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Aliment Pharmacol Ther. 2016, 44:447-59. 10.1111\/apt.13706","journal-title":"Aliment Pharmacol Ther"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.159285","article-title":"Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome","volume":"142","author":"Staudacher HM","year":"2012","unstructured":"Staudacher HM, Lomer MC, Anderson JL, Barrett JS, Muir JG, Irving PM, Whelan K. Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. J Nutr. 2012, 142:1510-8. 10.3945\/jn.112.159285","journal-title":"J Nutr"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.137","article-title":"Diagnosis and management of IBS","volume":"7","author":"Khan S","year":"2010","unstructured":"Khan S, Chang L. Diagnosis and management of IBS. 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N Engl J Med. 2017, 376:2566-78. 10.1056\/NEJMra1607547","journal-title":"N Engl J Med"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15325","article-title":"Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome","volume":"50","author":"Zamani M","year":"2019","unstructured":"Zamani M, Alizadeh-Tabari S, Zamani V. Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2019, 50:132-43. 10.1111\/apt.15325","journal-title":"Aliment Pharmacol Ther"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12001","article-title":"Nutrient intake in patients with irritable bowel syndrome compared with the general population","volume":"25","author":"B\u00f6hn L","year":"2013","unstructured":"B\u00f6hn L, St\u00f6rsrud S, Simr\u00e9n M. 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Int J Mol Med. 2014, 34:363-71. 10.3892\/ijmm.2014.1811","journal-title":"Int J Mol Med"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02736.x","article-title":"The growing case for an immunological component to irritable bowel syndrome","volume":"37","author":"Whorwell PJ","year":"2007","unstructured":"Whorwell PJ. The growing case for an immunological component to irritable bowel syndrome. Clin Exp Allergy. 2007, 37:805-7. 10.1111\/j.1365-2222.2007.02736.x","journal-title":"Clin Exp Allergy"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41348.x","article-title":"Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome","volume":"100","author":"Zar S","year":"2005","unstructured":"Zar S, Benson MJ, Kumar D. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol. 2005, 100:1550-7. 10.1111\/j.1572-0241.2005.41348.x","journal-title":"Am J Gastroenterol"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01226.x","article-title":"Discrepancies between reported food intolerance and sensitization test findings in irritable bowel syndrome patients","volume":"94","author":"Dainese R","year":"1999","unstructured":"Dainese R, Galliani EA, De Lazzari F, Di Leo V, Naccarato R. Discrepancies between reported food intolerance and sensitization test findings in irritable bowel syndrome patients. 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Gastroenterology. 2013, 144:903-911.e3. 10.1053\/j.gastro.2013.01.049","journal-title":"Gastroenterology"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.487","article-title":"Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial","volume":"106","author":"Biesiekierski JR","year":"2011","unstructured":"Biesiekierski JR, Newnham ED, Irving PM, et al.. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011, 106:508-14; quiz 515. 10.1038\/ajg.2010.487","journal-title":"Am J Gastroenterol"},{"key":"ref63","article-title":"Non-celiac gluten sensitivity. Is it in the gluten or the grain?","volume":"22","author":"Nijeboer P","year":"2013","unstructured":"Nijeboer P, Bontkes HJ, Mulder CJ, Bouma G. Non-celiac gluten sensitivity. Is it in the gluten or the grain?. J Gastrointestin Liver Dis. 2013, 22:435-40.","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref64","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","unstructured":"Drossman DA, Dumitrascu DL. Rome III: new standard for functional gastrointestinal disorders. J Gastrointestin Liver Dis. 2006, 15:237-41.","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00025","article-title":"The role of short-chain fatty acids from gut microbiota in gut-brain communication","volume":"11","author":"Silva YP","year":"2020","unstructured":"Silva YP, Bernardi A, Frozza RL. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front Endocrinol (Lausanne). 2020, 11:25. 10.3389\/fendo.2020.00025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch SV","year":"2016","unstructured":"Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med. 2016, 375:2369-79. 10.1056\/NEJMra1600266","journal-title":"N Engl J Med"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.5056\/jnm22093","article-title":"The role of short chain fatty acids in irritable bowel syndrome","volume":"28","author":"Jiang W","year":"2022","unstructured":"Jiang W, Wu J, Zhu S, Xin L, Yu C, Shen Z. The role of short chain fatty acids in irritable bowel syndrome. 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