{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T13:40:10Z","timestamp":1745242810742,"version":"3.40.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,21]]},"DOI":"10.7759\/cureus.82690","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T13:01:41Z","timestamp":1745240501000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of Yoga on Gene Expression: A Systematic Review of Randomised Controlled Trials"],"prefix":"10.7759","author":[{"given":"Selvaraj","family":"Giridharan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soni","family":"Soumian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaraj V","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawaher","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Yoga. its origin, history and development. (2025). Accessed: March 1, 2025: https:\/\/rijmri.com\/wp-content\/uploads\/2023\/01\/Yoga.pdf."},{"key":"ref2","article-title":"The Path of Yoga: An Essential Guide to Its Principles and Practices","author":"Feuerstein G","year":"2011","unstructured":"Feuerstein G. The Path of Yoga: An Essential Guide to Its Principles and Practices. Shambhala Publications, 2011."},{"key":"ref3","article-title":"Swami vivekananda's concept of jnana yoga, raja yoga, karma yoga and bhakti yoga","volume":"13","author":"Yogeshwar G","year":"1994","unstructured":"Yogeshwar G. Swami vivekananda's concept of jnana yoga, raja yoga, karma yoga and bhakti yoga. Anc Sci Life. 1994, 13:261-5.","journal-title":"Anc Sci Life"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.695939","article-title":"The relationship between yoga and spirituality: a systematic review of empirical research","volume":"12","author":"Csala B","year":"2021","unstructured":"Csala B, Springinsfeld CM, K\u00f6teles F. The relationship between yoga and spirituality: a systematic review of empirical research. Front Psychol. 2021, 12:695939. 10.3389\/fpsyg.2021.695939","journal-title":"Front Psychol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14288\/hfjc.v3i2.54","article-title":"Why yoga? An introduction to philosophy, practice, and the role of yoga in health promotion and disease prevention","volume":"3","author":"Chapman K","year":"2011","unstructured":"Chapman K, Bredin S. Why yoga? An introduction to philosophy, practice, and the role of yoga in health promotion and disease prevention. Health Fit J Can. 2011, 3:54. 10.14288\/hfjc.v3i2.54","journal-title":"Health Fit J Can"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.17761\/ijyt.15.1.p501l33535230737","article-title":"The yoga of healing: exploring yoga's holistic model for health and well-being","volume":"15","author":"Desikachar K","year":"2005","unstructured":"Desikachar K, Bragdon L, Bossart C. The yoga of healing: exploring yoga's holistic model for health and well-being. Int J Yoga Ther. 2005, 15:17-39. 10.17761\/ijyt.15.1.p501l33535230737","journal-title":"Int J Yoga Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0334","article-title":"The effects of yoga on positive mental health among healthy adults: a systematic review and meta-analysis","volume":"23","author":"Hendriks T","year":"2017","unstructured":"Hendriks T, de Jong J, Cramer H. The effects of yoga on positive mental health among healthy adults: a systematic review and meta-analysis. J Altern Complement Med. 2017, 23:505-17. 10.1089\/acm.2016.0334","journal-title":"J Altern Complement Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1437902","article-title":"Effects of yoga on stress in stressed adults: a systematic review and meta-analysis","volume":"15","author":"Schleinzer A","year":"2024","unstructured":"Schleinzer A, Moosburner A, Anheyer D, Burgahn L, Cramer H. Effects of yoga on stress in stressed adults: a systematic review and meta-analysis. Front Psychiatry. 2024, 15:1437902. 10.3389\/fpsyt.2024.1437902","journal-title":"Front Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106497","article-title":"Yoga-based interventions may reduce anxiety symptoms in anxiety disorders and depression symptoms in depressive disorders: a systematic review with meta-analysis and meta-regression","volume":"57","author":"Mart\u00ednez-Calderon J","year":"2023","unstructured":"Mart\u00ednez-Calderon J, Casuso-Holgado MJ, Mu\u00f1oz-Fernandez MJ, Garcia-Mu\u00f1oz C, Heredia-Rizo AM. Yoga-based interventions may reduce anxiety symptoms in anxiety disorders and depression symptoms in depressive disorders: a systematic review with meta-analysis and meta-regression. Br J Sports Med. 2023, 57:1442-9. 