{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:13:00Z","timestamp":1785031980814,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,3]]},"DOI":"10.7759\/cureus.76850","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T13:29:47Z","timestamp":1735910987000},"source":"Crossref","is-referenced-by-count":1,"title":["Expression Profiling of Reelin (RELN) Gene in Patients With Schizophrenia from North Karnataka"],"prefix":"10.7759","author":[{"given":"Nilima","family":"Dongre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Shattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Ramdurg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurushantappa S","family":"Kadakol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn187","article-title":"The neurodevelopmental hypothesis of schizophrenia, revisited","volume":"35","author":"Fatemi SH","year":"2009","unstructured":"Fatemi SH, Folsom TD. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull. 2009, 35:528-48. 10.1093\/schbul\/sbn187","journal-title":"Schizophr Bull"},{"key":"ref2","unstructured":"Global burden of schizophrenia in the year 2000. Version 1 estimates. (2006). Accessed: February 27, 2013: https:\/\/citeseerx.ist.psu.edu\/document?repid=rep1&amp;type=pdf&amp;doi=14d26ed60ce9c9d40ad5917302ca0977f0d4f827."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5455\/2320-6012.ijrms20140874","article-title":"Pharmacoepidemiological survey of schizophrenia in central India","volume":"2","author":"Rode SB","year":"2014","unstructured":"Rode SB, Salankar HV, Verma PR, Sinha U, Ajagallay RK. Pharmacoepidemiological survey of schizophrenia in central India. Int J Res Med Sci. 2014, 2:1058-62. 10.5455\/2320-6012.ijrms20140874","journal-title":"Int J Res Med Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbl065","article-title":"Competing definitions of schizophrenia: what can be learned from polydiagnostic studies?","volume":"33","author":"Jansson LB","year":"2007","unstructured":"Jansson LB, Parnas J. Competing definitions of schizophrenia: what can be learned from polydiagnostic studies?. Schizophr Bull. 2007, 33:1178-200. 10.1093\/schbul\/sbl065","journal-title":"Schizophr Bull"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/psychiatry.IndianJPsychiatry_639_19","article-title":"Subjective cognitive complaints and its relation to objective cognitive performance, clinical profile, clinical insight, and social functioning in patients of schizophrenia: a cross-sectional study","volume":"62","author":"Baliga SP","year":"2020","unstructured":"Baliga SP, Kamath RM, Kedare JS. Subjective cognitive complaints and its relation to objective cognitive performance, clinical profile, clinical insight, and social functioning in patients of schizophrenia: a cross-sectional study. Indian J Psychiatry. 2020, 62:178-85. 10.4103\/psychiatry.IndianJPsychiatry_639_19","journal-title":"Indian J Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0000000000000235","article-title":"Association between RELN polymorphisms and schizophrenia in a Han population from Northeast China","volume":"29","author":"Bai W","year":"2019","unstructured":"Bai W, Fu Y, Yu X, Zhu B, Duan R, Yu Y, Kou C. Association between RELN polymorphisms and schizophrenia in a Han population from Northeast China. Psychiatr Genet. 2019, 29:232-6. 10.1097\/YPG.0000000000000235","journal-title":"Psychiatr Genet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.10.014","article-title":"Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: a meta-analysis","volume":"609","author":"Li W","year":"2015","unstructured":"Li W, Guo X, Xiao S. Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: a meta-analysis. Neurosci Lett. 2015, 609:42-7. 10.1016\/j.neulet.2015.10.014","journal-title":"Neurosci Lett"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby058","article-title":"Global epidemiology and burden of schizophrenia: findings from the Global Burden of Disease Study 2016","volume":"44","author":"Charlson FJ","year":"2018","unstructured":"Charlson FJ, Ferrari AJ, Santomauro DF, et al.. Global epidemiology and burden of schizophrenia: findings from the Global Burden of Disease Study 2016. Schizophr Bull. 2018, 44:1195-203. 10.1093\/schbul\/sby058","journal-title":"Schizophr Bull"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155174","article-title":"Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia","volume":"320","author":"Walsh T","year":"2008","unstructured":"Walsh T, McClellan JM, McCarthy SE, et al.. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science. 2008, 320:539-43. 