{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T04:04:12Z","timestamp":1742616252484,"version":"3.40.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,20]]},"DOI":"10.7759\/cureus.80925","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T05:24:01Z","timestamp":1742534641000},"source":"Crossref","is-referenced-by-count":0,"title":["Silent Signals: Analyzing Repolarization Heterogeneity and Autonomic Modulation in Children With Euthyroid Hashimoto\u2019s Thyroiditis"],"prefix":"10.7759","author":[{"given":"Ozlem","family":"Turan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba Burcu Ozturk","family":"Gomec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.425","article-title":"Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents","volume":"3","author":"\u00d6zen S","year":"2011","unstructured":"\u00d6zen S, Berk \u00d6, \u015eim\u015fek DG, Darcan S. Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J Clin Res Pediatr Endocrinol. 2011, 3:192-7. 10.4274\/jcrpe.425","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.11142","article-title":"Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in Lower Silesia, Poland","volume":"4","author":"Zak T","year":"2005","unstructured":"Zak T, Noczy\u0144ska A, Wasikowa R, Zaleska-Dorobisz U, Golenko A. Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in Lower Silesia, Poland. Hormones (Athens). 2005, 4:45-8. 10.14310\/horm.2002.11142","journal-title":"Hormones (Athens)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-8","article-title":"Hashimoto's thyroiditis in childhood: presentation modes and evolution over time","volume":"39","author":"De Luca F","year":"2013","unstructured":"De Luca F, Santucci S, Corica D, Pitrolo E, Romeo M, Aversa T. Hashimoto's thyroiditis in childhood: presentation modes and evolution over time. Ital J Pediatr. 2013, 39:8. 10.1186\/1824-7288-39-8","journal-title":"Ital J Pediatr"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00309","article-title":"Long-term follow-up and outcomes of autoimmune thyroiditis in childhood","volume":"11","author":"Admoni O","year":"2020","unstructured":"Admoni O, Rath S, Almagor T, Elias-Assad G, Tenenbaum-Rakover Y. Long-term follow-up and outcomes of autoimmune thyroiditis in childhood. Front Endocrinol (Lausanne). 2020, 11:309. 10.3389\/fendo.2020.00309","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/0118715303243951231024112208","article-title":"The thyroid-cardiac axis: thyroid function, cardiac rhythmology, and sudden cardiac death","volume":"24","author":"Spartalis M","year":"2024","unstructured":"Spartalis M, Spartalis E, Paschou SA, Iliopoulos DC, Siasos G. The thyroid-cardiac axis: thyroid function, cardiac rhythmology, and sudden cardiac death. Endocr Metab Immune Disord Drug Targets. 2024, 24:1127-30. 10.2174\/0118715303243951231024112208","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01240.x","article-title":"Cardiac autonomic function and global left ventricular performance in autoimmune eauthyroid chronic thyroiditis: is treatment necessary at the euthyroid stage?","volume":"28","author":"Akgul E","year":"2011","unstructured":"Akgul E, Kutuk U, Ertek S, Cesur M, Cehreli S, Tore HF, Erdogan G. Cardiac autonomic function and global left ventricular performance in autoimmune eauthyroid chronic thyroiditis: is treatment necessary at the euthyroid stage?. Echocardiography. 2011, 28:15-21. 10.1111\/j.1540-8175.2010.01240.x","journal-title":"Echocardiography"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13286","article-title":"Evaluation of QT dispersion and Tp-e interval in children with subclinical hypothyroidism","volume":"41","author":"Ak\u0131n A","year":"2018","unstructured":"Ak\u0131n A, Unal E, Y\u0131ld\u0131r\u0131m R, Ture M, Bal\u0131k H, Haspolat YK. Evaluation of QT dispersion and Tp-e interval in children with subclinical hypothyroidism. Pacing Clin Electrophysiol. 2018, 41:372-5. 10.1111\/pace.13286","journal-title":"Pacing Clin Electrophysiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/2042018816684423","article-title":"Evaluation of Tp-e interval, Tp-e\/QT ratio and Tp-e\/QTc ratio in patients with subclinical hypothyroidism","volume":"8","author":"G\u00fcrdal A","year":"2017","unstructured":"G\u00fcrdal A, Ero\u011flu H, Helvaci F, et al.. Evaluation of Tp-e interval, Tp-e\/QT ratio and Tp-e\/QTc ratio in patients with subclinical hypothyroidism. Ther Adv Endocrinol Metab. 2017, 8:25-32. 10.1177\/2042018816684423","journal-title":"Ther Adv Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021190","article-title":"Effect of thyrotropin suppressive therapy on heart rate variability and QT dispersion in patients with differentiated thyroid cancer","volume":"99","author":"Liu C","year":"2020","unstructured":"Liu C, Lv H, Li Q, et al.. Effect of thyrotropin suppressive therapy on heart rate variability and QT dispersion in patients with differentiated thyroid cancer. Medicine (Baltimore). 2020, 99:21190. 