10.1136\/bjsports-2022-106497","journal-title":"Br J Sports Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-1484","article-title":"Effects of yoga on health-related quality, physical health and psychological health in women with breast cancer receiving chemotherapy: a systematic review and meta-analysis","volume":"10","author":"Yi LJ","year":"2021","unstructured":"Yi LJ, Tian X, Jin YF, Luo MJ, Jim\u00e9nez-Herrera MF. Effects of yoga on health-related quality, physical health and psychological health in women with breast cancer receiving chemotherapy: a systematic review and meta-analysis. Ann Palliat Med. 2021, 10:1961-75. 10.21037\/apm-20-1484","journal-title":"Ann Palliat Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102643","article-title":"Yoga for secondary prevention of coronary heart disease: a systematic review and meta-analysis","volume":"57","author":"Li J","year":"2021","unstructured":"Li J, Gao X, Hao X, et al.. Yoga for secondary prevention of coronary heart disease: a systematic review and meta-analysis. Complement Ther Med. 2021, 57:102643. 10.1016\/j.ctim.2020.102643","journal-title":"Complement Ther Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000372","article-title":"Yoga in the management of chronic disease: a systematic review and meta-analysis","volume":"53","author":"Desveaux L","year":"2015","unstructured":"Desveaux L, Lee A, Goldstein R, Brooks D. Yoga in the management of chronic disease: a systematic review and meta-analysis. Med Care. 2015, 53:653-61. 10.1097\/MLR.0000000000000372","journal-title":"Med Care"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002416","article-title":"Yoga for treating low back pain: a systematic review and meta-analysis","volume":"163","author":"Anheyer D","year":"2022","unstructured":"Anheyer D, Haller H, Lauche R, Dobos G, Cramer H. Yoga for treating low back pain: a systematic review and meta-analysis. Pain. 2022, 163:e504-17. 10.1097\/j.pain.0000000000002416","journal-title":"Pain"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/ijoy.ijoy_141_23","article-title":"Beyond the Mat: exploring the potential clinical benefits of yoga on epigenetics and gene expression: a narrative review of the current scientific evidence","volume":"16","author":"Giridharan S","year":"2023","unstructured":"Giridharan S. Beyond the Mat: exploring the potential clinical benefits of yoga on epigenetics and gene expression: a narrative review of the current scientific evidence. Int J Yoga. 2023, 16:64-71. 10.4103\/ijoy.ijoy_141_23","journal-title":"Int J Yoga"},{"key":"ref15","article-title":"The effects of mindfulness-based therapies on epigenetic modifications and gene expression: a review","volume":"6","author":"Kumarage I","year":"2024","unstructured":"Kumarage I. The effects of mindfulness-based therapies on epigenetic modifications and gene expression: a review. Am J Multidiscip Res Dev. 2024, 6:41-54.","journal-title":"Am J Multidiscip Res Dev"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2012.10.002","article-title":"Regulation of gene expression by yoga, meditation and related practices: a review of recent studies","volume":"6","author":"Saatcioglu F","year":"2013","unstructured":"Saatcioglu F. Regulation of gene expression by yoga, meditation and related practices: a review of recent studies. Asian J Psychiatr. 2013, 6:74-7. 10.1016\/j.ajp.2012.10.002","journal-title":"Asian J Psychiatr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.01767","article-title":"Molecules of silence: effects of meditation on gene expression and epigenetics","volume":"11","author":"Venditti S","year":"2020","unstructured":"Venditti S, Verdone L, Reale A, Vetriani V, Caserta M, Zampieri M. Molecules of silence: effects of meditation on gene expression and epigenetics. Front Psychol. 2020, 11:1767. 10.3389\/fpsyg.2020.01767","journal-title":"Front Psychol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-75980-2_7","article-title":"Remodeling the epigenome through meditation: effects on brain, body, and well-being","author":"Venditti S","year":"2025","unstructured":"Venditti S. Remodeling the epigenome through meditation: effects on brain, body, and well-being. Neuroepigenetics Mechanisms in Health and Disease. van Zundert B, Montecino M (ed): Springer, Switzerland; 2025. 