{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T05:25:12Z","timestamp":1736832312766,"version":"3.33.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,13]]},"DOI":"10.7759\/cureus.77380","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T17:45:57Z","timestamp":1736790357000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Remission in Graves\u2019 Disease Patients Treated With Antithyroid Drugs: A Retrospective Study"],"prefix":"10.7759","author":[{"given":"Raghad S","family":"Alzahrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazeed H","family":"Aljabri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasan S","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feras M","family":"Fatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay J","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali S","family":"Alsudais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhaib","family":"Radi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12395","article-title":"Human autoimmune diseases: a comprehensive update","volume":"278","author":"Wang L","year":"2015","unstructured":"Wang L, Wang FS, Gershwin ME. Human autoimmune diseases: a comprehensive update. J Intern Med. 2015, 278:369-95. 10.1111\/joim.12395","journal-title":"J Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.359","article-title":"Exploring the \"thyroid-skin connection\": concepts, questions, and clinical relevance","volume":"130","author":"Paus R","year":"2010","unstructured":"Paus R. Exploring the \"thyroid-skin connection\": concepts, questions, and clinical relevance. J Invest Dermatol. 2010, 130:7-10. 10.1038\/jid.2009.359","journal-title":"J Invest Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.1.5415","article-title":"Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease","volume":"84","author":"Costagliola S","year":"1999","unstructured":"Costagliola S, Morgenthaler NG, Hoermann R, et al.. Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease. J Clin Endocrinol Metab. 1999, 84:90-7. 10.1210\/jcem.84.1.5415","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030","article-title":"Graves' disease","volume":"375","author":"Smith TJ","year":"2016","unstructured":"Smith TJ, Heged\u00fcs L. Graves' disease. N Engl J Med. 2016, 375:1552-65. 10.1056\/NEJMra1510030","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010263431707","article-title":"Graves' disease","volume":"343","author":"Weetman AP","year":"2000","unstructured":"Weetman AP. Graves' disease. N Engl J Med. 2000, 343:1236-48. 10.1056\/NEJM200010263431707","journal-title":"N Engl J Med"},{"key":"ref6","article-title":"Sabiston textbook of surgery: the biological basis of modern surgical practice 21st ed","author":"Suh I","year":"2022","unstructured":"Suh I, Sosa JA. Sabiston textbook of surgery: the biological basis of modern surgical practice 21st ed. Townsend C, Beauchamp R, Evers B, Mattox K (ed): Elsevier, 2022."},{"key":"ref7","article-title":"Thyroid and parathyroid glands","author":"O'Connell PR","year":"2018","unstructured":"O'Connell PR, McCaskie AW, Williams NS. Thyroid and parathyroid glands.  Bailey &amp; Love's Short Practice of Surgery. O'Connell PR, McCaskie AW, Williams NS  (ed): CRC Press, Boca Raton, FL; 2018. 1015:1025."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/2042018811408488","article-title":"Current concepts in Graves' disease","volume":"2","author":"Girgis CM","year":"2011","unstructured":"Girgis CM, Champion BL, Wall JR. Current concepts in Graves' disease. Ther Adv Endocrinol Metab. 2011, 2:135-44. 10.1177\/2042018811408488","journal-title":"Ther Adv Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract11030065","article-title":"Prevalence and characteristics of thyroid abnormalities and its association with anemia in ASIR region of Saudi Arabia: a cross-sectional study","volume":"11","author":"Alqahtani SA","year":"2021","unstructured":"Alqahtani SA. Prevalence and characteristics of thyroid abnormalities and its association with anemia in ASIR region of Saudi Arabia: a cross-sectional study. Clin Pract. 2021, 11:494-504. 10.3390\/clinpract11030065","journal-title":"Clin Pract"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104713","article-title":"Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics","volume":"9","author":"Tomer Y","year":"2014","unstructured":"Tomer Y. Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu Rev Pathol. 2014, 9:147-56. 10.1146\/annurev-pathol-012513-104713","journal-title":"Annu Rev Pathol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7554.1369","article-title":"Diagnosis and management of thyrotoxicosis","volume":"332","author":"Pearce EN","year":"2006","unstructured":"Pearce EN. Diagnosis and management of thyrotoxicosis. BMJ. 2006, 332:1369-73. 