{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:13:03Z","timestamp":1744949583457,"version":"3.40.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,17]]},"DOI":"10.7759\/cureus.82420","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T09:54:46Z","timestamp":1744883686000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Treatment Outcomes of Vitamin B12 and Folic Acid Supplementation in Obsessive-Compulsive Disorder Patients With Deficiencies: A Comparative Analysis"],"prefix":"10.7759","author":[{"given":"Sultana","family":"Algin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanbir","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Munaim","family":"Reza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Akter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusrat Jahan","family":"Tanzilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Ahsanul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahnuma","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miral","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mainul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12195","article-title":"Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings","volume":"68","author":"Nakao T","year":"2014","unstructured":"Nakao T, Okada K, Kanba S. Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin Neurosci. 2014, 68:587-605. 10.1111\/pcn.12195","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx088","article-title":"Mapping compulsivity in the DSM-5 obsessive compulsive and related disorders: Cognitive domains, neural circuitry, and treatment","volume":"21","author":"Fineberg NA","year":"2018","unstructured":"Fineberg NA, Apergis-Schoute AM, Vaghi MM, et al.. Mapping compulsivity in the DSM-5 obsessive compulsive and related disorders: Cognitive domains, neural circuitry, and treatment. Int J Neuropsychopharmacol. 2018, 21:42-58. 10.1093\/ijnp\/pyx088","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02433-2","article-title":"The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis","volume":"13","author":"Blanco-Vieira T","year":"2023","unstructured":"Blanco-Vieira T, Radua J, Marcelino L, Bloch M, Mataix-Cols D, do Ros\u00e1rio MC. The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis. Transl Psychiatry. 2023, 13:230. 10.1038\/s41398-023-02433-2","journal-title":"Transl Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13101453","article-title":"Duration of untreated illness in patients with obsessive-compulsive disorder and its impact on long-term outcome: a systematic review","volume":"13","author":"Perris F","year":"2023","unstructured":"Perris F, Cipolla S, Catapano P, et al.. Duration of untreated illness in patients with obsessive-compulsive disorder and its impact on long-term outcome: a systematic review. J Pers Med. 2023, 13:1453. 10.3390\/jpm13101453","journal-title":"J Pers Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.202000296","article-title":"Defining and addressing gaps in care for obsessive-compulsive disorder in the United States","volume":"72","author":"Senter MS","year":"2021","unstructured":"Senter MS, Patel SR, Dixon LB, Myers RW, Simpson HB. Defining and addressing gaps in care for obsessive-compulsive disorder in the United States. Psychiatr Serv. 2021, 72:784-93. 10.1176\/appi.ps.202000296","journal-title":"Psychiatr Serv"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-91618-4","article-title":"Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with drug-naive obsessive-compulsive disorder","volume":"15","author":"Ding Y","year":"2025","unstructured":"Ding Y, Lu S, Wang S, Wang Y, Wu C, Du Y, Fang J. Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with drug-naive obsessive-compulsive disorder. Sci Rep. 2025, 15:6703. 10.1038\/s41598-025-91618-4","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.79667","article-title":"Unraveling gender differences in obsessive-compulsive disorder: a focus on key micronutrients","volume":"17","author":"Algin S","year":"2025","unstructured":"Algin S, Sajib MW, Ahmed SN, et al.. Unraveling gender differences in obsessive-compulsive disorder: a focus on key micronutrients. Cureus. 2025, 17:e79667. 