{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:44:56Z","timestamp":1741067096560,"version":"3.38.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"DOI":"10.7759\/cureus.79960","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T15:41:41Z","timestamp":1741016501000},"source":"Crossref","is-referenced-by-count":0,"title":["Mixtures of Diethyl Azelate as Novel Nonopioid Modalities for Pain Management"],"prefix":"10.7759","author":[{"given":"Elzbieta","family":"Izbicka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T","family":"Streeper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja SN","year":"2020","unstructured":"Raja SN, Carr DB, Cohen M, et al.. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020, 161:1976-82. 10.1097\/j.pain.0000000000001939","journal-title":"Pain"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89465","article-title":"Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling","volume":"12","author":"Petersen EN","year":"2024","unstructured":"Petersen EN, Pavel MA, Hansen SS, et al.. Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling. Elife. 2024, 12:RP89465. 10.7554\/eLife.89465","journal-title":"Elife"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-1981(00)00120-7","article-title":"Inhibition of phospholipase A(2) as a therapeutic target","volume":"1488","author":"Yedgar S","year":"2000","unstructured":"Yedgar S, Lichtenberg D, Schnitzer E. Inhibition of phospholipase A(2) as a therapeutic target. Biochim Biophys Acta. 2000, 1488:182-7. 10.1016\/s1388-1981(00)00120-7","journal-title":"Biochim Biophys Acta"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.01.001","article-title":"The phospholipase D superfamily as therapeutic targets","volume":"36","author":"Frohman MA","year":"2015","unstructured":"Frohman MA. The phospholipase D superfamily as therapeutic targets. Trends Pharmacol Sci. 2015, 36:137-44. 10.1016\/j.tips.2015.01.001","journal-title":"Trends Pharmacol Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718811060","article-title":"Historical review: opiate addiction and opioid receptors","volume":"28","author":"Wang S","year":"2019","unstructured":"Wang S. Historical review: opiate addiction and opioid receptors. Cell Transplant. 2019, 28:233-8. 10.1177\/0963689718811060","journal-title":"Cell Transplant"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004259117","article-title":"Studies on the mechanism of general anesthesia","volume":"117","author":"Pavel MA","year":"2020","unstructured":"Pavel MA, Petersen EN, Wang H, Lerner RA, Hansen SB. Studies on the mechanism of general anesthesia. Proc Natl Acad Sci U S A. 2020, 117:13757-66. 10.1073\/pnas.2004259117","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12594","article-title":"Adaptive membrane fluidity modulation: a feedback regulated homeostatic system hiding in plain sight","volume":"35","author":"Izbicka E","year":"2021","unstructured":"Izbicka E, Streeper RT. Adaptive membrane fluidity modulation: a feedback regulated homeostatic system hiding in plain sight. In Vivo. 2021, 35:2991-3000. 10.21873\/invivo.12594","journal-title":"In Vivo"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12603","article-title":"Adaptive membrane fluidity modulation: a feedback regulated homeostatic system and target for pharmacological intervention","volume":"35","author":"Izbicka E","year":"2021","unstructured":"Izbicka E, Streeper RT, Louden C. Adaptive membrane fluidity modulation: a feedback regulated homeostatic system and target for pharmacological intervention. In Vivo. 2021, 35:3073-95. 10.21873\/invivo.12603","journal-title":"In Vivo"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12679","article-title":"Diethyl azelate for the treatment of brown recluse spider bite, a neglected orphan indication","volume":"36","author":"Streeper RT","year":"2022","unstructured":"Streeper RT, Izbicka E. Diethyl azelate for the treatment of brown recluse spider bite, a neglected orphan indication. In Vivo. 2022, 36:86-93. 10.21873\/invivo.12679","journal-title":"In Vivo"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12996","article-title":"Membrane active immunomodulator as a novel therapy for an infectious bacterial disease, Buruli ulcer","volume":"36","author":"Izbicka E","year":"2022","unstructured":"Izbicka E, Streeper RT, Louden C. Membrane active immunomodulator as a novel therapy for an infectious bacterial disease, Buruli ulcer. In Vivo. 2022, 36:2615-29. 10.21873\/invivo.12996","journal-title":"In Vivo"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11890","article-title":"11.