{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:07:34Z","timestamp":1744862854138,"version":"3.40.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,16]]},"DOI":"10.7759\/cureus.82348","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:46:31Z","timestamp":1744793191000},"source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up"],"prefix":"10.7759","author":[{"given":"Toshihiko","family":"Matsuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Asada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Obika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Omichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10102118","article-title":"Rheumatoid arthritis associated episcleritis and scleritis: an update on treatment perspectives","volume":"10","author":"Promelle V","year":"2021","unstructured":"Promelle V, Goeb V, Gueudry J. Rheumatoid arthritis associated episcleritis and scleritis: an update on treatment perspectives. J Clin Med. 2021, 10:2118. 10.3390\/jcm10102118","journal-title":"J Clin Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-006-0408-z","article-title":"Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: case series and literature review","volume":"51","author":"Matsuo T","year":"2007","unstructured":"Matsuo T. Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: case series and literature review. Jpn J Ophthalmol. 2007, 51:131-8. 10.1007\/s10384-006-0408-z","journal-title":"Jpn J Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7595","article-title":"ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: case report and literature review","volume":"11","author":"Matsuo T","year":"2023","unstructured":"Matsuo T, Hiramatsu-Asano S, Sawachika H, Nishimura H. ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: case report and literature review. Clin Case Rep. 2023, 11:e7595. 10.1002\/ccr3.7595","journal-title":"Clin Case Rep"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i32.5836","article-title":"Ophthalmic manifestations in patients with inflammatory bowel disease: a review","volume":"23","author":"Troncoso LL","year":"2017","unstructured":"Troncoso LL, Biancardi AL, de Moraes HV Jr, Zaltman C. Ophthalmic manifestations in patients with inflammatory bowel disease: a review. World J Gastroenterol. 2017, 23:5836-48. 10.3748\/wjg.v23.i32.5836","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2000.078002228.x","article-title":"Bilateral necrotizing scleritis and blindness in the myelodysplastic syndrome presumably due to relapsing polychondritis","volume":"78","author":"Loeffler KU","year":"2000","unstructured":"Loeffler KU, McLean IW. Bilateral necrotizing scleritis and blindness in the myelodysplastic syndrome presumably due to relapsing polychondritis. Acta Ophthalmol Scand. 2000, 78:228-31. 10.1034\/j.1600-0420.2000.078002228.x","journal-title":"Acta Ophthalmol Scand"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(02)01165-x","article-title":"Ocular and extracutaneous involvement in pyoderma gangrenosum","volume":"109","author":"Miserocchi E","year":"2002","unstructured":"Miserocchi E, Modorati G, Foster CS, Brancato R. Ocular and extracutaneous involvement in pyoderma gangrenosum. Ophthalmology. 2002, 109:1941-3. 10.1016\/s0161-6420(02)01165-x","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01912-1","article-title":"Extracutaneous involvement of pyoderma gangrenosum","volume":"311","author":"Borda LJ","year":"2019","unstructured":"Borda LJ, Wong LL, Marzano AV, Ortega-Loayza AG. Extracutaneous involvement of pyoderma gangrenosum. Arch Dermatol Res. 2019, 311:425-34. 10.1007\/s00403-019-01912-1","journal-title":"Arch Dermatol Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(94)70215-2","article-title":"Sweet\u2019s syndrome (acute febrile neutrophilic dermatosis)","volume":"31","author":"von den Driesch P","year":"1994","unstructured":"von den Driesch P. Sweet\u2019s syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol. 1994, 31:535-56. 10.1016\/s0190-9622(94)70215-2","journal-title":"J Am Acad Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-34","article-title":"Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis","volume":"2","author":"Cohen PR","year":"2007","unstructured":"Cohen PR. Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis. 2007, 2:34. 10.1186\/1750-1172-2-34","journal-title":"Orphanet J Rare Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.02.006","article-title":"Ocular involvement in acute febrile neutrophilic dermatosis (Sweet syndrome): new cases and review of the literature","volume":"53","author":"Gottlieb CC","year":"2008","unstructured":"Gottlieb CC, Mishra A, Belliveau D, Green P, Heathcote JG. Ocular involvement in acute febrile neutrophilic dermatosis (Sweet syndrome): new cases and review of the literature. Surv Ophthalmol. 