{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:10:32Z","timestamp":1739855432940,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,17]]},"DOI":"10.7759\/cureus.79155","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T12:56:06Z","timestamp":1739796966000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Multi-territorial Ischemic Stroke As the Initial Presentation of Thrombotic Thrombocytopenic Purpura"],"prefix":"10.7759","author":[{"given":"Noah","family":"Reichman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Marie Nicole","family":"Biso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Masoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03489-9","article-title":"Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI","volume":"23","author":"Zhang Z","year":"2023","unstructured":"Zhang Z, He M. Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI. BMC Neurol. 2023, 23:435. 10.1186\/s12883-023-03489-9","journal-title":"BMC Neurol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-709857","article-title":"Thrombotic thrombocytopenic purpura","volume":"129","author":"Joly BS","year":"2017","unstructured":"Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017, 129:2836-46. 10.1182\/blood-2016-10-709857","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034434","article-title":"Thrombotic thrombocytopenic purpura (ADAMTS13 [a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13] deficiency) as cause of recurrent multiterritory ischemic strokes","volume":"53","author":"Albo Z","year":"2022","unstructured":"Albo Z, Mathew C, Catton R, Silver B, Moonis M. Thrombotic thrombocytopenic purpura (ADAMTS13 [a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13] deficiency) as cause of recurrent multiterritory ischemic strokes. Stroke. 2022, 53:237-40. 10.1161\/STROKEAHA.121.034434","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100420","article-title":"Conformation of the von Willebrand factor\/factor VIII complex in quasi-static flow","volume":"296","author":"Parker ET","year":"2021","unstructured":"Parker ET, Lollar P. Conformation of the von Willebrand factor\/factor VIII complex in quasi-static flow. J Biol Chem. 2021, 296:100420. 10.1016\/j.jbc.2021.100420","journal-title":"J Biol Chem"},{"key":"ref5","article-title":"Thrombotic thrombocytopenic purpura","author":"Stanley M","year":"2023","unstructured":"Stanley M, Killeen RB, Michalski JM. Thrombotic thrombocytopenic purpura. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.530","article-title":"Clinical and laboratory diagnosis of TTP: an integrated approach","volume":"2018","author":"Chiasakul T","year":"2018","unstructured":"Chiasakul T, Cuker A. Clinical and laboratory diagnosis of TTP: an integrated approach. Hematology Am Soc Hematol Educ Program. 2018, 2018:530-8. 10.1182\/asheducation-2018.1.530","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2018-02-791533","article-title":"The role of ADAMTS13 testing in the diagnosis and management of thrombotic microangiopathies and thrombosis","volume":"132","author":"Masias C","year":"2018","unstructured":"Masias C, Cataland SR. The role of ADAMTS13 testing in the diagnosis and management of thrombotic microangiopathies and thrombosis. Blood. 2018, 132:903-10.","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03073-1","article-title":"Two ischemic stroke events within 48\u00a0h: a case report of an unusual presentation of thrombotic thrombocytopenic purpura","volume":"23","author":"Jameie M","year":"2023","unstructured":"Jameie M, Heydari S, Ghabaee M, Amirifard H. Two ischemic stroke events within 48\u00a0h: a case report of an unusual presentation of thrombotic thrombocytopenic purpura. BMC Neurol. 2023, 23:47. 10.1186\/s12883-023-03073-1","journal-title":"BMC Neurol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000513574","article-title":"Identification of biomarkers in patients with thrombotic thrombocytopenic purpura presenting with large and small ischemic stroke","volume":"11","author":"Lin C","year":"2021","unstructured":"Lin C, Memon R, Sui J, Zheng XL. Identification of biomarkers in patients with thrombotic thrombocytopenic purpura presenting with large and small ischemic stroke. Cerebrovasc Dis Extra. 2021, 11:29-36. 10.1159\/000513574","journal-title":"Cerebrovasc Dis Extra"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06549-z","article-title":"Large vessel stroke and isolated thrombocytopenia as presenting features of thrombotic thrombocytopenic purpura","volume":"44","author":"Romozzi M","year":"2023","unstructured":"Romozzi M, Vitali F, Marca GD, Monforte M, Broccolini A. Large vessel stroke and isolated thrombocytopenia as presenting features of thrombotic thrombocytopenic purpura. Neurol Sci. 2023, 44:1461-3. 