{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:11:29Z","timestamp":1739941889322,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,18]]},"DOI":"10.7759\/cureus.79204","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T09:56:56Z","timestamp":1739872616000},"source":"Crossref","is-referenced-by-count":0,"title":["Epstein-Barr Virus Infection Complicated by a Splenic Infarct in a Patient With Methylenetetrahydrofolate Reductase (MTHFR) Mutation"],"prefix":"10.7759","author":[{"given":"Hassan","family":"Fawaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hassan","family":"Hodroj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Charbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Kreidieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707","article-title":"Epstein-Barr virus infection","volume":"343","author":"Cohen JI","year":"2000","unstructured":"Cohen JI. Epstein-Barr virus infection. N Engl J Med. 2000, 343:481-92. 10.1056\/NEJM200008173430707","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001116","article-title":"Infectious mononucleosis","volume":"362","author":"Luzuriaga K","year":"2010","unstructured":"Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med. 2010, 362:1993-2000. 10.1056\/NEJMcp1001116","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.57187\/smw.2023.40081","article-title":"Splenic rupture or infarction associated with Epstein-Barr virus infectious mononucleosis: a systematic literature review","volume":"153","author":"Toti JM","year":"2023","unstructured":"Toti JM, Gatti B, Hunjan I, et al.. Splenic rupture or infarction associated with Epstein-Barr virus infectious mononucleosis: a systematic literature review. Swiss Med Wkly. 2023, 153:40081. 10.57187\/smw.2023.40081","journal-title":"Swiss Med Wkly"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2018.1492148","article-title":"A practical approach to infarction of the spleen as a rare manifestation of multiple common diseases","volume":"50","author":"Wand O","year":"2018","unstructured":"Wand O, Tayer-Shifman OE, Khoury S, Hershko AY. A practical approach to infarction of the spleen as a rare manifestation of multiple common diseases. Ann Med. 2018, 50:494-500. 10.1080\/07853890.2018.1492148","journal-title":"Ann Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6934149","article-title":"Splenic complications of Babesia microti infection in humans: a systematic review","volume":"2020","author":"Dumic I","year":"2020","unstructured":"Dumic I, Madrid C, Rueda Prada L, Nordstrom CW, Taweesedt PT, Ramanan P. Splenic complications of Babesia microti infection in humans: a systematic review. Can J Infect Dis Med Microbiol. 2020, 2020:6934149. 10.1155\/2020\/6934149","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v90i10-S.8758","article-title":"Hereditary thrombophilia","volume":"90","author":"Dautaj A","year":"2019","unstructured":"Dautaj A, Krasi G, Bushati V, et al.. Hereditary thrombophilia. Acta Biomed. 2019, 90:44-6. 10.23750\/abm.v90i10-S.8758","journal-title":"Acta Biomed"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013311","article-title":"Homocysteine and MTHFR mutations","volume":"132","author":"Moll S","year":"2015","unstructured":"Moll S, Varga EA. Homocysteine and MTHFR mutations. Circulation. 2015, 132:e6-9. 10.1161\/CIRCULATIONAHA.114.013311","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102162","article-title":"Celiac disease and thrombotic events: systematic review of published cases","volume":"14","author":"Pantic N","year":"2022","unstructured":"Pantic N, Pantic I, Jevtic D, et al.. Celiac disease and thrombotic events: systematic review of published cases. Nutrients. 2022, 14:2162. 10.3390\/nu14102162","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000173730","article-title":"Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction","volume":"36","author":"Guler N","year":"2008","unstructured":"Guler N, Yapici O, Erdem D, Ogur G, Ozatli D, Bakir T. Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction. Pathophysiol Haemost Thromb. 2008, 36:102-4. 