{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:26:05Z","timestamp":1736400365184,"version":"3.32.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"DOI":"10.7759\/cureus.77141","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:40:36Z","timestamp":1736350836000},"source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and Prognostic Factors in Patients With Untreated Head and Neck Squamous Cell Carcinoma"],"prefix":"10.7759","author":[{"given":"Hisashi","family":"Kessoku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Mizunari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Report of Head and Neck Cancer Registry of Japan. clinical statistics of registered patients, 2019. (2019). Accessed: September 18, 2023: http:\/\/www.jshnc.umin.ne.jp\/pdf\/HNCreport_2019.pdf."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2929","article-title":"Oral cavity carcinoma: current management, controversies, and future directions","volume":"33","author":"Chinn SB","year":"2015","unstructured":"Chinn SB, Myers JN. Oral cavity carcinoma: current management, controversies, and future directions. J Clin Oncol. 2015, 33:3269-76. 10.1200\/JCO.2015.61.2929","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31047","article-title":"Treatment outcome in head and neck cancer with distant metastasis at initial diagnosis","volume":"134","author":"Omata J","year":"2024","unstructured":"Omata J, Ueki Y, Takahashi Y, et al.. Treatment outcome in head and neck cancer with distant metastasis at initial diagnosis. Laryngoscope. 2024, 134:1679-86. 10.1002\/lary.31047","journal-title":"Laryngoscope"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26460","article-title":"Untreated head and neck cancer: natural history and associated factors","volume":"43","author":"Zolkind P","year":"2021","unstructured":"Zolkind P, Lee JJ, Jackson RS, Pipkorn P, Massa ST. Untreated head and neck cancer: natural history and associated factors. Head Neck. 2021, 43:89-97. 10.1002\/hed.26460","journal-title":"Head Neck"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-8049(00)00054-x","article-title":"Natural history of untreated head and neck cancer","volume":"36","author":"Kowalski LP","year":"2000","unstructured":"Kowalski LP, Carvalho AL. Natural history of untreated head and neck cancer. Eur J Cancer. 2000, 36:1032-7. 10.1016\/s0959-8049(00)00054-x","journal-title":"Eur J Cancer"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02325.x","article-title":"The natural history of untreated squamous cell carcinoma of the head and neck: how we do it","volume":"36","author":"Jeannon JP","year":"2011","unstructured":"Jeannon JP, Ofu E, Balfour A, Bowman J, Simo R. The natural history of untreated squamous cell carcinoma of the head and neck: how we do it. Clin Otolaryngol. 2011, 36:384-8. 10.1111\/j.1749-4486.2011.02325.x","journal-title":"Clin Otolaryngol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4392-8","article-title":"Untreated head and neck cancer in Korea: a national cohort study","volume":"274","author":"Choi HG","year":"2017","unstructured":"Choi HG, Park B, Ahn SH. Untreated head and neck cancer in Korea: a national cohort study. Eur Arch Otorhinolaryngol. 2017, 274:1643-50. 10.1007\/s00405-016-4392-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13260","article-title":"Natural history of untreated squamous cell carcinoma of the head and neck","volume":"44","author":"Liu F","year":"2019","unstructured":"Liu F, Yuan S, Fang Q, Sun Q. Natural history of untreated squamous cell carcinoma of the head and neck. Clin Otolaryngol. 2019, 44:200-3. 10.1111\/coa.13260","journal-title":"Clin Otolaryngol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"von Elm E","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007, 147:573-7. 10.7326\/0003-4819-147-8-200710160-00010","journal-title":"Ann Intern Med"},{"key":"ref10","unstructured":"Common Toxicity Criteria (CTC), Version 2.0. (1999). Accessed. September 18, 2023: https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/ctcv20_4-30-992.pdf."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24565","article-title":"Survival outcomes in elderly patients with untreated upper aerodigestive tract cancer","volume":"39","author":"Hughley BB","year":"2017","unstructured":"Hughley BB, Sperry SM, Thomsen TA, Charlton ME, Pagedar NA. Survival outcomes in elderly patients with untreated upper aerodigestive tract cancer. Head Neck. 2017, 39:215-8. 