\tOral azelaic acid ester decreases markers of insulin resistance in overweight human male subjects","volume":"34","author":"Streeper RT","year":"2020","unstructured":"Streeper RT, Louden C, Izbicka E. 11.\tOral azelaic acid ester decreases markers of insulin resistance in overweight human male subjects. In Vivo. 2020, 34:1173-86. 10.21873\/invivo.11890","journal-title":"In Vivo"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041733","article-title":"Effects of dimethyl sulfoxide in cholesterol-containing lipid membranes: a comparative study of experiments in silico and with cells","volume":"7","author":"de M\u00e9norval MA","year":"2012","unstructured":"de M\u00e9norval MA, Mir LM, Fern\u00e1ndez ML, Reigada R. Effects of dimethyl sulfoxide in cholesterol-containing lipid membranes: a comparative study of experiments in silico and with cells. PLoS One. 2012, 7:e41733. 10.1371\/journal.pone.0041733","journal-title":"PLoS One"},{"key":"ref13","article-title":"Medical use of dimethyl sulfoxide (DMSO)","volume":"5","author":"Swanson BN","year":"1985","unstructured":"Swanson BN. Medical use of dimethyl sulfoxide (DMSO). Rev Clin Basic Pharm. 1985, 5:1-33.","journal-title":"Rev Clin Basic Pharm"},{"key":"ref14","article-title":"Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology","volume":"5","author":"Capriotti K","year":"2012","unstructured":"Capriotti K, Capriotti JA. Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology. J Clin Aesthet Dermatol. 2012, 5:24-6.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1792-3","article-title":"Oral dimethyl sulfoxide for systemic amyloid A amyloidosis complication in chronic inflammatory disease: a retrospective patient chart review","volume":"41","author":"Amemori S","year":"2006","unstructured":"Amemori S, Iwakiri R, Endo H, et al.. Oral dimethyl sulfoxide for systemic amyloid A amyloidosis complication in chronic inflammatory disease: a retrospective patient chart review. J Gastroenterol. 2006, 41:444-9. 10.1007\/s00535-006-1792-3","journal-title":"J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21121709","article-title":"Natural terpenes as penetration enhancers for transdermal drug delivery","volume":"21","author":"Chen J","year":"2016","unstructured":"Chen J, Jiang QD, Chai YP, Zhang H, Peng P, Yang XX. Natural terpenes as penetration enhancers for transdermal drug delivery. Molecules. 2016, 21:1709. 10.3390\/molecules21121709","journal-title":"Molecules"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/18715230113126660021","article-title":"Skin repair properties of d-Limonene and perillyl alcohol in murine models","volume":"13","author":"d'Alessio PA","year":"2014","unstructured":"d'Alessio PA, Mirshahi M, Bisson JF, Bene MC. Skin repair properties of d-Limonene and perillyl alcohol in murine models. Antiinflamm Antiallergy Agents Med Chem. 2014, 13:29-35. 10.2174\/18715230113126660021","journal-title":"Antiinflamm Antiallergy Agents Med Chem"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.02.009","article-title":"Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation","volume":"13","author":"Mills C","year":"2012","unstructured":"Mills C, Leblond D, Joshi S, et al.. Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation. J Pain. 2012, 13:519-23. 10.1016\/j.jpain.2012.02.009","journal-title":"J Pain"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.02.003","article-title":"Quantitative sensory testing: a comprehensive protocol for clinical trials","volume":"10","author":"Rolke R","year":"2006","unstructured":"Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD. Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain. 2006, 10:77-88. 10.1016\/j.ejpain.2005.02.003","journal-title":"Eur J Pain"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3791\/54130","article-title":"A protocol of manual tests to measure sensation and pain in humans","volume":"(118)","author":"Kostek M","year":"2016","unstructured":"Kostek M, Polaski A, Kolber B, Ramsey A, Kranjec A, Szucs K. A protocol of manual tests to measure sensation and pain in humans. J Vis Exp. 2016, (118):e54130. 10.3791\/54130","journal-title":"J Vis Exp"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90522-m","article-title":"Dimethylsulfoxide (DMSO) blocks conduction in peripheral nerve C fibers: a possible mechanism of analgesia","volume":"150","author":"Evans MS","year":"1993","unstructured":"Evans MS, Reid KH, Sharp JB, Jr.