10.7759\/cureus.79667","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2019-100159","article-title":"Nutritional and herbal supplements in the treatment of obsessive compulsive disorder","volume":"33","author":"Kuygun Karc\u0131 C","year":"2020","unstructured":"Kuygun Karc\u0131 C, G\u00fcl Celik G. Nutritional and herbal supplements in the treatment of obsessive compulsive disorder. Gen Psychiatr. 2020, 33:e100159. 10.1136\/gpsych-2019-100159","journal-title":"Gen Psychiatr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.24869\/psyd.2019.69","article-title":"Double blind controlled study of adding folic acid to fluoxetine in the treatment of OCD","volume":"31","author":"Tural \u00dc","year":"2019","unstructured":"Tural \u00dc, \u00c7orap\u00e7\u0131o\u011flu A, Bo\u015fgelmez \u015e, K\u00f6ro\u011flu G, \u00dcnver H, Duman C, \u00d6nder E. Double blind controlled study of adding folic acid to fluoxetine in the treatment of OCD. Psychiatr Danub. 2019, 31:69-77. 10.24869\/psyd.2019.69","journal-title":"Psychiatr Danub"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.04.032","article-title":"Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder","volume":"254","author":"Esnafo\u011flu E","year":"2017","unstructured":"Esnafo\u011flu E, Yaman E. Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder. Psychiatry Res. 2017, 254:232-7. 10.1016\/j.psychres.2017.04.032","journal-title":"Psychiatry Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3473-4","article-title":"The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review","volume":"39","author":"Enderami A","year":"2018","unstructured":"Enderami A, Zarghami M, Darvishi-Khezri H. The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review. Neurol Sci. 2018, 39:1667-75. 10.1007\/s10072-018-3473-4","journal-title":"Neurol Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.754165","article-title":"Changes of serum homocysteine and vitamin B12, but not folate are correlated with obsessive-compulsive disorder: a systematic review and meta-analysis of case-control studies","volume":"13","author":"Yan S","year":"2022","unstructured":"Yan S, Liu H, Yu Y, Han N, Du W. Changes of serum homocysteine and vitamin B12, but not folate are correlated with obsessive-compulsive disorder: a systematic review and meta-analysis of case-control studies. Front Psychiatry. 2022, 13:754165. 10.3389\/fpsyt.2022.754165","journal-title":"Front Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S67668","article-title":"Vitamin B12, folate, and homocysteine levels in patients with obsessive-compulsive disorder","volume":"10","author":"T\u00fcrksoy N","year":"2014","unstructured":"T\u00fcrksoy N, Bilici R, Yal\u00e7\u0131ner A, Ozdemir Y\u00d6, Ornek I, Tufan AE, Kara A. Vitamin B12, folate, and homocysteine levels in patients with obsessive-compulsive disorder. Neuropsychiatr Dis Treat. 2014, 10:1671-5. 10.2147\/NDT.S67668","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000022","article-title":"The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis","volume":"47","author":"Firth J","year":"2017","unstructured":"Firth J, Stubbs B, Sarris J, Rosenbaum S, Teasdale S, Berk M, Yung AR. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychol Med. 2017, 47:1515-27. 10.1017\/S0033291717000022","journal-title":"Psychol Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2023.05.008","article-title":"Postpartum depression: aetiology, pathogenesis and the role of nutrients and dietary supplements in prevention and management","volume":"31","author":"Rupanagunta GP","year":"2023","unstructured":"Rupanagunta GP, Nandave M, Rawat D, Upadhyay J, Rashid S, Ansari MN. Postpartum depression: aetiology, pathogenesis and the role of nutrients and dietary supplements in prevention and management. Saudi Pharm J. 2023, 31:1274-93. 10.1016\/j.jsps.2023.05.008","journal-title":"Saudi Pharm J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2024.29.3.137","article-title":"Can supplementing vitamin B12 improve mental health outcomes?: a literature review","volume":"29","author":"Reis da Silva T","year":"2024","unstructured":"Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024, 29:137-46. 