10.1159\/000173730","journal-title":"Pathophysiol Haemost Thromb"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000081","article-title":"Wandering spleen: 'presentation in adolescent with high thrombotic risk'","volume":"25","author":"Tchidjou HK","year":"2014","unstructured":"Tchidjou HK, Castelluzzo MA, Messia V, et al.. Wandering spleen: 'presentation in adolescent with high thrombotic risk'. Blood Coagul Fibrinolysis. 2014, 25:530-3. 10.1097\/MBC.0000000000000081","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.03.005","article-title":"Epstein-Barr virus-associated venous thromboembolism: a case report and review of the literature","volume":"122","author":"Mashav N","year":"2008","unstructured":"Mashav N, Saar N, Chundadze T, Steinvil A, Justo D. Epstein-Barr virus-associated venous thromboembolism: a case report and review of the literature. Thromb Res. 2008, 122:570-1. 10.1016\/j.thromres.2008.03.005","journal-title":"Thromb Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.07.007","article-title":"Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk","volume":"22","author":"Waldman WJ","year":"2008","unstructured":"Waldman WJ, Williams MV Jr, Lemeshow S, et al.. Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk. Brain Behav Immun. 2008, 22:215-23. 10.1016\/j.bbi.2007.07.007","journal-title":"Brain Behav Immun"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000437098","article-title":"Homocysteine-induced endothelial dysfunction","volume":"67","author":"Lai WK","year":"2015","unstructured":"Lai WK, Kan MY. Homocysteine-induced endothelial dysfunction. Ann Nutr Metab. 2015, 67:1-12. 10.1159\/000437098","journal-title":"Ann Nutr Metab"},{"key":"ref14","article-title":"[Splenic thrombosis and celiac disease: a fortuitous association?]","volume":"29","author":"Andr\u00e8s E","year":"2000","unstructured":"Andr\u00e8s E, Pflumio F, Knab MC, et al.. [Splenic thrombosis and celiac disease: a fortuitous association?]. Presse Med. 2000, 29:1933-4.","journal-title":"Presse Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5758\/vsi.2014.30.4.113","article-title":"Clinical implications of methylenetetrahydrofolate reductase mutations and plasma homocysteine levels in patients with thromboembolic occlusion","volume":"30","author":"Park WC","year":"2014","unstructured":"Park WC, Chang JH. Clinical implications of methylenetetrahydrofolate reductase mutations and plasma homocysteine levels in patients with thromboembolic occlusion. Vasc Specialist Int. 2014, 30:113-9. 10.5758\/vsi.2014.30.4.113","journal-title":"Vasc Specialist Int"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.19.3.511","article-title":"Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment","volume":"19","author":"Salomon O","year":"1999","unstructured":"Salomon O, Steinberg DM, Zivelin A, et al.. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. Arterioscler Thromb Vasc Biol. 1999, 19:511-8. 10.1161\/01.atv.19.3.511","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12739","article-title":"A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing","volume":"6","author":"Deloughery TG","year":"2022","unstructured":"Deloughery TG, Hunt BJ, Barnes GD, et al.. A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing. Res Pract Thromb Haemost. 2022, 6:e12739. 10.1002\/rth2.12739","journal-title":"Res Pract Thromb Haemost"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16075","article-title":"Hyperhomocysteinaemia and the risk of recurrent venous thrombosis: results from the MEGA follow-up study","volume":"187","author":"Hensen AD","year":"2019","unstructured":"Hensen AD, Lijfering WM, Cannegieter SC, Rosendaal FR, van Hylckama Vlieg A. Hyperhomocysteinaemia and the risk of recurrent venous thrombosis: results from the MEGA follow-up study. Br J Haematol. 2019, 187:219-26. 10.1111\/bjh.16075","journal-title":"Br J Haematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/332685-epstein-barr-virus-infection-complicated-by-a-splenic-infarct-in-a-patient-with-methylenetetrahydrofolate-reductase-mthfr-mutation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T09:56:58Z","timestamp":1739872618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/332685-epstein-barr-virus-infection-complicated-by-a-splenic-infarct-in-a-patient-with-methylenetetrahydrofolate-reductase-mthfr-mutation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.79204","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}