108:231-60. 10.1007\/978-3-031-75980-2_7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57541","article-title":"Effectiveness of yoga in modulating markers of immunity and inflammation: a systematic review and meta-analysis","volume":"16","author":"Mishra B","year":"2024","unstructured":"Mishra B, Agarwal A, George JA, et al.. Effectiveness of yoga in modulating markers of immunity and inflammation: a systematic review and meta-analysis. Cureus. 2024, 16:e57541. 10.7759\/cureus.57541","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-018-9914-y","article-title":"Yoga and immune system functioning: a systematic review of randomized controlled trials","volume":"41","author":"Falkenberg RI","year":"2018","unstructured":"Falkenberg RI, Eising C, Peters ML. Yoga and immune system functioning: a systematic review of randomized controlled trials. J Behav Med. 2018, 41:467-82. 10.1007\/s10865-018-9914-y","journal-title":"J Behav Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4365429","article-title":"Epigenetic mechanisms of integrative medicine","volume":"2017","author":"Kanherkar RR","year":"2017","unstructured":"Kanherkar RR, Stair SE, Bhatia-Dey N, Mills PJ, Chopra D, Csoka AB. Epigenetic mechanisms of integrative medicine. Evid Based Complement Alternat Med. 2017, 2017:4365429. 10.1155\/2017\/4365429","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01699-1","article-title":"The effects of meditation on length of telomeres in healthy individuals: a systematic review","volume":"10","author":"Dasanayaka NN","year":"2021","unstructured":"Dasanayaka NN, Sirisena ND, Samaranayake N. The effects of meditation on length of telomeres in healthy individuals: a systematic review. Syst Rev. 2021, 10:151. 10.1186\/s13643-021-01699-1","journal-title":"Syst Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2019.1707827","article-title":"Meditation and telomere length: a meta-analysis","volume":"35","author":"Schutte NS","year":"2020","unstructured":"Schutte NS, Malouff JM, Keng SL. Meditation and telomere length: a meta-analysis. Psychol Health. 2020, 35:901-15. 10.1080\/08870446.2019.1707827","journal-title":"Psychol Health"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00670","article-title":"What is the molecular signature of mind body interventions? A systematic review of gene expression changes induced by meditation and related practices","volume":"8","author":"Buric I","year":"2017","unstructured":"Buric I, Farias M, Jong J, Mee C, Brazil IA. What is the molecular signature of mind body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017, 8:670. 10.3389\/fimmu.2017.00670","journal-title":"Front Immunol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.234","article-title":"Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women","volume":"6","author":"Harkess KN","year":"2016","unstructured":"Harkess KN, Ryan J, Delfabbro PH, Cohen-Woods S. Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women. Transl Psychiatry. 2016, 6:e965. 10.1038\/tp.2016.234","journal-title":"Transl Psychiatry"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_3196_20","article-title":"HLA-G 3'UTR polymorphisms & response to a yoga-based lifestyle intervention in rheumatoid arthritis: a randomized controlled trial","volume":"155","author":"Gautam S","year":"2022","unstructured":"Gautam S, Kumar U, Mishra R, Dada R. HLA-G 3'UTR polymorphisms &amp; response to a yoga-based lifestyle intervention in rheumatoid arthritis: a randomized controlled trial. Indian J Med Res. 2022, 155:253-63. 10.4103\/ijmr.IJMR_3196_20","journal-title":"Indian J Med Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.164","article-title":"Meditation and vacation effects have an impact on disease-associated molecular phenotypes","volume":"6","author":"Epel ES","year":"2016","unstructured":"Epel ES, Puterman E, Lin J, et al.. Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl Psychiatry. 2016, 6:e880. 10.1038\/tp.2016.164","journal-title":"Transl Psychiatry"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.02259","article-title":"Effect of an 8-week yoga-based lifestyle intervention on psycho-neuro-immune axis, disease activity, and perceived quality of life in rheumatoid arthritis patients: a randomized controlled trial","volume":"11","author":"Gautam S","year":"2020","unstructured":"Gautam S, Kumar M, Kumar U, Dada R. Effect of an 8-week yoga-based lifestyle intervention on psycho-neuro-immune axis, disease activity, and perceived quality of life in rheumatoid arthritis patients: a randomized controlled trial. Front Psychol. 