10.12968\/bjcn.2024.29.3.137","journal-title":"Br J Community Nurs"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpmh.2024.11.001","article-title":"Prediction of pharmacological response in OCD using machine learning techniques and clinical and neuropsychological variables","volume":"18","author":"Tub\u00edo-Fungueiri\u00f1o M","year":"2025","unstructured":"Tub\u00edo-Fungueiri\u00f1o M, Cernadas E, Fern\u00e1ndez-Delgado M, et al.. Prediction of pharmacological response in OCD using machine learning techniques and clinical and neuropsychological variables. Span J Psychiatry Ment Health. 2025, 18:51-7. 10.1016\/j.sjpmh.2024.11.001","journal-title":"Span J Psychiatry Ment Health"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721001744","article-title":"Genetics of obsessive-compulsive disorder","volume":"51","author":"Mahjani B","year":"2021","unstructured":"Mahjani B, Bey K, Boberg J, Burton C. Genetics of obsessive-compulsive disorder. Psychol Med. 2021, 51:2247-59. 10.1017\/S0033291721001744","journal-title":"Psychol Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/camh.12387","article-title":"The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents","volume":"25","author":"Esnafoglu E","year":"2020","unstructured":"Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020, 25:249-55. 10.1111\/camh.12387","journal-title":"Child Adolesc Ment Health"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v2.i6.86","article-title":"Obsessive-compulsive disorder: evidence-based treatments and future directions for research","volume":"2","author":"Lack CW","year":"2012","unstructured":"Lack CW. Obsessive-compulsive disorder: evidence-based treatments and future directions for research. World J Psychiatry. 2012, 2:86-90. 10.5498\/wjp.v2.i6.86","journal-title":"World J Psychiatry"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19ac13182","article-title":"Pharmacotherapy for treatment-resistant obsessive-compulsive disorder","volume":"81","author":"Kayser RR","year":"2020","unstructured":"Kayser RR. Pharmacotherapy for treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry. 2020, 81:10.4088\/JCP.19ac13182","journal-title":"J Clin Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/psychiatryint4030022","article-title":"Study of adverse drug reaction of anti-depressants in adult patients: a Nepalese perspective","volume":"4","author":"Shahi UB","year":"2023","unstructured":"Shahi UB, Acharya A, Timalsina S, Gautam A, Swain KC, Panthi S. Study of adverse drug reaction of anti-depressants in adult patients: a Nepalese perspective. Int J Psychiatry Med. 2023, 4:220-34. 10.3390\/psychiatryint4030022","journal-title":"Int J Psychiatry Med"},{"key":"ref23","unstructured":"Biorender. (2025). Accessed. March 19, 2025: https:\/\/www.biorender.com\/."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2020.32.131-134","article-title":"Assessment of the antidepressant side effects occurrence in patients treated in primary care","volume":"32","author":"Ramic E","year":"2020","unstructured":"Ramic E, Prasko S, Gavran L, Spahic E. Assessment of the antidepressant side effects occurrence in patients treated in primary care. Mater Sociomed. 2020, 32:131-4. 10.5455\/msm.2020.32.131-134","journal-title":"Mater Sociomed"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.061960","article-title":"Adverse reactions to antidepressants","volume":"195","author":"Uher R","year":"2009","unstructured":"Uher R, Farmer A, Henigsberg N, et al.. Adverse reactions to antidepressants. Br J Psychiatry. 2009, 195:202-10. 10.1192\/bjp.bp.108.061960","journal-title":"Br J Psychiatry"},{"key":"ref26","article-title":"Adaptation and validation of the Bangla version of the Yale-Brown Obsessive-Compulsive Scale","volume":"7","author":"Islam M","year":"2021","unstructured":"Islam M, Nahar JS, Mullick MS, Algin S, Chowdhury NS. Adaptation and validation of the Bangla version of the Yale-Brown Obsessive-Compulsive Scale. Int J Ment Health Psychiatr. 2021, 7:1000201.","journal-title":"Int J Ment Health Psychiatr"},{"key":"ref27","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner J","year":"2007","unstructured":"Busner J, Targum SD. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont). 2007, 4:28-37.","journal-title":"Psychiatry (Edgmont)"},{"key":"ref28","unstructured":"Bangladesh country profile. (2016). Accessed. March 22, 2025: https:\/\/data.worldbank.org\/country\/bangladesh."