{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:40:28Z","timestamp":1766050828768,"version":"3.38.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,4]]},"DOI":"10.7759\/cureus.80044","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:23:11Z","timestamp":1741119791000},"source":"Crossref","is-referenced-by-count":3,"title":["Concomitant Use of Intravenous Remimazolam With Inhalation Anesthesia and Subsequent Emergence Delirium in Children: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Yukie","family":"Nitta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Shiroshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanta","family":"Kido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000250914.91881.a8","article-title":"Emergence delirium in children: many questions, few answers","volume":"104","author":"Vlajkovic GP","year":"2007","unstructured":"Vlajkovic GP, Sindjelic RP. Emergence delirium in children: many questions, few answers. Anesth Analg. 2007, 104:84-91. 10.1213\/01.ane.0000250914.91881.a8","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew477","article-title":"Paediatric emergence delirium: a comprehensive review and interpretation of the literature","volume":"118","author":"Mason KP","year":"2017","unstructured":"Mason KP. Paediatric emergence delirium: a comprehensive review and interpretation of the literature. Br J Anaesth. 2017, 118:335-43. 10.1093\/bja\/aew477","journal-title":"Br J Anaesth"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007084.pub2","article-title":"Effects of sevoflurane versus other general anaesthesia on emergence agitation in children","volume":"2014","author":"Costi D","year":"2014","unstructured":"Costi D, Cyna AM, Ahmed S, et al.. Effects of sevoflurane versus other general anaesthesia on emergence agitation in children. Cochrane Database Syst Rev. 2014, 2014:CD007084. 10.1002\/14651858.CD007084.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12669","article-title":"Does a prophylactic dose of propofol reduce emergence agitation in children receiving anesthesia? A systematic review and meta-analysis","volume":"25","author":"van Hoff SL","year":"2015","unstructured":"van Hoff SL, O'Neill ES, Cohen LC, Collins BA. Does a prophylactic dose of propofol reduce emergence agitation in children receiving anesthesia? A systematic review and meta-analysis. Paediatr Anaesth. 2015, 25:668-76. 10.1111\/pan.12669","journal-title":"Paediatr Anaesth"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1031010","article-title":"Efficacy of propofol for the prevention of emergence agitation after sevoflurane anaesthesia in children: a meta-analysis","volume":"9","author":"Xiao Y","year":"2022","unstructured":"Xiao Y, Jin X, Zhang Y, Huang T, Zhou L, Gao J. Efficacy of propofol for the prevention of emergence agitation after sevoflurane anaesthesia in children: a meta-analysis. Front Surg. 2022, 9:1031010. 10.3389\/fsurg.2022.1031010","journal-title":"Front Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxab298","article-title":"New perspectives on propofol allergy","volume":"78","author":"Johnson JL","year":"2021","unstructured":"Johnson JL, Hawthorne A, Bounds M, Weldon DJ. New perspectives on propofol allergy. Am J Health Syst Pharm. 2021, 78:2195-203. 10.1093\/ajhp\/zxab298","journal-title":"Am J Health Syst Pharm"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S381611","article-title":"Remimazolam for the Prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study","volume":"16","author":"Yang X","year":"2022","unstructured":"Yang X, Lin C, Chen S, Huang Y, Cheng Q, Yao Y. Remimazolam for the Prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study. Drug Des Devel Ther. 2022, 16:3413-20. 10.2147\/DDDT.S381611","journal-title":"Drug Des Devel Ther"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2096-3882.2023.05.010","article-title":"Effect of remimazolam on emergence agitation in children undergoing tooth decay treatment after sevoflurane anesthesia","volume":"43","author":"Tao M","year":"2023","unstructured":"Tao M, Qing B, Fengchao Z, Junli C. Effect of remimazolam on emergence agitation in children undergoing tooth decay treatment after sevoflurane anesthesia. J Xuzhou Med Univ. 2023, 43:362-6. 10.3969\/j.issn.2096-3882.2023.05.010","journal-title":"J Xuzhou Med Univ"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005077","article-title":"Effect of remimazolam on emergence delirium in children undergoing laparoscopic surgery: a double-blinded randomized trial","volume":"141","author":"Cai YH","year":"2024","unstructured":"Cai YH, Zhong JW, Ma HY, et al.. Effect of remimazolam on emergence delirium in children undergoing laparoscopic surgery: a double-blinded randomized trial. Anesthesiology. 2024, 141:500-10. 10.1097\/ALN.0000000000005077","journal-title":"Anesthesiology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000142","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston M","year":"2019","unstructured":"Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, Thomas J. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019, 10:ED000142. 10.1002\/14651858.ED000142","journal-title":"Cochrane Database Syst Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200405000-00015","article-title":"Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale","volume":"100","author":"Sikich N","year":"2004","unstructured":"Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology. 2004, 100:1138-45. 10.1097\/00000542-200405000-00015","journal-title":"Anesthesiology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan - a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani M","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan - a web and mobile app for systematic reviews. Syst Rev. 2016, 5:210. 