10.1136\/bmj.332.7554.1369","journal-title":"BMJ"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.04.003","article-title":"Laboratory tests of thyroid function: uses and limitations","volume":"36","author":"Dufour DR","year":"2007","unstructured":"Dufour DR. Laboratory tests of thyroid function: uses and limitations. Endocrinol Metab Clin North Am. 2007, 36:579-94, v. 10.1016\/j.ecl.2007.04.003","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.2106.ed3","article-title":"The American Thyroid Association\/American Association of Clinical Endocrinologists guidelines for hyperthyroidism and other causes of thyrotoxicosis: a European perspective","volume":"21","author":"Kahaly GJ","year":"2011","unstructured":"Kahaly GJ, Bartalena L, Heged\u00fcs L. The American Thyroid Association\/American Association of Clinical Endocrinologists guidelines for hyperthyroidism and other causes of thyrotoxicosis: a European perspective. Thyroid. 2011, 21:585-91. 10.1089\/thy.2011.2106.ed3","journal-title":"Thyroid"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0652","article-title":"Long-term antithyroid drug treatment: a systematic review and meta-analysis","volume":"27","author":"Azizi F","year":"2017","unstructured":"Azizi F, Malboosbaf R. Long-term antithyroid drug treatment: a systematic review and meta-analysis. Thyroid. 2017, 27:1223-31. 10.1089\/thy.2016.0652","journal-title":"Thyroid"},{"key":"ref15","article-title":"Graves' hyperthyroidism in nonpregnant adults: overview of treatment","author":"Ross D","year":"2025","unstructured":"Ross D. Graves' hyperthyroidism in nonpregnant adults: overview of treatment. UpToDate. Cooper D (ed): UpToDate, Waltham, MA; 2025."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.3.8333","article-title":"High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease","volume":"87","author":"Alexander EK","year":"2002","unstructured":"Alexander EK, Larsen PR. High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease. J Clin Endocrinol Metab. 2002, 87:1073-7. 10.1210\/jcem.87.3.8333","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2019.34.1.29","article-title":"Graves' disease: can it be cured?","volume":"34","author":"Wiersinga WM","year":"2019","unstructured":"Wiersinga WM. Graves' disease: can it be cured?. Endocrinol Metab (Seoul). 2019, 34:29-38. 10.3803\/EnM.2019.34.1.29","journal-title":"Endocrinol Metab (Seoul)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1306-5","article-title":"Epidemiology, management and outcomes of Graves' disease-real life data","volume":"56","author":"Hussain YS","year":"2017","unstructured":"Hussain YS, Hookham JC, Allahabadia A, Balasubramanian SP. Epidemiology, management and outcomes of Graves' disease-real life data. Endocrine. 2017, 56:568-78. 10.1007\/s12020-017-1306-5","journal-title":"Endocrine"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0678","article-title":"Anniversary review: antithyroid drug therapy: 70 years later","volume":"179","author":"Burch HB","year":"2018","unstructured":"Burch HB, Cooper DS. Anniversary review: antithyroid drug therapy: 70 years later. Eur J Endocrinol. 2018, 179:R261-74. 10.1530\/EJE-18-0678","journal-title":"Eur J Endocrinol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1785-z","article-title":"Long-term remission following antithyroid drug withdrawal in patients with Graves' hyperthyroidism: parameters with prognostic value","volume":"63","author":"Garc\u00eda-Mayor RV","year":"2019","unstructured":"Garc\u00eda-Mayor RV, \u00c1lvarez-V\u00e1zquez P, Fluiters E, Valverde D, Andrade A. Long-term remission following antithyroid drug withdrawal in patients with Graves' hyperthyroidism: parameters with prognostic value. Endocrine. 2019, 63:316-22. 10.1007\/s12020-018-1785-z","journal-title":"Endocrine"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5945178","article-title":"Predictors of initial and sustained remission in patients treated with antithyroid drugs for Graves' hyperthyroidism: the RISG study","volume":"2019","author":"Karmisholt J","year":"2019","unstructured":"Karmisholt J, Andersen SL, Bulow-Pedersen I, Carl\u00e9 A, Krejbjerg A, Nygaard B. Predictors of initial and sustained remission in patients treated with antithyroid drugs for Graves' hyperthyroidism: the RISG study. J Thyroid Res. 2019, 2019:5945178. 10.1155\/2019\/5945178","journal-title":"J Thyroid Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0881","article-title":"Does age or sex relate to severity or treatment prognosis in Graves' disease?","volume":"31","author":"Suzuki N","year":"2021","unstructured":"Suzuki N, Noh JY, Yoshimura R, et al.. Does age or sex relate to severity or treatment prognosis in Graves' disease?. Thyroid. 