{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:20:10Z","timestamp":1769278810068,"version":"3.49.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,17]]},"DOI":"10.7759\/cureus.82432","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:54:46Z","timestamp":1744890886000},"source":"Crossref","is-referenced-by-count":5,"title":["3D Bioprinting: Shaping the Future of Periodontal Tissue Regeneration and Disease Management"],"prefix":"10.7759","author":[{"given":"Jahnavi  R","family":"Acharya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav  A","family":"Girdhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirishkumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirav H","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiren  H","family":"Patadiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali Narsinhbhai","family":"Zinjala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mainul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.971223","article-title":"Your health is in your mouth: a comprehensive view to promote general wellness","volume":"3","author":"Barranca-Enr\u00edquez A","year":"2022","unstructured":"Barranca-Enr\u00edquez A, Romo-Gonz\u00e1lez T. Your health is in your mouth: a comprehensive view to promote general wellness. Front Oral Health. 2022, 3:971223. 10.3389\/froh.2022.971223","journal-title":"Front Oral Health"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.4103\/aihb.aihb_3_24","article-title":"Evaluation of salivary parameters and oral health status in periodontally healthy subjects and chronic periodontitis subjects","volume":"14","author":"Kurien VT","year":"2024","unstructured":"Kurien VT, Shanker RK, Hegde S, Onisha V, Pillai SA. Evaluation of salivary parameters and oral health status in periodontally healthy subjects and chronic periodontitis subjects. Adv Hum Biol. 2024, 14:203-9.","journal-title":"Adv Hum Biol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.58667","article-title":"The interplay between diabetes and oral health: a comprehensive bibliometric analysis of clinical trials (1967-2024)","volume":"16","author":"Dagli N","year":"2024","unstructured":"Dagli N, Haque M, Kumar S. The interplay between diabetes and oral health: a comprehensive bibliometric analysis of clinical trials (1967-2024). Cureus. 2024, 16:e58667. 10.7759\/cureus.58667","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10010071","article-title":"Materials for dentoalveolar bioprinting: current state of the art","volume":"10","author":"Amoli MS","year":"2022","unstructured":"Amoli MS, EzEldeen M, Jacobs R, Bloemen V. Materials for dentoalveolar bioprinting: current state of the art. Biomedicines. 2022, 10:71. 10.3390\/biomedicines10010071","journal-title":"Biomedicines"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.991821","article-title":"Bioprinting and biomaterials for dental alveolar tissue regeneration","volume":"11","author":"Ostrovidov S","year":"2023","unstructured":"Ostrovidov S, Ramalingam M, Bae H, Orive G, Fujie T, Shi X, Kaji H. Bioprinting and biomaterials for dental alveolar tissue regeneration. Front Bioeng Biotechnol. 2023, 11:991821. 10.3389\/fbioe.2023.991821","journal-title":"Front Bioeng Biotechnol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-019-00502-5","article-title":"Three-dimensional ultrastructural imaging and quantitative analysis of the periodontal ligament","volume":"95","author":"Hirashima S","year":"2020","unstructured":"Hirashima S, Kanazawa T, Ohta K, Nakamura KI. Three-dimensional ultrastructural imaging and quantitative analysis of the periodontal ligament. Anat Sci Int. 2020, 95:1-11. 