10.1097\/MD.0000000000021190","journal-title":"Medicine (Baltimore)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2006.07.009","article-title":"Heart rate variability and QT dispersion in patients with subclinical hypothyroidism","volume":"60","author":"Galetta F","year":"2006","unstructured":"Galetta F, Franzoni F, Fallahi P, et al.. Heart rate variability and QT dispersion in patients with subclinical hypothyroidism. Biomed Pharmacother. 2006, 60:425-30. 10.1016\/j.biopha.2006.07.009","journal-title":"Biomed Pharmacother"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951113001224","article-title":"An evaluation of heart rate variability and its modifying factors in children with type 1 diabetes","volume":"24","author":"\u00d6zg\u00fcr S","year":"2014","unstructured":"\u00d6zg\u00fcr S, Ceylan \u00d6, \u015eenocak F, et al.. An evaluation of heart rate variability and its modifying factors in children with type 1 diabetes. Cardiol Young. 2014, 24:872-9. 10.1017\/S1047951113001224","journal-title":"Cardiol Young"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation, and clinical use","volume":"93","year":"1996","unstructured":"Heart rate variability. standards of measurement, physiological interpretation, and clinical use. Circulation. 1996, 93:1043-65. 10.1161\/01.CIR.93.5.1043","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14121261","article-title":"Hypothyroidism and heart rate variability: implications for cardiac autonomic regulation","volume":"14","author":"Bogdan C","year":"2024","unstructured":"Bogdan C, Ivan VM, Apostol A, Sandu OE, Maralescu FM, Lighezan DF. Hypothyroidism and heart rate variability: implications for cardiac autonomic regulation. Diagnostics (Basel). 2024, 14:1261. 10.3390\/diagnostics14121261","journal-title":"Diagnostics (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipej.2016.10.002","article-title":"P-wave dispersion: an update","volume":"16","author":"P\u00e9rez-Riera AR","year":"2016","unstructured":"P\u00e9rez-Riera AR, de Abreu LC, Barbosa-Barros R, Grindler J, Fernandes-Cardoso A, Baranchuk A. P-wave dispersion: an update. Indian Pacing Electrophysiol J. 2016, 16:126-33. 10.1016\/j.ipej.2016.10.002","journal-title":"Indian Pacing Electrophysiol J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/2048004016639443","article-title":"P-wave dispersion: what we know till now?","volume":"5","author":"Okutucu S","year":"2016","unstructured":"Okutucu S, Aytemir K, Oto A. P-wave dispersion: what we know till now?. JRSM Cardiovasc Dis. 2016, 5:2048004016639443. 10.1177\/2048004016639443","journal-title":"JRSM Cardiovasc Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202307_32974","article-title":"Evaluation of Tp-E interval and Tp-E\/Qtc ratios in patients with overt hypothyroidism and subclinical hypothyroidism","volume":"27","author":"Sari A","year":"2023","unstructured":"Sari A, Dural IE, Aksu U, Korucu C, Bozkurt E, Apaydin M. Evaluation of Tp-E interval and Tp-E\/Qtc ratios in patients with overt hypothyroidism and subclinical hypothyroidism. Eur Rev Med Pharmacol Sci. 2023, 27:6176-81. 10.26355\/eurrev_202307_32974","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang RM","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V, et al.. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015, 16:233-70. 10.1093\/ehjci\/jev014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.738517","article-title":"Abnormal cardiac repolarization in thyroid diseases: results of an observational study","volume":"8","author":"Aweimer A","year":"2021","unstructured":"Aweimer A, Schiedat F, Sch\u00f6ne D, et al.. Abnormal cardiac repolarization in thyroid diseases: results of an observational study. Front Cardiovasc Med. 2021, 8:738517. 10.3389\/fcvm.2021.738517","journal-title":"Front Cardiovasc Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","author":"Klein I","year":"2001","unstructured":"Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001, 344:501-9. 10.1056\/NEJM200102153440707","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000141503","article-title":"Subclinical hypothyroidism is characterized by increased QT interval dispersion among women","volume":"17","author":"Bakiner O","year":"2008","unstructured":"Bakiner O, Ertorer ME, Haydardedeoglu FE, Bozkirli E, Tutuncu NB, Demirag NG. Subclinical hypothyroidism is characterized by increased QT interval dispersion among women. Med Princ Pract. 2008, 17:390-4. 10.1159\/000141503","journal-title":"Med Princ Pract"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.053","article-title":"Interatrial conduction time and incident atrial fibrillation: a prospective cohort study","volume":"11","author":"Deftereos S","year":"2014","unstructured":"Deftereos S, Kossyvakis C, Efremidis M, et al.. Interatrial conduction time and incident atrial fibrillation: a prospective cohort study. Heart Rhythm. 2014, 11:1095-101. 