10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan X","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol. 2014, 14:135. 10.1186\/1471-2288-14-135","journal-title":"BMC Med Res Methodol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt G","year":"2011","unstructured":"Guyatt G, Oxman AD, Akl EA, et al.. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011, 64:383-94. 10.1016\/j.jclinepi.2010.04.026","journal-title":"J Clin Epidemiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13752","article-title":"The effect of ketamine on emergence agitation in children: a systematic review and meta-analysis","volume":"29","author":"Ng KT","year":"2019","unstructured":"Ng KT, Sarode D, Lai YS, Teoh WY, Wang CY. The effect of ketamine on emergence agitation in children: a systematic review and meta-analysis. Paediatr Anaesth. 2019, 29:1163-72. 10.1111\/pan.13752","journal-title":"Paediatr Anaesth"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00329","article-title":"The effect of dexmedetomidine on emergence agitation or delirium in children after anesthesia - a systematic review and meta-analysis of clinical studies","volume":"8","author":"Rao Y","year":"2020","unstructured":"Rao Y, Zeng R, Jiang X, Li J, Wang X. The effect of dexmedetomidine on emergence agitation or delirium in children after anesthesia - a systematic review and meta-analysis of clinical studies. Front Pediatr. 2020, 8:329. 10.3389\/fped.2020.00329","journal-title":"Front Pediatr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110488","article-title":"Association of pharmacological prophylaxis with the risk of pediatric emergence delirium after sevoflurane anesthesia: an updated network meta-analysis","volume":"75","author":"Wang HY","year":"2021","unstructured":"Wang HY, Chen TY, Li DJ, et al.. Association of pharmacological prophylaxis with the risk of pediatric emergence delirium after sevoflurane anesthesia: an updated network meta-analysis. J Clin Anesth. 2021, 75:110488. 10.1016\/j.jclinane.2021.110488","journal-title":"J Clin Anesth"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.08.019","article-title":"Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children","volume":"131","author":"Gao YQ","year":"2023","unstructured":"Gao YQ, Ihmsen H, Hu ZY, et al.. Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. Br J Anaesth. 2023, 131:914-20. 10.1016\/j.bja.2023.08.019","journal-title":"Br J Anaesth"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1999.00364.x","article-title":"The use of propofol infusions in paediatric anaesthesia: a practical guide","volume":"9","author":"McFarlan CS","year":"1999","unstructured":"McFarlan CS, Anderson BJ, Short TG. The use of propofol infusions in paediatric anaesthesia: a practical guide. Paediatr Anaesth. 1999, 9:209-16. 10.1046\/j.1460-9592.1999.00364.x","journal-title":"Paediatr Anaesth"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.797","article-title":"Effects of vitamin D receptor, cytochrome P450 3A, and cytochrome P450 oxidoreductase genetic polymorphisms on the pharmacokinetics of remimazolam in healthy Chinese volunteers","volume":"10","author":"Hu K","year":"2021","unstructured":"Hu K, Xiang Q, Wang Z, et al.. Effects of vitamin D receptor, cytochrome P450 3A, and cytochrome P450 oxidoreductase genetic polymorphisms on the pharmacokinetics of remimazolam in healthy Chinese volunteers. Clin Pharmacol Drug Dev. 2021, 10:22-9. 10.1002\/cpdd.797","journal-title":"Clin Pharmacol Drug Dev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2098-5","article-title":"Emergence agitation in children: risk factors, prevention, and treatment","volume":"30","author":"Kanaya A","year":"2016","unstructured":"Kanaya A. Emergence agitation in children: risk factors, prevention, and treatment. J Anesth. 2016, 30:261-7. 10.1007\/s00540-015-2098-5","journal-title":"J Anesth"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000594","article-title":"European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium","volume":"34","author":"Aldecoa C","year":"2017","unstructured":"Aldecoa C, Bettelli G, Bilotta F, et al.. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesthesiol. 2017, 34:192-214. 10.1097\/EJA.0000000000000594","journal-title":"Eur J Anaesthesiol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004641","article-title":"American Society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention","volume":"130","author":"Hughes CG","year":"2020","unstructured":"Hughes CG, Boncyk CS, Culley DJ, et al.. American Society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention. Anesth Analg. 2020, 130:1572-90. 10.1213\/ANE.0000000000004641","journal-title":"Anesth Analg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S349232","article-title":"Evidence-based guideline on management of postoperative delirium in older people for low resource setting: systematic review article","volume":"15","author":"Mossie A","year":"2022","unstructured":"Mossie A, Regasa T, Neme D, Awoke Z, Zemedkun A, Hailu S. Evidence-based guideline on management of postoperative delirium in older people for low resource setting: systematic review article. Int J Gen Med. 2022, 15:4053-65. 10.2147\/IJGM.S349232","journal-title":"Int J Gen Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/344788-concomitant-use-of-intravenous-remimazolam-with-inhalation-anesthesia-and-subsequent-emergence-delirium-in-children-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:23:13Z","timestamp":1741119793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/344788-concomitant-use-of-intravenous-remimazolam-with-inhalation-anesthesia-and-subsequent-emergence-delirium-in-children-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.80044","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,4]]}}}