{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:17:09Z","timestamp":1762255029111,"version":"3.34.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,29]]},"DOI":"10.7759\/cureus.78191","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T14:48:13Z","timestamp":1738162093000},"source":"Crossref","is-referenced-by-count":1,"title":["Insights Gained From an Ultrarare Case of Progressive Osseous Heteroplasia With Severe Complications"],"prefix":"10.7759","author":[{"given":"Ana","family":"Coimbra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jandira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06371-4","article-title":"Progressive osseous heteroplasia in a 5-year-old boy with a novel mutation in exon 2 of GNAS: a case presentation and literature review","volume":"24","author":"Ma J","year":"2023","unstructured":"Ma J, Mo W, Sun J, Li Y, Han T, Mao H. Progressive osseous heteroplasia in a 5-year-old boy with a novel mutation in exon 2 of GNAS: a case presentation and literature review. BMC Musculoskelet Disord. 2023, 24:247. 10.1186\/s12891-023-06371-4","journal-title":"BMC Musculoskelet Disord"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_502_19","article-title":"Progressive osseous heteroplasia: a rare case report","volume":"11","author":"Sahu K","year":"2020","unstructured":"Sahu K, Rout AN, Mohapatra L, Mohanty P. Progressive osseous heteroplasia: a rare case report. Indian Dermatol Online J. 2020, 11:604-6. 10.4103\/idoj.IDOJ_502_19","journal-title":"Indian Dermatol Online J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.11.2084","article-title":"Progressive osseous heteroplasia","volume":"15","author":"Kaplan FS","year":"2000","unstructured":"Kaplan FS, Shore EM. Progressive osseous heteroplasia. J Bone Miner Res. 2000, 15:2084-94. 10.1359\/jbmr.2000.15.11.2084","journal-title":"J Bone Miner Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.09.002","article-title":"GNAS mutations and heterotopic ossification","volume":"109","author":"Bastepe M","year":"2018","unstructured":"Bastepe M. GNAS mutations and heterotopic ossification. Bone. 2018, 109:80-5. 10.1016\/j.bone.2017.09.002","journal-title":"Bone"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2023.101665","article-title":"Progressive osseous heteroplasia: a case report with an unexpected trigger","volume":"18","author":"Boncompagni A","year":"2023","unstructured":"Boncompagni A, Lucas-Herald AK, Beattie P, et al.. Progressive osseous heteroplasia: a case report with an unexpected trigger. Bone Rep. 2023, 18:101665. 10.1016\/j.bonr.2023.101665","journal-title":"Bone Rep"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.04.001","article-title":"Progressive osseous heteroplasia is not a Mendelian trait but a type 2 segmental manifestation of GNAS inactivation disorders: a hypothesis","volume":"59","author":"Happle R","year":"2016","unstructured":"Happle R. Progressive osseous heteroplasia is not a Mendelian trait but a type 2 segmental manifestation of GNAS inactivation disorders: a hypothesis. Eur J Med Genet. 2016, 59:290-4. 10.1016\/j.ejmg.2016.04.001","journal-title":"Eur J Med Genet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S51064","article-title":"Progressive osseous heteroplasia: diagnosis, treatment, and prognosis","volume":"8","author":"Pignolo RJ","year":"2015","unstructured":"Pignolo RJ, Ramaswamy G, Fong JT, Shore EM, Kaplan FS. Progressive osseous heteroplasia: diagnosis, treatment, and prognosis. Appl Clin Genet. 2015, 8:37-48. 10.2147\/TACG.S51064","journal-title":"Appl Clin Genet"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.2106\/00004623-199403000-00013","article-title":"Progressive osseous heteroplasia: a distinct developmental disorder of heterotopic ossification. Two new case reports and follow-up of three previously reported cases","volume":"76","author":"Kaplan FS","year":"1994","unstructured":"Kaplan FS, Craver R, MacEwen GD, et al.. Progressive osseous heteroplasia: a distinct developmental disorder of heterotopic ossification. Two new case reports and follow-up of three previously reported cases. J Bone Joint Surg Am. 1994, 76:425-36.","journal-title":"J Bone Joint Surg Am"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02533-9","article-title":"Pseudohypoparathyroidism, acrodysostosis, progressive osseous heteroplasia: different names for the same spectrum of diseases?","volume":"72","author":"Elli FM","year":"2021","unstructured":"Elli FM, Mantovani G. Pseudohypoparathyroidism, acrodysostosis, progressive osseous heteroplasia: different names for the same spectrum of diseases?. Endocrine. 