{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:31:36Z","timestamp":1781530296964,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,19]]},"DOI":"10.7759\/cureus.77679","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:35:11Z","timestamp":1737340511000},"source":"Crossref","is-referenced-by-count":1,"title":["A Case of Cerebral Amyloid Angiopathy With Recurrent Hemorrhagic and Ischemic Strokes Under Direct Oral Anticoagulant Therapy for Atrial Fibrillation"],"prefix":"10.7759","author":[{"given":"Junichi","family":"Uemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yagita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00208-3","article-title":"The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study","volume":"21","author":"Charidimou A","year":"2022","unstructured":"Charidimou A, Boulouis G, Frosch MP, et al.. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Lancet Neurol. 2022, 21:714-25. 10.1016\/S1474-4422(22)00208-3","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-1052-1","article-title":"The clinical dilemma of anticoagulation use in patients with cerebral amyloid angiopathy and atrial fibrillation","volume":"20","author":"Cannistraro RJ","year":"2018","unstructured":"Cannistraro RJ, Meschia JF. The clinical dilemma of anticoagulation use in patients with cerebral amyloid angiopathy and atrial fibrillation. Curr Cardiol Rep. 2018, 20:106. 10.1007\/s11886-018-1052-1","journal-title":"Curr Cardiol Rep"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020974464","article-title":"A practical approach to the management of cerebral amyloid angiopathy","volume":"16","author":"Kozberg MG","year":"2021","unstructured":"Kozberg MG, Perosa V, Gurol ME, van Veluw SJ. A practical approach to the management of cerebral amyloid angiopathy. Int J Stroke. 2021, 16:356-69. 10.1177\/1747493020974464","journal-title":"Int J Stroke"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12247704","article-title":"When atrial fibrillation meets cerebral amyloid angiopathy: current evidence and strategies","volume":"12","author":"Merella P","year":"2023","unstructured":"Merella P, Casu G, Chessa P, Atzori E, Bandino S, Deiana G. When atrial fibrillation meets cerebral amyloid angiopathy: current evidence and strategies. J Clin Med. 2023, 12:7704. 10.3390\/jcm12247704","journal-title":"J Clin Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4078","article-title":"Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation","volume":"73","author":"Auriel E","year":"2016","unstructured":"Auriel E, Charidimou A, Gurol ME, et al.. Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation. JAMA Neurol. 2016, 73:197-202. 10.1001\/jamaneurol.2015.4078","journal-title":"JAMA Neurol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr172","article-title":"Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study","volume":"134","author":"Gregoire SM","year":"2011","unstructured":"Gregoire SM, Charidimou A, Gadapa N, et al.. Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study. Brain. 2011, 134:2376-86. 10.1093\/brain\/awr172","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004668","article-title":"Evolution of DWI lesions in cerebral amyloid angiopathy: evidence for ischemia","volume":"89","author":"van Veluw SJ","year":"2017","unstructured":"van Veluw SJ, Lauer A, Charidimou A, et al.. Evolution of DWI lesions in cerebral amyloid angiopathy: evidence for ischemia. Neurology. 2017, 89:2136-42. 10.1212\/WNL.0000000000004668","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00290","article-title":"New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy","volume":"6","author":"Saito S","year":"2014","unstructured":"Saito S, Ihara M. New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. Front Aging Neurosci. 2014, 6:290. 10.3389\/fnagi.2014.00290","journal-title":"Front Aging Neurosci"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061992","article-title":"Potential therapeutic approaches for cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"21","author":"Tanaka M","year":"2020","unstructured":"Tanaka M, Saito S, Inoue T, Satoh-Asahara N, Ihara M. Potential therapeutic approaches for cerebral amyloid angiopathy and Alzheimer\u2019s disease. Int J Mol Sci. 2020, 21:1992. 10.3390\/ijms21061992","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072295","article-title":"Low-dose phosphodiesterase III inhibitor reduces the vascular amyloid burden in amyloid-\u03b2 protein precursor transgenic mice","volume":"21","author":"Yakushiji Y","year":"2020","unstructured":"Yakushiji Y, Kawamoto K, Uchihashi K, et al.. Low-dose phosphodiesterase III inhibitor reduces the vascular amyloid burden in amyloid-\u03b2 protein precursor transgenic mice. Int J Mol Sci. 2020, 21:2295. 10.3390\/ijms21072295","journal-title":"Int J Mol Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01678-7","article-title":"Memantine, a noncompetitive N-methyl-D-aspartate receptor antagonist, attenuates cerebral amyloid angiopathy by increasing insulin-degrading enzyme expression","volume":"56","author":"Inoue Y","year":"2019","unstructured":"Inoue Y, Ueda M, Masuda T, Misumi Y, Yamashita T, Ando Y. Memantine, a noncompetitive N-methyl-D-aspartate receptor antagonist, attenuates cerebral amyloid angiopathy by increasing insulin-degrading enzyme expression. Mol Neurobiol. 