{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:51:12Z","timestamp":1785282672404,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,12]]},"DOI":"10.7759\/cureus.78906","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:46:36Z","timestamp":1739385996000},"source":"Crossref","is-referenced-by-count":2,"title":["Recurrent Vulvovaginal Candidiasis Caused by Fluconazole-Resistant Candida albicans: A Retrospective Study"],"prefix":"10.7759","author":[{"given":"Sreethish","family":"Sasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaaeldin","family":"Abdelmajid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husam","family":"Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna","family":"Al-Maslamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullatif","family":"Al-khal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010027","article-title":"Vulvovaginal candidiasis: a current understanding and burning questions","volume":"6","author":"Willems HM","year":"2020","unstructured":"Willems HM, Ahmed SS, Liu J, Xu Z, Peters BM. Vulvovaginal candidiasis: a current understanding and burning questions. J Fungi (Basel). 2020, 6:27. 10.3390\/jof6010027","journal-title":"J Fungi (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2011.00860.x","article-title":"Chronic vulvovaginal candidiasis: what we know and what we have yet to learn","volume":"53","author":"Fischer G","year":"2012","unstructured":"Fischer G. Chronic vulvovaginal candidiasis: what we know and what we have yet to learn. Australas J Dermatol. 2012, 53:247-54. 10.1111\/j.1440-0960.2011.00860.x","journal-title":"Australas J Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab1057","article-title":"Vulvovaginal candidiasis: a review of the evidence for the 2021 Centers for Disease Control and Prevention of Sexually Transmitted Infections Treatment Guidelines","volume":"74","author":"Nyirjesy P","year":"2022","unstructured":"Nyirjesy P, Brookhart C, Lazenby G, Schwebke J, Sobel JD. Vulvovaginal candidiasis: a review of the evidence for the 2021 Centers for Disease Control and Prevention of Sexually Transmitted Infections Treatment Guidelines. Clin Infect Dis. 2022, 74:S162-8. 10.1093\/cid\/ciab1057","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0267866","article-title":"Possible misdiagnosis, inappropriate empiric treatment, and opportunities for increased diagnostic testing for patients with vulvovaginal candidiasis-United States, 2018","volume":"17","author":"Benedict K","year":"2022","unstructured":"Benedict K, Lyman M, Jackson BR. Possible misdiagnosis, inappropriate empiric treatment, and opportunities for increased diagnostic testing for patients with vulvovaginal candidiasis-United States, 2018. PLoS One. 2022, 17:e0267866. 10.1371\/journal.pone.0267866","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.934353","article-title":"Management of recurrent vulvovaginal candidosis: narrative review of the literature and European expert panel opinion","volume":"12","author":"Donders G","year":"2022","unstructured":"Donders G, Sziller IO, Paavonen J, et al.. Management of recurrent vulvovaginal candidosis: narrative review of the literature and European expert panel opinion. Front Cell Infect Microbiol. 2022, 12:934353. 10.3389\/fcimb.2022.934353","journal-title":"Front Cell Infect Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen LE","year":"2014","unstructured":"Cowen LE, Sanglard D, Howard SJ, Rogers PD, Perlin DS. Mechanisms of antifungal drug resistance. Cold Spring Harb Perspect Med. 2014, 5:a019752. 10.1101\/cshperspect.a019752","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/0956462418785451","article-title":"2018 European (IUSTI\/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge","volume":"29","author":"Sherrard J","year":"2018","unstructured":"Sherrard J, Wilson J, Donders G, Mendling W, Jensen JS. 2018 European (IUSTI\/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge. Int J STD AIDS. 2018, 29:1258-72. 10.1177\/0956462418785451","journal-title":"Int J STD AIDS"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/20503121221115201","article-title":"Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis","volume":"10","author":"Neal CM","year":"2022","unstructured":"Neal CM, Martens MG. Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis. SAGE Open Med. 2022, 10:20503121221115201. 10.1177\/20503121221115201","journal-title":"SAGE Open Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.029","article-title":"Individualized decreasing-dose maintenance fluconazole regimen for recurrent vulvovaginal candidiasis (ReCiDiF trial)","volume":"199","author":"Donders G","year":"2008","unstructured":"Donders G, Bellen G, Byttebier G, et al.. Individualized decreasing-dose maintenance fluconazole regimen for recurrent vulvovaginal candidiasis (ReCiDiF trial). Am J Obstet Gynecol. 2008, 199:613.e1-9. 10.1016\/j.ajog.2008.06.029","journal-title":"Am J Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2013.02.001","article-title":"Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical","volume":"17","author":"Colombo AL","year":"2013","unstructured":"Colombo AL, Guimar\u00e3es T, Camargo LF, et al.. Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical. Braz J Infect Dis. 2013, 17:283-312. 10.1016\/j.bjid.2013.02.001","journal-title":"Braz J Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20495","article-title":"Efficacy and safety of oteseconazole in recurrent vulvovaginal candidiasis (RVVC) - a systematic review and meta-analysis","volume":"9","author":"Siddiqui T","year":"2023","unstructured":"Siddiqui T, Kumar KA, Iqbal A, Doultani PR, Ashraf T, Eqbal F, Siddiqui SI. Efficacy and safety of oteseconazole in recurrent vulvovaginal candidiasis (RVVC) - a systematic review and meta-analysis. Heliyon. 2023, 9:e20495. 10.1016\/j.heliyon.2023.e20495","journal-title":"Heliyon"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S339349","article-title":"Ibrexafungerp for the treatment of vulvovaginal candidiasis: design, development and place in therapy","volume":"17","author":"Phillips NA","year":"2023","unstructured":"Phillips NA, Rocktashel M, Merjanian L. Ibrexafungerp for the treatment of vulvovaginal candidiasis: design, development and place in therapy. Drug Des Devel Ther. 2023, 17:363-7. 10.2147\/DDDT.S339349","journal-title":"Drug Des Devel Ther"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4331-y","article-title":"The colonization with Candida species is more harmful in the second trimester of pregnancy","volume":"295","author":"Holzer I","year":"2017","unstructured":"Holzer I, Farr A, Kiss H, Hagmann M, Petricevic L. The colonization with Candida species is more harmful in the second trimester of pregnancy. Arch Gynecol Obstet. 2017, 295:891-5. 10.1007\/s00404-017-4331-y","journal-title":"Arch Gynecol Obstet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12697","article-title":"Effect of asymptomatic vaginal colonization with Candida albicans on pregnancy outcome","volume":"94","author":"Farr A","year":"2015","unstructured":"Farr A, Kiss H, Holzer I, Husslein P, Hagmann M, Petricevic L. Effect of asymptomatic vaginal colonization with Candida albicans on pregnancy outcome. Acta Obstet Gynecol Scand. 2015, 94:989-96. 10.1111\/aogs.12697","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-015-0018-2","article-title":"Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis","volume":"4","author":"Roberts CL","year":"2015","unstructured":"Roberts CL, Algert CS, Rickard KL, Morris JM. Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis. Syst Rev. 2015, 4:31. 10.1186\/s13643-015-0018-2","journal-title":"Syst Rev"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.29063\/ajrh2020\/v24i3.4","article-title":"Vaginal Candida infection in pregnancy and its implications for fetal well-being","volume":"24","author":"Sule-Odu AO","year":"2020","unstructured":"Sule-Odu AO, Akadri AA, Oluwole AA, Osinupebi OA, Andu BA, Akiseku AK, Lawal AI. Vaginal Candida infection in pregnancy and its implications for fetal well-being. Afr J Reprod Health. 2020, 24:33-40. 10.29063\/ajrh2020\/v24i3.4","journal-title":"Afr J Reprod Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.37.5.4187","article-title":"Vaginal discharge during pregnancy and associated adverse maternal and perinatal outcomes","volume":"37","author":"Khaskheli M","year":"2021","unstructured":"Khaskheli M, Baloch S, Baloch AS, Shah SG. Vaginal discharge during pregnancy and associated adverse maternal and perinatal outcomes. Pak J Med Sci. 2021, 37:1302-8. 10.12669\/pjms.37.5.4187","journal-title":"Pak J Med Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1712701","article-title":"Antepartum vaginal Candida colonization and the risk for obstetrical tears","volume":"35","author":"Hizkiyahu R","year":"2022","unstructured":"Hizkiyahu R, Baumfeld Y, Paz Levy D, Lanxner Battat T, Imterat M, Weintraub AY. Antepartum vaginal Candida colonization and the risk for obstetrical tears. J Matern Fetal Neonatal Med. 2022, 35:75-9. 10.1080\/14767058.2020.1712701","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1469125","article-title":"Longitudinal trajectory of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis during pregnancy as well as the impact on pregnancy outcomes: a preliminary study","volume":"32","author":"Hu CY","year":"2019","unstructured":"Hu CY, Li FL, Hua XG, Jiang W, Zhang XJ. Longitudinal trajectory of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis during pregnancy as well as the impact on pregnancy outcomes: a preliminary study. J Matern Fetal Neonatal Med. 2019, 32:3612-7. 10.1080\/14767058.2018.1469125","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/341567-recurrent-vulvovaginal-candidiasis-caused-by-fluconazole-resistant-candida-albicans-a-retrospective-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:46:38Z","timestamp":1739385998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/341567-recurrent-vulvovaginal-candidiasis-caused-by-fluconazole-resistant-candida-albicans-a-retrospective-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.78906","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,12]]}}}