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Accessed: January 27, 2025: https:\/\/icd.who.int\/en."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000314","article-title":"Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders","volume":"35","author":"Fineberg NA","year":"2020","unstructured":"Fineberg NA, Hollander E, Pallanti S, et al.. Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders. Int Clin Psychopharmacol. 2020, 35:173-93. 10.1097\/YIC.0000000000000314","journal-title":"Int Clin Psychopharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac046","article-title":"Cognitive flexibility, OCD and the brain","volume":"145","author":"Robbins TW","year":"2022","unstructured":"Robbins TW. Cognitive flexibility, OCD and the brain. 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