2021, 72:611-8. 10.1007\/s12020-020-02533-9","journal-title":"Endocrine"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000491045","article-title":"Inactivating PTH\/PTHrP signaling disorders","volume":"51","author":"Mantovani G","year":"2019","unstructured":"Mantovani G, Elli FM. Inactivating PTH\/PTHrP signaling disorders. Front Horm Res. 2019, 51:147-59. 10.1159\/000491045","journal-title":"Front Horm Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.807812","article-title":"Corrigendum: case report: two monochorionic twins with a critically different course of progressive osseous heteroplasia","volume":"9","author":"Justicia-Grande AJ","year":"2021","unstructured":"Justicia-Grande AJ, G\u00f3mez-R\u00edal J, Rivero-Calle I, et al.. Corrigendum: case report: two monochorionic twins with a critically different course of progressive osseous heteroplasia. Front Pediatr. 2021, 9:807812. 10.3389\/fped.2021.807812","journal-title":"Front Pediatr"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_584_20","article-title":"Progressive osseous heteroplasia is not an autosomal dominant trait but reflects superimposed mosaicism in different GNAS inactivation disorders","volume":"12","author":"Happle R","year":"2021","unstructured":"Happle R. Progressive osseous heteroplasia is not an autosomal dominant trait but reflects superimposed mosaicism in different GNAS inactivation disorders. Indian Dermatol Online J. 2021, 12:316-8. 10.4103\/idoj.IDOJ_584_20","journal-title":"Indian Dermatol Online J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.03.007","article-title":"Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities","volume":"40","author":"Pacifici M","year":"2018","unstructured":"Pacifici M. Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities. Curr Opin Pharmacol. 2018, 40:51-8. 10.1016\/j.coph.2018.03.007","journal-title":"Curr Opin Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2015.14","article-title":"The Hedgehog signalling pathway in bone formation","volume":"7","author":"Yang J","year":"2015","unstructured":"Yang J, Andre P, Ye L, Yang YZ. The Hedgehog signalling pathway in bone formation. Int J Oral Sci. 2015, 7:73-9. 10.1038\/ijos.2015.14","journal-title":"Int J Oral Sci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb2233","article-title":"A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification","volume":"13","author":"Cong Q","year":"2021","unstructured":"Cong Q, Liu Y, Zhou T, et al.. A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification. Sci Transl Med. 2021, 13:eabb2233. 10.1126\/scitranslmed.abb2233","journal-title":"Sci Transl Med"},{"key":"ref16","article-title":"Total ankylosis of the upper left limb: a case of progressive osseous heteroplasia","volume":"4","author":"Birjandinejad A","year":"2016","unstructured":"Birjandinejad A, Taraz-Jamshidi MH, Hosseinian SH. Total ankylosis of the upper left limb: a case of progressive osseous heteroplasia. Arch Bone Jt Surg. 2016, 4:285-8.","journal-title":"Arch Bone Jt Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.03.001","article-title":"Heterotopic ossification: the keys to the kingdom","volume":"109","author":"Kaplan FS","year":"2018","unstructured":"Kaplan FS, Pignolo RJ, Shore EM. Heterotopic ossification: the keys to the kingdom. Bone. 2018, 109:1-2. 10.1016\/j.bone.2018.03.001","journal-title":"Bone"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/323225-insights-gained-from-an-ultrarare-case-of-progressive-osseous-heteroplasia-with-severe-complications","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T14:48:16Z","timestamp":1738162096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/323225-insights-gained-from-an-ultrarare-case-of-progressive-osseous-heteroplasia-with-severe-complications"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.78191","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}