J Pharm Med Sci. 2013, 2:15-20.","journal-title":"Mintage J Pharm Med Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07240","article-title":"Phytochemistry, pharmacological activity, and potential health benefits of Gly cyrrhiza glabra","volume":"7","author":"Hasan MK","year":"2021","unstructured":"Hasan MK, Ara I, Mondal MS, Kabir Y. Phytochemistry, pharmacological activity, and potential health benefits of Gly cyrrhiza glabra. Heliyon. 2021, 7:07240. 10.1016\/j.heliyon.2021.e07240","journal-title":"Heliyon"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080052","article-title":"A licorice extract reduces lipopolysaccharide-induced proinflammatory cytokine secretion by macrophages and whole blood","volume":"79","author":"Bodet C","year":"2008","unstructured":"Bodet C, La VD, Gafner S, Bergeron C, Grenier D. A licorice extract reduces lipopolysaccharide-induced proinflammatory cytokine secretion by macrophages and whole blood. J Periodontol. 2008, 79:1752-61. 10.1902\/jop.2008.080052","journal-title":"J Periodontol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.29228\/jrp.202","article-title":"Formulation and in-vitro characterization of herbal licorice gel for periodontal therapy","volume":"26","author":"Khan SF","year":"2022","unstructured":"Khan SF, Shetty B, Khan AM, Fazal I. Formulation and in-vitro characterization of herbal licorice gel for periodontal therapy. J Pharm Res. 2022, 26:1-9. 10.29228\/jrp.202","journal-title":"J Pharm Res"},{"key":"ref20","article-title":"Mucoadhesive and drug release properties of benzocaine gel","volume":"2","author":"Jelvehgari M","year":"2006","unstructured":"Jelvehgari M, Rashidi MR, Samadi H. Mucoadhesive and drug release properties of benzocaine gel. Iran J Pharm Sci. 2006, 2:185-94.","journal-title":"Iran J Pharm Sci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.33393\/dti.2023.2583","article-title":"Licorice as a herbal extract in periodontal therapy","volume":"17","author":"Khan SF","year":"2023","unstructured":"Khan SF, Shetty B, Fazal I, et al.. Licorice as a herbal extract in periodontal therapy. Drug Target Insights. 2023, 17:70-7. 10.33393\/dti.2023.2583","journal-title":"Drug Target Insights"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.26477\/idj.v38i1.72","article-title":"The Iraqi method of natural liquorice as a mouth rinse and its effect in patient with chronic periodontitis","volume":"38","author":"Ali A","year":"2016","unstructured":"Ali A, Mohammed R. The Iraqi method of natural liquorice as a mouth rinse and its effect in patient with chronic periodontitis. Iraqi Dent J. 2016, 38:43-7. 10.26477\/idj.v38i1.72","journal-title":"Iraqi Dent J"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_517_20","article-title":"Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis - a randomized controlled clinical trial","volume":"26","author":"Sharma S","year":"2022","unstructured":"Sharma S, Sogi GM, Saini V, Chakraborty T, Sudan J. Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis - a randomized controlled clinical trial. J Indian Soc Periodontol. 2022, 26:51-7. 10.4103\/jisp.jisp_517_20","journal-title":"J Indian Soc Periodontol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4103\/ijohr.ijohr_18_17","article-title":"Assessment of the efficacy of licorice versus 0.2% chlorhexidine oral rinse on plaque-induced gingivitis: a randomized clinical trial","volume":"3","author":"Jain P","year":"2017","unstructured":"Jain P, Sontakke P, Walia S, Yadav P, Biswas G, Kaur D. Assessment of the efficacy of licorice versus 0.2% chlorhexidine oral rinse on plaque-induced gingivitis: a randomized clinical trial. Indian J Oral Heal Res. 2017, 3:15-8. 10.4103\/ijohr.ijohr_18_17","journal-title":"Indian J Oral Heal Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4103\/jicdro.jicdro_7_19","article-title":"Glycyrrhiza glabra: an efficient medicinal plant for control of periodontitis-a randomized clinical trial","volume":"11","author":"Madan S","year":"2019","unstructured":"Madan S, Kashyap S, Mathur G. Glycyrrhiza glabra: an efficient medicinal plant for control of periodontitis-a randomized clinical trial. J Int Clin Dent Res Organ. 2019, 11:32-5. 10.4103\/jicdro.jicdro_7_19","journal-title":"J Int Clin Dent Res Organ"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.04.019","article-title":"The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells","volume":"70","author":"Choi EM","year":"2005","unstructured":"Choi EM. The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. Biochem Pharmacol. 2005, 70:363-8. 10.1016\/j.bcp.2005.04.019","journal-title":"Biochem Pharmacol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/286353-assessment-of-the-efficacy-of-subgingivally-delivered-liquorice-gel-on-clinical-parameters-and-prostaglandin-e2-levels-in-chronic-periodontitis-a-clinico-biochemical-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T11:37:29Z","timestamp":1735817849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/286353-assessment-of-the-efficacy-of-subgingivally-delivered-liquorice-gel-on-clinical-parameters-and-prostaglandin-e2-levels-in-chronic-periodontitis-a-clinico-biochemical-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.76781","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,2]]}}}