{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:21:54Z","timestamp":1792030914721,"version":"4.4.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"DOI":"10.7759\/cureus.81643","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T09:17:30Z","timestamp":1743671850000},"source":"Crossref","is-referenced-by-count":5,"title":["Detection of the mecA Gene and Its Association With Antimicrobial Resistance Among Coagulase-Negative Staphylococci Isolated From Clinical Samples in a Tertiary Care Hospital: A Cross-Sectional Study"],"prefix":"10.7759","author":[{"given":"Vanlal","family":"Tluanpuii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.195374","article-title":"Coagulase-negative staphylococci causing blood stream infection at an Indian tertiary care hospital: prevalence, antimicrobial resistance and molecular characterisation","volume":"34","author":"Singh S","year":"2016","unstructured":"Singh S, Dhawan B, Kapil A, Kabra SK, Suri A, Sreenivas V, Das BK. Coagulase-negative staphylococci causing blood stream infection at an Indian tertiary care hospital: prevalence, antimicrobial resistance and molecular characterisation. Indian J Med Microbiol. 2016, 34:500-5. 10.4103\/0255-0857.195374","journal-title":"Indian J Med Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S274163","article-title":"Antibiotic resistance and mecA gene characterization of coagulase-negative staphylococci isolated from clinical samples in Nepal","volume":"13","author":"Shrestha LB","year":"2020","unstructured":"Shrestha LB, Bhattarai NR, Rai K, Khanal B. Antibiotic resistance and mecA gene characterization of coagulase-negative staphylococci isolated from clinical samples in Nepal. Infect Drug Resist. 2020, 13:3163-9. 10.2147\/IDR.S274163","journal-title":"Infect Drug Resist"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236713","article-title":"Antimicrobial resistance and virulence determinants in coagulase-negative staphylococci isolated mainly from preterm neonates","volume":"15","author":"Al-Haqan A","year":"2020","unstructured":"Al-Haqan A, Boswihi SS, Pathan S, Udo EE. Antimicrobial resistance and virulence determinants in coagulase-negative staphylococci isolated mainly from preterm neonates. PLoS One. 2020, 15:e0236713. 10.1371\/journal.pone.0236713","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02723","article-title":"Factors contributing to the evolution of mecA-mediated \u03b2-lactam resistance in Staphylococci: update and new insights from whole genome sequencing (WGS)","volume":"9","author":"Miragaia M","year":"2018","unstructured":"Miragaia M. Factors contributing to the evolution of mecA-mediated \u03b2-lactam resistance in Staphylococci: update and new insights from whole genome sequencing (WGS). Front Microbiol. 2018, 9:2723. 10.3389\/fmicb.2018.02723","journal-title":"Front Microbiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/10282","article-title":"","author":"Tripathi KD","year":"2019","unstructured":"Tripathi KD. Essentials of Medical Pharmacology. Jaypee Brothers Medical Publishers (P) Ltd, New Delhi; 2019. 10.5005\/jp\/books\/10282"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8050659","article-title":"Virulence characteristics of mecA-positive multidrug-resistant clinical coagulase-negative staphylococci","volume":"8","author":"Chon JW","year":"2020","unstructured":"Chon JW, Lee UJ, Bensen R, et al.. Virulence characteristics of mecA-positive multidrug-resistant clinical coagulase-negative staphylococci. Microorganisms. 2020, 8:659. 10.3390\/microorganisms8050659","journal-title":"Microorganisms"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00109-13","article-title":"Coagulase-negative staphylococci","volume":"27","author":"Becker K","year":"2014","unstructured":"Becker K, Heilmann C, Peters G. Coagulase-negative staphylococci. Clin Microbiol Rev. 2014, 27:870-926. 10.1128\/CMR.00109-13","journal-title":"Clin Microbiol Rev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mjafi.2016.03.007","article-title":"Prevalence and molecular characterization of methicillin resistance among coagulase-negative staphylococci at a tertiary care center","volume":"72","author":"Bhatt P","year":"2016","unstructured":"Bhatt P, Tandel K, Singh A, Kumar M, Grover N, Sahni AK. Prevalence and molecular characterization of methicillin resistance among coagulase-negative staphylococci at a tertiary care center. Med J Armed Forces India. 2016, 72:54-8. 10.1016%2Fj.mjafi.2016.03.007","journal-title":"Med J Armed Forces India"},{"key":"ref9","article-title":"Study of coagulase negative staphylococci isolated from clinical specimens in tertiary care hospital from Western Maharashtra","volume":"4","author":"Mane P","year":"2015","unstructured":"Mane P, Mane M, Mohite ST, Patil SR. Study of coagulase negative staphylococci isolated from clinical specimens in tertiary care hospital from Western Maharashtra. Int J Sc Research. 