10.1007\/s12565-019-00502-5","journal-title":"Anat Sci Int"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.4103\/aihb.aihb_150_23","article-title":"Revitalising dentin surfaces: unlocking periodontal regeneration potential through cutting-edge citric acid techniques","volume":"14","author":"Pujara MJ","year":"2024","unstructured":"Pujara MJ, Gupta SS, Patel VI, Pujara JA. Revitalising dentin surfaces: unlocking periodontal regeneration potential through cutting-edge citric acid techniques. Adv Hum Biol. 2024, 14:196-202.","journal-title":"Adv Hum Biol"},{"key":"ref8","article-title":"Effect of cryopreservation on the structural and functional integrity of human periodontal ligament stem cells: a systematic review","volume":"9","author":"Pandya Rk","year":"2019","unstructured":"Pandya Rk, Shah M, Shroff Y, Vyas M. Effect of cryopreservation on the structural and functional integrity of human periodontal ligament stem cells: a systematic review. Adv Hum Biol. 2019, 9:21-7.","journal-title":"Adv Hum Biol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.62270","article-title":"Alcohol and periodontal disease: a narrative review","volume":"16","author":"Gandhi UH","year":"2024","unstructured":"Gandhi UH, Benjamin A, Gajjar S, et al.. Alcohol and periodontal disease: a narrative review. Cureus. 2024, 16:e62270. 10.7759\/cureus.62270","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti MS","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018, 89:S159-72. 10.1002\/JPER.18-0006","journal-title":"J Periodontol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-04003-9","article-title":"Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application","volume":"15","author":"Wen S","year":"2024","unstructured":"Wen S, Zheng X, Yin W, et al.. Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application. Stem Cell Res Ther. 2024, 15:389. 10.1186\/s13287-024-04003-9","journal-title":"Stem Cell Res Ther"},{"key":"ref12","article-title":"Tissue engineering in maxillary bone defects","volume":"7","author":"Khodakaram-Tafti A","year":"2018","unstructured":"Khodakaram-Tafti A, Mehrabani D, Shaterzadeh-Yazdi H, Zamiri B, Omidi M. Tissue engineering in maxillary bone defects. World J Plast Surg. 2018, 7:3-11.","journal-title":"World J Plast Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.09.005","article-title":"Mechanism of alveolar bone destruction in periodontitis - periodontal bacteria and inflammation","volume":"57","author":"Usui M","year":"2021","unstructured":"Usui M, Onizuka S, Sato T, Kokabu S, Ariyoshi W, Nakashima K. Mechanism of alveolar bone destruction in periodontitis - periodontal bacteria and inflammation. Jpn Dent Sci Rev. 2021, 57:201-8. 10.1016\/j.jdsr.2021.09.005","journal-title":"Jpn Dent Sci Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-024-00325-9","article-title":"Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches","volume":"16","author":"Ge J","year":"2024","unstructured":"Ge J, Zhu X, Weng C, et al.. Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches. Int J Oral Sci. 2024, 16:58. 10.1038\/s41368-024-00325-9","journal-title":"Int J Oral Sci"},{"key":"ref15","unstructured":"BioRender. (2025). Accessed. March 11, 2025: https:\/\/app.biorender.com\/."},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.4103\/aihb.aihb_32_21","article-title":"Assessment of alveolar bone loss at mandibular first molar on panoramic radiographs","volume":"11","author":"Mhatre A","year":"2021","unstructured":"Mhatre A, Shetty D, Shetty A, Dharmadhikari S, Wadkar P. Assessment of alveolar bone loss at mandibular first molar on panoramic radiographs. Adv Hum Biol. 2021, 11:S85-9.","journal-title":"Adv Hum Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13337","article-title":"Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: the Global Burden of Disease 2021 study","volume":"59","author":"Nascimento GG","year":"2024","unstructured":"Nascimento GG, Alves-Costa S, Romandini M. Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: the Global Burden of Disease 2021 study. J Periodontal Res. 2024, 59:823-67. 10.1111\/jre.13337","journal-title":"J Periodontal Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwz054","article-title":"The controlled direct effect of early-life socioeconomic position on periodontitis in a birth cohort","volume":"188","author":"Schuch HS","year":"2019","unstructured":"Schuch HS, Nascimento GG, Peres KG, et al.. The controlled direct effect of early-life socioeconomic position on periodontitis in a birth cohort. Am J Epidemiol. 