2021, 31:1409-15. 10.1089\/thy.2020.0881","journal-title":"Thyroid"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0365","article-title":"Disease presentation and remission rate in Graves' disease treated with antithyroid drugs: is gender really a factor?","volume":"25","author":"Diker-Cohen T","year":"2019","unstructured":"Diker-Cohen T, Duskin-Bitan H, Shimon I, Hirsch D, Akirov A, Tsvetov G, Robenshtok E. Disease presentation and remission rate in Graves' disease treated with antithyroid drugs: is gender really a factor?. Endocr Pract. 2019, 25:43-50. 10.4158\/EP-2018-0365","journal-title":"Endocr Pract"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0126","article-title":"Hypothyroidism during antithyroid drug treatment with methimazole is a favorable prognostic indicator in patients with Graves' disease","volume":"20","author":"Choo YK","year":"2010","unstructured":"Choo YK, Yoo WS, Kim DW, Chung HK. Hypothyroidism during antithyroid drug treatment with methimazole is a favorable prognostic indicator in patients with Graves' disease. Thyroid. 2010, 20:949-54. 10.1089\/thy.2009.0126","journal-title":"Thyroid"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-9895-0","article-title":"Predictors of long-term remission in patients with Graves' disease: a single center experience","volume":"44","author":"Anagnostis P","year":"2013","unstructured":"Anagnostis P, Adamidou F, Polyzos SA, et al.. Predictors of long-term remission in patients with Graves' disease: a single center experience. Endocrine. 2013, 44:448-53. 10.1007\/s12020-013-9895-0","journal-title":"Endocrine"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0180","article-title":"Increased remission rates after long-term methimazole therapy in patients with Graves' disease: results of a randomized clinical trial","volume":"29","author":"Azizi F","year":"2019","unstructured":"Azizi F, Amouzegar A, Tohidi M, et al.. Increased remission rates after long-term methimazole therapy in patients with Graves' disease: results of a randomized clinical trial. Thyroid. 2019, 29:1192-200. 10.1089\/thy.2019.0180","journal-title":"Thyroid"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01730-1","article-title":"Appropriate duration of antithyroid drug treatment as a predictor for relapse of Graves' disease: a systematic scoping review","volume":"45","author":"Azizi F","year":"2022","unstructured":"Azizi F, Abdi H, Mehran L, Amouzegar A. Appropriate duration of antithyroid drug treatment as a predictor for relapse of Graves' disease: a systematic scoping review. J Endocrinol Invest. 2022, 45:1139-50. 10.1007\/s40618-021-01730-1","journal-title":"J Endocrinol Invest"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.01.022","article-title":"Risk factors for the relapse of Graves' disease treated with antithyroid drugs: a systematic review and meta-analysis","volume":"42","author":"Shi H","year":"2020","unstructured":"Shi H, Sheng R, Hu Y, Liu X, Jiang L, Wang Z, Cui D. Risk factors for the relapse of Graves' disease treated with antithyroid drugs: a systematic review and meta-analysis. Clin Ther. 2020, 42:662-675.e4. 10.1016\/j.clinthera.2020.01.022","journal-title":"Clin Ther"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14374","article-title":"Comparison of long-term antithyroid drugs versus radioactive iodine or surgery for Graves' disease: a review of the literature","volume":"95","author":"El Kawkgi OM","year":"2021","unstructured":"El Kawkgi OM, Ross DS, Stan MN. Comparison of long-term antithyroid drugs versus radioactive iodine or surgery for Graves' disease: a review of the literature. Clin Endocrinol (Oxf). 2021, 95:3-12. 10.1111\/cen.14374","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02032.x","article-title":"Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves' hyperthyroidism","volume":"60","author":"He CT","year":"2004","unstructured":"He CT, Hsieh AT, Pei D, et al.. Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves' hyperthyroidism. Clin Endocrinol (Oxf). 2004, 60:676-81. 10.1111\/j.1365-2265.2004.02032.x","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/332473-predictors-of-remission-in-graves-disease-patients-treated-with-antithyroid-drugs-a-retrospective-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T17:45:58Z","timestamp":1736790358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/332473-predictors-of-remission-in-graves-disease-patients-treated-with-antithyroid-drugs-a-retrospective-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.77380","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}