{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T04:06:17Z","timestamp":1744517177628,"version":"3.40.4"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,11]]},"DOI":"10.7759\/cureus.82117","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:34:18Z","timestamp":1744432458000},"source":"Crossref","is-referenced-by-count":0,"title":["Tirofiban-Induced Profound Thrombocytopenia: A Case Report"],"prefix":"10.7759","author":[{"given":"Zeina","family":"Al Achkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fakhoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama F","family":"Zeindeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annoir","family":"Shayya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C338","article-title":"Glycoprotein IIb\/IIIa receptor inhibitors in percutaneous coronary intervention and acute coronary syndrome","volume":"37","author":"Crouch MA","year":"2003","unstructured":"Crouch MA, Nappi JM, Cheang KI. Glycoprotein IIb\/IIIa receptor inhibitors in percutaneous coronary intervention and acute coronary syndrome. Ann Pharmacother. 2003, 37:860-75. 10.1345\/aph.1C338","journal-title":"Ann Pharmacother"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Lawton JS","year":"2022","unstructured":"Lawton JS, Tamis-Holland JE, Bangalore S, et al.. 2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022, 145:e18-e114. 10.1161\/CIR.0000000000001038","journal-title":"Circulation"},{"key":"ref3","unstructured":"MedWatch. The FDA Safety Information and Adverse Event Reporting Program. (2024). Accessed: May 31, 2024: https:\/\/www.fda.gov\/safety\/medwatch-fda-safety-information-and-adverse-event-reporting-program."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2020.1747783","article-title":"Tirofiban-induced thrombocytopenia: a rare but severe adverse effect","volume":"10","author":"Rawala MS","year":"2020","unstructured":"Rawala MS, Ahmed AS, Posina K, Sundaram V. Tirofiban-induced thrombocytopenia: a rare but severe adverse effect. J Community Hosp Intern Med Perspect. 2020, 10:171-3. 10.1080\/20009666.2020.1747783","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.08.066","article-title":"Frequency and management of thrombocytopenia with the glycoprotein IIb\/IIIa receptor antagonists","volume":"97","author":"Huxtable LM","year":"2006","unstructured":"Huxtable LM, Tafreshi MJ, Rakkar AN. Frequency and management of thrombocytopenia with the glycoprotein IIb\/IIIa receptor antagonists. Am J Cardiol. 2006, 97:426-9. 10.1016\/j.amjcard.2005.08.066","journal-title":"Am J Cardiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.V100.6.2071","article-title":"Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb\/IIIa","volume":"100","author":"Bougie DW","year":"2002","unstructured":"Bougie DW, Wilker PR, Wuitschick ED, et al.. Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb\/IIIa. Blood. 2002, 100:2071-6. 10.1182\/BLOOD.V100.6.2071","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01829.x","article-title":"Thrombocytopenia associated with the use of GPIIb\/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb\/IIIa inhibitors","volume":"4","author":"Aster RH","year":"2006","unstructured":"Aster RH, Curtis BR, Bougie DW, Dunkley S, Greinacher A, Warkentin TE, Chong BH. Thrombocytopenia associated with the use of GPIIb\/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb\/IIIa inhibitors. J Thromb Haemost. 2006, 4:678-9. 10.1111\/j.1538-7836.2006.01829.x","journal-title":"J Thromb Haemost"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00252-6","article-title":"Occurrence and clinical significance of thrombocytopenia in a population undergoing high-risk percutaneous coronary revascularization","volume":"32","author":"Berkowitz SD","year":"1998","unstructured":"Berkowitz SD, Sane DC, Sigmon KN, et al.. Occurrence and clinical significance of thrombocytopenia in a population undergoing high-risk percutaneous coronary revascularization. J Am Coll Cardiol. 1998, 32:311-9. 