10.1016\/j.hrthm.2014.03.053","journal-title":"Heart Rhythm"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2000.tb00910.x","article-title":"P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation","volume":"23","author":"Aytemir K","year":"2000","unstructured":"Aytemir K, Ozer N, Atalar E, et al.. P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol. 2000, 23:1109-12. 10.1111\/j.1540-8159.2000.tb00910.x","journal-title":"Pacing Clin Electrophysiol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13255","article-title":"Evaluation of P-wave dispersion, diastolic function, and atrial electromechanical conduction in pediatric patients with subclinical hypothyroidism","volume":"33","author":"Irdem A","year":"2016","unstructured":"Irdem A, Ayd\u0131n Sahin D, Kervancioglu M, Baspinar O, Sucu M, Keskin M, Kilinc M. Evaluation of P-wave dispersion, diastolic function, and atrial electromechanical conduction in pediatric patients with subclinical hypothyroidism. Echocardiography. 2016, 33:1397-401. 10.1111\/echo.13255","journal-title":"Echocardiography"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296413","article-title":"Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: a systematic review and meta-analysis","volume":"19","author":"Singh H","year":"2024","unstructured":"Singh H, Shahid MZ, Harrison SL, Lane DA, Lip GY, Logantha SJ. Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: a systematic review and meta-analysis. PLoS One. 2024, 19:0296413. 10.1371\/journal.pone.0296413","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.1969","article-title":"Cardiac function in newborns with congenital hypothyroidism: association with thyroid-stimulating hormone levels","volume":"7","author":"\u00d6ner T","year":"2015","unstructured":"\u00d6ner T, \u00d6zdemir R, Doks\u00f6z \u00d6, et al.. Cardiac function in newborns with congenital hypothyroidism: association with thyroid-stimulating hormone levels. J Clin Res Pediatr Endocrinol. 2015, 7:307-11. 10.4274\/jcrpe.1969","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951119002968","article-title":"P wave dispersion, Tpeak-Tend interval, and Tp-e\/QT ratio in children with psoriasis","volume":"30","author":"\u00c7etin M","year":"2020","unstructured":"\u00c7etin M, Yavuz \u0130H, G\u00fcm\u00fc\u015fta\u015f M, Yavuz G\u00d6. P wave dispersion, Tpeak-Tend interval, and Tp-e\/QT ratio in children with psoriasis. Cardiol Young. 2020, 30:318-22. 10.1017\/S1047951119002968","journal-title":"Cardiol Young"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345374","article-title":"Evaluation of autonomic activity in patients with subclinical hypothyroidism","volume":"28","author":"Sahin I","year":"2005","unstructured":"Sahin I, Turan N, Kosar F, Taskapan C, Gunen H. Evaluation of autonomic activity in patients with subclinical hypothyroidism. J Endocrinol Invest. 2005, 28:209-13. 10.1007\/BF03345374","journal-title":"J Endocrinol Invest"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0269277","article-title":"Heart rate variability in hypothyroid patients: a systematic review and meta-analysis","volume":"17","author":"Brusseau V","year":"2022","unstructured":"Brusseau V, Tauveron I, Bagheri R, et al.. Heart rate variability in hypothyroid patients: a systematic review and meta-analysis. PLoS One. 2022, 17:0269277. 10.1371\/journal.pone.0269277","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.226.191","article-title":"Cardiac autonomic regulation is disturbed in children with euthyroid Hashimoto thyroiditis","volume":"226","author":"Kilic A","year":"2012","unstructured":"Kilic A, Gulgun M, Tascilar ME, Sari E, Yokusoglu M. Cardiac autonomic regulation is disturbed in children with euthyroid Hashimoto thyroiditis. Tohoku J Exp Med. 2012, 226:191-5. 10.1620\/tjem.226.191","journal-title":"Tohoku J Exp Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2019.2018.0273","article-title":"Subclinical myocardial dysfunction demonstrated by speckle tracking echocardiography in children with euthyroid Hashimoto\u2019s thyroiditis","volume":"11","author":"Azak E","year":"2019","unstructured":"Azak E, U\u00e7akt\u00fcrk SA, \u00c7etin \u0130\u0130, G\u00fcrsu HA, Mengen E, Pamuk U. Subclinical myocardial dysfunction demonstrated by speckle tracking echocardiography in children with euthyroid Hashimoto\u2019s thyroiditis. J Clin Res Pediatr Endocrinol. 2019, 11:410-8. 10.4274\/jcrpe.galenos.2019.2018.0273","journal-title":"J Clin Res Pediatr Endocrinol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/346412-silent-signals-analyzing-repolarization-heterogeneity-and-autonomic-modulation-in-children-with-euthyroid-hashimotos-thyroiditis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T05:24:05Z","timestamp":1742534645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/346412-silent-signals-analyzing-repolarization-heterogeneity-and-autonomic-modulation-in-children-with-euthyroid-hashimotos-thyroiditis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.80925","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,20]]}}}