2019, 188:1101-8. 10.1093\/aje\/kwz054","journal-title":"Am J Epidemiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/02537176221123221","article-title":"Tobacco industry and surrogate advertising in South East Asia region: moves and countermoves","volume":"45","author":"Bhatia G","year":"2022","unstructured":"Bhatia G, Sarkar S. Tobacco industry and surrogate advertising in South East Asia region: moves and countermoves. Indian J Psychol Med. 2022, 45:185-8. 10.1177\/02537176221123221","journal-title":"Indian J Psychol Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12820","article-title":"Betel and tobacco chewing habit and its relation to risk factors for periodontal disease","volume":"24","author":"Giovannoni ML","year":"2018","unstructured":"Giovannoni ML, Valdivia-Gandur I, Lozano de Luaces V, Varela V\u00e9liz H, Balasubbaiah Y, Chimenos-K\u00fcstner E. Betel and tobacco chewing habit and its relation to risk factors for periodontal disease. Oral Dis. 2018, 24:829-39. 10.1111\/odi.12820","journal-title":"Oral Dis"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.4103\/2321-8568.190318","article-title":"Harvesting mesenchymal stem cells for dental tissue regeneration","volume":"6","author":"Kathiriya D","year":"2016","unstructured":"Kathiriya D, Murali R, Krishna M, Kakkad K, Thakkar PA. Harvesting mesenchymal stem cells for dental tissue regeneration. Adv Hum Biol. 2016, 6:73-5.","journal-title":"Adv Hum Biol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.75618","article-title":"Evaluation of biomaterials in periodontal regeneration: a literature review","volume":"16","author":"Pranathi V","year":"2024","unstructured":"Pranathi V, Koduganti RR, Muthyala S, Kanchanapally SP, Muthyala N, Shingade V. Evaluation of biomaterials in periodontal regeneration: a literature review. Cureus. 2024, 16:e75618. 10.7759\/cureus.75618","journal-title":"Cureus"},{"key":"ref23","article-title":"The efficacy of ozonated water in one-stage full-mouth disinfection amongst chronic periodontitis patients: a randomized control trial","author":"Jayasri S","year":"2024","unstructured":"Jayasri S, Bakkeer SH, Elangovan GP, Vivekanandan G, Surya D, Saranya S. The efficacy of ozonated water in one-stage full-mouth disinfection amongst chronic periodontitis patients: a randomized control trial. Adv Hum Biol. 2024,","journal-title":"Adv Hum Biol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.07.004","article-title":"3D bioprinting of tissues and organs for regenerative medicine","volume":"132","author":"Vijayavenkataraman S","year":"2018","unstructured":"Vijayavenkataraman S, Yan WC, Lu WF, Wang CH, Fuh JY. 3D bioprinting of tissues and organs for regenerative medicine. Adv Drug Deliv Rev. 2018, 132:296-332. 10.1016\/j.addr.2018.07.004","journal-title":"Adv Drug Deliv Rev"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14100530","article-title":"Advancing dentistry through bioprinting: personalization of oral tissues","volume":"14","author":"Shopova D","year":"2023","unstructured":"Shopova D, Mihaylova A, Yaneva A, Bakova D. Advancing dentistry through bioprinting: personalization of oral tissues. J Funct Biomater. 2023, 14:530. 10.3390\/jfb14100530","journal-title":"J Funct Biomater"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics9080480","article-title":"3D bioprinting techniques and bioinks for periodontal tissues regeneration-a literature review","volume":"9","author":"Almeida ND","year":"2024","unstructured":"Almeida ND, Carneiro CA, de Marco AC, Porto VC, Fran\u00e7a R. 3D bioprinting techniques and bioinks for periodontal tissues regeneration-a literature review. Biomimetics (Basel). 2024, 9:480. 