2019, 56:8573-88. 10.1007\/s12035-019-01678-7","journal-title":"Mol Neurobiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000502832","article-title":"A clinico-radiological study of cerebral amyloid angiopathy-related inflammation","volume":"48","author":"Coulette S","year":"2019","unstructured":"Coulette S, Renard D, Lehmann S, et al.. A clinico-radiological study of cerebral amyloid angiopathy-related inflammation. Cerebrovasc Dis. 2019, 48:38-44. 10.1159\/000502832","journal-title":"Cerebrovasc Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1782","article-title":"Association between immunosuppressive treatment and outcomes of cerebral amyloid angiopathy-related inflammation","volume":"77","author":"Regenhardt RW","year":"2020","unstructured":"Regenhardt RW, Thon JM, Das AS, et al.. Association between immunosuppressive treatment and outcomes of cerebral amyloid angiopathy-related inflammation. JAMA Neurol. 2020, 77:1261-9. 10.1001\/jamaneurol.2020.1782","journal-title":"JAMA Neurol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004218","article-title":"Teaching NeuroImages: cerebral amyloid angiopathy-related inflammation presenting with isolated leptomeningitis","volume":"89","author":"Kang P","year":"2017","unstructured":"Kang P, Bucelli RC, Ferguson CJ, Corbo JC, Kim AH, Day GS. Teaching NeuroImages: cerebral amyloid angiopathy-related inflammation presenting with isolated leptomeningitis. Neurology. 2017, 89:e66-7. 10.1212\/WNL.0000000000004218","journal-title":"Neurology"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-21-0162","article-title":"JCS\/JHRS 2021 Guideline focused update on non-pharmacotherapy of cardiac arrhythmias","volume":"86","author":"Nogami A","year":"2022","unstructured":"Nogami A, Kurita T, Kusano K, et al.. JCS\/JHRS 2021 Guideline focused update on non-pharmacotherapy of cardiac arrhythmias. Circ J. 2022, 86:337-63. 10.1253\/circj.CJ-21-0162","journal-title":"Circ J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa726","article-title":"Less dementia after catheter ablation for atrial fibrillation: a nationwide cohort study","volume":"41","author":"Kim D","year":"2020","unstructured":"Kim D, Yang PS, Sung JH, et al.. Less dementia after catheter ablation for atrial fibrillation: a nationwide cohort study. Eur Heart J. 2020, 41:4483-93. 10.1093\/eurheartj\/ehaa726","journal-title":"Eur Heart J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00838-5","article-title":"Left atrial appendage closure for patients with cerebral amyloid angiopathy and atrial fibrillation: the LAA-CAA cohort","volume":"12","author":"Schrag M","year":"2021","unstructured":"Schrag M, Mac Grory B, Nackenoff A, et al.. Left atrial appendage closure for patients with cerebral amyloid angiopathy and atrial fibrillation: the LAA-CAA cohort. Transl Stroke Res. 2021, 12:259-65. 10.1007\/s12975-020-00838-5","journal-title":"Transl Stroke Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.067","article-title":"Left  atrial appendage closure versus direct oral anticoagulants in high-risk patients with atrial fibrillation","volume":"75","author":"Osmancik P","year":"2020","unstructured":"Osmancik P, Herman D, Neuzil P, et al.. Left  atrial appendage closure versus direct oral anticoagulants in high-risk patients with atrial fibrillation. J Am Coll Cardiol. 2020, 75:3122-35. 10.1016\/j.jacc.2020.04.067","journal-title":"J Am Coll Cardiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8362-2","article-title":"Comparison of cerebrospinal fluid profiles in Alzheimer's disease with multiple cerebral microbleeds and cerebral amyloid angiopathy-related inflammation","volume":"264","author":"Kimura A","year":"2017","unstructured":"Kimura A, Takemura M, Saito K, et al.. Comparison of cerebrospinal fluid profiles in Alzheimer's disease with multiple cerebral microbleeds and cerebral amyloid angiopathy-related inflammation. J Neurol. 2017, 264:373-81. 10.1007\/s00415-016-8362-2","journal-title":"J Neurol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-022-00511-x","article-title":"PET imaging for the evaluation of cerebral amyloid angiopathy: a systematic review","volume":"10","author":"Dondi F","year":"2022","unstructured":"Dondi F, Bertoli M, Lucchini S, Cerudelli E, Albano D, Bertagna F. PET imaging for the evaluation of cerebral amyloid angiopathy: a systematic review. Clin Transl Imag. 2022, 10:391-401. 10.1007\/s40336-022-00511-x","journal-title":"Clin Transl Imag"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/329580-a-case-of-cerebral-amyloid-angiopathy-with-recurrent-hemorrhagic-and-ischemic-strokes-under-direct-oral-anticoagulant-therapy-for-atrial-fibrillation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:35:13Z","timestamp":1737340513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/329580-a-case-of-cerebral-amyloid-angiopathy-with-recurrent-hemorrhagic-and-ischemic-strokes-under-direct-oral-anticoagulant-therapy-for-atrial-fibrillation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,19]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.77679","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,19]]}}}