2008, 53:219-26. 10.1016\/j.survophthal.2008.02.006","journal-title":"Surv Ophthalmol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000357729","article-title":"Sight-threatening ocular manifestations of acute febrile neutrophilic dermatosis (Sweet's syndrome)","volume":"228","author":"Baartman B","year":"2014","unstructured":"Baartman B, Kosari P, Warren CC, Ali S, Jorizzo JL, Sato M, Kurup SK. Sight-threatening ocular manifestations of acute febrile neutrophilic dermatosis (Sweet's syndrome). Dermatology. 2014, 228:193-7. 10.1159\/000357729","journal-title":"Dermatology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2010.509531","article-title":"Retinal vasoproliferative granulomatous lesion associated with hand pyoderma caused by Streptococcus pyogenes","volume":"19","author":"Matsuo T","year":"2011","unstructured":"Matsuo T, Tamaki M, Oono T. Retinal vasoproliferative granulomatous lesion associated with hand pyoderma caused by Streptococcus pyogenes. Ocul Immunol Inflamm. 2011, 19:58-61. 10.3109\/09273948.2010.509531","journal-title":"Ocul Immunol Inflamm"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13493","article-title":"The genetics of pyoderma gangrenosum and implications for treatment: a systematic review","volume":"172","author":"DeFilippis EM","year":"2015","unstructured":"DeFilippis EM, Feldman SR, Huang WW. The genetics of pyoderma gangrenosum and implications for treatment: a systematic review. Br J Dermatol. 2015, 172:1487-97. 10.1111\/bjd.13493","journal-title":"Br J Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.032","article-title":"Pyoderma gangrenosum in hematologic malignancies: a systematic review","volume":"82","author":"Montagnon CM","year":"2020","unstructured":"Montagnon CM, Fracica EA, Patel AA, et al.. Pyoderma gangrenosum in hematologic malignancies: a systematic review. J Am Acad Dermatol. 2020, 82:1346-59. 10.1016\/j.jaad.2019.09.032","journal-title":"J Am Acad Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.5.643","article-title":"Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome","volume":"144","author":"Hamada T","year":"2008","unstructured":"Hamada T, Matsuura H, Oono T, et al.. Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome. Arch Dermatol. 2008, 144:643-8. 10.1001\/archderm.144.5.643","journal-title":"Arch Dermatol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2020.106461","article-title":"Sweet's syndrome associated with hematological malignancies","volume":"99","author":"Maller B","year":"2020","unstructured":"Maller B, Bigness A, Moi\u00f1o D, Greene J. Sweet's syndrome associated with hematological malignancies. Leuk Res. 2020, 99:106461. 10.1016\/j.leukres.2020.106461","journal-title":"Leuk Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.343","article-title":"Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort","volume":"106","author":"Vavricka SR","year":"2011","unstructured":"Vavricka SR, Brun L, Ballabeni P, et al.. Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort. Am J Gastroenterol. 2011, 106:110-9. 10.1038\/ajg.2010.343","journal-title":"Am J Gastroenterol"},{"key":"ref18","article-title":"The association of Beh\u00e7et's disease with myelodysplastic syndrome in Japan: a review of the literature","volume":"24","author":"Tada Y","year":"2006","unstructured":"Tada Y, Koarada S, Haruta Y, Mitamura M, Ohta A, Nagasawa K. The association of Beh\u00e7et's disease with myelodysplastic syndrome in Japan: a review of the literature. Clin Exp Rheumatol. 2006, 24:S115-9.","journal-title":"Clin Exp Rheumatol"},{"key":"ref19","article-title":"A reappraisal of the association between Beh\u00e7et's disease, myelodysplastic syndrome and the presence of trisomy 8: a systematic literature review","volume":"33","author":"Esatoglu SN","year":"2015","unstructured":"Esatoglu SN, Hatemi G, Salihoglu A, Hatemi I, Soysal T, Celik AF. A reappraisal of the association between Beh\u00e7et's disease, myelodysplastic syndrome and the presence of trisomy 8: a systematic literature review. Clin Exp Rheumatol. 2015, 33:S145-51.","journal-title":"Clin Exp Rheumatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26984","article-title":"Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Garcia-Manero G","year":"2023","unstructured":"Garcia-Manero G. Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management. Am J Hematol. 2023, 98:1307-25. 10.1002\/ajh.26984","journal-title":"Am J Hematol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000242685.55001.67","article-title":"Diffuse bone marrow uptake on F-18 FDG PET in patients with myelodysplastic syndromes","volume":"31","author":"Inoue K","year":"2006","unstructured":"Inoue K, Okada K, Harigae H, et al.. Diffuse bone marrow uptake on F-18 FDG PET in patients with myelodysplastic syndromes. Clin Nucl Med. 2006, 31:721-3. 