10.3390\/biomimetics9080480","journal-title":"Biomimetics (Basel)"},{"key":"ref27","doi-asserted-by":"crossref","DOI":"10.4103\/aihb.aihb_26_24","article-title":"Four-dimensional printing: an evolution in making","volume":"14","author":"Verma A","year":"2024","unstructured":"Verma A, Prasad DK. Four-dimensional printing: an evolution in making. Adv Hum Biol. 2024, 14:177-81.","journal-title":"Adv Hum Biol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1356580","article-title":"The 3-dimensional printing for dental tissue regeneration: the state of the art and future challenges","volume":"12","author":"Zhao F","year":"2024","unstructured":"Zhao F, Zhang Z, Guo W. The 3-dimensional printing for dental tissue regeneration: the state of the art and future challenges. Front Bioeng Biotechnol. 2024, 12:1356580. 10.3389\/fbioe.2024.1356580","journal-title":"Front Bioeng Biotechnol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12090902","article-title":"3D printed and bioprinted membranes and scaffolds for the periodontal tissue regeneration: a narrative review","volume":"12","author":"Sufaru IG","year":"2022","unstructured":"Sufaru IG, Macovei G, Stoleriu S, Martu MA, Luchian I, Kappenberg-Nitescu DC, Solomon SM. 3D printed and bioprinted membranes and scaffolds for the periodontal tissue regeneration: a narrative review. Membranes (Basel). 2022, 12:902. 10.3390\/membranes12090902","journal-title":"Membranes (Basel)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_46_19","article-title":"Role of three-dimensional printing in periodontal regeneration and repair: literature review","volume":"23","author":"Gul M","year":"2019","unstructured":"Gul M, Arif A, Ghafoor R. Role of three-dimensional printing in periodontal regeneration and repair: literature review. J Indian Soc Periodontol. 2019, 23:504-10. 10.4103\/jisp.jisp_46_19","journal-title":"J Indian Soc Periodontol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020416","article-title":"A review of 3D printing technology in pharmaceutics: technology and applications, now and future","volume":"15","author":"Wang S","year":"2023","unstructured":"Wang S, Chen X, Han X, et al.. A review of 3D printing technology in pharmaceutics: technology and applications, now and future. Pharmaceutics. 2023, 15:416. 10.3390\/pharmaceutics15020416","journal-title":"Pharmaceutics"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/ph14040362","article-title":"3D bioprinting of functional skin substitutes: from current achievements to future goals","volume":"14","author":"Manita PG","year":"2021","unstructured":"Manita PG, Garcia-Orue I, Santos-Vizcaino E, Hernandez RM, Igartua M. 3D bioprinting of functional skin substitutes: from current achievements to future goals. Pharmaceuticals (Basel). 2021, 14:362. 10.3390\/ph14040362","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1567489","article-title":"Inkjet dispensing technologies: recent advances for novel drug discovery","volume":"14","author":"Machekposhti SA","year":"2019","unstructured":"Machekposhti SA, Mohaved S, Narayan RJ. Inkjet dispensing technologies: recent advances for novel drug discovery. Expert Opin Drug Discov. 2019, 14:101-13. 10.1080\/17460441.2019.1567489","journal-title":"Expert Opin Drug Discov"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.194","article-title":"3D bioprinting and its innovative approach for biomedical applications","volume":"4","author":"Tripathi S","year":"2023","unstructured":"Tripathi S, Mandal SS, Bauri S, Maiti P. 3D bioprinting and its innovative approach for biomedical applications. MedComm (2020). 2023, 4:e194. 10.1002\/mco2.194","journal-title":"MedComm (2020)"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-023-01881-y","article-title":"3D printing approaches to engineer cardiac tissue","volume":"25","author":"Lu TY","year":"2023","unstructured":"Lu TY, Xiang Y, Tang M, Chen S. 3D printing approaches to engineer cardiac tissue. Curr Cardiol Rep. 2023, 25:505-14. 10.1007\/s11886-023-01881-y","journal-title":"Curr Cardiol Rep"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1255782","article-title":"Laser-induced forward transfer based laser bioprinting in biomedical applications","volume":"11","author":"Chang J","year":"2023","unstructured":"Chang J, Sun X. Laser-induced forward transfer based laser bioprinting in biomedical applications. Front Bioeng Biotechnol. 2023, 11:1255782. 