{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T04:40:18Z","timestamp":1741236018731,"version":"3.38.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"DOI":"10.7759\/cureus.80114","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T04:02:41Z","timestamp":1741233761000},"source":"Crossref","is-referenced-by-count":0,"title":["Relapsed Acute Myeloid Leukemia With Early Presentation As Leukemia Cutis, Refractory to Second-Line Treatment"],"prefix":"10.7759","author":[{"given":"Emin","family":"Gayibov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Karambelkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virushnee","family":"Senthilkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita J","family":"Dsouza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit K","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-023-01566-x","article-title":"Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia","volume":"15","author":"Humphries S","year":"2023","unstructured":"Humphries S, Bond DR, Germon ZP, Keely S, Enjeti AK, Dun MD, Lee HJ. Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia. Clin Epigenetics. 2023, 15:150. 10.1186\/s13148-023-01566-x","journal-title":"Clin Epigenetics"},{"key":"ref2","unstructured":"National Cancer Institute. Cancer Stat Facts. Leukemia - Acute Myeloid Leukemia (AML). (2023). Accessed: November 26, 2024: https:\/\/seer.cancer.gov\/statfacts\/html\/amyl.html."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51423","article-title":"Changes in five-year survival for people with acute leukaemia in South Australia, 1980-2016","volume":"216","author":"Beckmann K","year":"2022","unstructured":"Beckmann K, Kearney BJ AM, Yeung D, Hiwase D, Li M, Roder DM. Changes in five-year survival for people with acute leukaemia in South Australia, 1980-2016. Med J Aust. 2022, 216:296-302. 10.5694\/mja2.51423","journal-title":"Med J Aust"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.6004\/jadpro.2020.11.8.4","article-title":"Acute myeloid leukemia: advanced practice management from presentation to cure","volume":"11","author":"Beaton M","year":"2020","unstructured":"Beaton M, Peterson GJ, O'Brien K. Acute myeloid leukemia: advanced practice management from presentation to cure. J Adv Pract Oncol. 2020, 11:836-44. 10.6004\/jadpro.2020.11.8.4","journal-title":"J Adv Pract Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27625","article-title":"Acute myeloid leukemia: 2025 update on diagnosis, risk-stratification, and management","volume":"2","author":"Shimony S","year":"2025","unstructured":"Shimony S, Stahl M, Stone RM. Acute myeloid leukemia: 2025 update on diagnosis, risk-stratification, and management. Am J Hematol. 2025, 2:5. 10.1002\/ajh.27625","journal-title":"Am J Hematol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2021.030","article-title":"Extramedullary involvement in acute myeloid leukemia: a single-center ten years' experience","volume":"13","author":"Fianchi L","year":"2021","unstructured":"Fianchi L, Quattrone M, Criscuolo M, et al.. Extramedullary involvement in acute myeloid leukemia: a single-center ten years' experience. Mediterr J Hematol Infect Dis. 2021, 13:30. 10.4084\/MJHID.2021.030","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2012.0120","article-title":"Management of extramedullary leukemia as a presentation of acute myeloid leukemia","volume":"10","author":"Slomowitz SJ","year":"2012","unstructured":"Slomowitz SJ, Shami PJ. Management of extramedullary leukemia as a presentation of acute myeloid leukemia. J Natl Compr Canc Netw. 2012, 10:1165-9. 10.6004\/jnccn.2012.0120","journal-title":"J Natl Compr Canc Netw"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34459","article-title":"Molecular annotation of extramedullary acute myeloid leukemia identifies high prevalence of targetable mutations","volume":"128","author":"Ball S","year":"2022","unstructured":"Ball S, Knepper TC, Deutsch YE, et al.. Molecular annotation of extramedullary acute myeloid leukemia identifies high prevalence of targetable mutations. Cancer. 2022, 128:3880-7. 