(DMSO. Dimethylsulfoxide (DMSO) blocks conduction in peripheral nerve C fibers: a possible mechanism of analgesia. Neurosci Lett. 1993, 150:145-8. 10.1016\/0304-3940(93)90522-m","journal-title":"Neurosci Lett"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1967.tb34922.x","article-title":"The employment of dimethyl sulfoxide as an antiinflammatory agent and steroid-transporter in diversified clinical diseases","volume":"141","author":"Steinberg A","year":"1967","unstructured":"Steinberg A. The employment of dimethyl sulfoxide as an antiinflammatory agent and steroid-transporter in diversified clinical diseases. Ann N Y Acad Sci. 1967, 141:532-50. 10.1111\/j.1749-6632.1967.tb34922.x","journal-title":"Ann N Y Acad Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199212000-00012","article-title":"Synergistic cytotoxicity of combinations of dimethyl sulfoxide and antineoplastic agents against P388 leukemia in CD-F1 mice","volume":"3","author":"Pommier RF","year":"1992","unstructured":"Pommier RF, Woltering EA, Milo G, Fletcher WS. Synergistic cytotoxicity of combinations of dimethyl sulfoxide and antineoplastic agents against P388 leukemia in CD-F1 mice. Anticancer Drugs. 1992, 3:635-9. 10.1097\/00001813-199212000-00012","journal-title":"Anticancer Drugs"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.2174\/138955713804484686","article-title":"Menthol--pharmacology of an important naturally medicinal \"cool\"","volume":"13","author":"Farco JA","year":"2013","unstructured":"Farco JA, Grundmann O. Menthol--pharmacology of an important naturally medicinal \"cool\". Mini Rev Med Chem. 2013, 13:124-31.","journal-title":"Mini Rev Med Chem"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X241254229","article-title":"The pharmacological effects and potential applications of limonene from citrus plants: a review","volume":"19","author":"Chen X","year":"2024","unstructured":"Chen X, Ding Y, H G, et al.. The pharmacological effects and potential applications of limonene from citrus plants: a review. Natural Products Commun. 2024, 19:1-12. 10.1177\/1934578X241254229","journal-title":"Natural Products Commun"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01238.x","article-title":"Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects","volume":"163","author":"Russo EB","year":"2011","unstructured":"Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011, 163:1344-64. 10.1111\/j.1476-5381.2011.01238.x","journal-title":"Br J Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/ph16070913","article-title":"Mitigation of insulin resistance by natural products from a new class of molecules, membrane-active immunomodulators","volume":"16","author":"Izbicka E","year":"2023","unstructured":"Izbicka E, Streeper RT. Mitigation of insulin resistance by natural products from a new class of molecules, membrane-active immunomodulators. Pharmaceuticals (Basel). 2023, 16:913. 10.3390\/ph16070913","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01845-w","article-title":"Pathology of pain and its implications for therapeutic interventions","volume":"9","author":"Cao B","year":"2024","unstructured":"Cao B, Xu Q, Shi Y, et al.. Pathology of pain and its implications for therapeutic interventions. Signal Transduct Target Ther. 2024, 9:155. 10.1038\/s41392-024-01845-w","journal-title":"Signal Transduct Target Ther"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008609.pub2","article-title":"Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews","volume":"5","author":"Derry S","year":"2017","unstructured":"Derry S, Wiffen PJ, Kalso EA, et al.. Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2017, 5:CD008609. 10.1002\/14651858.CD008609.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe6374","article-title":"Phospholipase A(2) inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression","volume":"7","author":"Wei Y","year":"2021","unstructured":"Wei Y, Yan L, Luo L, et al.. Phospholipase A(2) inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression. Sci Adv. 2021, 7:eabe6374. 10.1126\/sciadv.abe6374","journal-title":"Sci Adv"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/343273-mixtures-of-diethyl-azelate-as-novel-nonopioid-modalities-for-pain-management","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T15:41:44Z","timestamp":1741016504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/343273-mixtures-of-diethyl-azelate-as-novel-nonopioid-modalities-for-pain-management"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.79960","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,3]]}}}