10.3389\/fbioe.2023.1255782","journal-title":"Front Bioeng Biotechnol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076357","article-title":"3D bioprinting for next-generation personalized medicine","volume":"24","author":"Lam EH","year":"2023","unstructured":"Lam EH, Yu F, Zhu S, Wang Z. 3D bioprinting for next-generation personalized medicine. Int J Mol Sci. 2023, 24:6357. 10.3390\/ijms24076357","journal-title":"Int J Mol Sci"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/polym12081717","article-title":"3D bioprinting in tissue engineering for medical applications: the classic and the hybrid","volume":"12","author":"Xie Z","year":"2020","unstructured":"Xie Z, Gao M, Lobo AO, Webster TJ. 3D bioprinting in tissue engineering for medical applications: the classic and the hybrid. Polymers (Basel). 2020, 12:1717. 10.3390\/polym12081717","journal-title":"Polymers (Basel)"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201901044","article-title":"Extrusion and microfluidic-based bioprinting to fabricate biomimetic tissues and organs","volume":"5","author":"Davoodi E","year":"2020","unstructured":"Davoodi E, Sarikhani E, Montazerian H, et al.. Extrusion and microfluidic-based bioprinting to fabricate biomimetic tissues and organs. Adv Mater Technol. 2020, 5:1901044. 10.1002\/admt.201901044","journal-title":"Adv Mater Technol"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab6f0d","article-title":"Assessment methodologies for extrusion-based bioink printability","volume":"12","author":"Gillispie G","year":"2020","unstructured":"Gillispie G, Prim P, Copus J, et al.. Assessment methodologies for extrusion-based bioink printability. Biofabrication. 2020, 12:022003. 10.1088\/1758-5090\/ab6f0d","journal-title":"Biofabrication"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2021.02.001","article-title":"Printability-a key issue in extrusion-based bioprinting","volume":"11","author":"Naghieh S","year":"2021","unstructured":"Naghieh S, Chen X. Printability-a key issue in extrusion-based bioprinting. J Pharm Anal. 2021, 11:564-79. 10.1016\/j.jpha.2021.02.001","journal-title":"J Pharm Anal"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2024.112853","article-title":"Advancements in tissue and organ 3D bioprinting: current techniques, applications, and future perspectives","volume":"240","author":"Mirshafiei M","year":"2024","unstructured":"Mirshafiei M, Rashedi H, Yazdian F, Rahdar A, Baino F. Advancements in tissue and organ 3D bioprinting: current techniques, applications, and future perspectives. Mater Des. 2024, 240:112853.","journal-title":"Mater Des"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902026","article-title":"Hydrogel bioink reinforcement for additive manufacturing: a focused review of emerging strategies","volume":"32","author":"Chimene D","year":"2020","unstructured":"Chimene D, Kaunas R, Gaharwar AK. Hydrogel bioink reinforcement for additive manufacturing: a focused review of emerging strategies. Adv Mater. 2020, 32:1902026. 10.1002\/adma.201902026","journal-title":"Adv Mater"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.18063\/ijb.759","article-title":"Hydrogels for 3D bioprinting in tissue engineering and regenerative medicine: current progress and challenges","volume":"9","author":"Fang W","year":"2023","unstructured":"Fang W, Yang M, Wang L, et al.. Hydrogels for 3D bioprinting in tissue engineering and regenerative medicine: current progress and challenges. Int J Bioprint. 2023, 9:759. 10.18063\/ijb.759","journal-title":"Int J Bioprint"},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.3389\/fmech.2020.589171","article-title":"Current developments in 3D bioprinting for tissue and organ regeneration-a review","volume":"6","author":"Agarwal S","year":"2020","unstructured":"Agarwal S, Saha S, Balla VK, Pal A, Barui A, Bodhak S. Current developments in 3D bioprinting for tissue and organ regeneration-a review. Front Mech Eng. 2020, 6:","journal-title":"Front Mech Eng"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3390\/gels8030179","article-title":"Natural hydrogel-based bio-inks for 3D bioprinting in tissue engineering: a review","volume":"8","author":"Fatimi A","year":"2022","unstructured":"Fatimi A, Okoro OV, Podstawczyk D, Siminska-Stanny J, Shavandi A. Natural hydrogel-based bio-inks for 3D bioprinting in tissue engineering: a review. Gels. 2022, 8:179. 