{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:08:24Z","timestamp":1784660904412,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,26]]},"DOI":"10.7759\/cureus.81253","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T01:13:46Z","timestamp":1743038026000},"source":"Crossref","is-referenced-by-count":2,"title":["Gastrinoma: A Case of Chronic Diarrhea"],"prefix":"10.7759","author":[{"given":"Putha Venkata Lakshmi","family":"Sahithi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venugopal Prudvesh Kumar Reddy","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwanth","family":"Kandagaddala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinusha","family":"Mulagapaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdhu Pragna","family":"Onteddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal K","family":"Onteddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000503073","article-title":"De novo gastrinoma: A case report","volume":"27","author":"Barbosa A","year":"2020","unstructured":"Barbosa A, Gomes F, Fonseca L, Maia T, Almeida J. De novo gastrinoma: A case report. GE Port J Gastroenterol. 2020, 27:192-6. 10.1159\/000503073","journal-title":"GE Port J Gastroenterol"},{"key":"ref2","article-title":"Gastrinoma","author":"Jensen RT","year":"2000","unstructured":"Jensen RT, Ito T, Feingold KR. Gastrinoma. Endotext, South Dartmouth (MA); 2000."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2019","article-title":"Misdiagnosed gastrinoma: A case report","volume":"7","author":"Sun QK","year":"2014","unstructured":"Sun QK, Wang W, Zhou HC, et al.. Misdiagnosed gastrinoma: A case report. Oncol Lett. 2014, 7:2089-92. 10.3892\/ol.2014.2019","journal-title":"Oncol Lett"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.14740\/gr734w","article-title":"Zollinger-Ellison syndrome: A rare case of chronic diarrhea","volume":"9","author":"Aamar A","year":"2016","unstructured":"Aamar A, Madhani K, Virk H, Butt Z. Zollinger-Ellison syndrome: A rare case of chronic diarrhea. Gastroenterology Res. 2016, 9:103-4. 10.14740\/gr734w","journal-title":"Gastroenterology Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i35.5890","article-title":"Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies","volume":"27","author":"Rossi RE","year":"2021","unstructured":"Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S. Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies. World J Gastroenterol. 2021, 27:5890-907. 10.3748\/wjg.v27.i35.5890","journal-title":"World J Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509073331005","article-title":"Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations","volume":"333","author":"Zimmer T","year":"1995","unstructured":"Zimmer T, St\u00f6lzel U, B\u00e4der M, et al.. Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations. N Engl J Med. 1995, 333:634-6. 10.1056\/NEJM199509073331005","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13267","article-title":"All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update","volume":"35","author":"Chatzipanagiotou O","year":"2023","unstructured":"Chatzipanagiotou O, Schizas D, Vailas M, et al.. All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update. J Neuroendocrinol. 2023, 35:e13267. 10.1111\/jne.13267","journal-title":"J Neuroendocrinol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.06.018","article-title":"Chronic diarrhea responding to proton pump inhibitors: A clinical sign of Zollinger-Ellison syndrome","volume":"122","author":"Zimmer V","year":"2009","unstructured":"Zimmer V, Schilling MK, Buecker A, Lammert F, Raedle J. Chronic diarrhea responding to proton pump inhibitors: A clinical sign of Zollinger-Ellison syndrome. Am J Med. 2009, 122:e9-e10. 10.1016\/j.amjmed.2009.06.018","journal-title":"Am J Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01961-w","article-title":"Sporadic and MEN1-related gastrinoma and Zollinger-Ellison syndrome: Differences in clinical characteristics and survival outcomes","volume":"46","author":"Massironi S","year":"2023","unstructured":"Massironi S, Rossi RE, Laffusa A, et al.. Sporadic and MEN1-related gastrinoma and Zollinger-Ellison syndrome: Differences in clinical characteristics and survival outcomes. J Endocrinol Invest. 2023, 46:957-65. 10.1007\/s40618-022-01961-w","journal-title":"J Endocrinol Invest"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2484\/rcr.v10i1.827","article-title":"Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle","volume":"10","author":"Yang RH","year":"2015","unstructured":"Yang RH, Chu YK. Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle. Radiol Case Rep. 2015, 10:827. 10.2484\/rcr.v10i1.827","journal-title":"Radiol Case Rep"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1148\/rg.306105523","article-title":"Pancreatic endocrine tumors: Radiologic-clinicopathologic correlation","volume":"30","author":"Lewis RB","year":"2010","unstructured":"Lewis RB, Lattin GE Jr, Paal E. Pancreatic endocrine tumors: Radiologic-clinicopathologic correlation. Radiographics. 2010, 30:1445-64. 10.1148\/rg.306105523","journal-title":"Radiographics"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4397","article-title":"Clinical treatment of gastrinoma: A case report and review of the literature","volume":"11","author":"Zhang WD","year":"2016","unstructured":"Zhang WD, Liu DR, Wang P, Zhao JG, Wang ZF, Chen LI. Clinical treatment of gastrinoma: A case report and review of the literature. Oncol Lett. 2016, 11:3433-7. 10.3892\/ol.2016.4397","journal-title":"Oncol Lett"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i30.4537","article-title":"Differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review","volume":"26","author":"Khan MS","year":"2020","unstructured":"Khan MS, Walter T, Buchanan-Hughes A, Worthington E, Keeber L, Feuilly M, Grande E. Differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review. World J Gastroenterol. 2020, 26:4537-56. 10.3748\/wjg.v26.i30.4537","journal-title":"World J Gastroenterol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082468","article-title":"Differential diagnosis and management of diarrhea in patients with neuroendocrine tumors","volume":"9","author":"Pusceddu S","year":"2020","unstructured":"Pusceddu S, Rossi RE, Torchio M, et al.. Differential diagnosis and management of diarrhea in patients with neuroendocrine tumors. J Clin Med. 2020, 9:2468. 10.3390\/jcm9082468","journal-title":"J Clin Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316158","article-title":"Lanreotide in metastatic enteropancreatic neuroendocrine tumors","volume":"371","author":"Caplin ME","year":"2014","unstructured":"Caplin ME, Pavel M, \u0106wik\u0142a JB, et al.. Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med. 2014, 371:224-33. 10.1056\/NEJMoa1316158","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.8510","article-title":"Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group","volume":"27","author":"Rinke A","year":"2009","unstructured":"Rinke A, M\u00fcller HH, Schade-Brittinger C, et al.. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group. J Clin Oncol. 2009, 27:4656-63. 10.1200\/JCO.2009.22.8510","journal-title":"J Clin Oncol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000513218","article-title":"Temozolomide alone or combined with capecitabine for the treatment of metastatic neuroendocrine neoplasia: A \"real-world\" data analysis","volume":"111","author":"Bongiovanni A","year":"2021","unstructured":"Bongiovanni A, Liverani C, Foca F, et al.. Temozolomide alone or combined with capecitabine for the treatment of metastatic neuroendocrine neoplasia: A \"real-world\" data analysis. Neuroendocrinology. 2021, 111:895-906. 10.1159\/000513218","journal-title":"Neuroendocrinology"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607427","article-title":"Phase 3 trial of (177)Lu-Dotatate for midgut neuroendocrine tumors","volume":"376","author":"Strosberg J","year":"2017","unstructured":"Strosberg J, El-Haddad G, Wolin E, et al.. Phase 3 trial of (177)Lu-Dotatate for midgut neuroendocrine tumors. N Engl J Med. 2017, 376:125-35. 10.1056\/NEJMoa1607427","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25646","article-title":"Peptide receptor radioligand therapy is an effective treatment for the long-term stabilization of malignant gastrinomas","volume":"117","author":"Grozinsky-Glasberg S","year":"2011","unstructured":"Grozinsky-Glasberg S, Barak D, Fraenkel M, et al.. Peptide receptor radioligand therapy is an effective treatment for the long-term stabilization of malignant gastrinomas. Cancer. 2011, 117:1377-85. 10.1002\/cncr.25646","journal-title":"Cancer"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/343583-gastrinoma-a-case-of-chronic-diarrhea","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T01:13:48Z","timestamp":1743038028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/343583-gastrinoma-a-case-of-chronic-diarrhea"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.81253","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}