2015, 4:1437-40.","journal-title":"Int J Sc Research"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fofid%2Fofaa553","article-title":"Reliability of mecA in predicting phenotypic susceptibilities of coagulase-negative staphylococci and Staphylococcus aureus","volume":"7","author":"Williams MC","year":"2020","unstructured":"Williams MC, Dominguez SR, Prinzi A, Lee K, Parker SK. Reliability of mecA in predicting phenotypic susceptibilities of coagulase-negative staphylococci and Staphylococcus aureus. Open Forum Infect Dis. 2020, 7:553. 10.1093%2Fofid%2Fofaa553","journal-title":"Open Forum Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-260","article-title":"Comparison of methods for the detection of biofilm production in coagulase-negative staphylococci","volume":"3","author":"Oliveira A","year":"2010","unstructured":"Oliveira A, Cunha Mde L. Comparison of methods for the detection of biofilm production in coagulase-negative staphylococci. BMC Res Notes. 2010, 3:260. 10.1186\/1756-0500-3-260","journal-title":"BMC Res Notes"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45565-0","article-title":"Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India","volume":"53","author":"Jain A","year":"2004","unstructured":"Jain A, Agarwal J, Bansal S. Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India. J Med Microbiol. 2004, 53:941-4. 10.1099\/jmm.0.45565-0","journal-title":"J Med Microbiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.11025","article-title":"Methicillin and vancomycin resistance in coagulase-negative staphylococci isolated from the nostrils of hospitalized patients","volume":"14","author":"Al-Tamimi M","year":"2020","unstructured":"Al-Tamimi M, Abu-Raideh J, Himsawi N, Khasawneh A, Hawamdeh H. Methicillin and vancomycin resistance in coagulase-negative staphylococci isolated from the nostrils of hospitalized patients. J Infect Dev Ctries. 2020, 14:28-35. 10.3855\/jidc.11025","journal-title":"J Infect Dev Ctries"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-006-0502-7","article-title":"Characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus: a new type of MRSA","volume":"13","author":"Hososaka Y","year":"2007","unstructured":"Hososaka Y, Hanaki H, Endo H, et al.. Characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus: a new type of MRSA. J Infect Chemother. 2007, 13:79-86. 10.1007\/s10156-006-0502-7","journal-title":"J Infect Chemother"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs13205-017-0753-2","article-title":"Virulence factors associated with coagulase negative staphylococci isolated from human infections","volume":"7","author":"Soumya KR","year":"2017","unstructured":"Soumya KR, Philip S, Sugathan S, Mathew J, Radhakrishnan EK. Virulence factors associated with coagulase negative staphylococci isolated from human infections. 3 Biotech. 2017, 7:140. 10.1007%2Fs13205-017-0753-2","journal-title":"3 Biotech"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0732-8893(01)00345-5","article-title":"Simultaneous detection of the mecA and ileS-2 genes in coagulase-negative staphylococci isolated from Brazilian hospitals by multiplex PCR","volume":"42","author":"Ferreira RB","year":"2002","unstructured":"Ferreira RB, Nunes AP, Kokis VM, et al.. Simultaneous detection of the mecA and ileS-2 genes in coagulase-negative staphylococci isolated from Brazilian hospitals by multiplex PCR. Diagn Microbiol Infect Dis. 2002, 42:205-12. 10.1016\/s0732-8893(01)00345-5","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mjafi.2016.07.009","article-title":"Drug sensitivity pattern of various Staphylococcus species isolated at a tertiary care hospital","volume":"72","author":"Singh L","year":"2016","unstructured":"Singh L, Cariappa MP, Das NK. Drug sensitivity pattern of various Staphylococcus species isolated at a tertiary care hospital. Med J Armed Forces India. 2016, 72:62-6. 10.1016%2Fj.mjafi.2016.07.009","journal-title":"Med J Armed Forces India"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2019.0395","article-title":"Prevalence and molecular determinants of antimicrobial resistance in clinical isolates of Staphylococcus haemolyticus from India","volume":"27","author":"Manoharan M","year":"2021","unstructured":"Manoharan M, Sistla S, Ray P. Prevalence and molecular determinants of antimicrobial resistance in clinical isolates of Staphylococcus haemolyticus from India. Microb Drug Resist. 2021, 27:501-8. 10.1089\/mdr.2019.0395","journal-title":"Microb Drug Resist"},{"key":"ref19","article-title":"Speciation and antibiogram of coagulase-negative staphylococci (CoNS) in a tertiary care hospital","volume":"5","author":"Jayakumar R","year":"2018","unstructured":"Jayakumar R, Aurumugam V, Srinivasagam M. Speciation and antibiogram of coagulase-negative staphylococci (CoNS) in a tertiary care hospital. Indian J Micro Res. 2018, 5:194-7.","journal-title":"Indian J Micro Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.18502%2Fijm.v13i1.5489","article-title":"Comparison of PCR and phenotypic methods for the detection of methicillin resistant Staphylococcus aureus","volume":"13","author":"Madhavan A","year":"2021","unstructured":"Madhavan A, Sachu A, Balakrishnan A, Vasudevan A, Balakrishnan S, Vasudevapanicker J. Comparison of PCR and phenotypic methods for the detection of methicillin resistant Staphylococcus aureus. Iran J Microbiol. 