10.3390\/gels8030179","journal-title":"Gels"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083971","article-title":"3D bioprinting of human tissues: biofabrication, bioinks, and bioreactors","volume":"22","author":"Zhang J","year":"2021","unstructured":"Zhang J, Wehrle E, Rubert M, M\u00fcller R. 3D bioprinting of human tissues: biofabrication, bioinks, and bioreactors. Int J Mol Sci. 2021, 22:3971. 10.3390\/ijms22083971","journal-title":"Int J Mol Sci"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1039\/c8lc01037d","article-title":"Effective bioprinting resolution in tissue model fabrication","volume":"19","author":"Miri AK","year":"2019","unstructured":"Miri AK, Mirzaee I, Hassan S, Mesbah Oskui S, Nieto D, Khademhosseini A, Zhang YS. Effective bioprinting resolution in tissue model fabrication. Lab Chip. 2019, 19:2019-37. 10.1039\/c8lc01037d","journal-title":"Lab Chip"},{"key":"ref49","article-title":"Injectable and 3D-printed hydrogels: state-of-the-art platform for bone regeneration in dentistry","volume":"161","author":"Budi HS","year":"2024","unstructured":"Budi HS, Jameel Al-azzawi MF, Al-Dolaimy F, et al.. Injectable and 3D-printed hydrogels: state-of-the-art platform for bone regeneration in dentistry. Inorg Chem Commun. 2024, 161:112026.","journal-title":"Inorg Chem Commun"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.JPBS_691_20","article-title":"Evaluation of bone regeneration around implants with and without flap elevation","volume":"13","author":"Sinha S","year":"2021","unstructured":"Sinha S, Kumar S, Sonoo PR, Kumar U, Siddhartha R, Singh SK. Evaluation of bone regeneration around implants with and without flap elevation. J Pharm Bioallied Sci. 2021, 13:S699-705. 10.4103\/jpbs.JPBS_691_20","journal-title":"J Pharm Bioallied Sci"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.4103\/aihb.aihb_195_24","article-title":"A cutting-edge innovation: europium-doped monetite-infused carrageenan - hyaluronic acid membrane enhances soft-tissue regeneration","author":"Prenetha R","year":"2025","unstructured":"Prenetha R, Suresh N, Gurumoorthy K, Sivalingam C, Rakshagan V. A cutting-edge innovation: europium-doped monetite-infused carrageenan - hyaluronic acid membrane enhances soft-tissue regeneration. Adv Hum Biol. 2025,","journal-title":"Adv Hum Biol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.664188","article-title":"3D bioprinting of vascularized tissues for in vitro and in vivo applications","volume":"9","author":"Chen EP","year":"2021","unstructured":"Chen EP, Toksoy Z, Davis BA, Geibel JP. 3D bioprinting of vascularized tissues for in vitro and in vivo applications. Front Bioeng Biotechnol. 2021, 9:664188. 10.3389\/fbioe.2021.664188","journal-title":"Front Bioeng Biotechnol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1177\/20417314241308022","article-title":"Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges","volume":"16","author":"Mathur V","year":"2025","unstructured":"Mathur V, Agarwal P, Kasturi M, Srinivasan V, Seetharam RN, Vasanthan KS. Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges. J Tissue Eng. 2025, 16:20417314241308022. 10.1177\/20417314241308022","journal-title":"J Tissue Eng"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02759-z","article-title":"Beyond hype: unveiling the real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids","volume":"22","author":"Zhao X","year":"2024","unstructured":"Zhao X, Li N, Zhang Z, et al.. Beyond hype: unveiling the real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids. J Nanobiotechnology. 2024, 22:500. 