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Vet World. 2015, 8:584-9. 10.14202\/vetworld.2015.584-589","journal-title":"Vet World"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.22038\/ajp.2017.17885.1696","article-title":"Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice","volume":"7","author":"Khanavi M","year":"2017","unstructured":"Khanavi M, Maadani S, Farahanikia B, Eftekhari M, Sharifzadeh M. Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice. Avicenna J Phytomed. 2017, 7:426-35. 10.22038\/ajp.2017.17885.1696","journal-title":"Avicenna J Phytomed"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.91873","article-title":"Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats","volume":"44","author":"Vijayalakshmi","year":"2012","unstructured":"Vijayalakshmi, Adiga S, Bhat P, Chaturvedi A, Bairy KL, Kamath S. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J Pharmacol. 2012, 44:82-7. 10.4103\/0253-7613.91873","journal-title":"Indian J Pharmacol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v14.i2.28","article-title":"Anticancer potential of Ferula assa-foetida and its constituents, a powerful plant for cancer therapy","volume":"14","author":"Sirizi MA","year":"2023","unstructured":"Sirizi MA, Alizadeh Ghalenoei J, Allahtavakoli M, Forouzanfar H, Bagheri SM. 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