10.1002\/hed.24565","journal-title":"Head Neck"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000316","article-title":"Social relationships and mortality risk: a meta-analytic review","volume":"7","author":"Holt-Lunstad J","year":"2010","unstructured":"Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010, 7:e1000316. 10.1371\/journal.pmed.1000316","journal-title":"PLoS Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.11.013","article-title":"Functional and cognitive impairment, social environment, frailty and adverse health outcomes in older patients with head and neck cancer, a systematic review","volume":"64","author":"van Deudekom FJ","year":"2017","unstructured":"van Deudekom FJ, Schimberg AS, Kallenberg MH, Slingerland M, van der Velden LA, Mooijaart SP. Functional and cognitive impairment, social environment, frailty and adverse health outcomes in older patients with head and neck cancer, a systematic review. Oral Oncol. 2017, 64:27-36. 10.1016\/j.oraloncology.2016.11.013","journal-title":"Oral Oncol"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1987.03400210067027","article-title":"The effect of marital status on stage, treatment, and survival of cancer patients","volume":"258","author":"Goodwin JS","year":"1987","unstructured":"Goodwin JS, Hunt WC, Key CR, Samet JM. The effect of marital status on stage, treatment, and survival of cancer patients. JAMA. 1987, 258:3125-30.","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29171","article-title":"Marital status and head and neck cancer outcomes","volume":"121","author":"Inverso G","year":"2015","unstructured":"Inverso G, Mahal BA, Aizer AA, Donoff RB, Chau NG, Haddad RI. Marital status and head and neck cancer outcomes. Cancer. 2015, 121:1273-8. 10.1002\/cncr.29171","journal-title":"Cancer"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27116","article-title":"Refusal of cancer-directed surgery in head and neck squamous cell carcinoma patients","volume":"129","author":"Crippen MM","year":"2019","unstructured":"Crippen MM, Elias ML, Weisberger JS, Brady JS, Eloy JA, Baredes S, Park RC. Refusal of cancer-directed surgery in head and neck squamous cell carcinoma patients. Laryngoscope. 2019, 129:1368-73. 10.1002\/lary.27116","journal-title":"Laryngoscope"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp398","article-title":"Psychological distress among male patients and male spouses: what do oncologists need to know?","volume":"21","author":"Goldzweig G","year":"2010","unstructured":"Goldzweig G, Andritsch E, Hubert A, Brenner B, Walach N, Perry S, Baider L. Psychological distress among male patients and male spouses: what do oncologists need to know?. Ann Oncol. 2010, 21:877-83. 10.1093\/annonc\/mdp398","journal-title":"Ann Oncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/0022146518790560","article-title":"Marriage, social control, and health behavior: a dyadic analysis of same-sex and different-sex couples","volume":"59","author":"Umberson D","year":"2018","unstructured":"Umberson D, Donnelly R, Pollitt AM. Marriage, social control, and health behavior: a dyadic analysis of same-sex and different-sex couples. J Health Soc Behav. 2018, 59:429-46. 10.1177\/0022146518790560","journal-title":"J Health Soc Behav"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061754","article-title":"Social support in a cancer patient-informal caregiver dyad: a scoping review","volume":"15","author":"Pasek M","year":"2023","unstructured":"Pasek M, Go\u017adzialska A, Jochymek M, Caruso R. Social support in a cancer patient-informal caregiver dyad: a scoping review. Cancers (Basel). 2023, 15:1754. 10.3390\/cancers15061754","journal-title":"Cancers (Basel)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/331067-outcomes-and-prognostic-factors-in-patients-with-untreated-head-and-neck-squamous-cell-carcinoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:40:40Z","timestamp":1736350840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/331067-outcomes-and-prognostic-factors-in-patients-with-untreated-head-and-neck-squamous-cell-carcinoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.77141","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}