10.1186\/s12951-024-02759-z","journal-title":"J Nanobiotechnology"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37528-0","article-title":"Periodontal regeneration by allogeneic transplantation of adipose tissue derived multi-lineage progenitor stem cells in vivo","volume":"9","author":"Venkataiah VS","year":"2019","unstructured":"Venkataiah VS, Handa K, Njuguna MM, et al.. Periodontal regeneration by allogeneic transplantation of adipose tissue derived multi-lineage progenitor stem cells in vivo. Sci Rep. 2019, 9:921. 10.1038\/s41598-018-37528-0","journal-title":"Sci Rep"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36981","article-title":"Three-dimensional printing of extracellular matrix (ECM)-mimicking scaffolds: a critical review of the current ECM materials","volume":"108","author":"Da Silva K","year":"2020","unstructured":"Da Silva K, Kumar P, Choonara YE, du Toit LC, Pillay V. Three-dimensional printing of extracellular matrix (ECM)-mimicking scaffolds: a critical review of the current ECM materials. J Biomed Mater Res A. 2020, 108:2324-50. 10.1002\/jbm.a.36981","journal-title":"J Biomed Mater Res A"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra02082f","article-title":"Three-dimensional cell printing of gingival fibroblast\/acellular dermal matrix\/gelatin-sodium alginate scaffolds and their biocompatibility evaluation in vitro","volume":"10","author":"Liu P","year":"2020","unstructured":"Liu P, Li Q, Yang Q, Zhang S, Lin C, Zhang G, Tang Z. Three-dimensional cell printing of gingival fibroblast\/acellular dermal matrix\/gelatin-sodium alginate scaffolds and their biocompatibility evaluation in vitro. RSC Adv. 2020, 10:15926-35. 10.1039\/d0ra02082f","journal-title":"RSC Adv"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071062","article-title":"3D bioprinting of a bioactive composite scaffold for cell delivery in periodontal tissue regeneration","volume":"13","author":"Miao G","year":"2023","unstructured":"Miao G, Liang L, Li W, et al.. 3D bioprinting of a bioactive composite scaffold for cell delivery in periodontal tissue regeneration. Biomolecules. 2023, 13:1062. 10.3390\/biom13071062","journal-title":"Biomolecules"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612881","article-title":"In vitro and in vivo biological assessments of 3D-bioprinted scaffolds for dental applications","volume":"24","author":"Mohd N","year":"2023","unstructured":"Mohd N, Razali M, Fauzi MB, Abu Kasim NH. In vitro and in vivo biological assessments of 3D-bioprinted scaffolds for dental applications. Int J Mol Sci. 2023, 24:12881. 10.3390\/ijms241612881","journal-title":"Int J Mol Sci"},{"key":"ref60","article-title":"Comparative evaluation of remineralising efficacy of bioactive glass agent and nano-hydroxyapatite dentifrices on artificial carious lesion in primary teeth: an in vitro study","volume":"10","author":"Khandelwal JR","year":"2020","unstructured":"Khandelwal JR, Bargale S, Dave BH, Poonacha K, Kariya PB, Vaidya S. Comparative evaluation of remineralising efficacy of bioactive glass agent and nano-hydroxyapatite dentifrices on artificial carious lesion in primary teeth: an in vitro study. Adv Hum Biol. 2020, 10:129-33.","journal-title":"Adv Hum Biol"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102661","article-title":"3D bioprinting of engineered tissue flaps with hierarchical vessel networks (VesselNet) for direct host-to-implant perfusion","volume":"33","author":"Szklanny AA","year":"2021","unstructured":"Szklanny AA, Machour M, Redenski I, et al.. 3D bioprinting of engineered tissue flaps with hierarchical vessel networks (VesselNet) for direct host-to-implant perfusion. Adv Mater. 2021, 33:2102661. 10.1002\/adma.202102661","journal-title":"Adv Mater"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/355043-3d-bioprinting-shaping-the-future-of-periodontal-tissue-regeneration-and-disease-management","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:54:49Z","timestamp":1744890889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/355043-3d-bioprinting-shaping-the-future-of-periodontal-tissue-regeneration-and-disease-management"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":61,"URL":"https:\/\/doi.org\/10.7759\/cureus.82432","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}