{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:27:19Z","timestamp":1789345639991,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,11]]},"DOI":"10.7759\/cureus.82074","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:34:11Z","timestamp":1744371251000},"source":"Crossref","is-referenced-by-count":1,"title":["The Role of Anesthesia in Sedation and Weaning From Mechanical Ventilation: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Majed M","family":"Madkhali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manssour M","family":"Alfaifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman Y","family":"Safhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser M","family":"Shmakhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwa H","family":"Alammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed M","family":"Qaysi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaal A","family":"Hamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleha M","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad A","family":"Rajhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roaa G","family":"Shaikhain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman  F","family":"Alsubaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed N","family":"Alazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa M","family":"Hadaddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.05.004","article-title":"Mechanical ventilation: state of the art","volume":"92","author":"Pham T","year":"2017","unstructured":"Pham T, Brochard LJ, Slutsky AS. Mechanical ventilation: state of the art. Mayo Clin Proc. 2017, 92:1382-400. 10.1016\/j.mayocp.2017.05.004","journal-title":"Mayo Clin Proc"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707","article-title":"Ventilator-induced lung injury","volume":"369","author":"Slutsky AS","year":"2013","unstructured":"Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med. 2013, 369:2126-36. 10.1056\/NEJMra1208707","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182783b72","article-title":"Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit","volume":"41","author":"Barr J","year":"2013","unstructured":"Barr J, Fraser GL, Puntillo K, et al.. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013, 41:263-306. 10.1097\/CCM.0b013e3182783b72","journal-title":"Crit Care Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical practice guidelines for the prevention and management of pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"46","author":"Devlin JW","year":"2018","unstructured":"Devlin JW, Skrobik Y, G\u00e9linas C, et al.. Clinical practice guidelines for the prevention and management of pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018, 46:e825-73. 10.1097\/CCM.0000000000003299","journal-title":"Crit Care Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2830-2","article-title":"Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study","volume":"39","author":"Shehabi Y","year":"2013","unstructured":"Shehabi Y, Chan L, Kadiman S, et al.. Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med. 2013, 39:910-8. 10.1007\/s00134-013-2830-2","journal-title":"Intensive Care Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a168c5","article-title":"Daily sedation interruption versus targeted light sedation strategies in ICU patients","volume":"41","author":"Hughes CG","year":"2013","unstructured":"Hughes CG, Girard TD, Pandharipande PP. Daily sedation interruption versus targeted light sedation strategies in ICU patients. Crit Care Med. 2013, 41:S39-45. 10.1097\/CCM.0b013e3182a168c5","journal-title":"Crit Care Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a16898","article-title":"Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials","volume":"41","author":"Fraser GL","year":"2013","unstructured":"Fraser GL, Devlin JW, Worby CP, et al.. Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials. Crit Care Med. 2013, 41:S30-8. 10.1097\/CCM.0b013e3182a16898","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.56","article-title":"Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial","volume":"301","author":"Riker RR","year":"2009","unstructured":"Riker RR, Shehabi Y, Bokesch PM, et al.. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009, 301:489-99. 10.1001\/jama.2009.56","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1906759","article-title":"Nonsedation or light sedation in critically ill, mechanically ventilated patients","volume":"382","author":"Olsen HT","year":"2020","unstructured":"Olsen HT, Nedergaard HK, Str\u00f8m T, et al.. Nonsedation or light sedation in critically ill, mechanically ventilated patients. N Engl J Med. 2020, 382:1103-11. 10.1056\/NEJMoa1906759","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.22.2644","article-title":"Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial","volume":"298","author":"Pandharipande PP","year":"2007","unstructured":"Pandharipande PP, Pun BT, Herr DL, et al.. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007, 298:2644-53. 10.1001\/jama.298.22.2644","journal-title":"JAMA"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.304","article-title":"Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials","volume":"307","author":"Jakob SM","year":"2012","unstructured":"Jakob SM, Ruokonen E, Grounds RM, et al.. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012, 307:1151-60. 10.1001\/jama.2012.304","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043382846","article-title":"Propofol: therapeutic indications and side-effects","volume":"10","author":"Marik PE","year":"2004","unstructured":"Marik PE. Propofol: therapeutic indications and side-effects. Curr Pharm Des. 2004, 10:3639-49. 10.2174\/1381612043382846","journal-title":"Curr Pharm Des"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208705","article-title":"Sedation and delirium in the intensive care unit","volume":"370","author":"Reade MC","year":"2014","unstructured":"Reade MC, Finfer S. Sedation and delirium in the intensive care unit. N Engl J Med. 2014, 370:444-54. 10.1056\/NEJMra1208705","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904710","article-title":"Early sedation with dexmedetomidine in critically ill patients","volume":"380","author":"Shehabi Y","year":"2019","unstructured":"Shehabi Y, Howe BD, Bellomo R, et al.. Early sedation with dexmedetomidine in critically ill patients. N Engl J Med. 2019, 380:2506-17. 10.1056\/NEJMoa1904710","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03967-5","article-title":"Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study","volume":"26","author":"Zhou Y","year":"2022","unstructured":"Zhou Y, Yang J, Wang B, et al.. Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study. Crit Care. 2022, 26:122. 10.1186\/s13054-022-03967-5","journal-title":"Crit Care"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1386-2","article-title":"Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study","volume":"20","author":"Conti G","year":"2016","unstructured":"Conti G, Ranieri VM, Costa R, et al.. Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study. Crit Care. 2016, 20:206. 10.1186\/s13054-016-1386-2","journal-title":"Crit Care"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/cc11250","article-title":"Replacement of fentanyl infusion by enteral methadone decreases the weaning time from mechanical ventilation: a randomized controlled trial","volume":"16","author":"Wanzuita R","year":"2012","unstructured":"Wanzuita R, Poli-de-Figueiredo LF, Pfuetzenreiter F, Cavalcanti AB, Westphal GA. Replacement of fentanyl infusion by enteral methadone decreases the weaning time from mechanical ventilation: a randomized controlled trial. Crit Care. 2012, 16:R49. 10.1186\/cc11250","journal-title":"Crit Care"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377","article-title":"The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions","volume":"52","author":"Downs SH","year":"1998","unstructured":"Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998, 52:377-84. 10.1136\/jech.52.6.377","journal-title":"J Epidemiol Community Health"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-0636-2","article-title":"Effect of sedation regimen on weaning from mechanical ventilation in the intensive care unit","volume":"38","author":"Nunes SL","year":"2018","unstructured":"Nunes SL, Forsberg S, Blomqvist H, Berggren L, S\u00f6rberg M, Sarapohja T, Wickerts CJ. Effect of sedation regimen on weaning from mechanical ventilation in the intensive care unit. Clin Drug Investig. 2018, 38:535-43. 10.1007\/s40261-018-0636-2","journal-title":"Clin Drug Investig"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1003800115","article-title":"The effect of dexmedetomidine on agitation during weaning of mechanical ventilation in critically ill patients","volume":"38","author":"Shehabi Y","year":"2010","unstructured":"Shehabi Y, Nakae H, Hammond N, Bass F, Nicholson L, Chen J. The effect of dexmedetomidine on agitation during weaning of mechanical ventilation in critically ill patients. Anaesth Intensive Care. 2010, 38:82-90. 10.1177\/0310057X1003800115","journal-title":"Anaesth Intensive Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/360524-the-role-of-anesthesia-in-sedation-and-weaning-from-mechanical-ventilation-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:34:11Z","timestamp":1744371251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/360524-the-role-of-anesthesia-in-sedation-and-weaning-from-mechanical-ventilation-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.82074","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,11]]}}}