10.1126\/science.1155174","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.32474\/SJPBS.2019.03.000158","article-title":"A review on gender differences in schizophrenia in Indian settings","volume":"3","author":"Marathe A","year":"2019","unstructured":"Marathe A, Wagani R. A review on gender differences in schizophrenia in Indian settings. SJPBS. 2019, 3:277-80. 10.32474\/SJPBS.2019.03.000158","journal-title":"SJPBS"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/374719a0","article-title":"A protein related to extracellular matrix proteins deleted in the mouse mutant reeler","volume":"374","author":"D'Arcangelo G","year":"1995","unstructured":"D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995, 374:719-23. 10.1038\/374719a0","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.117.200907","article-title":"Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis","volume":"211","author":"Pillinger T","year":"2017","unstructured":"Pillinger T, Beck K, Stubbs B, Howes OD. Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis. Br J Psychiatry. 2017, 211:339-49. 10.1192\/bjp.bp.117.200907","journal-title":"Br J Psychiatry"},{"key":"ref13","article-title":"Metabolic disturbances in schizophrenia patients with positive, negative and cognitive symptoms","volume":"11","author":"Uma Devi P","year":"2009","unstructured":"Uma Devi P, Murugam S. Metabolic disturbances in schizophrenia patients with positive, negative and cognitive symptoms. JK Science. 2009, 11:114-8.","journal-title":"JK Science"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s41065-020-00158-6","article-title":"Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment","volume":"157","author":"Yin J","year":"2020","unstructured":"Yin J, Lu Y, Yu S, Dai Z, Zhang F, Yuan J. Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment. Hereditas. 2020, 157:43. 10.1186\/s41065-020-00158-6","journal-title":"Hereditas"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-022-00278-0","article-title":"DNA methylation levels of RELN promoter region in ultra-high risk, first episode and chronic schizophrenia cohorts of schizophrenia","volume":"8","author":"Kho SH","year":"2022","unstructured":"Kho SH, Yee JY, Puang SJ, et al.. DNA methylation levels of RELN promoter region in ultra-high risk, first episode and chronic schizophrenia cohorts of schizophrenia. Schizophrenia (Heidelb). 2022, 8:81. 10.1038\/s41537-022-00278-0","journal-title":"Schizophrenia (Heidelb)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.04.012","article-title":"The impact of body mass index in gene expression of reelin pathway mediators in individuals with schizophrenia and mood disorders: a post-mortem study","volume":"102","author":"Brietzke E","year":"2018","unstructured":"Brietzke E, Trevizol AP, Fries GR, Subramaniapillai M, Kapczinski F, McIntyre RS, Mansur RB. The impact of body mass index in gene expression of reelin pathway mediators in individuals with schizophrenia and mood disorders: a post-mortem study. J Psychiatr Res. 2018, 102:186-91. 10.1016\/j.jpsychires.2018.04.012","journal-title":"J Psychiatr Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0312-z","article-title":"Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study","volume":"116","author":"Habl G","year":"2009","unstructured":"Habl G, Zink M, Petroianu G, et al.. Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study. J Neural Transm (Vienna). 2009, 116:1657-65. 10.1007\/s00702-009-0312-z","journal-title":"J Neural Transm (Vienna)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031829","article-title":"New strategies for the treatment of neuropsychiatric disorders based on reelin dysfunction","volume":"23","author":"Tsuneura Y","year":"2022","unstructured":"Tsuneura Y, Nakai T, Mizoguchi H, Yamada K. New strategies for the treatment of neuropsychiatric disorders based on reelin dysfunction. Int J Mol Sci. 2022, 23:1829. 10.3390\/ijms23031829","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-013-0415-z","article-title":"Metabolic issues in schizophrenic patients receiving antipsychotic treatment","volume":"29","author":"Gupta A","year":"2014","unstructured":"Gupta A, Dadheech G, Yadav D, Sharma P, Gautam S. Metabolic issues in schizophrenic patients receiving antipsychotic treatment. Indian J Clin Biochem. 2014, 29:196-201. 10.1007\/s12291-013-0415-z","journal-title":"Indian J Clin Biochem"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/314132-expression-profiling-of-reelin-reln-gene-in-patients-with-schizophrenia-from-north-karnataka","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T13:29:49Z","timestamp":1735910989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/314132-expression-profiling-of-reelin-reln-gene-in-patients-with-schizophrenia-from-north-karnataka"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.76850","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,3]]}}}