{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:20:05Z","timestamp":1789154405112,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,12]]},"DOI":"10.7759\/cureus.78925","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T06:46:06Z","timestamp":1739429166000},"source":"Crossref","is-referenced-by-count":1,"title":["The Interplay Between Hypocalcemia and Atrioventricular Nodal Blocking Agents in Inducing a Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH)-Like Phenomenon With Serial Serum Drug Concentrations"],"prefix":"10.7759","author":[{"given":"Fumiya","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Ichiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuyo","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Namera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.06.002","article-title":"Clinical characteristics of BRASH syndrome: systematic scoping review","volume":"103","author":"Shah P","year":"2022","unstructured":"Shah P, Gozun M, Keitoku K, Kimura N, Yeo J, Czech T, Nishimura Y. Clinical characteristics of BRASH syndrome: systematic scoping review. Eur J Intern Med. 2022, 103:57-61. 10.1016\/j.ejim.2022.06.002","journal-title":"Eur J Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2020.05.001","article-title":"BRASH syndrome: bradycardia, renal failure, AV blockade, shock, and hyperkalemia","volume":"59","author":"Farkas JD","year":"2020","unstructured":"Farkas JD, Long B, Koyfman A, Menson K. BRASH syndrome: bradycardia, renal failure, AV blockade, shock, and hyperkalemia. J Emerg Med. 2020, 59:216-23. 10.1016\/j.jemermed.2020.05.001","journal-title":"J Emerg Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02452-7","article-title":"The BRASH syndrome: an interaction of bradycardia, renal failure, AV block, shock and hyperkalemia","volume":"16","author":"Schnaubelt S","year":"2021","unstructured":"Schnaubelt S, Roeggla M, Spiel AO, Schukro C, Domanovits H. The BRASH syndrome: an interaction of bradycardia, renal failure, AV block, shock and hyperkalemia. Intern Emerg Med. 2021, 16:509-11. 10.1007\/s11739-020-02452-7","journal-title":"Intern Emerg Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemrpt.2024.100105","article-title":"Don't Be-RASH: a case report","volume":"3","author":"Smetana SD","year":"2024","unstructured":"Smetana SD, Nacca NE, Schult RF, DeAngelis J. Don't Be-RASH: a case report. JEM Rep. 2024, 3:100105. 10.1016\/j.jemrpt.2024.100105","journal-title":"JEM Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s43678-024-00651-1","article-title":"BRASH syndrome progressing rapidly to cardiogenic shock: a case with confirmed excessive amlodipine concentration","volume":"26","author":"Lai PC","year":"2024","unstructured":"Lai PC, Weng TI, Yu JH. BRASH syndrome progressing rapidly to cardiogenic shock: a case with confirmed excessive amlodipine concentration. CJEM. 2024, 26:280-2. 10.1007\/s43678-024-00651-1","journal-title":"CJEM"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02915-5","article-title":"Revisited: therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics","volume":"24","author":"Schulz M","year":"2020","unstructured":"Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S. Revisited: therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics. Crit Care. 2020, 24:195. 10.1186\/s13054-020-02915-5","journal-title":"Crit Care"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12386","article-title":"Dialysate-induced hypocalcemia presenting as acute intradialytic hypotension: a case report, safety review, and recommendations","volume":"20","author":"Thurlow JS","year":"2016","unstructured":"Thurlow JS, Yuan CM. Dialysate-induced hypocalcemia presenting as acute intradialytic hypotension: a case report, safety review, and recommendations. Hemodial Int. 2016, 20:E8-11. 10.1111\/hdi.12386","journal-title":"Hemodial Int"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0736(89)90026-5","article-title":"Hypocalcemic torsades de pointes","volume":"22","author":"Akiyama T","year":"1989","unstructured":"Akiyama T, Batchelder J, Worsman J, Moses HW, Jedlinski M. Hypocalcemic torsades de pointes. J Electrocardiology. 1989, 22:89-92. 10.1016\/0022-0736(89)90026-5","journal-title":"J Electrocardiology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-013-9371-1","article-title":"Reversible cardiac dysfunction associated with hypocalcemia: a systematic review and meta-analysis of individual patient data","volume":"19","author":"Newman DB","year":"2014","unstructured":"Newman DB, Fidahussein SS, Kashiwagi DT, et al.. Reversible cardiac dysfunction associated with hypocalcemia: a systematic review and meta-analysis of individual patient data. Heart Fail Rev. 2014, 19:199-205. 10.1007\/s10741-013-9371-1","journal-title":"Heart Fail Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25444","article-title":"Bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia syndrome as a clinical profile leading to the diagnosis of transthyretin amyloidosis: a report of two cases","volume":"14","author":"Takahashi K","year":"2022","unstructured":"Takahashi K, Sakaue T, Uemura S, Okura T, Ikeda S. Bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia syndrome as a clinical profile leading to the diagnosis of transthyretin amyloidosis: a report of two cases. Cureus. 2022, 14:e25444. 10.7759\/cureus.25444","journal-title":"Cureus"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2024.03.005","article-title":"BRASH syndrome: a rare but reversible cause of sinus node dysfunction","volume":"10","author":"Habib A","year":"2024","unstructured":"Habib A, Butt K, Ibrahim R, Shaaban A, Lee HS. BRASH syndrome: a rare but reversible cause of sinus node dysfunction. HeartRhythm Case Rep. 2024, 10:398-401. 10.1016\/j.hrcr.2024.03.005","journal-title":"HeartRhythm Case Rep"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68106","article-title":"BRASH (bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia) syndrome: a frequently underrecognized condition often confused with simple hyperkalemia","volume":"16","author":"Singh K","year":"2024","unstructured":"Singh K, Patel KN. BRASH (bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia) syndrome: a frequently underrecognized condition often confused with simple hyperkalemia. Cureus. 2024, 16:e68106. 10.7759\/cureus.68106","journal-title":"Cureus"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv202","article-title":"Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society","volume":"17","author":"Boriani G","year":"2015","unstructured":"Boriani G, Savelieva I, Dan GA, et al.. Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society. Europace. 2015, 17:1169-96. 10.1093\/europace\/euv202","journal-title":"Europace"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.324001","article-title":"Cardiovascular consequences of uremic metabolites: an overview of the involved signaling pathways","volume":"134","author":"Curaj A","year":"2024","unstructured":"Curaj A, Vanholder R, Loscalzo J, Quach K, Wu Z, Jankowski V, Jankowski J. Cardiovascular consequences of uremic metabolites: an overview of the involved signaling pathways. Circ Res. 2024, 134:592-613. 10.1161\/CIRCRESAHA.123.324001","journal-title":"Circ Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/339490-the-interplay-between-hypocalcemia-and-atrioventricular-nodal-blocking-agents-in-inducing-a-bradycardia-renal-failure-atrioventricular-nodal-blockade-shock-and-hyperkalemia-brash-like-phenomenon-with-serial-serum-drug-concentrations","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T06:46:10Z","timestamp":1739429170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/339490-the-interplay-between-hypocalcemia-and-atrioventricular-nodal-blocking-agents-in-inducing-a-bradycardia-renal-failure-atrioventricular-nodal-blockade-shock-and-hyperkalemia-brash-like-phenomenon-with-serial-serum-drug-concentrations"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":14,"URL":"https:\/\/doi.org\/10.7759\/cureus.78925","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,12]]}}}