10.1097\/01.rlu.0000242685.55001.67","journal-title":"Clin Nucl Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1720979","article-title":"Hemorrhage in essential thrombocythemia or polycythemia vera: epidemiology, location, risk factors, and lessions learned from the literature","volume":"121","author":"Nicol C","year":"2021","unstructured":"Nicol C, Lacut K, Pan-Petesch B, Lippert E, Ianotto JC. Hemorrhage in essential thrombocythemia or polycythemia vera: epidemiology, location, risk factors, and lessions learned from the literature. Thromb Haemost. 2021, 121:553-64. 10.1055\/s-0040-1720979","journal-title":"Thromb Haemost"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2013119","article-title":"Isolated deletion of the long arm of chromosome 20 [del(20q12)] in myelodysplastic syndrome: a case report and literature review","volume":"54","author":"Padhi S","year":"2013","unstructured":"Padhi S, Varghese RG, Phansalkar MD, Sarangi R. Isolated deletion of the long arm of chromosome 20 [del(20q12)] in myelodysplastic syndrome: a case report and literature review. Singapore Med J. 2013, 54:e185-9. 10.11622\/smedj.2013119","journal-title":"Singapore Med J"},{"key":"ref24","article-title":"Myelodysplastic syndrome with fibrosis and complex karyotype arising in a patient with essential thrombocythaemia","volume":"40","author":"Mansor NA","year":"2018","unstructured":"Mansor NA, Yusof N, Tang YL, Ithnin A, Azma RZ, Tumian NR, Shuib S. Myelodysplastic syndrome with fibrosis and complex karyotype arising in a patient with essential thrombocythaemia. Malays J Pathol. 2018, 40:191-7.","journal-title":"Malays J Pathol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.431","article-title":"Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea-induced t-MDS\/AML","volume":"4","author":"Horton JD","year":"2016","unstructured":"Horton JD, Arbini AA, Perle MA, Raphael BG. Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea-induced t-MDS\/AML. Clin Case Rep. 2016, 4:46-50. 10.1002\/ccr3.431","journal-title":"Clin Case Rep"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000163","article-title":"Myelodysplastic syndrome\/myeloproliferative neoplasm overlap syndromes: a focused review","volume":"2020","author":"Patnaik MM","year":"2020","unstructured":"Patnaik MM, Lasho T. Myelodysplastic syndrome\/myeloproliferative neoplasm overlap syndromes: a focused review. Hematology Am Soc Hematol Educ Program. 2020, 2020:460-4. 10.1182\/hematology.2020000163","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.18037","article-title":"Myelodysplastic\/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS\/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis","volume":"59","author":"Aoyama Y","year":"2019","unstructured":"Aoyama Y, Sakai K, Kodaka T, et al.. Myelodysplastic\/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS\/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis. J Clin Exp Hematop. 2019, 59:29-33. 10.3960\/jslrt.18037","journal-title":"J Clin Exp Hematop"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1324258","article-title":"Neutrophilic and eosinophilic dermatoses associated with hematological malignancy","volume":"10","author":"Maronese CA","year":"2023","unstructured":"Maronese CA, Derlino F, Moltrasio C, Cattaneo D, Iurlo A, Marzano AV. Neutrophilic and eosinophilic dermatoses associated with hematological malignancy. Front Med (Lausanne). 2023, 10:1324258. 10.3389\/fmed.2023.1324258","journal-title":"Front Med (Lausanne)"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15050","article-title":"VEXAS syndrome: a review of cutaneous findings and treatments in an emerging autoinflammatory disease","volume":"33","author":"Saad AJ","year":"2024","unstructured":"Saad AJ, Patil MK, Cruz N, Lam CS, O'Brien C, Nambudiri VE. VEXAS syndrome: a review of cutaneous findings and treatments in an emerging autoinflammatory disease. Exp Dermatol. 2024, 33:e15050. 10.1111\/exd.15050","journal-title":"Exp Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/358067-bilateral-scleritis-and-neutrophilic-dermatosis-with-cytogenetic-chromosomal-aberrancy-related-to-pyoderma-gangrenosum-a-case-report-of-a-20-year-follow-up","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:46:32Z","timestamp":1744793192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/358067-bilateral-scleritis-and-neutrophilic-dermatosis-with-cytogenetic-chromosomal-aberrancy-related-to-pyoderma-gangrenosum-a-case-report-of-a-20-year-follow-up"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.82348","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,16]]}}}