10.1007\/s10072-022-06549-z","journal-title":"Neurol Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7070189","article-title":"Recurrent strokes in a woman with a hstory of thrombotic thrombocytopenic purpura","volume":"2023","author":"Adimora I","year":"2023","unstructured":"Adimora I, Zhang B, Idowu M. Recurrent strokes in a woman with a hstory of thrombotic thrombocytopenic purpura. Case Rep Med. 2023, 2023:7070189. 10.1155\/2023\/7070189","journal-title":"Case Rep Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7425320","article-title":"Atypical thrombotic thrombocytopenic purpura presenting as stroke","volume":"2019","author":"Badugu P","year":"2019","unstructured":"Badugu P, Idowu M. Atypical thrombotic thrombocytopenic purpura presenting as stroke. Case Rep Hematol. 2019, 2019:7425320. 10.1155\/2019\/7425320","journal-title":"Case Rep Hematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106431","article-title":"Cerebral infarction due to severe ADAMTS-13 deficiency with normal hematological parameters: a cause of cryptogenic stroke","volume":"31","author":"Matthews A","year":"2022","unstructured":"Matthews A, Yui J, Chiang EY, et al.. Cerebral infarction due to severe ADAMTS-13 deficiency with normal hematological parameters: a cause of cryptogenic stroke. J Stroke Cerebrovasc Dis. 2022, 31:106431. 10.1016\/j.jstrokecerebrovasdis.2022.106431","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722610","article-title":"Cerebral infarction in immune thrombotic thrombocytopenic purpura is associated with old age, hypertension, smoking, and anti-ADAMTS13 IG, but not with mortality","volume":"5","author":"Memon R","year":"2021","unstructured":"Memon R, Sui J, Lin C, Zheng XL. Cerebral infarction in immune thrombotic thrombocytopenic purpura is associated with old age, hypertension, smoking, and anti-ADAMTS13 IG, but not with mortality. TH Open. 2021, 5:1-7. 10.1055\/s-0040-1722610","journal-title":"TH Open"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11830-y","article-title":"Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome","volume":"270","author":"Neuman L","year":"2023","unstructured":"Neuman L, Joseph A, Bouzid R, et al.. Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. J Neurol. 2023, 270:5023-33. 10.1007\/s00415-023-11830-y","journal-title":"J Neurol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272290","article-title":"Neurological manifestations in thrombotic microangiopathy: imaging features, risk factors and clinical course","volume":"17","author":"de Castro JT","year":"2022","unstructured":"de Castro JT, Appenzeller S, Colella MP, et al.. Neurological manifestations in thrombotic microangiopathy: imaging features, risk factors and clinical course. PLoS One. 2022, 17:0272290. 10.1371\/journal.pone.0272290","journal-title":"PLoS One"},{"key":"ref17","unstructured":"Thrombotic thrombocytopenic purpura (TTP) . (2022). Accessed. 2022 March 24: https:\/\/www.nhlbi.nih.gov\/health\/thrombotic-thrombocytopenic-purpura."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.539","article-title":"Beyond plasma exchange: novel therapies for thrombotic thrombocytopenic purpura","volume":"2018","author":"Dane K","year":"2018","unstructured":"Dane K, Chaturvedi S. Beyond plasma exchange: novel therapies for thrombotic thrombocytopenic purpura. Hematology Am Soc Hematol Educ Program. 2018, 2018:539-47. 10.1182\/asheducation-2018.1.539","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7661","article-title":"Thrombotic thrombocytopenic purpura masquerading as acute ischemic stroke","volume":"12","author":"Filatov A","year":"2020","unstructured":"Filatov A, Kassar E, Cole O. Thrombotic thrombocytopenic purpura masquerading as acute ischemic stroke. Cureus. 2020, 12:7661. 10.7759\/cureus.7661","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7326\/aimcc.2023.0424","article-title":"Recurrent strokes in a hypertensive smoker: an atypical case and review of thrombotic thrombocytopenic purpura","volume":"2","author":"Ramesh N","year":"2023","unstructured":"Ramesh N, Chitra SKR, Ikoro U, Deshpande S, Singh V, Mehta V, Posner A. Recurrent strokes in a hypertensive smoker: an atypical case and review of thrombotic thrombocytopenic purpura. Ann Intern Med Clin Cases. 2023, 2:10.7326\/aimcc.2023.0424","journal-title":"Ann Intern Med Clin Cases"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/311971-recurrent-multi-territorial-ischemic-stroke-as-the-initial-presentation-of-thrombotic-thrombocytopenic-purpura","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T12:56:08Z","timestamp":1739796968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/311971-recurrent-multi-territorial-ischemic-stroke-as-the-initial-presentation-of-thrombotic-thrombocytopenic-purpura"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.79155","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,17]]}}}