10.1002\/cncr.34459","journal-title":"Cancer"},{"key":"ref9","article-title":"Leukemia cutis as the presenting sign of acute myeloid leukemia in an HIV+ patient","volume":"7","author":"Garcia N","year":"2023","unstructured":"Garcia N, McRae C, Smith A, et al.. Leukemia cutis as the presenting sign of acute myeloid leukemia in an HIV+ patient. SKIN J Cutan Med. 2023, 7:821-3.","journal-title":"SKIN J Cutan Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14759","article-title":"Leukemia cutis with chronic myelomonocytic leukemia presenting with a variety of skin lesions","volume":"20","author":"Wada S","year":"2022","unstructured":"Wada S, Namiki T, Miura K, Yokozeki H. Leukemia cutis with chronic myelomonocytic leukemia presenting with a variety of skin lesions. J Dtsch Dermatol Ges. 2022, 20:701-3. 10.1111\/ddg.14759","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref11","article-title":"Leukemia cutis as the presenting symptom of acute myeloid leukemia: report of three cases","volume":"24","author":"Moyer AB","year":"2018","unstructured":"Moyer AB, Rembold J, Lee NE, et al.. Leukemia cutis as the presenting symptom of acute myeloid leukemia: report of three cases. Dermatol Online J. 2018, 24:5.","journal-title":"Dermatol Online J"},{"key":"ref12","unstructured":"Lyndon B. Johnson Hospital Clinical Laboratory. Laboratory reference ranges. (2024). Accessed. November 26, 2024: https:\/\/healthlibrary.harrishealth.org\/Library\/TestsProcedures\/."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/cdr.cdr_120_20","article-title":"Leukemia cutis: a sign of relapse","volume":"6","author":"Chitapur UG","year":"2022","unstructured":"Chitapur UG, Athanikar SB, Panchagavi AB, et al.. Leukemia cutis: a sign of relapse. Clin Dermatol Rev. 2022, 6:53. 10.4103\/cdr.cdr_120_20","journal-title":"Clin Dermatol Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.31897","article-title":"Aleukemic leukemia cutis","volume":"73","author":"Vishalakshi V","year":"2007","unstructured":"Vishalakshi V, Torsekar RG, Shinde S. Aleukemic leukemia cutis. Indian J Dermatol Venereol Leprol. 2007, 73:109-11. 10.4103\/0378-6323.31897","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref15","article-title":"Clinical characterization of leukemia cutis presentation","volume":"104","author":"Haidari W","year":"2019","unstructured":"Haidari W, Strowd LC. Clinical characterization of leukemia cutis presentation. Cutis. 2019, 104:326-30.","journal-title":"Cutis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0052","article-title":"Association of leukemia cutis with survival in acute myeloid leukemia","volume":"155","author":"Wang CX","year":"2019","unstructured":"Wang CX, Pusic I, Anadkat MJ. Association of leukemia cutis with survival in acute myeloid leukemia. JAMA Dermatol. 2019, 155:826-32. 10.1001\/jamadermatol.2019.0052","journal-title":"JAMA Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1309\/WYACYWF6NGM3WBRT","article-title":"Leukemia cutis","volume":"129","author":"Cho-Vega JH","year":"2008","unstructured":"Cho-Vega JH, Medeiros LJ, Prieto VG, Vega F. Leukemia cutis. Am J Clin Pathol. 2008, 129:130-42. 10.1309\/WYACYWF6NGM3WBRT","journal-title":"Am J Clin Pathol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03774.x","article-title":"Leukaemia cutis and leukaemic vasculitis","volume":"143","author":"Payda\u015f S","year":"2000","unstructured":"Payda\u015f S, Zorludemir S. Leukaemia cutis and leukaemic vasculitis. Br J Dermatol. 2000, 143:773-9. 10.1046\/j.1365-2133.2000.03774.x","journal-title":"Br J Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.190851","article-title":"Leukemia cutis preceding bone marrow relapse in acute monocytic leukemia","volume":"82","author":"Khoshnaw N","year":"2016","unstructured":"Khoshnaw N, Muhammad BA. Leukemia cutis preceding bone marrow relapse in acute monocytic leukemia. Indian J Dermatol Venereol Leprol. 2016, 82:713-6. 10.4103\/0378-6323.190851","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0046-y","article-title":"Leukemia cutis preceding systemic relapse of acute myeloid leukemia","volume":"87","author":"Stern M","year":"2008","unstructured":"Stern M, Halter J, Buser A, Rov\u00f2 A, Dirnhofer S, H\u00e4usermann P. Leukemia cutis preceding systemic relapse of acute myeloid leukemia. Int J Hematol. 2008, 87:108-9. 10.1007\/s12185-008-0046-y","journal-title":"Int J Hematol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.78049","article-title":"Sarcoidosis with generalized lymphadenopathy: a clinical mimic of lymphoma","volume":"17","author":"Wagle L","year":"2025","unstructured":"Wagle L, Timshina A, Regmi R, Abdulmahdi M. Sarcoidosis with generalized lymphadenopathy: a clinical mimic of lymphoma. Cureus. 