10.1016\/s0735-1097(98)00252-6","journal-title":"J Am Coll Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.8.938","article-title":"Images in cardiovascular medicine. Abciximab-associated pseudothrombocytopenia","volume":"101","author":"Holmes MB","year":"2000","unstructured":"Holmes MB, Kabbani S, Watkins MW, Battle RW, Schneider DJ. Images in cardiovascular medicine. Abciximab-associated pseudothrombocytopenia. Circulation. 2000, 101:938-9. 10.1161\/01.cir.101.8.938","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.696749","article-title":"Profound thrombocytopenia related with tirofiban: will it be enough to only stop medicine?","volume":"24","author":"Teke H\u00dc","year":"2013","unstructured":"Teke H\u00dc, Teke D. Profound thrombocytopenia related with tirofiban: will it be enough to only stop medicine?. Platelets. 2013, 24:335-7. 10.3109\/09537104.2012.696749","journal-title":"Platelets"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.059188","article-title":"Heparin induced thrombocytopenia: diagnosis and management update","volume":"83","author":"Ahmed I","year":"2007","unstructured":"Ahmed I, Majeed A, Powell R. Heparin induced thrombocytopenia: diagnosis and management update. Postgrad Med J. 2007, 83:575-82. 10.1136\/pgmj.2007.059188","journal-title":"Postgrad Med J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422402","article-title":"Thrombotic thrombocytopenic purpura associated with clopidogrel","volume":"342","author":"Bennett CL","year":"2000","unstructured":"Bennett CL, Connors JM, Carwile JM, et al.. Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med. 2000, 342:1773-7. 10.1056\/NEJM200006153422402","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200210000-00017","article-title":"Platelet glycoprotein IIb\/IIIa inhibitors: overview and implications for the anesthesiologist","volume":"95","author":"Chun R","year":"2002","unstructured":"Chun R, Orser BA, Madan M. Platelet glycoprotein IIb\/IIIa inhibitors: overview and implications for the anesthesiologist. Anesth Analg. 2002, 95:879-88. 10.1213\/00000539-200210000-00017","journal-title":"Anesth Analg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.6-5-446","article-title":"New strategies for prophylactic platelet transfusion in patients with hematologic diseases","volume":"6","author":"Wandt H","year":"2001","unstructured":"Wandt H, Ehninger G, Gallmeier WM. New strategies for prophylactic platelet transfusion in patients with hematologic diseases. Oncologist. 2001, 6:446-50. 10.1634\/theoncologist.6-5-446","journal-title":"Oncologist"},{"key":"ref15","article-title":"Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000\/microL versus 20,000\/microL","volume":"83","author":"Navarro JT","year":"1998","unstructured":"Navarro JT, Hern\u00e1ndez JA, Ribera JM, et al.. Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000\/microL versus 20,000\/microL. Haematologica. 1998, 83:998-1000.","journal-title":"Haematologica"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02440.x","article-title":"A case of profound and prolonged tirofiban-induced thrombocytopenia and its correction by intravenous immunoglobulin G","volume":"5","author":"Clofent-Sanchez G","year":"2007","unstructured":"Clofent-Sanchez G, Harizi H, Nurden A, Coste P, Jais C, Nurden P. A case of profound and prolonged tirofiban-induced thrombocytopenia and its correction by intravenous immunoglobulin G. J Thromb Haemost. 2007, 5:1068-70. 10.1111\/j.1538-7836.2007.02440.x","journal-title":"J Thromb Haemost"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127867.41621.85","article-title":"Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting","volume":"109","author":"Merlini PA","year":"2004","unstructured":"Merlini PA, Rossi M, Menozzi A, et al.. Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting. Circulation. 2004, 109:2203-6. 10.1161\/01.CIR.0000127867.41621.85","journal-title":"Circulation"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/356281-tirofiban-induced-profound-thrombocytopenia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:34:21Z","timestamp":1744432461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/356281-tirofiban-induced-profound-thrombocytopenia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.82117","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,11]]}}}