2021, 13:31-6. 10.18502%2Fijm.v13i1.5489","journal-title":"Iran J Microbiol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3609-3614.2003","article-title":"Coagulase-negative staphylococci: comparison of phenotypic and genotypic oxacillin susceptibility tests and evaluation of the agar screening test by using different concentrations of oxacillin","volume":"41","author":"Ferreira RB","year":"2003","unstructured":"Ferreira RB, Iorio NL, Malvar KL, Nunes AP, Fonseca LS, Bastos CC, Santos KR. Coagulase-negative staphylococci: comparison of phenotypic and genotypic oxacillin susceptibility tests and evaluation of the agar screening test by using different concentrations of oxacillin. J Clin Microbiol. 2003, 41:3609-14. 10.1128\/JCM.41.8.3609-3614.2003","journal-title":"J Clin Microbiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1590\/s1413-86702008000400012","article-title":"Identification and detection of methicillin resistance in non-epidermidis coagulase-negative staphylococci","volume":"12","author":"Secchi C","year":"2008","unstructured":"Secchi C, Antunes AL, Perez LR, Cantarelli VV, d'Azevedo PA. Identification and detection of methicillin resistance in non-epidermidis coagulase-negative staphylococci. Braz J Infect Dis. 2008, 12:316-20. 10.1590\/s1413-86702008000400012","journal-title":"Braz J Infect Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318060cc03","article-title":"Clinical and molecular epidemiologic characteristics of coagulase-negative staphylococcal bloodstream infections in intensive care neonates","volume":"26","author":"Hira V","year":"2007","unstructured":"Hira V, Sluijter M, Estev\u00e3o S, et al.. Clinical and molecular epidemiologic characteristics of coagulase-negative staphylococcal bloodstream infections in intensive care neonates. Pediatr Infect Dis J. 2007, 26:607-12. 10.1097\/INF.0b013e318060cc03","journal-title":"Pediatr Infect Dis J"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.12980%2FAPJTB.4.2014C423","article-title":"PCR-based identification of methicillin-resistant Staphylococcus aureus strains and their antibiotic resistance profiles","volume":"4","author":"Pournajaf A","year":"2014","unstructured":"Pournajaf A, Ardebili A, Goudarzi L, Khodabandeh M, Narimani T, Abbaszadeh H. PCR-based identification of methicillin-resistant Staphylococcus aureus strains and their antibiotic resistance profiles. Asian Pac J Trop Biomed. 2014, 4:293. 10.12980%2FAPJTB.4.2014C423","journal-title":"Asian Pac J Trop Biomed"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.1.111","article-title":"Comparison of PCR detection of mecA with methicillin and oxacillin disc susceptibility testing in coagulase-negative staphylococci","volume":"45","author":"Graham JC","year":"2000","unstructured":"Graham JC, Murphy OM, Stewart D, Kearns AM, Galloway A, Freeman R. Comparison of PCR detection of mecA with methicillin and oxacillin disc susceptibility testing in coagulase-negative staphylococci. J Antimicrob Chemother. 2000, 45:111-3. 10.1093\/jac\/45.1.111","journal-title":"J Antimicrob Chemother"},{"key":"ref26","article-title":"Methicillin-resistant Staphylococcus epidermidis in infection of hip arthroplasties","volume":"76","author":"James PJ","year":"1994","unstructured":"James PJ, Butcher IA, Gardner ER, Hamblen DL. Methicillin-resistant Staphylococcus epidermidis in infection of hip arthroplasties. J Bone Joint Surg Br. 1994, 76:725-7.","journal-title":"J Bone Joint Surg Br"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v17i4.7","article-title":"Prevalence of mecA gene among staphylococci from clinical samples of a tertiary hospital in Benin City, Nigeria","volume":"17","author":"Ibadin EE","year":"2017","unstructured":"Ibadin EE, Enabulele IO, Muinah F. Prevalence of mecA gene among staphylococci from clinical samples of a tertiary hospital in Benin City, Nigeria. Afr Health Sci. 2017, 17:1000-10. 10.4314\/ahs.v17i4.7","journal-title":"Afr Health Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/294836-detection-of-the-meca-gene-and-its-association-with-antimicrobial-resistance-among-coagulase-negative-staphylococci-isolated-from-clinical-samples-in-a-tertiary-care-hospital-a-cross-sectional-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T09:17:47Z","timestamp":1743671867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/294836-detection-of-the-meca-gene-and-its-association-with-antimicrobial-resistance-among-coagulase-negative-staphylococci-isolated-from-clinical-samples-in-a-tertiary-care-hospital-a-cross-sectional-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.81643","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,3]]}}}