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280455","article-title":"Post-intervention acceptability of multicomponent intervention for management of hypertension in rural Bangladesh, Pakistan, and Sri Lanka- a qualitative study","volume":"18","author":"Jafar TH","year":"2023","unstructured":"Jafar TH, Tavajoh S, de Silva HA, et al.. Post-intervention acceptability of multicomponent intervention for management of hypertension in rural Bangladesh, Pakistan, and Sri Lanka- a qualitative study. PLoS ONE. 2023, 18:e0280455. 10.1371\/journal.pone.0280455","journal-title":"PLoS ONE"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33927","article-title":"Exploring the barriers to feminine healthcare access among marginalized women in Bangladesh and facilitating access through a voice bot","volume":"10","author":"Puja SS","year":"2024","unstructured":"Puja SS, Neha NN, Alif OR, Sultan TJ, Husna MG, Jahan I, Noor J. Exploring the barriers to feminine healthcare access among marginalized women in Bangladesh and facilitating access through a voice bot. Heliyon. 2024, 10:e33927. 10.1016\/j.heliyon.2024.e33927","journal-title":"Heliyon"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-020-1274-3","article-title":"Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis","volume":"9","author":"Semahegn A","year":"2020","unstructured":"Semahegn A, Torpey K, Manu A, Assefa N, Tesfaye G, Ankomah A. Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis. Syst Rev. 2020, 9:17. 10.1186\/s13643-020-1274-3","journal-title":"Syst Rev"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.75","article-title":"Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations","volume":"9","author":"Stanger O","year":"2009","unstructured":"Stanger O, Fowler B, Piertzik K, et al.. Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations. Expert Rev Neurother. 2009, 9:1393-412. 10.1586\/ern.09.75","journal-title":"Expert Rev Neurother"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2022.01.001","article-title":"Neuropsychiatric manifestations in vitamin B12 deficiency","volume":"119","author":"Sahu P","year":"2022","unstructured":"Sahu P, Thippeswamy H, Chaturvedi SK. Neuropsychiatric manifestations in vitamin B12 deficiency. Vitam Horm. 2022, 119:457-70. 10.1016\/bs.vh.2022.01.001","journal-title":"Vitam Horm"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10112741","article-title":"Homocysteine, cognitive functions, and degenerative dementias: state of the art","volume":"10","author":"Luzzi S","year":"2022","unstructured":"Luzzi S, Cherubini V, Falsetti L, Viticchi G, Silvestrini M, Toraldo A. Homocysteine, cognitive functions, and degenerative dementias: state of the art. Biomedicines. 2022, 10:2741. 10.3390\/biomedicines10112741","journal-title":"Biomedicines"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/psyrad\/kkad025","article-title":"Insight in obsessive-compulsive disorder: conception, clinical characteristics, neuroimaging, and treatment","volume":"3","author":"Huang Y","year":"2023","unstructured":"Huang Y, Weng Y, Lan L, Zhu C, Shen T, Tang W, Lai HY. Insight in obsessive-compulsive disorder: conception, clinical characteristics, neuroimaging, and treatment. Psychoradiology. 2023, 3:kkad025. 10.1093\/psyrad\/kkad025","journal-title":"Psychoradiology"},{"key":"ref36","article-title":"Role of vitamin B12 and folic acid in obsessive-compulsive disorder: review article","volume":"92","author":"Hussein MH","year":"2023","unstructured":"Hussein MH, Gado OM, Fouad AA, Khalil YA. Role of vitamin B12 and folic acid in obsessive-compulsive disorder: review article. Egyptian J Hosp Med. 2023, 92:6158-62.","journal-title":"Egyptian J Hosp Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/355317-evaluating-treatment-outcomes-of-vitamin-b12-and-folic-acid-supplementation-in-obsessive-compulsive-disorder-patients-with-deficiencies-a-comparative-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T09:54:48Z","timestamp":1744883688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/355317-evaluating-treatment-outcomes-of-vitamin-b12-and-folic-acid-supplementation-in-obsessive-compulsive-disorder-patients-with-deficiencies-a-comparative-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":36,"URL":"https:\/\/doi.org\/10.7759\/cureus.82420","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}