2025, 17:e78049. 10.7759\/cureus.78049","journal-title":"Cureus"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-020-08788-4","article-title":"Cutaneous vasculitis: review on diagnosis and clinicopathologic correlations","volume":"61","author":"Frumholtz L","year":"2021","unstructured":"Frumholtz L, Laurent-Roussel S, Lipsker D, Terrier B. Cutaneous vasculitis: review on diagnosis and clinicopathologic correlations. Clin Rev Allergy Immunol. 2021, 61:181-93. 10.1007\/s12016-020-08788-4","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"D\u00f6hner H","year":"2022","unstructured":"D\u00f6hner H, Wei AH, Appelbaum FR, et al.. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022, 140:1345-77. 10.1182\/blood.2022016867","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-604520","article-title":"An update of current treatments for adult acute myeloid leukemia","volume":"127","author":"Dombret H","year":"2016","unstructured":"Dombret H, Gardin C. An update of current treatments for adult acute myeloid leukemia. Blood. 2016, 127:53-61. 10.1182\/blood-2015-08-604520","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002904","article-title":"Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial","volume":"4","author":"Voso MT","year":"2020","unstructured":"Voso MT, Larson RA, Jones D, et al.. Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial. Blood Adv. 2020, 4:4945-54. 10.1182\/bloodadvances.2020002904","journal-title":"Blood Adv"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-019-0173-z","article-title":"Isocitrate dehydrogenase inhibitors in acute myeloid leukemia","volume":"7","author":"Liu X","year":"2019","unstructured":"Liu X, Gong Y. Isocitrate dehydrogenase inhibitors in acute myeloid leukemia. Biomark Res. 2019, 7:22. 10.1186\/s40364-019-0173-z","journal-title":"Biomark Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-868752","article-title":"Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia","volume":"133","author":"DiNardo CD","year":"2019","unstructured":"DiNardo CD, Pratz K, Pullarkat V, et al.. Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia. Blood. 2019, 133:7-17. 10.1182\/blood-2018-08-868752","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0093-9","article-title":"Extramedullary relapses after allogeneic stem cell transplantation for acute myeloid leukemia: clinical characteristics, incidence, risk factors and outcomes","volume":"53","author":"Alhashim N","year":"2018","unstructured":"Alhashim N, Aljurf M, Hassanein M, et al.. Extramedullary relapses after allogeneic stem cell transplantation for acute myeloid leukemia: clinical characteristics, incidence, risk factors and outcomes. Bone Marrow Transplant. 2018, 53:838-43. 10.1038\/s41409-018-0093-9","journal-title":"Bone Marrow Transplant"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2019.11.051","article-title":"Spontaneous splenic rupture in a patient with chronic myeloid leukemia: a case report","volume":"66","author":"Rueda-Esteban R","year":"2020","unstructured":"Rueda-Esteban R, Stozitzky Mu\u00f1oz N, Barrios D\u00edaz M, Garc\u00eda Sierra A, Perdomo CF. Spontaneous splenic rupture in a patient with chronic myeloid leukemia: a case report. Int J Surg Case Rep. 2020, 66:122-5. 10.1016\/j.ijscr.2019.11.051","journal-title":"Int J Surg Case Rep"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09848-z","article-title":"Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data","volume":"39","author":"Lenk L","year":"2020","unstructured":"Lenk L, Alsadeq A, Schewe DM. Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data. Cancer Metastasis Rev. 2020, 39:173-87. 10.1007\/s10555-020-09848-z","journal-title":"Cancer Metastasis Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/336219-relapsed-acute-myeloid-leukemia-with-early-presentation-as-leukemia-cutis-refractory-to-second-line-treatment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T04:02:51Z","timestamp":1741233771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/336219-relapsed-acute-myeloid-leukemia-with-early-presentation-as-leukemia-cutis-refractory-to-second-line-treatment"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.80114","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,5]]}}}