2020, 11:2259. 10.3389\/fpsyg.2020.02259","journal-title":"Front Psychol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.03.004","article-title":"Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: a randomized controlled trial","volume":"58","author":"Gautam S","year":"2021","unstructured":"Gautam S, Kumar U, Kumar M, Rana D, Dada R. Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: a randomized controlled trial. Mitochondrion. 2021, 58:147-59. 10.1016\/j.mito.2021.03.004","journal-title":"Mitochondrion"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42231-w","article-title":"Yoga maintains Th17\/Treg cell homeostasis and reduces the rate of T cell aging in rheumatoid arthritis: a randomized controlled trial","volume":"13","author":"Gautam S","year":"2023","unstructured":"Gautam S, Kumar R, Kumar U, Kumar S, Luthra K, Dada R. Yoga maintains Th17\/Treg cell homeostasis and reduces the rate of T cell aging in rheumatoid arthritis: a randomized controlled trial. Sci Rep. 2023, 13:14924. 10.1038\/s41598-023-42231-w","journal-title":"Sci Rep"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.5812\/jcma-146528","article-title":"Modulation of microRNA-133B in post mastectomy pain syndrome following yoga intervention","volume":"9","author":"Saxena AK","year":"2024","unstructured":"Saxena AK, Gondode P, Chilkoti GT, Sharma T, Banerjee BD. Modulation of microRNA-133B in post mastectomy pain syndrome following yoga intervention. J Cell Mol Anesth. 2024, 9:e146528. 10.5812\/jcma-146528","journal-title":"J Cell Mol Anesth"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/abm\/kaab043","article-title":"Role of yoga and its plausible mechanism in the mitigation of DNA damage in type-2 diabetes: a randomized clinical trial","volume":"56","author":"Nair RG","year":"2022","unstructured":"Nair RG, Vasudev MM, Mavathur R. Role of yoga and its plausible mechanism in the mitigation of DNA damage in type-2 diabetes: a randomized clinical trial. Ann Behav Med. 2022, 56:235-44. 10.1093\/abm\/kaab043","journal-title":"Ann Behav Med"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.898293","article-title":"Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: a randomized controlled trial","volume":"9","author":"Sharma P","year":"2022","unstructured":"Sharma P, Yadav RK, Khadgawat R, Dada R. Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: a randomized controlled trial. Front Med (Lausanne). 2022, 9:898293. 10.3389\/fmed.2022.898293","journal-title":"Front Med (Lausanne)"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02807-0","article-title":"Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer's disease","volume":"14","author":"Grzenda A","year":"2024","unstructured":"Grzenda A, Siddarth P, Milillo MM, Aguilar-Faustino Y, Khalsa DS, Lavretsky H. Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer's disease. Transl Psychiatry. 2024, 14:96. 10.1038\/s41398-024-02807-0","journal-title":"Transl Psychiatry"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015574","article-title":"Brain education-based meditation for patients with hypertension and\/or type 2 diabetes: a pilot randomized controlled trial","volume":"98","author":"Lee SH","year":"2019","unstructured":"Lee SH, Hwang SM, Kang DH, Yang HJ. Brain education-based meditation for patients with hypertension and\/or type 2 diabetes: a pilot randomized controlled trial. Medicine (Baltimore). 2019, 98:e15574. 10.1097\/MD.0000000000015574","journal-title":"Medicine (Baltimore)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/356812-effects-of-yoga-on-gene-expression-a-systematic-review-of-randomised-controlled-trials","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T13:01:43Z","timestamp":1745240503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/356812-effects-of-yoga-on-gene-expression-a-systematic-review-of-randomised-controlled-trials"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":37,"URL":"https:\/\/doi.org\/10.7759\/cureus.82690","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,21]]}}}